Motif ID: FOSL2.p2

Z-value: 1.003


Transcription factors associated with FOSL2.p2:

Gene SymbolEntrez IDGene Name
FOSL2 2355 FOS-like antigen 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSL2chr2_+_28469199,
chr2_+_28469850
0.543.0e-02Click!


Activity profile for motif FOSL2.p2.

activity profile for motif FOSL2.p2


Sorted Z-values histogram for motif FOSL2.p2

Sorted Z-values for motif FOSL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_27528105 2.551 CLU
clusterin
chr2_-_215967442 2.238 FN1
fibronectin 1
chr6_-_138470160 2.192 NM_022121
PERP
PERP, TP53 apoptosis effector
chr3_+_134976965 2.182 TF
transferrin
chr7_+_23252802 2.049 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr11_-_102174102 1.902 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr11_-_102174032 1.891 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr7_+_23252915 1.815 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23252911 1.815 GPNMB
glycoprotein (transmembrane) nmb
chr5_+_150000394 1.778 NM_001109974
NM_007286
SYNPO

synaptopodin

chr11_-_114593838 1.650 CADM1
cell adhesion molecule 1
chr7_+_23252909 1.583 GPNMB
glycoprotein (transmembrane) nmb
chr5_-_149515613 1.526 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr6_+_83129641 1.465 NM_006670
TPBG
trophoblast glycoprotein
chr20_+_42776888 1.413 WISP2
WNT1 inducible signaling pathway protein 2
chr11_+_57123927 1.348 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr16_+_55199978 1.335 NM_005953
MT2A
metallothionein 2A
chr8_-_27528215 1.301 NM_001831
CLU
clusterin
chr7_+_23252945 1.259 GPNMB
glycoprotein (transmembrane) nmb
chr7_-_107430566 1.244 NM_002291
LAMB1
laminin, beta 1
chr6_-_134538526 1.235 SGK1
serum/glucocorticoid regulated kinase 1
chr11_+_101488380 1.180 NM_001195045
YAP1
Yes-associated protein 1
chr3_+_189413414 1.155 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_+_169326641 1.128 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr11_-_6298284 1.086 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr8_-_13018123 1.045 NM_001164271
DLC1
deleted in liver cancer 1
chr12_-_90097384 0.993 NM_133503
DCN
decorin
chr19_-_40939756 0.945 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr20_+_42777298 0.934 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr12_+_110689094 0.919 ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
chr5_+_35892747 0.919 NM_002185
IL7R
interleukin 7 receptor
chr14_-_93924663 0.919 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr12_+_13240868 0.918 NM_001423
EMP1
epithelial membrane protein 1
chr21_+_46367216 0.913 COL6A2
collagen, type VI, alpha 2
chr14_-_93924873 0.908 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr12_+_76749199 0.905 NM_014903
NAV3
neuron navigator 3
chr3_-_31998241 0.902 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr11_-_8695974 0.881 ST5
suppression of tumorigenicity 5
chrX_-_10761729 0.878 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr12_+_13240987 0.872 EMP1
epithelial membrane protein 1
chr10_-_95350949 0.870 NM_006744
RBP4
retinol binding protein 4, plasma
chr4_+_169989680 0.837 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr15_+_65245546 0.801 NM_001145104
SMAD3
SMAD family member 3
chrX_+_115481774 0.796 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr2_+_151922350 0.787 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr17_-_45617899 0.772 COL1A1
collagen, type I, alpha 1
chr19_-_62028185 0.770 NM_001146186
PEG3
paternally expressed 3
chr18_+_19706979 0.749 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr12_-_105057940 0.733 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr11_+_2881080 0.730 SLC22A18
solute carrier family 22, member 18
chr17_+_7423662 0.727 CD68
CD68 molecule
chr12_+_10256682 0.717 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr17_+_7423704 0.717 CD68
CD68 molecule
chr3_-_188936941 0.715 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr16_-_62573 0.714 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr3_-_115826481 0.712 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr17_+_7423528 0.709 NM_001251
NM_001040059
CD68

CD68 molecule

chr7_+_93862137 0.707 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr21_-_26465005 0.706 NM_000484
NM_001136129
NM_001136130
NM_201413
NM_201414
APP




