Motif ID: FOXO1,3,4.p2

Z-value: 1.554


Transcription factors associated with FOXO1,3,4.p2:

Gene SymbolEntrez IDGene Name
FOXO1 2308 forkhead box O1
FOXO3 2309 forkhead box O3
FOXO4 4303 forkhead box O4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXO3chr6_+_1089877030.702.3e-03Click!
FOXO1chr13_-_40138607-0.312.5e-01Click!
FOXO4chrX_+_70232362-0.263.3e-01Click!


Activity profile for motif FOXO1,3,4.p2.

activity profile for motif FOXO1,3,4.p2


Sorted Z-values histogram for motif FOXO1,3,4.p2

Sorted Z-values for motif FOXO1,3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO1,3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_150569574 7.183 TM4SF1
transmembrane 4 L six family member 1
chr1_-_56817823 4.533 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr9_+_74956614 4.076 ANXA1
annexin A1
chr7_+_134114957 3.784 CALD1
caldesmon 1
chr16_+_54070302 3.738 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr4_+_26194643 3.683 NM_018317
TBC1D19
TBC1 domain family, member 19
chr1_-_56817802 3.489 PPAP2B
phosphatidic acid phosphatase type 2B
chr4_-_81213207 3.243


chr1_-_56817568 3.060 PPAP2B
phosphatidic acid phosphatase type 2B
chr22_+_31526801 2.811 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr1_-_56817717 2.682 PPAP2B
phosphatidic acid phosphatase type 2B
chr18_-_20106187 2.593 NM_018030
OSBPL1A
oxysterol binding protein-like 1A
chr9_+_74956601 2.532 ANXA1
annexin A1
chr8_+_70567634 2.515 SULF1
sulfatase 1
chr3_+_62280435 2.421 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr10_-_90740935 2.392 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr12_+_51777715 2.374 IGFBP6
insulin-like growth factor binding protein 6
chr6_+_121798443 2.339 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr4_+_54790020 2.329 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr12_+_51777684 2.296 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr6_-_105734535 2.205 NM_022361
POPDC3
popeye domain containing 3
chr13_-_37070862 2.139 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr5_-_42847716 2.131 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr5_+_125828685 2.124 NM_001146322
GRAMD3
GRAM domain containing 3
chr7_-_94902149 2.087 NM_000305
NM_001018161
PON2

paraoxonase 2

chr9_+_74956494 2.080 NM_000700
ANXA1
annexin A1
chr5_+_125786975 2.068 GRAMD3
GRAM domain containing 3
chr8_-_13178399 2.042 DLC1
deleted in liver cancer 1
chr7_+_75892187 2.005 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr16_+_54072969 1.990 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr7_-_47545717 1.969 NM_022748
TNS3
tensin 3
chr2_-_217248967 1.966 IGFBP5
insulin-like growth factor binding protein 5
chr14_-_68424653 1.966 ACTN1
actinin, alpha 1
chr2_-_162808123 1.896 NM_004460
FAP
fibroblast activation protein, alpha
chr11_+_834111 1.872 TSPAN4
tetraspanin 4
chr11_+_834445 1.859 NM_001025237
TSPAN4
tetraspanin 4
chr9_-_16717887 1.847 BNC2
basonuclin 2
chr11_+_834062 1.837 NM_001025234
TSPAN4
tetraspanin 4
chr3_+_156280604 1.742 NM_007288
MME
membrane metallo-endopeptidase
chr2_+_189547358 1.668 COL3A1
collagen, type III, alpha 1
chr8_+_70567581 1.658 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr17_+_1612056 1.656 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr7_-_124192265 1.648 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr5_+_125786717 1.648 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr15_+_30721161 1.624 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chrX_-_10605726 1.617 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr2_-_217268492 1.608 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr5_-_125956996 1.566 ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr9_+_123123364 1.554 GSN
gelsolin
chr5_-_125958503 1.553 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr17_+_1611983 1.503 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr9_+_696744 1.500 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr6_+_123152044 1.476 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr6_-_134540666 1.469 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr2_+_189547323 1.466 NM_000090
COL3A1
collagen, type III, alpha 1
chr12_-_8706533 1.453 MFAP5
microfibrillar associated protein 5
chr2_-_151052391 1.451 NM_005168
RND3
Rho family GTPase 3
chr20_+_44771532 1.447 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr12_+_12935222 1.437 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr2_-_237987579 1.409 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr4_+_41309668 1.405 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr12_-_9159707 1.401 A2M
alpha-2-macroglobulin
chr2_+_189547377 1.365 COL3A1
collagen, type III, alpha 1
chr12_-_9159789 1.365 NM_000014
A2M
alpha-2-macroglobulin
chr12_-_9159780 1.362 A2M
alpha-2-macroglobulin
chrX_-_114158388 1.360 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chrX_-_37964924 1.353 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr20_+_19863716 1.348 RIN2
Ras and Rab interactor 2
chr5_-_39430180 1.337 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr8_-_134378630 1.334 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr3_-_150903749 1.333 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr15_-_70288071 1.330 PKM2
pyruvate kinase, muscle
chr3_+_156280772 1.328 NM_007289
MME
membrane metallo-endopeptidase
chr11_-_8695974 1.327 ST5
suppression of tumorigenicity 5
chr5_+_140871107 1.323


chr8_-_62764839 1.322 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chrX_+_102498035 1.313 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr10_+_123912930 1.296 TACC2
transforming, acidic coiled-coil containing protein 2
chr3_+_133518900 1.292 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr6_+_36752244 1.246 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr3_+_133518966 1.245 ACPP
acid phosphatase, prostate
chr1_-_103269356 1.238 COL11A1
collagen, type XI, alpha 1
chr1_-_31618405 1.223 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr1_-_199732323 1.221 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr14_+_93646831 1.219 NM_001130080
NM_005532
IFI27

interferon, alpha-inducible protein 27

chr12_-_8706746 1.209 MFAP5
microfibrillar associated protein 5
chr2_-_189752575 1.182 NM_000393
COL5A2
collagen, type V, alpha 2
chr8_-_18585721 1.175 PSD3
pleckstrin and Sec7 domain containing 3
chr8_+_31616809 1.161 NM_013962
NRG1
neuregulin 1
chr1_-_166373434 1.157 GPR161
G protein-coupled receptor 161
chr3_+_189425886 1.154 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_+_1612092 1.154 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr9_+_123083540 1.151 GSN
gelsolin
chrX_-_100801472 1.150 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr21_+_29439768 1.132 C21orf7
chromosome 21 open reading frame 7
chr5_-_151046638 1.126 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr21_+_29374743 1.117 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr11_-_27637771 1.116 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr1_+_161308318 1.079 NM_001113380
RGS4
regulator of G-protein signaling 4
chr12_-_8706637 1.069 NM_003480
MFAP5
microfibrillar associated protein 5
chr1_+_162795328 1.064 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr22_+_36928972 1.061 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr17_+_1612031 1.061 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr8_-_125648576 1.050 MTSS1
metastasis suppressor 1
chr11_-_27700180 1.049 NM_170731
BDNF
brain-derived neurotrophic factor
chr12_+_77963563 1.026 NM_001135806
SYT1
synaptotagmin I
chr2_-_237987554 1.023 COL6A3
collagen, type VI, alpha 3
chr11_+_119862014 1.009 ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr4_+_154293719 1.004 NM_001130067
TRIM2
tripartite motif containing 2
chr2_-_218865451 0.997 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr11_+_129484540 0.989 APLP2
amyloid beta (A4) precursor-like protein 2
chr6_-_122807439 0.983 SERINC1
serine incorporator 1
chr1_-_201420927 0.983 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr1_+_160868932 0.976 DDR2
discoidin domain receptor tyrosine kinase 2
chr5_+_36644187 0.975 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_-_32658215 0.972 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_237987509 0.971 COL6A3
collagen, type VI, alpha 3
chr5_+_102229612 0.960 PAM
peptidylglycine alpha-amidating monooxygenase
chr1_+_160868822 0.929 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr21_+_36429079 0.929 NM_001236
CBR3
carbonyl reductase 3
chr1_-_201422533 0.913 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr11_-_102174102 0.882 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr11_+_101488380 0.879 NM_001195045
YAP1
Yes-associated protein 1
chr12_+_55201854 0.871 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr1_-_201422450 0.866 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr1_+_144236346 0.866 NM_003637
ITGA10
integrin, alpha 10
chr22_+_36928011 0.860 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr3_-_152403636 0.859 NM_013308
GPR171
G protein-coupled receptor 171
chr1_+_203179976 0.859 NM_001160331
NFASC
neurofascin
chr1_+_169421011 0.856 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr7_+_12217343 0.851 NM_001134232
NM_018374
TMEM106B

transmembrane protein 106B

chr8_-_93144366 0.836 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_171621721 0.835 NM_001185056
CLDN11
claudin 11
chr15_+_97009194 0.825 IGF1R
insulin-like growth factor 1 receptor
chr9_-_14076901 0.807 NFIB
nuclear factor I/B
chr11_-_17147863 0.805 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr9_-_109291575 0.801 KLF4
Kruppel-like factor 4 (gut)
chr4_-_102487649 0.797 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr1_+_86662356 0.797 NM_006536
CLCA2
chloride channel accessory 2
chr8_+_19215279 0.797 NM_001174160
NM_022071
NM_001174159
SH2D4A


