Motif ID: CRX.p2

Z-value: 1.165


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CRXchr19_+_530169100.601.4e-02Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74497998 3.193 ALB
albumin
chr4_+_89115892 2.922 SPP1
secreted phosphoprotein 1
chrX_-_131401319 2.846 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr4_+_74488910 2.789 ALB
albumin
chr4_+_89115923 2.689 SPP1
secreted phosphoprotein 1
chr4_+_89115862 2.524 SPP1
secreted phosphoprotein 1
chr4_+_74498042 2.472 ALB
albumin
chr4_+_74500748 2.361 ALB
albumin
chr4_+_74488947 2.124 ALB
albumin
chr3_+_50281582 1.973 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr4_+_74496575 1.904 ALB
albumin
chr8_-_81155564 1.793 NM_001025252
TPD52
tumor protein D52
chr18_+_53865455 1.761 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_-_118670968 1.758 KIAA1598
KIAA1598
chr4_+_74488835 1.741 NM_000477
ALB
albumin
chr4_+_74496660 1.671 ALB
albumin
chr4_-_155753249 1.671 FGG
fibrinogen gamma chain
chr3_+_50281309 1.619 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr2_-_88208650 1.592 NM_001443
FABP1
fatty acid binding protein 1, liver
chr4_-_155753272 1.566 FGG
fibrinogen gamma chain
chr13_-_47916803 1.548 NM_005767
LPAR6
lysophosphatidic acid receptor 6
chr17_-_36346240 1.511 KRT23
keratin 23 (histone deacetylase inducible)
chr4_-_155753207 1.462 FGG
fibrinogen gamma chain
chr4_-_155753287 1.446 FGG
fibrinogen gamma chain
chr21_-_42060334 1.432 RIPK4
receptor-interacting serine-threonine kinase 4
chr3_+_123526700 1.409 NM_005213
CSTA
cystatin A (stefin A)
chr2_+_228386800 1.387 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr12_-_88270375 1.368 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr4_-_155753332 1.355 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr12_-_88270369 1.351 DUSP6
dual specificity phosphatase 6
chr1_-_167822334 1.287 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr10_+_7785360 1.252 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_-_167822248 1.245 F5
coagulation factor V (proaccelerin, labile factor)
chr10_-_116408046 1.225 NM_002313
ABLIM1
actin binding LIM protein 1
chr1_+_205344200 1.186 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr16_-_54424517 1.159 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr10_-_101831579 1.075 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr7_+_29486010 0.989 NM_001039936
CHN2
chimerin (chimaerin) 2
chr14_-_23846993 0.986 CIDEB
cell death-inducing DFFA-like effector b
chr18_+_27425727 0.975 NM_000371
TTR
transthyretin
chr4_+_74491272 0.974 ALB
albumin
chr14_-_23847000 0.957 CIDEB
cell death-inducing DFFA-like effector b
chr11_+_61279436 0.947 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr11_+_43622348 0.947


