Motif ID: EVI1.p2

Z-value: 0.539


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MECOMchr3_-_170864111-0.302.6e-01Click!


Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_50699965 1.712 HLF
hepatic leukemia factor
chr4_+_74493918 1.333 ALB
albumin
chr10_+_7785347 1.302 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785331 1.298 ITIH2
inter-alpha (globulin) inhibitor H2
chr4_+_74500748 1.218 ALB
albumin
chr4_+_74520796 1.191 NM_001134
AFP
alpha-fetoprotein
chr10_+_7785360 1.061 ITIH2
inter-alpha (globulin) inhibitor H2
chr14_+_94117545 0.988 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr14_+_94117511 0.975 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr10_+_7785290 0.938 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_-_159459814 0.877 APOA2
apolipoprotein A-II
chr4_+_74491272 0.808 ALB
albumin
chr8_-_17812151 0.793


chr10_+_7785235 0.715 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr11_+_22652894 0.708 NM_005256
GAS2
growth arrest-specific 2
chr3_+_187813405 0.646 AHSG
alpha-2-HS-glycoprotein
chr4_+_74496575 0.640 ALB
albumin
chr1_+_50342168 0.632 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_-_159459999 0.628 NM_001643
APOA2
apolipoprotein A-II
chr1_-_145163779 0.577 NM_001144829
NM_001144830
NM_001461
FMO5


flavin containing monooxygenase 5


chr1_-_145163520 0.572 FMO5
flavin containing monooxygenase 5
chr11_+_60765219 0.569 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr5_+_139856688 0.557 ANKHD1
ankyrin repeat and KH domain containing 1
chrX_+_115481774 0.539 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr4_+_155703581 0.537 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr17_-_59437782 0.535 NM_000873
ICAM2
intercellular adhesion molecule 2
chr4_+_74496660 0.530 ALB
albumin
chr11_+_60746396 0.501 NM_001079808
PGA5
PGA3
PGA4
pepsinogen 5, group I (pepsinogen A)
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr20_-_45418818 0.496 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr11_+_22646229 0.489 NM_177553
GAS2
growth arrest-specific 2
chr14_+_94117483 0.470 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr11_-_33847937 0.450 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33848061 0.446 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_-_23500706 0.445 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr11_-_33848013 0.438 LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_+_32003180 0.381 NM_000063
NM_001145903
C2

complement component 2

chrX_-_74292800 0.376 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr7_-_87180499 0.367 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr17_-_53849888 0.367 RNF43
ring finger protein 43
chr14_-_93914634 0.365 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr4_+_71096830 0.362 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr4_+_74498042 0.360 ALB
albumin
chr2_-_88946767 0.342


chr4_+_89115862 0.341 SPP1
secreted phosphoprotein 1
chr2_+_170259195 0.340 NM_144711
NM_001008489
PHOSPHO2-KLHL23
KLHL23
PHOSPHO2
PHOSPHO2-KLHL23 read-through transcript
kelch-like 23 (Drosophila)
phosphatase, orphan 2
chr6_+_144654565 0.339 NM_007124
UTRN
utrophin
chr14_+_94148466 0.338 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr17_-_53849929 0.337 NM_017763
RNF43
ring finger protein 43
chr3_-_180467483 0.330 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr3_-_8668723 0.328 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr18_+_53865455 0.327 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_-_131375217 0.325 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr12_+_21059896 0.324 NM_001009562
LST-3TM12
organic anion transporter LST-3b
chr16_-_71650034 0.323 NM_001164766
ZFHX3
zinc finger homeobox 3
chr3_+_52803823 0.313 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr22_+_21340757 0.305


