Motif ID: ATF4.p2

Z-value: 1.196


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_38246509-0.476.8e-02Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_140270749 1.721 NM_004333
 BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr19_+_18145578 1.611 NM_006332
 IFI30
interferon, gamma-inducible protein 30
chr19_+_18145631 1.600 IFI30
interferon, gamma-inducible protein 30
chr11_+_67107852 1.437 GSTP1
glutathione S-transferase pi 1
chr4_+_75529716 1.394 NM_001657
 AREG
amphiregulin
chr16_+_22732982 1.379 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr7_-_105712565 1.368 NAMPT
nicotinamide phosphoribosyltransferase
chr1_+_26368969 1.362 NM_015871
 ZNF593
zinc finger protein 593
chr4_+_75699652 1.361 NM_001657
 AREG
amphiregulin
chr7_+_5598964 1.344 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr12_+_131194967 1.313 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr17_+_54124928 1.309 RAD51C
RAD51 homolog C (S. cerevisiae)
chr17_-_8092098 1.259 NM_025099
 CTC1
CTS telomere maintenance complex component 1
chr17_+_54124952 1.221 NM_002876
NM_058216
 RAD51C

RAD51 homolog C (S. cerevisiae)

chr11_+_4072635 1.182 RRM1
ribonucleotide reductase M1
chr11_+_4072653 1.154 RRM1
ribonucleotide reductase M1
chr18_+_18767275 1.143 NM_002894
 RBBP8
retinoblastoma binding protein 8
chr19_-_60610971 1.124 UBE2S
ubiquitin-conjugating enzyme E2S
chr11_+_4072499 1.120 NM_001033
 RRM1
ribonucleotide reductase M1
chr18_+_55718171 1.113 NM_021127
 PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
4.10 2.01e-02 GO:0000723 telomere maintenance
4.02 2.60e-02 GO:0032200 telomere organization
3.15 2.51e-02 GO:0031497 chromatin assembly
2.77 1.05e-02 GO:0071103 DNA conformation change
2.66 4.85e-02 GO:0006333 chromatin assembly or disassembly
2.05 4.32e-02 GO:0051325 interphase
1.95 5.89e-05 GO:0022403 cell cycle phase
1.92 1.26e-03 GO:0000278 mitotic cell cycle
1.88 1.57e-03 GO:0051276 chromosome organization
1.86 9.03e-05 GO:0022402 cell cycle process
1.86 1.70e-02 GO:0006974 response to DNA damage stimulus
1.76 4.78e-02 GO:0006259 DNA metabolic process
1.75 2.96e-02 GO:0006396 RNA processing
1.67 1.03e-02 GO:0033554 cellular response to stress
1.65 2.89e-03 GO:0007049 cell cycle
1.62 1.51e-09 GO:0090304 nucleic acid metabolic process
1.57 1.13e-10 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.53 5.89e-04 GO:0006996 organelle organization
1.52 3.03e-04 GO:0016070 RNA metabolic process
1.51 3.79e-10 GO:0034641 cellular nitrogen compound metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
11.62 4.08e-02 GO:0005663 DNA replication factor C complex
2.84 3.07e-02 GO:0032993 protein-DNA complex
2.61 1.76e-02 GO:0000775 chromosome, centromeric region
2.52 2.93e-02 GO:0000793 condensed chromosome
2.25 9.02e-07 GO:0044427 chromosomal part
2.22 5.83e-08 GO:0005694 chromosome
1.67 1.25e-06 GO:0005654 nucleoplasm
1.58 3.66e-07 GO:0031981 nuclear lumen
1.55 7.68e-08 GO:0044428 nuclear part
1.51 4.24e-07 GO:0070013 intracellular organelle lumen
1.49 9.22e-07 GO:0043233 organelle lumen
1.48 1.38e-06 GO:0031974 membrane-enclosed lumen
1.38 2.80e-13 GO:0005634 nucleus
1.36 6.47e-04 GO:0043228 non-membrane-bounded organelle
1.36 6.47e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.35 1.02e-02 GO:0005829 cytosol
1.30 6.62e-04 GO:0032991 macromolecular complex
1.28 7.18e-07 GO:0044446 intracellular organelle part
1.26 3.00e-06 GO:0044422 organelle part
1.22 6.51e-10 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.58 1.99e-05 GO:0030554 adenyl nucleotide binding
1.58 2.64e-05 GO:0032559 adenyl ribonucleotide binding
1.58 3.47e-05 GO:0005524 ATP binding
1.48 2.13e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.47 3.02e-04 GO:0017076 purine nucleotide binding
1.46 3.58e-04 GO:0032553 ribonucleotide binding
1.46 3.58e-04 GO:0032555 purine ribonucleotide binding
1.44 8.88e-05 GO:0000166 nucleotide binding
1.43 5.70e-07 GO:0003676 nucleic acid binding
1.43 3.32e-04 GO:0003677 DNA binding
1.19 2.59e-05 GO:0005515 protein binding
1.19 3.95e-02 GO:0003824 catalytic activity
1.10 1.34e-04 GO:0005488 binding