chr4_+_89115825 0.904 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr3_-_195553297 0.874 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr14_-_23847024 0.868 CIDEB
cell death-inducing DFFA-like effector b
chr2_+_101974737 0.858 NM_004633
IL1R2
interleukin 1 receptor, type II
chr4_-_187114407 0.851 SORBS2
sorbin and SH3 domain containing 2
chr22_-_36305883 0.830 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr10_-_82039158 0.792 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr1_-_166779825 0.792 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr8_-_17797127 0.782 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr15_+_57691272 0.778 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr1_+_205329206 0.759 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr2_-_96311367 0.753 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr4_-_84254912 0.752 PLAC8
placenta-specific 8
chr14_-_23846904 0.750 CIDEB
cell death-inducing DFFA-like effector b
chr9_-_74757735 0.741 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr12_-_9123126 0.735 A2M
alpha-2-macroglobulin
chr12_-_88270128 0.735 DUSP6
dual specificity phosphatase 6
chr17_-_61655915 0.734 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr20_-_33706532 0.727 RBM12
RNA binding motif protein 12
chr17_+_38306339 0.727 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr10_-_52315390 0.726 A1CF
APOBEC1 complementation factor
chr4_+_71096830 0.717 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr5_+_70980724 0.714 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr1_+_116744992 0.702 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr4_-_187114863 0.700 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr17_-_23721351 0.697 VTN
vitronectin
chr14_+_20226762 0.697 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr3_-_69254226 0.686 NM_198271
LMOD3
leiomodin 3 (fetal)
chr2_-_25954805 0.677 NM_018263
ASXL2
additional sex combs like 2 (Drosophila)
chr2_-_25954833 0.664 ASXL2
additional sex combs like 2 (Drosophila)
chr2_+_113601608 0.664 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr11_+_101488380 0.652 NM_001195045
YAP1
Yes-associated protein 1
chr8_-_8788149 0.651 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chrX_-_2892288 0.648 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr17_-_23721420 0.645 VTN
vitronectin
chr4_-_84254932 0.644 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr4_-_186969041 0.643 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr11_+_73034870 0.632 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr10_+_4995685 0.631 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr3_+_50279993 0.620 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr16_+_22432344 0.614 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr9_-_111230926 0.612 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr4_-_84254873 0.611 PLAC8
placenta-specific 8
chrX_-_102205736 0.607 BEX1
brain expressed, X-linked 1
chr16_-_10581944 0.594 NM_001424
EMP2
epithelial membrane protein 2
chr1_-_172153087 0.593 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr6_+_32021687 0.584 NM_001710
CFB
complement factor B
chr10_-_7722747 0.581 ITIH5
inter-alpha (globulin) inhibitor H5
chr12_-_31370351 0.580 FAM60A
family with sequence similarity 60, member A
chr4_+_166519392 0.580 NM_001873
CPE
carboxypeptidase E
chr12_-_9159789 0.579 NM_000014
A2M
alpha-2-macroglobulin
chr2_+_234255322 0.564 NM_019077
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr14_-_93859394 0.560 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr7_+_94374862 0.556 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr6_+_32021742 0.556 CFB
complement factor B
chr4_-_88531245 0.549 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr19_-_13910167 0.548 NM_024825
PODNL1
podocan-like 1
chr12_-_9159780 0.534 A2M
alpha-2-macroglobulin
chr4_-_15686838 0.525 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr2_+_113601616 0.525 IL1RN
interleukin 1 receptor antagonist
chr14_-_23107106 0.519 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr6_+_10693964 0.517 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr2_+_211050653 0.514 NM_001122633
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr12_-_31370387 0.511 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chrX_-_106248674 0.511 RBM41
RNA binding motif protein 41
chr14_-_94677807 0.509 NM_030621
DICER1
dicer 1, ribonuclease type III
chr7_+_57513824 0.507 NM_001159279
ZNF716
zinc finger protein 716
chr4_+_69996780 0.504 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr9_-_122852356 0.502 NM_001735
C5
complement component 5
chr9_-_72063559 0.502 LOC100507299
hypothetical LOC100507299
chr1_+_13388652 0.497 NM_001099852
PRAMEF20
PRAME family member 20
chr12_-_9159707 0.497 A2M
alpha-2-macroglobulin
chr3_-_11660395 0.479 NM_001128219
VGLL4
vestigial like 4 (Drosophila)
chr1_-_180621272 0.478 GLUL
glutamate-ammonia ligase
chr3_-_47073910 0.466 SETD2
SET domain containing 2
chr18_+_31488530 0.465 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr6_+_32021831 0.459 CFB
complement factor B
chr20_-_48686832 0.455 NM_080829
FAM65C
family with sequence similarity 65, member C
chr22_+_23329113 0.455 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr17_-_7023378 0.451 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chrX_-_106248706 0.450 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr10_+_102722275 0.448 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr4_+_187424336 0.447 F11
coagulation factor XI
chr12_-_31370305 0.447 FAM60A
family with sequence similarity 60, member A
chr3_-_121884091 0.441 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr4_-_186969202 0.439 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr13_-_47885018 0.436 LPAR6
lysophosphatidic acid receptor 6
chr1_-_45868775 0.434 GPBP1L1
GC-rich promoter binding protein 1-like 1
chr18_+_13601664 0.430 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr10_+_4995597 0.422 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr20_+_30161173 0.417 TM9SF4
transmembrane 9 superfamily protein member 4
chr13_-_47885248 0.415 LPAR6
lysophosphatidic acid receptor 6
chr2_+_234245243 0.414 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr6_+_7052798 0.410 NM_001168344
RREB1
ras responsive element binding protein 1
chr2_+_211129567 0.397 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr20_-_16501911 0.397 NM_024704
KIF16B
kinesin family member 16B
chr10_+_123744131 0.397 TACC2
transforming, acidic coiled-coil containing protein 2
chr10_-_5035967 0.393 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr2_+_234209838 0.386 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr3_-_172227461 0.385 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr11_-_36576352 0.384 NM_000536
RAG2
recombination activating gene 2
chr16_-_31390926 0.384


