Motif ID: NRF1.p2

Z-value: 4.188


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NRF1chr7_+_1290387650.953.4e-08Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_91738953 6.063 NM_001134419
NM_003503
 CDC7

cell division cycle 7 homolog (S. cerevisiae)

chr1_+_91739241 5.511 NM_001134420
 CDC7
cell division cycle 7 homolog (S. cerevisiae)
chr7_+_99865340 5.064 MEPCE
methylphosphate capping enzyme
chr7_+_99865189 4.301 NM_019606
 MEPCE
methylphosphate capping enzyme
chr14_+_100263066 3.612 DLK1
delta-like 1 homolog (Drosophila)
chr19_-_40928131 3.534 NM_001040425
NM_144987
 U2AF1L4

U2 small nuclear RNA auxiliary factor 1-like 4

chr21_-_32573195 3.530 NM_018944
 MIS18A
MIS18 kinetochore protein homolog A (S. pombe)
chr6_-_153346283 3.502 NM_001142522
 FBXO5
F-box protein 5
chr5_+_162820094 3.443 NM_001142556
NM_001142557
NM_012484
NM_012485
 HMMR



hyaluronan-mediated motility receptor (RHAMM)



chr11_+_64785888 3.378 NM_002689
 POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr14_+_100263028 3.361 DLK1
delta-like 1 homolog (Drosophila)
chr5_-_88215034 3.199 NM_001193350
NM_002397
 MEF2C

myocyte enhancer factor 2C

chr19_+_5574119 3.198 SAFB
scaffold attachment factor B
chr19_-_48950912 3.150 C19orf61
chromosome 19 open reading frame 61
chr9_+_109085643 3.080 RAD23B
RAD23 homolog B (S. cerevisiae)
chr5_-_88214720 2.989 MEF2C
myocyte enhancer factor 2C
chr15_-_66900266 2.979 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr13_-_49554089 2.882 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr1_+_3763704 2.880 NM_004402
 DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr19_-_55124490 2.861 NUP62
nucleoporin 62kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 101 entries
enrichment   p-value GO term description
3.73 3.00e-07 GO:0006406 mRNA export from nucleus
3.67 4.74e-08 GO:0006405 RNA export from nucleus
3.54 1.12e-03 GO:0006413 translational initiation
3.33 1.35e-07 GO:0051168 nuclear export
3.08 7.16e-03 GO:0000723 telomere maintenance
3.02 1.05e-02 GO:0032200 telomere organization
2.88 4.66e-03 GO:0031124 mRNA 3'-end processing
2.86 7.10e-07 GO:0051028 mRNA transport
2.82 4.40e-03 GO:0006302 double-strand break repair
2.80 3.02e-07 GO:0050657 nucleic acid transport
2.80 3.02e-07 GO:0050658 RNA transport
2.80 3.02e-07 GO:0051236 establishment of RNA localization
2.79 2.02e-07 GO:0006403 RNA localization
2.79 9.16e-05 GO:0031497 chromatin assembly
2.77 1.90e-04 GO:0006334 nucleosome assembly
2.75 2.66e-06 GO:0006323 DNA packaging
2.75 2.72e-03 GO:0000956 nuclear-transcribed mRNA catabolic process
2.74 1.26e-02 GO:0006368 transcription elongation from RNA polymerase II promoter
2.73 1.15e-07 GO:0071103 DNA conformation change
2.72 5.60e-03 GO:0006200 ATP catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 55 entries
enrichment   p-value GO term description
4.80 7.01e-03 GO:0005665 DNA-directed RNA polymerase II, core complex
2.90 1.24e-03 GO:0000786 nucleosome
2.75 3.39e-03 GO:0000922 spindle pole
2.72 4.36e-07 GO:0044455 mitochondrial membrane part
2.69 3.09e-03 GO:0070469 respiratory chain
2.67 9.54e-03 GO:0005746 mitochondrial respiratory chain
2.66 5.76e-05 GO:0032993 protein-DNA complex
2.55 5.79e-12 GO:0000785 chromatin
2.45 1.70e-02 GO:0005643 nuclear pore
2.45 3.90e-02 GO:0000777 condensed chromosome kinetochore
2.41 7.96e-20 GO:0044427 chromosomal part
2.35 3.59e-02 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
2.33 1.33e-02 GO:0046930 pore complex
2.31 4.27e-21 GO:0005694 chromosome
2.23 1.11e-03 GO:0000775 chromosome, centromeric region
2.22 9.18e-04 GO:0000793 condensed chromosome
2.19 2.53e-03 GO:0005681 spliceosomal complex
2.17 5.64e-03 GO:0000151 ubiquitin ligase complex
2.15 1.99e-04 GO:0044454 nuclear chromosome part
2.04 1.05e-04 GO:0000228 nuclear chromosome

Gene overrepresentation in function category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
7.47 3.04e-02 GO:0017070 U6 snRNA binding
3.03 2.75e-02 GO:0003899 DNA-directed RNA polymerase activity
3.03 2.75e-02 GO:0034062 RNA polymerase activity
2.95 1.25e-02 GO:0003743 translation initiation factor activity
2.45 3.75e-02 GO:0042393 histone binding
2.29 3.34e-03 GO:0016779 nucleotidyltransferase activity
2.14 1.32e-04 GO:0003682 chromatin binding
1.93 7.75e-03 GO:0043566 structure-specific DNA binding
1.89 9.06e-15 GO:0003723 RNA binding
1.84 7.12e-03 GO:0016881 acid-amino acid ligase activity
1.79 5.85e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.70 8.39e-04 GO:0016874 ligase activity
1.69 6.24e-03 GO:0016887 ATPase activity
1.63 9.10e-03 GO:0003712 transcription cofactor activity
1.62 1.01e-02 GO:0000988 protein binding transcription factor activity
1.62 1.01e-02 GO:0000989 transcription factor binding transcription factor activity
1.54 9.25e-26 GO:0003676 nucleic acid binding
1.46 6.63e-12 GO:0003677 DNA binding
1.42 2.48e-02 GO:0016462 pyrophosphatase activity
1.41 2.86e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides