Motif ID: ALX1.p2

Z-value: 1.027


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ALX1chr12_+_841980150.458.3e-02Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_42738535 2.742 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr12_-_9913199 2.440 CLEC2B
C-type lectin domain family 2, member B
chr2_-_224974954 2.054 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr7_-_149960218 1.971 GIMAP6
GTPase, IMAP family member 6
chr19_-_53444733 1.945 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr4_-_91979113 1.935 NM_183049
TMSL3
thymosin-like 3
chr12_-_9913724 1.815 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr3_+_160473729 1.753 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr6_+_12825818 1.721 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr1_+_78243181 1.560 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr3_-_15357878 1.414 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr11_+_5667494 1.306 NM_006074
TRIM22
tripartite motif containing 22
chr7_-_149960612 1.281 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr8_+_98772537 1.272 MTDH
metadherin
chr4_-_159312973 1.132 FAM198B
family with sequence similarity 198, member B
chr13_-_98757634 1.112 NM_004951
GPR183
G protein-coupled receptor 183
chr7_-_107667728 1.046 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr14_-_22354851 1.045 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chr3_-_69120188 0.973 C3orf64
chromosome 3 open reading frame 64
chr1_-_161380562 0.972 RGS5
regulator of G-protein signaling 5
chr19_-_53450953 0.964 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr17_-_26665220 0.950 NM_006495
EVI2B
ecotropic viral integration site 2B
chr10_-_27097782 0.942 ABI1
abl-interactor 1
chr17_-_26665213 0.936 EVI2B
ecotropic viral integration site 2B
chr18_-_49944986 0.924 MBD2
methyl-CpG binding domain protein 2
chr6_+_26359805 0.896 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr2_+_102320148 0.869 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr2_-_88946767 0.843


chr7_+_73826244 0.829 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr1_+_154120170 0.816 SYT11
synaptotagmin XI
chr1_-_161379606 0.814 RGS5
regulator of G-protein signaling 5
chrX_-_23835868 0.812 NM_024122
APOO
apolipoprotein O
chr12_+_52696908 0.787 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr7_+_115650240 0.781 NM_152829
TES
testis derived transcript (3 LIM domains)
chr14_-_105997732 0.779 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_-_26665194 0.768 EVI2B
ecotropic viral integration site 2B
chr17_-_26665144 0.763 EVI2B
ecotropic viral integration site 2B
chr10_+_13668944 0.757 NM_003675
PRPF18
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
chr14_+_100365390 0.733 MEG3
maternally expressed 3 (non-protein coding)
chr7_-_115458010 0.726 NM_001018058
NM_012252
TFEC

transcription factor EC

chr10_+_13668964 0.704 PRPF18
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
chr4_-_159313613 0.698 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr5_-_94442941 0.685 MCTP1
multiple C2 domains, transmembrane 1
chr5_-_94250357 0.641 MCTP1
multiple C2 domains, transmembrane 1
chr10_+_35524060 0.639 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr19_-_44518516 0.627 NM_004877
GMFG
glia maturation factor, gamma
chr3_-_170347019 0.622 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr19_+_21480229 0.618 NM_001001415
ZNF429
zinc finger protein 429
chr1_+_194887630 0.616 NM_000186
NM_001014975
CFH

complement factor H

chr21_-_38792173 0.611 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr4_-_70661018 0.608 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr6_-_133126278 0.602 NM_078488
VNN2
vanin 2
chr16_+_54072969 0.602 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr12_-_52939584 0.589 NM_001127322
CBX5
chromobox homolog 5
chr5_-_139706357 0.568 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr12_+_53177806 0.565 NCKAP1L
NCK-associated protein 1-like
chr4_-_103464491 0.565 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chrX_+_66705407 0.560 NM_001011645
AR
androgen receptor
chr4_+_109791181 0.545 NM_021227
OSTC
oligosaccharyltransferase complex subunit
chr12_+_53177789 0.530 NCKAP1L
NCK-associated protein 1-like
chr1_-_43509187 0.526 EBNA1BP2
EBNA1 binding protein 2
chrX_+_154764136 0.524 NM_001145149
NM_001185183
NM_005638
VAMP7


