Motif ID: PRRX1,2.p2

Z-value: 1.306


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRRX1chr1_+_1688999360.391.4e-01Click!
PRRX2chr9_+_1314678370.253.6e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_37070862 6.385 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr10_-_95231933 5.336 NM_013451
NM_133337
MYOF

myoferlin

chr12_-_90029328 4.759 LUM
lumican
chrX_+_135058402 4.717 NM_001159700
FHL1
four and a half LIM domains 1
chr11_+_5667494 4.643 NM_006074
TRIM22
tripartite motif containing 22
chr3_+_160269734 4.389 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr3_+_161040343 3.947 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr3_+_161040439 3.842 SCHIP1
schwannomin interacting protein 1
chr1_+_149299490 3.672 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_149299307 3.669 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_149299504 3.662 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_149299530 3.659 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr2_+_189547377 3.581 COL3A1
collagen, type III, alpha 1
chr12_-_90029672 3.568 NM_002345
LUM
lumican
chr20_+_9236446 3.291 NM_000933
PLCB4
phospholipase C, beta 4
chr2_-_190635566 3.254 NM_005259
MSTN
myostatin
chr12_-_90100710 3.254 DCN
decorin
chr3_-_55490401 3.239 WNT5A
wingless-type MMTV integration site family, member 5A
chr1_-_103269356 3.153 COL11A1
collagen, type XI, alpha 1
chr7_-_27171648 3.121 HOXA9
homeobox A9
chr9_-_14076901 3.109 NFIB
nuclear factor I/B
chr7_-_27171673 3.054 NM_152739
HOXA9
homeobox A9
chr4_-_91979113 2.998 NM_183049
TMSL3
thymosin-like 3
chr7_+_102340579 2.991 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr8_-_122722674 2.833 NM_005328
HAS2
hyaluronan synthase 2
chr2_+_189547323 2.708 NM_000090
COL3A1
collagen, type III, alpha 1
chr21_-_26175068 2.694 APP
amyloid beta (A4) precursor protein
chr9_-_14388981 2.640 NM_001190738
NFIB
nuclear factor I/B
chr20_+_9146036 2.634 NM_182797
PLCB4
phospholipase C, beta 4
chr8_-_49996353 2.607 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr2_+_189547358 2.548 COL3A1
collagen, type III, alpha 1
chr15_+_97990705 2.526 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr12_-_90100733 2.485 NM_001920
DCN
decorin
chr12_-_90100679 2.474 DCN
decorin
chr3_+_160473729 2.451 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr2_-_162808123 2.347 NM_004460
FAP
fibroblast activation protein, alpha
chr17_-_10393664 2.303 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chrX_+_114734074 2.294 NM_001136025
NM_001172335
PLS3

plastin 3

chr4_+_169654742 2.242 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chrX_-_13744933 2.166 GPM6B
glycoprotein M6B
chr3_+_35697432 2.133 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr6_+_121798443 2.077 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_+_84402962 2.048 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_52708460 2.019 NM_004503
HOXC6
homeobox C6
chr9_-_116920232 2.011 NM_002160
TNC
tenascin C
chr11_-_27698800 2.005 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr21_+_29439768 1.961 C21orf7
chromosome 21 open reading frame 7
chr11_+_35154775 1.940 CD44
CD44 molecule (Indian blood group)
chr6_+_83129641 1.919 NM_006670
TPBG
trophoblast glycoprotein
chr1_-_171441234 1.891 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr4_+_169789327 1.861 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr2_-_206790871 1.857 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr5_-_88155360 1.856 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr6_-_169395972 1.851 NM_003247
THBS2
thrombospondin 2
chr3_-_116272911 1.849 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr13_+_100902942 1.830 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr11_-_58099884 1.821 NM_004811
LPXN
leupaxin
chrX_-_10495476 1.799 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr6_-_169395847 1.773 THBS2
thrombospondin 2
chr12_-_48902692 1.746 NM_001113547
LIMA1
LIM domain and actin binding 1
chr6_-_46401363 1.745 NM_005822
RCAN2
regulator of calcineurin 2
chr5_-_39430180 1.741 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_-_115960807 1.719 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chrX_+_135079461 1.685 NM_001167819
FHL1
four and a half LIM domains 1
chr17_-_1211263 1.682 YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr3_-_69120188 1.675 C3orf64
chromosome 3 open reading frame 64
chr13_-_33148899 1.674 STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_210888010 1.666 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr17_-_10362583 1.656 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr12_+_52696908 1.633 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr9_-_13240313 1.631 NM_003829
MPDZ
multiple PDZ domain protein
chr5_+_125786975 1.628 GRAMD3
GRAM domain containing 3
chr5_+_125786717 1.627 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr3_-_115585178 1.622 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_71538456 1.600 MAP1B
microtubule-associated protein 1B
chr12_+_14429499 1.578 ATF7IP
activating transcription factor 7 interacting protein
chr8_-_102029997 1.557 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr10_+_11087259 1.551 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr11_+_113672378 1.530 NNMT
nicotinamide N-methyltransferase
chr9_+_74956614 1.528 ANXA1
annexin A1
chr16_+_7322751 1.491 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr10_+_11087280 1.485 CELF2
CUGBP, Elav-like family member 2
chr10_-_126706442 1.482 NM_022802
CTBP2
C-terminal binding protein 2
chr5_+_140751666 1.474 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr3_+_35696119 1.461 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr5_+_34723420 1.441 NM_001145523
RAI14
retinoic acid induced 14
chr2_-_55053398 1.432