chr1_+_166812466 0.382 NM_002995
XCL1
chemokine (C motif) ligand 1
chr2_+_62787534 0.381 NM_001142614
EHBP1
EH domain binding protein 1
chr13_-_47885653 0.378 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chrM_+_1670 0.378 USP47
ubiquitin specific peptidase 47
chr1_-_6585268 0.376 KLHL21
kelch-like 21 (Drosophila)
chr10_+_4995453 0.374 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr4_-_70115037 0.373 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr20_+_275725 0.373 NRSN2
neurensin 2
chr16_+_29597829 0.373 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr17_-_7023283 0.373 ASGR1
asialoglycoprotein receptor 1
chr16_+_29597965 0.370 QPRT
quinolinate phosphoribosyltransferase
chr9_-_74735669 0.367 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr18_+_54013575 0.366 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_27281729 0.356 NM_001944
DSG3
desmoglein 3
chr14_+_73073570 0.350 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr2_+_113591940 0.347 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr2_+_37282516 0.346 LOC100505876
hypothetical LOC100505876
chr17_+_76133337 0.344 RPTOR
regulatory associated protein of MTOR, complex 1
chr4_+_187424111 0.342 NM_000128
F11
coagulation factor XI
chr3_+_46594079 0.342 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr10_-_52315436 0.341 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chrM_+_12283 0.334


chr14_-_22610610 0.329 NM_001164816
NM_001164817
ACIN1

apoptotic chromatin condensation inducer 1

chr1_-_27871287 0.329 IFI6
interferon, alpha-inducible protein 6
chr14_-_20969706 0.327 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr19_-_46637265 0.326 NM_001167867
NM_001167868
ATP5SL

ATP5S-like

chr1_-_108032645 0.326 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr22_-_29694186 0.323 NM_014941
MORC2
MORC family CW-type zinc finger 2
chrM_+_4465 0.318


chr12_-_7979896 0.317 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chrX_-_110542040 0.317 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr2_-_215967442 0.316 FN1
fibronectin 1
chr4_+_70180805 0.311 NM_053039
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr17_-_71995401 0.310 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr9_-_103185621 0.309 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr3_-_47909001 0.307 MAP4
microtubule-associated protein 4
chrM_+_4770 0.306


chr14_-_22610572 0.304 ACIN1
apoptotic chromatin condensation inducer 1
chr17_+_69941430 0.303 NM_018653
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr1_-_153107084 0.303


chrX_-_24600661 0.297 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr14_+_23008723 0.295 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr10_-_69267774 0.294 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chrM_+_13453 0.290


chr19_-_13909877 0.289 PODNL1
podocan-like 1
chr1_-_24342158 0.288 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chrX_+_105856531 0.287 NM_194463
RNF128
ring finger protein 128
chr12_-_9159742 0.287 A2M
alpha-2-macroglobulin
chr10_+_102111361 0.286 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr10_+_57028755 0.284 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr2_+_170742900 0.283 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr11_-_118405288 0.279 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr7_+_116447527 0.274 ST7
suppression of tumorigenicity 7
chr8_-_145609737 0.272 SLC39A4
solute carrier family 39 (zinc transporter), member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.96 9.01e-03 GO:0007600 sensory perception

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.37 1.49e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.79 4.13e-02 GO:0008289 lipid binding