chr22_-_29290875 0.304 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr15_-_58706934 0.304 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr12_-_9804682 0.298 NM_001781
CD69
CD69 molecule
chr2_-_188127430 0.298 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr8_+_97575052 0.294 NM_002998
SDC2
syndecan 2
chr8_-_17797127 0.293 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr7_+_133862883 0.293 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chrM_+_1670 0.291 USP47
ubiquitin specific peptidase 47
chr4_+_89115892 0.290 SPP1
secreted phosphoprotein 1
chr12_+_887272 0.284 WNK1
WNK lysine deficient protein kinase 1
chr3_+_187813553 0.284 AHSG
alpha-2-HS-glycoprotein
chrX_-_76824726 0.283 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr3_-_147451509 0.281 PLSCR4
phospholipid scramblase 4
chr11_-_118405288 0.280 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr16_+_20682812 0.277 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr10_+_57028755 0.275 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr8_+_97575071 0.264 SDC2
syndecan 2
chr19_-_40996040 0.263 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr20_+_35445350 0.262 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr8_-_38127489 0.260 NM_000349
STAR
steroidogenic acute regulatory protein
chr3_-_13359746 0.259 NUP210
nucleoporin 210kDa
chr15_+_39839866 0.259 MGA
MAX gene associated
chr6_+_52637116 0.257 LOC730101
hypothetical LOC730101
chr7_+_94135384 0.256 PEG10
paternally expressed 10
chrX_+_15435351 0.252 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr16_+_68284252 0.251 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr1_+_111217244 0.251 NM_000560
CD53
CD53 molecule
chr1_+_210805319 0.246 NM_001030287
ATF3
activating transcription factor 3
chr12_+_13240983 0.245 EMP1
epithelial membrane protein 1
chr12_-_8110268 0.244 C3AR1
complement component 3a receptor 1
chr11_+_60727559 0.243 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr3_+_134978615 0.241 TF
transferrin
chr3_+_187813538 0.238 NM_001622
AHSG
alpha-2-HS-glycoprotein
chrX_-_2896285 0.237 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr19_-_52427698 0.236 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr2_+_138438277 0.235 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr16_-_45562840 0.234 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr16_-_48960186 0.233 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr4_-_40212670 0.232 NM_019027
RBM47
RNA binding motif protein 47
chr6_+_31623370 0.231 NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr4_+_74497998 0.231 ALB
albumin
chr12_-_7979896 0.229 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr3_-_195553297 0.228 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr6_+_31623331 0.228 NM_001144961
NM_005007
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr22_+_19458378 0.225 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr22_+_21464980 0.225


chr2_+_176761552 0.225 NM_024501
HOXD1
homeobox D1
chr6_+_32515596 0.224 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr16_-_24876357 0.223 ARHGAP17
Rho GTPase activating protein 17
chr4_+_89115825 0.221 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr4_-_70115037 0.221 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr16_+_28850760 0.221 NM_001178098
NM_001770
CD19

CD19 molecule

chr16_-_29817841 0.221 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr8_-_6407882 0.220 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr7_+_45899621 0.218


chr3_-_58175437 0.217 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr1_-_167822334 0.216 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr10_-_64698831 0.216 NM_004241
JMJD1C
jumonji domain containing 1C
chr7_+_137411717 0.216 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr1_-_159275334 0.214 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr7_-_149960218 0.213 GIMAP6
GTPase, IMAP family member 6
chr3_-_147451648 0.208 NM_001128306
NM_001177304
NM_020353
PLSCR4


phospholipid scramblase 4


chr1_-_159275357 0.208 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr12_-_9159707 0.207 A2M
alpha-2-macroglobulin
chr6_-_150109324 0.204 NM_198887
NUP43
nucleoporin 43kDa
chr6_+_32713160 0.204 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr8_-_19504285 0.203 NM_001130518
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr21_-_14840506 0.202 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr5_+_92944680 0.202 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr14_+_63750611 0.199 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr18_-_65775139 0.199 NM_006566
CD226
CD226 molecule
chr8_-_101384633 0.197 NM_015435
RNF19A
ring finger protein 19A
chr22_+_21543671 0.195 IGLV4-3
immunoglobulin lambda variable 4-3
chr11_-_5247948 0.195 NM_005330
HBE1
hemoglobin, epsilon 1
chr8_+_123863224 0.194 ZHX2
zinc fingers and homeoboxes 2
chr15_+_56511466 0.193 NM_000236
LIPC
lipase, hepatic
chr17_-_31441390 0.192 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr4_+_74499651 0.190 ALB
albumin
chr8_-_81155564 0.189 NM_001025252
TPD52
tumor protein D52
chr14_+_75058518 0.189 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr4_-_140280031 0.187 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr6_-_11340887 0.185 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr15_-_35178888 0.185 NM_172316
MEIS2
Meis homeobox 2
chr1_+_111217314 0.184 CD53
CD53 molecule
chr9_+_102987137 0.184 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr4_+_187424111 0.179 NM_000128
F11
coagulation factor XI
chr12_-_8110196 0.178 NM_004054
C3AR1
complement component 3a receptor 1
chr14_+_75058591 0.178 BATF
basic leucine zipper transcription factor, ATF-like
chr6_-_11340886 0.177 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr16_+_49288550 0.177 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr12_-_45506001 0.176 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chr1_-_24342158 0.175 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr1_-_9040141 0.174 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr3_+_63859114 0.170 NM_001177387
ATXN7
ataxin 7
chr3_+_123256902 0.168 NM_175862
CD86
CD86 molecule
chr9_+_79158164 0.168 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr10_-_69267774 0.167 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr4_-_89963177 0.167 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr2_+_143351695 0.166 KYNU
kynureninase
chr1_+_32512298 0.166 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr12_-_9159742 0.165 A2M
alpha-2-macroglobulin
chr1_-_180624380 0.164 GLUL
glutamate-ammonia ligase
chr2_+_88966170 0.160