vesicle-associated membrane protein 7


chr5_+_162862808 0.524 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr12_-_101036407 0.523 NM_024057
NUP37
nucleoporin 37kDa
chr18_+_28023984 0.517 NM_005925
MEP1B
meprin A, beta
chr12_+_29267863 0.508 NM_018099
FAR2
fatty acyl CoA reductase 2
chr1_+_150005754 0.508 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr12_-_52939636 0.508 NM_001127321
CBX5
chromobox homolog 5
chr13_-_22905822 0.505 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr10_-_21226536 0.505 NM_006393
NEBL
nebulette
chr11_-_76800525 0.486 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr4_+_68107039 0.483 NM_012108
STAP1
signal transducing adaptor family member 1
chr1_-_39119845 0.476 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP read-through transcript
gap junction protein, alpha 9, 59kDa
chrX_+_46935035 0.475 NM_153280
UBA1
ubiquitin-like modifier activating enzyme 1
chr3_+_150065732 0.474 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr12_+_53177758 0.472 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr17_+_18566060 0.471 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr2_+_132196533 0.454 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr9_-_116608113 0.452 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr1_-_89364273 0.438 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr22_-_22252376 0.438 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr1_+_74473672 0.425 NM_015978
TNNI3K
TNNI3 interacting kinase
chr6_+_110608284 0.420 NM_015891
CDC40
cell division cycle 40 homolog (S. cerevisiae)
chr9_-_131626237 0.417 TOR1A
torsin family 1, member A (torsin A)
chr14_-_105542441 0.416 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr3_-_127810087 0.413 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr8_-_98359347 0.404 NM_033512
TSPYL5
TSPY-like 5
chr6_+_153060722 0.393 NM_025107
MYCT1
myc target 1
chr3_+_8750485 0.391 NM_033337
NM_001234
CAV3

caveolin 3

chr14_+_100365162 0.389 MEG3
maternally expressed 3 (non-protein coding)
chr1_-_114215768 0.388 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr7_-_87694218 0.380 NM_198901
SRI
sorcin
chr4_-_38534802 0.374 NM_006068
TLR6
toll-like receptor 6
chr18_+_45342398 0.371 NM_006033
LIPG
lipase, endothelial
chr2_+_33592445 0.369 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr11_-_102174032 0.365 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr20_+_34019942 0.362 NM_080834
C20orf152
chromosome 20 open reading frame 152
chr18_+_31488530 0.357 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr7_-_7724762 0.342 NM_002947
RPA3
replication protein A3, 14kDa
chr12_+_9871343 0.337 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr8_-_82557956 0.337 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr7_+_77307382 0.335 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr3_+_69895310 0.332 NM_001184967
MITF
microphthalmia-associated transcription factor
chr16_+_28993770 0.331 RRN3P2
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr3_-_25658829 0.330 TOP2B
topoisomerase (DNA) II beta 180kDa
chr2_-_87102453 0.323 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr19_+_21116666 0.322 NM_133473
ZNF431
zinc finger protein 431
chr1_+_40508336 0.321 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr4_-_72868598 0.321 NM_000583
GC
group-specific component (vitamin D binding protein)
chr4_-_123761615 0.321 NM_021803
IL21
interleukin 21
chr16_+_55950195 0.318 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chrY_+_57623336 0.315 NM_001145149
NM_001185183
NM_005638
VAMP7


vesicle-associated membrane protein 7


chr8_+_70567581 0.313 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr9_+_110664366 0.312 NM_006687
ACTL7A
actin-like 7A
chr4_-_69570919 0.307 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr14_-_105623358 0.306 IGHA1
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_+_5602782 0.305 NM_021616
TRIM34
tripartite motif containing 34
chr4_-_164754106 0.303 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr1_+_159390379 0.302 UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr20_+_33223434 0.300 NM_006404
PROCR
protein C receptor, endothelial
chr1_+_12149637 0.292 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr11_+_63282639 0.289 RTN3
reticulon 3
chr19_-_34395947 0.288 NM_006003
UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr1_+_115373937 0.283 NM_000549
TSHB
thyroid stimulating hormone, beta
chr6_-_101435918 0.283 NM_006828
NM_022091
ASCC3

activating signal cointegrator 1 complex subunit 3

chr10_+_124310170 0.282 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr10_-_69095362 0.281 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr11_+_59580630 0.280 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr19_-_23661779 0.278 NM_138330
ZNF675
zinc finger protein 675
chr4_-_69116839 0.272 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chrX_+_80344215 0.270 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr14_-_34414603 0.270 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr9_-_131626219 0.263 TOR1A
torsin family 1, member A (torsin A)
chr6_-_31756119 0.262 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr22_-_37211467 0.262 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr9_-_138412709 0.258 NM_003086
SNAPC4
small nuclear RNA activating complex, polypeptide 4, 190kDa
chr11_-_128242342 0.256 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr14_+_87541220 0.254 NM_003608
GPR65
G protein-coupled receptor 65
chrX_-_100999204 0.253 NM_032946
NXF5
nuclear RNA export factor 5
chr4_+_106851415 0.250 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr17_+_63462276 0.250 NM_002266
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chrX_-_6156655 0.250 NM_181332
NLGN4X
neuroligin 4, X-linked
chr19_+_750281 0.249 PTBP1
polypyrimidine tract binding protein 1
chr8_+_70567634 0.248 SULF1
sulfatase 1
chr1_+_160002693 0.246 NM_007348
ATF6
activating transcription factor 6
chr12_-_69434598 0.245 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr12_-_7547552 0.244 NM_004244
NM_203416
CD163

