Motif ID: ATF5_CREB3.p2

Z-value: 1.289


Transcription factors associated with ATF5_CREB3.p2:

Gene SymbolEntrez IDGene Name
ATF5 22809 activating transcription factor 5
CREB3 10488 cAMP responsive element binding protein 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CREB3chr9_+_35722207-0.449.0e-02Click!
ATF5chr19_+_551242110.039.1e-01Click!


Activity profile for motif ATF5_CREB3.p2.

activity profile for motif ATF5_CREB3.p2


Sorted Z-values histogram for motif ATF5_CREB3.p2

Sorted Z-values for motif ATF5_CREB3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5_CREB3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_75699652 2.489 NM_001657
 AREG
amphiregulin
chr4_+_75529716 2.403 NM_001657
 AREG
amphiregulin
chr14_+_67156386 1.960 ARG2
arginase, type II
chr21_-_43671355 1.571 NM_173354
 SIK1
salt-inducible kinase 1
chr4_+_85723080 1.484 NM_001263
 CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr1_+_154297588 1.406 NM_020387
 RAB25
RAB25, member RAS oncogene family
chr16_+_22733307 1.378 NM_006043
 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr2_+_74914742 1.303 HK2
hexokinase 2
chr5_-_1935764 1.252 NM_016358
 IRX4
iroquois homeobox 4
chr20_-_55718351 1.230 NM_020182
 PMEPA1
prostate transmembrane protein, androgen induced 1
chr14_+_67156405 1.101 ARG2
arginase, type II
chr18_+_18767275 1.036 NM_002894
 RBBP8
retinoblastoma binding protein 8
chr1_+_26368969 0.989 NM_015871
 ZNF593
zinc finger protein 593
chr8_-_22606653 0.952 NM_004430
 EGR3
early growth response 3
chr12_+_4253143 0.942 NM_001759
 CCND2
cyclin D2
chr8_+_61753793 0.931 NM_017780
 CHD7
chromodomain helicase DNA binding protein 7
chr5_+_137829065 0.924 EGR1
early growth response 1
chr12_-_121946581 0.920 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr14_+_67156323 0.856 NM_001172
 ARG2
arginase, type II
chr1_-_183552833 0.839 IVNS1ABP
influenza virus NS1A binding protein

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
2.34 1.22e-05 GO:0000375 RNA splicing, via transesterification reactions
2.33 8.59e-03 GO:0050657 nucleic acid transport
2.33 8.59e-03 GO:0050658 RNA transport
2.33 8.59e-03 GO:0051236 establishment of RNA localization
2.32 3.78e-05 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.32 3.78e-05 GO:0000398 nuclear mRNA splicing, via spliceosome
2.32 2.76e-02 GO:0051028 mRNA transport
2.27 1.59e-02 GO:0006403 RNA localization
2.14 4.66e-02 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
2.11 6.91e-06 GO:0008380 RNA splicing
2.01 4.87e-02 GO:0006913 nucleocytoplasmic transport
1.82 1.14e-03 GO:0006397 mRNA processing
1.74 1.02e-05 GO:0006396 RNA processing
1.70 7.62e-04 GO:0016071 mRNA metabolic process
1.61 6.70e-06 GO:0006351 transcription, DNA-dependent
1.56 1.45e-12 GO:0010467 gene expression
1.55 7.08e-11 GO:0016070 RNA metabolic process
1.54 6.50e-05 GO:0032774 RNA biosynthetic process
1.52 2.28e-13 GO:0090304 nucleic acid metabolic process
1.52 2.01e-09 GO:0009059 macromolecule biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
4.98 6.04e-04 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
2.48 2.36e-02 GO:0071013 catalytic step 2 spliceosome
2.18 8.29e-03 GO:0005681 spliceosomal complex
1.67 1.32e-03 GO:0044427 chromosomal part
1.61 8.32e-04 GO:0005694 chromosome
1.60 3.37e-03 GO:0030529 ribonucleoprotein complex
1.57 1.16e-09 GO:0005654 nucleoplasm
1.56 1.77e-13 GO:0031981 nuclear lumen
1.56 1.49e-02 GO:0005730 nucleolus
1.54 1.03e-15 GO:0044428 nuclear part
1.46 5.27e-12 GO:0070013 intracellular organelle lumen
1.46 1.62e-02 GO:0044451 nucleoplasm part
1.44 7.66e-11 GO:0043233 organelle lumen
1.43 1.19e-10 GO:0031974 membrane-enclosed lumen
1.28 6.94e-14 GO:0005634 nucleus
1.22 3.01e-08 GO:0044446 intracellular organelle part
1.21 5.57e-08 GO:0044422 organelle part
1.21 4.34e-02 GO:0043228 non-membrane-bounded organelle
1.21 4.34e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.18 5.59e-13 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
1.69 1.35e-07 GO:0003723 RNA binding
1.54 3.44e-03 GO:0043565 sequence-specific DNA binding
1.51 1.10e-04 GO:0001071 nucleic acid binding transcription factor activity
1.51 1.10e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.49 2.14e-04 GO:0030528 transcription regulator activity
1.39 1.71e-04 GO:0030554 adenyl nucleotide binding
1.38 2.82e-04 GO:0032559 adenyl ribonucleotide binding
1.37 5.26e-04 GO:0005524 ATP binding
1.34 1.13e-08 GO:0003676 nucleic acid binding
1.34 9.36e-06 GO:0000166 nucleotide binding
1.34 2.62e-04 GO:0017076 purine nucleotide binding
1.33 3.73e-04 GO:0032553 ribonucleotide binding
1.33 3.73e-04 GO:0032555 purine ribonucleotide binding
1.33 6.79e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.30 1.05e-03 GO:0003677 DNA binding
1.16 1.94e-07 GO:0005515 protein binding