chr1_-_68470585 1.428 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr9_+_74956494 1.415 NM_000700
ANXA1
annexin A1
chr17_-_44037332 1.413 NM_018952
HOXB6
homeobox B6
chr5_-_111340421 1.410 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr1_-_42738535 1.400 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr1_+_194887630 1.377 NM_000186
NM_001014975
CFH

complement factor H

chr3_-_124821868 1.369 MYLK
myosin light chain kinase
chr10_+_63331018 1.346 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr5_+_125723686 1.332 NM_001146319
GRAMD3
GRAM domain containing 3
chr17_-_43977273 1.330 NM_002145
HOXB2
homeobox B2
chr1_-_89303478 1.324 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr5_+_36642213 1.303 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr22_-_34566367 1.277 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr8_+_54926920 1.276 NM_170587
RGS20
regulator of G-protein signaling 20
chr1_-_199732323 1.261 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr15_+_22772545 1.259 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr5_+_36642424 1.232 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_76027286 1.231 TMEM30A
transmembrane protein 30A
chr14_+_100365390 1.217 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_78243181 1.208 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr17_-_44026321 1.191 HOXB5
homeobox B5
chr10_+_17310263 1.181 NM_003380
VIM
vimentin
chr15_+_30721161 1.179 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr17_-_10265991 1.174 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr3_+_62280435 1.173 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr3_+_69895310 1.168 NM_001184967
MITF
microphthalmia-associated transcription factor
chr22_-_34566210 1.164 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr7_+_134226727 1.160 CALD1
caldesmon 1
chr4_+_26194643 1.160 NM_018317
TBC1D19
TBC1 domain family, member 19
chr6_-_152681171 1.151 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_+_69176391 1.141 CCND1
cyclin D1
chr2_-_44440358 1.129 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chrX_+_102517909 1.127 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr1_+_242283129 1.113 NM_006352
ZNF238
zinc finger protein 238
chrX_+_7147471 1.107 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chrX_+_55951280 1.079


chr8_+_9990471 1.067 NM_001135671
MSRA
methionine sulfoxide reductase A
chr5_+_141326620 1.064 NM_183399
RNF14
ring finger protein 14
chr22_-_34566276 1.058 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr4_+_169250281 1.056 NM_007193
ANXA10
annexin A10
chr2_-_151052391 1.044 NM_005168
RND3
Rho family GTPase 3
chr3_+_137224266 1.037 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr20_+_9406460 1.022 PLCB4
phospholipase C, beta 4
chr5_+_155686333 1.019 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr7_-_41709191 1.015 NM_002192
INHBA
inhibin, beta A
chr12_-_51298599 1.009 NM_175068
KRT73
keratin 73
chr5_-_88235624 0.990 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr7_+_134226690 0.961 NM_033139
NM_033140
CALD1

