Motif ID: E2F1..5.p2

Z-value: 6.392


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F5chr8_+_862871610.811.2e-04Click!
E2F3chr6_+_205100190.731.3e-03Click!
E2F1chr20_-_317378150.458.3e-02Click!
E2F4chr16_+_657835710.351.9e-01Click!
E2F2chr1_-_23729871-0.165.5e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_135544138 26.842 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
 MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr6_+_135544170 26.335 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135544214 21.273 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr7_-_99536966 12.561 MCM7
minichromosome maintenance complex component 7
chr7_-_99536929 12.499 MCM7
minichromosome maintenance complex component 7
chr11_-_33847507 12.165 LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_-_99536852 11.818 MCM7
minichromosome maintenance complex component 7
chr7_-_99537362 10.993 NM_005916
 MCM7
minichromosome maintenance complex component 7
chr11_-_33847937 10.809 NM_001142316
 LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33847834 10.616 LMO2
LIM domain only 2 (rhombotin-like 1)
chr22_+_34126104 10.204 NM_006739
 MCM5
minichromosome maintenance complex component 5
chr11_-_33848013 10.184 LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_-_52257500 10.129 NM_002388
 MCM3
minichromosome maintenance complex component 3
chr22_+_34126154 9.563 MCM5
minichromosome maintenance complex component 5
chr6_-_52257475 9.184 MCM3
minichromosome maintenance complex component 3
chr2_-_136350404 9.128 MCM6
minichromosome maintenance complex component 6
chr6_-_52257431 8.857 MCM3
minichromosome maintenance complex component 3
chr8_-_124477639 8.550 ATAD2
ATPase family, AAA domain containing 2
chr2_-_136350472 8.334 NM_005915
 MCM6
minichromosome maintenance complex component 6
chr4_-_56197115 8.334 NM_006681
 NMU
neuromedin U

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 149 entries
enrichment   p-value GO term description
9.35 3.76e-06 GO:0071897 DNA biosynthetic process
8.73 3.07e-03 GO:0002566 somatic diversification of immune receptors via somatic mutation
8.73 3.07e-03 GO:0016446 somatic hypermutation of immunoglobulin genes
8.42 2.72e-02 GO:0000731 DNA synthesis involved in DNA repair
7.48 2.52e-07 GO:0006270 DNA-dependent DNA replication initiation
7.34 3.75e-09 GO:0006271 DNA strand elongation involved in DNA replication
7.29 1.93e-06 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
6.86 1.04e-04 GO:2000104 negative regulation of DNA-dependent DNA replication
6.81 2.17e-08 GO:0022616 DNA strand elongation
6.73 3.31e-05 GO:0006298 mismatch repair
6.73 2.35e-03 GO:0006297 nucleotide-excision repair, DNA gap filling
6.50 2.28e-04 GO:0032201 telomere maintenance via semi-conservative replication
6.41 7.11e-05 GO:0090329 regulation of DNA-dependent DNA replication
6.41 1.62e-02 GO:0016447 somatic recombination of immunoglobulin gene segments
6.31 4.95e-03 GO:0007062 sister chromatid cohesion
6.23 1.52e-03 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
6.23 1.52e-03 GO:0016444 somatic cell DNA recombination
6.17 4.67e-04 GO:0000722 telomere maintenance via recombination
5.61 1.08e-13 GO:0006261 DNA-dependent DNA replication
5.61 1.66e-03 GO:0002200 somatic diversification of immune receptors

Gene overrepresentation in compartment category:

Showing 1 to 20 of 52 entries
enrichment   p-value GO term description
9.82 1.28e-04 GO:0042555 MCM complex
8.42 4.73e-03 GO:0035098 ESC/E(Z) complex
7.48 5.45e-04 GO:0032300 mismatch repair complex
6.73 4.08e-04 GO:0030894 replisome
6.73 4.08e-04 GO:0043601 nuclear replisome
6.17 8.11e-05 GO:0043596 nuclear replication fork
5.78 1.34e-07 GO:0005657 replication fork
5.61 3.10e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
5.28 1.79e-02 GO:0031519 PcG protein complex
4.78 1.44e-08 GO:0000786 nucleosome
4.64 1.20e-13 GO:0032993 protein-DNA complex
3.74 4.37e-06 GO:0071013 catalytic step 2 spliceosome
3.74 7.13e-03 GO:0000792 heterochromatin
3.34 1.44e-02 GO:0034708 methyltransferase complex
3.34 1.44e-02 GO:0035097 histone methyltransferase complex
3.29 3.72e-15 GO:0000785 chromatin
3.29 7.30e-08 GO:0005681 spliceosomal complex
3.23 3.14e-10 GO:0044454 nuclear chromosome part
3.19 1.30e-12 GO:0000228 nuclear chromosome
3.16 1.21e-32 GO:0005694 chromosome

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
11.22 2.77e-04 GO:0032135 DNA insertion or deletion binding
11.22 3.58e-02 GO:0032138 single base insertion or deletion binding
8.02 1.18e-05 GO:0030983 mismatched DNA binding
5.14 1.21e-03 GO:0003887 DNA-directed DNA polymerase activity
4.99 6.19e-04 GO:0034061 DNA polymerase activity
4.41 3.55e-07 GO:0003697 single-stranded DNA binding
4.16 3.40e-02 GO:0002039 p53 binding
3.83 1.63e-03 GO:0003684 damaged DNA binding
3.62 1.03e-04 GO:0008094 DNA-dependent ATPase activity
3.11 5.73e-10 GO:0043566 structure-specific DNA binding
3.04 1.85e-06 GO:0003690 double-stranded DNA binding
2.33 1.13e-03 GO:0003682 chromatin binding
1.95 2.12e-10 GO:0003723 RNA binding
1.75 4.01e-20 GO:0003677 DNA binding
1.73 4.46e-30 GO:0003676 nucleic acid binding
1.71 4.63e-02 GO:0003712 transcription cofactor activity
1.49 8.12e-03 GO:0030528 transcription regulator activity
1.49 9.93e-03 GO:0001071 nucleic acid binding transcription factor activity
1.49 9.93e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.47 1.20e-08 GO:0000166 nucleotide binding