chr6_+_167445284 0.158 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr2_-_188127294 0.156 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr3_+_143824955 0.155 NM_002670
PLS1
plastin 1
chr16_-_29797172 0.155 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr2_+_33514896 0.154 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_-_11340869 0.154 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr15_-_78050515 0.153 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr20_-_45360903 0.152 ZMYND8
zinc finger, MYND-type containing 8
chr15_-_32416336 0.152 NM_001042497
NM_133647
SLC12A6

solute carrier family 12 (potassium/chloride transporters), member 6

chr8_+_86287161 0.152 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr15_-_35179185 0.151 MEIS2
Meis homeobox 2
chr13_+_30207668 0.151 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr17_+_50697319 0.151 NM_002126
HLF
hepatic leukemia factor
chr17_-_53950191 0.151 NM_004687
MTMR4
myotubularin related protein 4
chr16_-_51139214 0.151 NM_001146188
TOX3
TOX high mobility group box family member 3
chr15_-_91078307 0.150 FAM174B
family with sequence similarity 174, member B
chr4_+_41309482 0.150 LIMCH1
LIM and calponin homology domains 1
chr6_+_31622606 0.149 NM_001144962
NM_001144963
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr2_-_144991386 0.149 ZEB2
zinc finger E-box binding homeobox 2
chr10_-_44794146 0.149 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr12_-_49708279 0.147 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr10_+_101532450 0.147 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr7_-_149960612 0.147 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr13_-_47885248 0.147 LPAR6
lysophosphatidic acid receptor 6
chr11_+_59580630 0.146 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr12_-_9159780 0.143 A2M
alpha-2-macroglobulin
chr7_-_115458064 0.143 TFEC
transcription factor EC
chr4_+_41309690 0.140 LIMCH1
LIM and calponin homology domains 1
chrX_-_43626537 0.139 NM_000898
MAOB
monoamine oxidase B
chr10_+_102722275 0.139 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr1_-_159546348 0.137 NM_000530
MPZ
myelin protein zero
chr1_-_180624494 0.137 GLUL
glutamate-ammonia ligase
chr2_-_88208650 0.137 NM_001443
FABP1
fatty acid binding protein 1, liver
chr11_+_59580705 0.136 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr8_-_125649926 0.132 MTSS1
metastasis suppressor 1
chr22_-_37214480 0.132 NM_001098505
NM_030881
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chrY_+_15145019 0.132 NM_014893
NLGN4Y
neuroligin 4, Y-linked
chr4_-_90197140 0.129 NM_014883
FAM13A
family with sequence similarity 13, member A
chr17_-_36451189 0.129 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr6_-_116529101 0.128 LOC100287673
hypothetical LOC100287673
chr13_-_47885653 0.128 NM_001162498
LPAR6
lysophosphatidic acid receptor 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.52 5.34e-04 GO:0050865 regulation of cell activation
2.56 5.62e-04 GO:0002694 regulation of leukocyte activation
1.69 2.93e-03 GO:0009611 response to wounding
1.99 5.09e-03 GO:0050776 regulation of immune response
1.98 7.34e-03 GO:0002684 positive regulation of immune system process
1.76 8.80e-03 GO:0002682 regulation of immune system process
8.33 1.25e-02 GO:0046640 regulation of alpha-beta T cell proliferation
1.23 1.31e-02 GO:0032501 multicellular organismal process
1.52 1.78e-02 GO:0002376 immune system process
2.56 1.83e-02 GO:0050863 regulation of T cell activation
2.49 2.19e-02 GO:0050867 positive regulation of cell activation
2.33 3.93e-02 GO:0051249 regulation of lymphocyte activation
2.44 4.55e-02 GO:0002696 positive regulation of leukocyte activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 1.61e-03 GO:0071944 cell periphery
1.28 2.25e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.53 2.92e-02 GO:0015171 amino acid transmembrane transporter activity
3.23 4.26e-02 GO:0005275 amine transmembrane transporter activity