caldesmon 1

chr5_-_88215034 0.957 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr11_-_104421240 0.950 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr1_-_191422346 0.935 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr7_-_87694218 0.927 NM_198901
SRI
sorcin
chr3_-_8786263 0.918 NM_000916
OXTR
oxytocin receptor
chr2_-_56004366 0.917 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr8_-_18710575 0.915 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr2_-_144994038 0.913 ZEB2
zinc finger E-box binding homeobox 2
chr7_+_129720209 0.908 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr1_+_100957883 0.901 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chrX_-_10504852 0.897 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr5_+_140723939 0.895 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr5_+_140742585 0.884 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr2_-_215949566 0.880 FN1
fibronectin 1
chr13_-_43908937 0.880 TSC22D1
TSC22 domain family, member 1
chr3_+_158637273 0.878 NM_002852
PTX3
pentraxin 3, long
chr12_-_88573949 0.876 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr3_-_168674502 0.872 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr11_-_104411065 0.865 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chrX_-_135577102 0.860 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr9_-_32516164 0.859 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr4_+_41395493 0.858 LIMCH1
LIM and calponin homology domains 1
chr1_+_63861474 0.851 NM_001172818
PGM1
phosphoglucomutase 1
chr9_+_96561750 0.849 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr12_-_103846186 0.846 NM_032148
SLC41A2
solute carrier family 41, member 2
chr1_+_169421011 0.841 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr5_+_35892747 0.837 NM_002185
IL7R
interleukin 7 receptor
chr9_+_114953048 0.836 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr9_+_78305368 0.833 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr13_+_51933228 0.830 CKAP2
cytoskeleton associated protein 2
chr4_+_174326464 0.824 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr10_+_75343352 0.822 PLAU
plasminogen activator, urokinase
chr8_-_120720200 0.819 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr10_+_11246934 0.819 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr10_+_11247059 0.814 CELF2
CUGBP, Elav-like family member 2
chr12_-_54392328 0.808 NM_001144997
ITGA7
integrin, alpha 7
chr21_-_26269298 0.804 APP
amyloid beta (A4) precursor protein
chr10_+_124310170 0.801 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr12_+_52697160 0.801 HOXC5
HOXC6
homeobox C5
homeobox C6
chrX_+_80343958 0.796 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr5_+_140790365 0.789 PCDHGA12
protocadherin gamma subfamily A, 12
chr10_-_69422391 0.785 HERC4
hect domain and RLD 4
chr15_-_75135496 0.785 TSPAN3
tetraspanin 3
chr5_+_65408500 0.783 ERBB2IP
erbb2 interacting protein
chr17_-_26665220 0.776 NM_006495
EVI2B
ecotropic viral integration site 2B
chr2_+_151922350 0.774 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr11_+_130745580 0.773 NM_001048209
NTM
neurotrimin
chr9_+_115396020 0.771 NM_144489
RGS3
regulator of G-protein signaling 3
chr11_+_131285747 0.770 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr9_+_114953087 0.769 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr11_-_27679617 0.767 NM_170733
BDNF
brain-derived neurotrophic factor
chr2_+_187162969 0.767 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr8_-_131483395 0.766 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr7_+_18501876 0.760 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr3_-_47932479 0.760


chr3_-_191322919 0.759 NM_001134418
LEPREL1
leprecan-like 1
chr5_+_53787187 0.758 NM_006308
HSPB3
heat shock 27kDa protein 3
chr4_-_40631397 0.754 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr16_+_6763810 0.752 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chrX_-_10761729 0.749 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chrX_-_13745108 0.748 GPM6B
glycoprotein M6B
chrX_+_135106578 0.747 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr6_+_114285209 0.744 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr6_+_36752244 0.733 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr9_-_14304036 0.728 NM_001190737
NM_005596
NFIB

nuclear factor I/B


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 1.70e-04 GO:0007155 cell adhesion
1.50 1.70e-04 GO:0022610 biological adhesion
1.15 1.98e-03 GO:0032501 multicellular organismal process
1.13 2.33e-03 GO:0050896 response to stimulus
1.19 2.52e-03 GO:0007165 signal transduction
1.69 7.87e-03 GO:0016337 cell-cell adhesion
1.16 1.08e-02 GO:0023052 signaling
1.98 2.40e-02 GO:0007156 homophilic cell adhesion
1.15 2.53e-02 GO:0051716 cellular response to stimulus
1.24 4.87e-02 GO:0007166 cell surface receptor linked signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 1.87e-05 GO:0005576 extracellular region
1.76 1.24e-04 GO:0005578 proteinaceous extracellular matrix
1.18 2.75e-04 GO:0071944 cell periphery
1.18 3.51e-04 GO:0005886 plasma membrane
1.36 5.31e-04 GO:0044421 extracellular region part
1.59 3.56e-03 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.47 7.22e-04 GO:0005509 calcium ion binding
1.27 2.32e-03 GO:0004871 signal transducer activity
1.27 2.32e-03 GO:0060089 molecular transducer activity
1.28 1.28e-02 GO:0004872 receptor activity
2.79 1.94e-02 GO:0005518 collagen binding