Motif ID: SMAD1..7,9.p2

Z-value: 1.713


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD6chr15_+_64787983-0.871.3e-05Click!
SMAD2chr18_-_437111430.647.0e-03Click!
SMAD1chr4_+_1466221540.514.5e-02Click!
SMAD5chr5_+_135496437-0.467.1e-02Click!
SMAD4chr18_+_46810598-0.467.4e-02Click!
SMAD7chr18_-_447310780.448.4e-02Click!
SMAD9chr13_-_36392370-0.332.2e-01Click!
SMAD3chr15_+_65145215-0.078.0e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_32623792 3.258 NM_013959
 NRG1
neuregulin 1
chr19_+_40299058 3.215 FXYD3
FXYD domain containing ion transport regulator 3
chr1_+_181422016 2.715 LAMC2
laminin, gamma 2
chr11_+_66580884 2.673 RHOD
ras homolog gene family, member D
chr15_-_81744469 2.610 NM_001717
 BNC1
basonuclin 1
chr5_-_151046680 2.456 NM_003118
 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chrX_-_37916138 2.360 SRPX
sushi-repeat containing protein, X-linked
chr2_-_110231431 2.150 NM_005434
 MALL
mal, T-cell differentiation protein-like
chrX_+_153767803 2.115 NM_001007523
NM_001007524
NM_012151
 F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr5_-_151046638 2.109 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chrX_-_154341451 2.095 NM_001007523
NM_001007524
NM_012151
 F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr20_-_14266200 2.045 NM_013281
NM_198391
 FLRT3

fibronectin leucine rich transmembrane protein 3

chr12_-_45759691 1.964 NM_001143668
NM_181847
 AMIGO2

adhesion molecule with Ig-like domain 2

chr1_+_181421796 1.701 NM_005562
NM_018891
 LAMC2

laminin, gamma 2

chr1_+_181421984 1.643 LAMC2
laminin, gamma 2
chr11_-_124871258 1.636 NM_005103
NM_022549
 FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr6_+_107066422 1.616 NM_001624
 AIM1
absent in melanoma 1
chr19_-_48976852 1.560 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr2_+_71148915 1.553 NM_017567
 NAGK
N-acetylglucosamine kinase
chr11_+_66580861 1.530 NM_014578
 RHOD
ras homolog gene family, member D

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
6.89 1.23e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
6.13 4.92e-02 GO:0048880 sensory system development
6.13 4.92e-02 GO:0048892 lateral line nerve development
6.13 4.92e-02 GO:0048895 lateral line nerve glial cell differentiation
6.13 4.92e-02 GO:0048925 lateral line system development
6.13 4.92e-02 GO:0048937 lateral line nerve glial cell development
6.13 4.92e-02 GO:0050935 iridophore differentiation
5.73 2.53e-02 GO:0060600 dichotomous subdivision of an epithelial terminal unit
5.73 2.53e-02 GO:0090184 positive regulation of kidney development
1.75 1.61e-02 GO:0007411 axon guidance
1.68 7.51e-03 GO:0048812 neuron projection morphogenesis
1.67 2.39e-03 GO:0032990 cell part morphogenesis
1.67 2.99e-03 GO:0048858 cell projection morphogenesis
1.65 2.84e-02 GO:0007409 axonogenesis
1.60 2.38e-02 GO:0019226 transmission of nerve impulse
1.60 2.38e-02 GO:0035637 multicellular organismal signaling
1.60 3.73e-02 GO:0031175 neuron projection development
1.57 3.65e-02 GO:0006935 chemotaxis
1.57 3.65e-02 GO:0042330 taxis
1.55 1.63e-02 GO:0032989 cellular component morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.62 2.19e-02 GO:0045202 synapse
1.49 3.55e-02 GO:0030054 cell junction
1.27 8.88e-08 GO:0071944 cell periphery
1.27 1.85e-07 GO:0005886 plasma membrane
1.27 1.33e-03 GO:0044459 plasma membrane part
1.17 7.48e-07 GO:0016020 membrane
1.16 1.11e-03 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
2.95 4.77e-02 GO:0003823 antigen binding
1.51 4.71e-02 GO:0008092 cytoskeletal protein binding