CD163 molecule

chr7_-_115458064 0.236 TFEC
transcription factor EC
chr8_-_117837224 0.235 EIF3H
eukaryotic translation initiation factor 3, subunit H
chr1_-_44593522 0.234 NM_024066
ERI3
ERI1 exoribonuclease family member 3
chr19_-_53305825 0.234 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr7_-_102070473 0.232 NM_001114403
UPK3BL
POLR2J2
uroplakin 3B-like
polymerase (RNA) II (DNA directed) polypeptide J2
chr2_+_87828718 0.232 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr15_-_57768725 0.230 BNIP2
BCL2/adenovirus E1B 19kDa interacting protein 2
chr9_+_27099138 0.229 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr1_+_166516901 0.229 NM_005149
TBX19
T-box 19
chr5_+_140709907 0.228 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr2_-_215605054 0.227 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr8_+_107807415 0.227 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr2_-_227952249 0.225 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr15_-_57768809 0.225 NM_004330
BNIP2
BCL2/adenovirus E1B 19kDa interacting protein 2
chr4_+_74566325 0.224 NM_001133
AFM
afamin
chr12_+_4569504 0.222 NM_003845
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr4_+_166350620 0.222 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr15_+_97990705 0.222 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr1_-_44593510 0.219 ERI3
ERI1 exoribonuclease family member 3
chr2_-_191580567 0.216 STAT1
signal transducer and activator of transcription 1, 91kDa
chr2_+_33514896 0.214 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_-_8656705 0.214 NM_020661
AICDA
activation-induced cytidine deaminase
chr6_-_88917600 0.214 NM_001160260
CNR1
cannabinoid receptor 1 (brain)
chrX_+_101740751 0.210 NM_001168479
NM_001168480
NM_001168485
ARMCX5


armadillo repeat containing, X-linked 5


chr2_+_228064531 0.210 AGFG1
ArfGAP with FG repeats 1
chr1_+_13903936 0.208 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chrX_-_11194015 0.205 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chrX_+_80344253 0.205 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr4_-_69218909 0.204 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chrM_-_8294 0.204 FTH1
ferritin, heavy polypeptide 1
chr19_-_34395861 0.204 UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr4_-_120462705 0.203 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr1_-_44593287 0.203 ERI3
ERI1 exoribonuclease family member 3
chr7_+_120378052 0.201 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr7_+_150319076 0.200 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr6_-_154692906 0.198 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chr5_-_39430180 0.195 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr8_-_117837202 0.195 EIF3H
eukaryotic translation initiation factor 3, subunit H
chr16_-_4836198 0.194 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr22_+_23532135 0.193 NM_001039948
NM_001098497
NM_001098498
NM_133454
SGSM1



small G protein signaling modulator 1



chr9_-_131626261 0.192 NM_000113
TOR1A
torsin family 1, member A (torsin A)
chr1_-_44593526 0.192 ERI3
ERI1 exoribonuclease family member 3
chr14_+_66901237 0.192 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr6_-_76022565 0.191 TMEM30A
transmembrane protein 30A
chr14_-_106193403 0.189 IGKV3-20
immunoglobulin kappa variable 3-20
chr10_-_48426868 0.188 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr1_+_153222393 0.188 NM_001184891
NM_001184892
NM_025207
NM_201398
FLAD1



FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)



chr19_-_23225001 0.185 ZNF724P
zinc finger protein 724, pseudogene
chr14_+_20306425 0.185 NM_022360
EDDM3B
epididymal protein 3B
chr5_+_68703036 0.184 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr19_-_22396915 0.183 NM_001098626
ZNF98
zinc finger protein 98
chr1_-_155788775 0.181 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr14_-_74669864 0.180 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.99 1.00e-03 GO:0006955 immune response
2.25 4.40e-03 GO:0050776 regulation of immune response
1.63 3.07e-02 GO:0002376 immune system process
6.35 4.04e-02 GO:0060338 regulation of type I interferon-mediated signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.70 5.03e-06 GO:0005576 extracellular region
1.80 4.96e-04 GO:0044421 extracellular region part
1.89 9.52e-04 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.10 5.28e-04 GO:0005125 cytokine activity
16.44 1.14e-03 GO:0005132 interferon-alpha/beta receptor binding