Motif ID: TBP.p2

Z-value: 3.495


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBPchr6_+_170705345-0.638.4e-03Click!


Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_151052391 11.064 NM_005168
 RND3
Rho family GTPase 3
chr16_+_55217085 10.697 NM_175617
 MT1E
metallothionein 1E
chr16_+_55217180 10.352 MT1E
metallothionein 1E
chr17_-_37034288 10.261 NM_000422
 KRT17
keratin 17
chr1_-_151630168 9.883 NM_002964
 S100A8
S100 calcium binding protein A8
chr1_+_151270301 9.791 NM_003125
 SPRR1B
small proline-rich protein 1B
chr21_-_27139143 9.477 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr10_+_53744043 9.261 NM_012242
 DKK1
dickkopf homolog 1 (Xenopus laevis)
chr16_+_55243311 9.253 NM_005947
 MT1B
metallothionein 1B
chr21_-_27139563 9.155 NM_006988
 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_-_51173238 8.914 NM_005554
 KRT6A
keratin 6A
chr2_-_216009015 8.793 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr12_-_51153788 8.663 NM_173086
 KRT6C
keratin 6C
chr12_-_51298599 8.356 NM_175068
 KRT73
keratin 73
chr11_-_2907169 8.070 NM_003311
 PHLDA2
pleckstrin homology-like domain, family A, member 2
chr3_+_62279707 8.008 C3orf14
chromosome 3 open reading frame 14
chr7_+_100557098 7.750 NM_000602
NM_001165413
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr15_-_61461127 7.629 NM_001218
NM_206925
 CA12

carbonic anhydrase XII

chr16_+_55273879 7.468 NM_005952
 MT1X
metallothionein 1X
chr8_-_23317571 7.278 LOXL2
lysyl oxidase-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 44 entries
enrichment   p-value GO term description
14.90 4.71e-06 GO:0031424 keratinization
9.45 9.88e-03 GO:0070301 cellular response to hydrogen peroxide
8.41 1.33e-03 GO:0034614 cellular response to reactive oxygen species
7.67 1.15e-02 GO:0030193 regulation of blood coagulation
7.63 3.20e-03 GO:0030216 keratinocyte differentiation
7.14 1.63e-03 GO:0009913 epidermal cell differentiation
7.11 2.08e-02 GO:0050818 regulation of coagulation
5.86 3.14e-02 GO:0034599 cellular response to oxidative stress
5.17 3.94e-07 GO:0008544 epidermis development
5.08 6.08e-03 GO:0000302 response to reactive oxygen species
4.19 2.12e-02 GO:0051789 response to protein stimulus
4.10 3.73e-07 GO:0010035 response to inorganic substance
4.02 1.80e-03 GO:0006936 muscle contraction
3.69 6.03e-03 GO:0003012 muscle system process
3.64 7.09e-03 GO:0006979 response to oxidative stress
3.48 4.46e-02 GO:0010038 response to metal ion
3.26 1.89e-03 GO:0006954 inflammatory response
3.16 6.02e-12 GO:0009888 tissue development
2.98 2.29e-02 GO:0030029 actin filament-based process
2.97 6.21e-05 GO:0009607 response to biotic stimulus

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
15.00 3.45e-05 GO:0001533 cornified envelope
12.86 7.95e-04 GO:0032982 myosin filament
9.94 3.51e-05 GO:0045095 keratin filament
9.11 5.65e-12 GO:0005882 intermediate filament
7.21 6.31e-10 GO:0045111 intermediate filament cytoskeleton
5.40 2.09e-02 GO:0016459 myosin complex
4.60 4.12e-04 GO:0043292 contractile fiber
4.56 1.06e-03 GO:0030016 myofibril
4.33 4.11e-03 GO:0044449 contractile fiber part
3.64 1.77e-18 GO:0005615 extracellular space
3.24 6.03e-18 GO:0044421 extracellular region part
2.82 1.57e-03 GO:0031012 extracellular matrix
2.68 3.00e-02 GO:0005578 proteinaceous extracellular matrix
2.67 2.01e-02 GO:0015629 actin cytoskeleton
2.59 4.28e-18 GO:0005576 extracellular region
2.03 6.19e-06 GO:0005856 cytoskeleton
1.97 3.87e-03 GO:0044430 cytoskeletal part
1.56 1.20e-03 GO:0043228 non-membrane-bounded organelle
1.56 1.20e-03 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
29.14 7.80e-04 GO:0046870 cadmium ion binding
7.11 3.70e-03 GO:0008307 structural constituent of muscle
6.77 1.35e-05 GO:0005200 structural constituent of cytoskeleton
6.62 6.39e-03 GO:0008009 chemokine activity
5.95 1.44e-02 GO:0042379 chemokine receptor binding
4.90 8.16e-08 GO:0005125 cytokine activity
4.82 2.71e-02 GO:0005201 extracellular matrix structural constituent
4.42 4.74e-03 GO:0008201 heparin binding
4.30 7.80e-20 GO:0005198 structural molecule activity
3.96 3.46e-03 GO:0005539 glycosaminoglycan binding
3.93 1.82e-03 GO:0001871 pattern binding
3.93 1.82e-03 GO:0030247 polysaccharide binding
3.79 3.70e-04 GO:0005126 cytokine receptor binding
2.86 1.13e-03 GO:0030246 carbohydrate binding
2.10 1.81e-04 GO:0005102 receptor binding
1.23 1.13e-02 GO:0005515 protein binding
1.12 4.12e-02 GO:0005488 binding