Motif ID: EGR1..3.p2

Z-value: 0.738


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR2chr10_-_642460800.601.3e-02Click!
EGR1chr5_+_137829065-0.078.0e-01Click!
EGR3chr8_-_226066530.019.6e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_32574185 1.054 NM_023009
 MARCKSL1
MARCKS-like 1
chr19_+_16296632 0.668 NM_016270
 KLF2
Kruppel-like factor 2 (lung)
chr19_+_16296734 0.648 KLF2
Kruppel-like factor 2 (lung)
chr2_+_233927892 0.580 DGKD
diacylglycerol kinase, delta 130kDa
chr17_-_76622967 0.555 FLJ90757
hypothetical LOC440465
chr9_+_127549437 0.526 NM_006195
 PBX3
pre-B-cell leukemia homeobox 3
chr3_-_172660545 0.509 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
 TNIK







TRAF2 and NCK interacting kinase







chr10_+_11099860 0.492 NM_006561
 CELF2
CUGBP, Elav-like family member 2
chr5_-_88215034 0.468 NM_001193350
NM_002397
 MEF2C

myocyte enhancer factor 2C

chr19_+_4920126 0.463 KDM4B
lysine (K)-specific demethylase 4B
chr10_+_11100075 0.456 CELF2
CUGBP, Elav-like family member 2
chr1_+_148388870 0.448 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr1_-_25128951 0.446 RUNX3
runt-related transcription factor 3
chr10_-_74925724 0.440 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr16_+_84204424 0.423 NM_014615
 KIAA0182
KIAA0182
chr1_+_148389039 0.411 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr15_-_58671929 0.401 NM_134262
 RORA
RAR-related orphan receptor A
chr19_-_2653738 0.398 NM_052847
 GNG7
guanine nucleotide binding protein (G protein), gamma 7
chr12_+_69046241 0.392 NM_014505
 KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr16_+_29725597 0.382



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 66 entries
enrichment   p-value GO term description
2.04 1.07e-02 GO:0040029 regulation of gene expression, epigenetic
2.01 4.52e-02 GO:0008629 induction of apoptosis by intracellular signals
1.90 3.43e-05 GO:0016569 covalent chromatin modification
1.90 4.84e-05 GO:0016570 histone modification
1.70 1.89e-06 GO:0016568 chromatin modification
1.54 3.55e-03 GO:0018193 peptidyl-amino acid modification
1.51 1.53e-05 GO:0010629 negative regulation of gene expression
1.51 6.28e-04 GO:0006325 chromatin organization
1.47 6.34e-04 GO:0051253 negative regulation of RNA metabolic process
1.45 3.79e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.43 1.13e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.41 2.52e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.41 2.90e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.41 3.49e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.40 9.64e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.40 7.14e-04 GO:0006468 protein phosphorylation
1.40 1.99e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.40 2.73e-03 GO:0051254 positive regulation of RNA metabolic process
1.39 2.25e-03 GO:0009890 negative regulation of biosynthetic process
1.39 9.00e-03 GO:0051172 negative regulation of nitrogen compound metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
2.98 4.72e-03 GO:0000932 cytoplasmic mRNA processing body
2.79 1.06e-04 GO:0035770 RNA granule
2.02 1.53e-03 GO:0016585 chromatin remodeling complex
1.34 3.34e-03 GO:0044451 nucleoplasm part
1.33 7.44e-07 GO:0005654 nucleoplasm
1.24 8.99e-05 GO:0031981 nuclear lumen
1.21 2.23e-04 GO:0044428 nuclear part
1.18 4.70e-11 GO:0005634 nucleus
1.17 1.39e-02 GO:0070013 intracellular organelle lumen
1.16 1.61e-02 GO:0031974 membrane-enclosed lumen
1.16 1.91e-02 GO:0043233 organelle lumen
1.10 4.37e-10 GO:0043226 organelle
1.10 9.27e-10 GO:0043229 intracellular organelle
1.10 1.52e-08 GO:0043227 membrane-bounded organelle
1.10 2.65e-08 GO:0043231 intracellular membrane-bounded organelle
1.08 3.11e-11 GO:0005622 intracellular
1.08 1.77e-10 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
2.28 2.37e-02 GO:0004702 receptor signaling protein serine/threonine kinase activity
1.70 1.71e-03 GO:0010843 promoter binding
1.69 1.48e-03 GO:0000975 regulatory region DNA binding
1.69 1.48e-03 GO:0001067 regulatory region nucleic acid binding
1.69 1.48e-03 GO:0044212 transcription regulatory region DNA binding
1.68 6.31e-03 GO:0003682 chromatin binding
1.59 4.79e-06 GO:0004674 protein serine/threonine kinase activity
1.57 7.41e-04 GO:0016563 transcription activator activity
1.50 1.72e-02 GO:0008134 transcription factor binding
1.49 1.01e-10 GO:0030528 transcription regulator activity
1.45 2.90e-03 GO:0019904 protein domain specific binding
1.44 2.98e-08 GO:0001071 nucleic acid binding transcription factor activity
1.44 2.98e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.41 2.47e-04 GO:0043565 sequence-specific DNA binding
1.39 3.15e-03 GO:0004672 protein kinase activity
1.36 1.83e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.34 2.79e-03 GO:0016301 kinase activity
1.31 2.33e-02 GO:0019899 enzyme binding
1.27 4.95e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.25 2.43e-06 GO:0003677 DNA binding