SH2 domain containing 4A


chr3_+_139550368 0.796 MRAS
muscle RAS oncogene homolog
chr17_+_23686674 0.792 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chrX_+_105932536 0.792 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr13_-_109600709 0.787 COL4A1
collagen, type IV, alpha 1
chr1_-_201422368 0.780 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr19_+_54723044 0.778 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr1_-_201422490 0.767 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr9_+_78283076 0.762 NM_001097635
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_-_166373159 0.762 GPR161
G protein-coupled receptor 161
chr3_-_58497913 0.762 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr11_+_112337199 0.760 NM_000615
NM_001076682
NM_181351
NCAM1


neural cell adhesion molecule 1


chr4_+_124540114 0.760 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr6_+_52393763 0.749 NM_001172420
EFHC1
EF-hand domain (C-terminal) containing 1
chr21_-_26175068 0.746 APP
amyloid beta (A4) precursor protein
chr1_-_238842071 0.738 NM_022469
GREM2
gremlin 2
chr2_+_201158955 0.735 AOX1
aldehyde oxidase 1
chr6_-_112682573 0.732 LAMA4
laminin, alpha 4
chr22_-_30016707 0.731 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr3_+_133798770 0.729 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr7_-_50740491 0.724 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr3_-_187309442 0.720 NM_004454
ETV5
ets variant 5
chr9_+_96561750 0.717 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr19_-_63353956 0.715 NM_024620
ZNF329
zinc finger protein 329
chr1_-_151866367 0.714 NM_001024212
S100A13
S100 calcium binding protein A13
chr12_-_74711642 0.712 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr9_+_114953087 0.706 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr11_-_2108035 0.686 IGF2
insulin-like growth factor 2 (somatomedin A)
chr20_+_43468617 0.680 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr11_-_102174032 0.677 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr18_+_30327341 0.670 DTNA
dystrobrevin, alpha
chr4_-_111339201 0.669 NM_001130721
NM_024090
ELOVL6

ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)

chr17_+_3324096 0.664 NM_001128085
ASPA
aspartoacylase
chr12_-_100979869 0.656 CCDC53
coiled-coil domain containing 53
chr2_+_201158975 0.656 NM_001159
AOX1
aldehyde oxidase 1
chr7_+_134114912 0.651 CALD1
caldesmon 1
chr1_+_224083047 0.646 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr19_-_14800275 0.643 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr2_-_192419896 0.641 SDPR
serum deprivation response
chr9_+_114953048 0.640 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr8_+_110443881 0.637 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr5_-_149515331 0.636 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr5_+_140751666 0.633 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr1_-_201422436 0.630 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr3_+_69895310 0.627 NM_001184967
MITF
microphthalmia-associated transcription factor
chr13_-_35842289 0.626 NM_001142294
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr11_-_8789457 0.623 NM_139157
ST5
suppression of tumorigenicity 5
chr8_-_27997306 0.622 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chrX_-_119487164 0.619 LAMP2
lysosomal-associated membrane protein 2
chr15_+_22772545 0.616 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr18_-_490583 0.608 NM_130386
COLEC12
collectin sub-family member 12
chr14_-_50480857 0.604 NM_001163940
NM_002863
PYGL

phosphorylase, glycogen, liver

chr12_-_100979893 0.600 CCDC53
coiled-coil domain containing 53
chr9_-_116920232 0.597 NM_002160
TNC
tenascin C
chr1_+_162795538 0.589 PBX1
pre-B-cell leukemia homeobox 1
chr2_-_192420168 0.586 NM_004657
SDPR
serum deprivation response
chr2_-_99319197 0.584 NM_005783
TXNDC9
thioredoxin domain containing 9
chr11_+_19328846 0.578 NM_001111018
NAV2
neuron navigator 2
chr12_+_52665196 0.576 NM_017409
HOXC10
homeobox C10
chr9_+_119506446 0.574 TLR4
toll-like receptor 4
chr6_-_57194977 0.571 NM_016277
RAB23
RAB23, member RAS oncogene family

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 1.55e-03 GO:0005576 extracellular region
2.04 5.05e-03 GO:0005578 proteinaceous extracellular matrix
2.75 6.07e-03 GO:0044420 extracellular matrix part
1.46 3.18e-02 GO:0044421 extracellular region part
1.21 4.02e-02 GO:0005886 plasma membrane
1.82 4.14e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
12.84 2.00e-02 GO:0047023 androsterone dehydrogenase activity
1.62 2.88e-02 GO:0005509 calcium ion binding
2.54 4.72e-02 GO:0019838 growth factor binding