amyloid beta (A4) precursor protein




chr13_-_37070862 0.705 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr11_+_120966280 0.700 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr15_-_68971665 0.694 NM_020147
THAP10
THAP domain containing 10
chr17_+_7423685 0.683 CD68
CD68 molecule
chr17_+_21131940 0.673 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr6_-_134538762 0.669 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr7_-_136678901 0.656 PTN
pleiotrophin
chr20_+_34206070 0.652 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr7_-_136678815 0.652 PTN
pleiotrophin
chr2_+_46779553 0.648 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr1_-_154941861 0.638 NM_001878
CRABP2
cellular retinoic acid binding protein 2
chr4_-_177950658 0.637 NM_005429
VEGFC
vascular endothelial growth factor C
chr1_+_152644292 0.622 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr7_+_116099648 0.616 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chrX_+_135079120 0.610 NM_001159704
FHL1
four and a half LIM domains 1
chr6_-_30820264 0.606 NM_003897
IER3
immediate early response 3
chr10_+_5126589 0.606 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr20_+_42777419 0.605 WISP2
WNT1 inducible signaling pathway protein 2
chr4_+_74498042 0.600 ALB
albumin
chr14_-_93919305 0.592 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr8_+_126511739 0.586 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr8_+_43114710 0.585 NM_152419
HGSNAT
heparan-alpha-glucosaminide N-acetyltransferase
chr10_+_5126556 0.571 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_-_121884091 0.568 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr9_+_78246401 0.563 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr5_-_150501393 0.555 NM_001193544
ANXA6
annexin A6
chr2_+_102136833 0.554 NM_000877
IL1R1
interleukin 1 receptor, type I
chrX_+_99785818 0.549 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr5_-_121441910 0.542 NM_002317
LOX
lysyl oxidase
chr11_-_102219450 0.539 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr17_-_7531456 0.539 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chr17_-_74433048 0.538 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr15_+_20443958 0.533 CYFIP1
cytoplasmic FMR1 interacting protein 1
chrY_+_13526169 0.532 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr21_-_26464915 0.526 APP
amyloid beta (A4) precursor protein
chr8_-_17797127 0.522 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr9_+_115382990 0.522 RGS3
regulator of G-protein signaling 3
chr6_+_107066422 0.520 NM_001624
AIM1
absent in melanoma 1
chr1_-_17180659 0.518 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr22_+_38246509 0.514 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr15_+_20444155 0.514 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr7_+_48094750 0.505 NM_181597
UPP1
uridine phosphorylase 1
chr2_-_165406098 0.502 COBLL1
COBL-like 1
chr17_+_77261440 0.500 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr10_-_88844666 0.499 NM_005271
GLUD1
glutamate dehydrogenase 1
chr19_+_11061037 0.499 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr7_+_142788521 0.495 ZYX
zyxin
chr15_+_20444164 0.495 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr4_-_89299034 0.494 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr15_+_20444124 0.493 NM_014608
CYFIP1
cytoplasmic FMR1 interacting protein 1
chr21_+_29439768 0.484 C21orf7
chromosome 21 open reading frame 7
chr9_-_115880425 0.483 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_+_77261477 0.481 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr14_-_23847024 0.476 CIDEB
cell death-inducing DFFA-like effector b
chrX_+_105823723 0.473 NM_024539
RNF128
ring finger protein 128
chr4_+_47181987 0.473 NM_020453
ATP10D
ATPase, class V, type 10D
chr11_+_696103 0.472 NM_022772
EPS8L2
EPS8-like 2
chr10_+_7785235 0.471 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chrX_-_133876914 0.470 NM_019556
MOSPD1
motile sperm domain containing 1
chr7_+_142788579 0.470 ZYX
zyxin
chr16_-_11587647 0.470 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr5_-_111340421 0.469 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr2_+_190916440 0.468 NM_001128928
NM_002194
INPP1

inositol polyphosphate-1-phosphatase

chr17_+_77261457 0.459


chr19_-_48866111 0.451 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr18_+_59593591 0.449 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr17_+_72958330 0.444 SEPT9
septin 9
chr10_+_5126613 0.443 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_-_8668723 0.442 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr7_+_142788566 0.440 ZYX
zyxin
chr17_+_72827227 0.439 SEPT9
septin 9
chr3_+_11153778 0.439 NM_001098213
HRH1
histamine receptor H1
chr11_-_27700180 0.438 NM_170731
BDNF
brain-derived neurotrophic factor
chrX_+_99786044 0.438 SRPX2
sushi-repeat containing protein, X-linked 2
chr10_+_7785360 0.436 ITIH2
inter-alpha (globulin) inhibitor H2
chr14_-_23846993 0.435 CIDEB
cell death-inducing DFFA-like effector b
chr9_-_109291866 0.434 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr9_+_123123364 0.430 GSN
gelsolin
chr1_-_108032645 0.429 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr7_+_142788569 0.421 ZYX
zyxin
chr9_-_16717887 0.421 BNC2
basonuclin 2
chr7_-_93357881 0.418 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr18_+_258147 0.418


chr6_+_138230045 0.416 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr3_-_127258299 0.414 NM_001008487
SLC41A3
solute carrier family 41, member 3
chr7_+_142788480 0.410 NM_001010972
NM_003461
ZYX

zyxin

chr5_-_138561897 0.410 SIL1
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
chrX_+_135079461 0.410 NM_001167819
FHL1
four and a half LIM domains 1
chr3_+_69216747 0.409 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr7_+_142788517 0.407 ZYX
zyxin
chr17_-_38421363 0.406 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr10_-_101759630 0.406 NM_015221
DNMBP
dynamin binding protein
chr17_+_72958207 0.406 NM_001113496
SEPT9
septin 9
chr17_-_74432800 0.400 TIMP2
TIMP metallopeptidase inhibitor 2
chr9_-_115880366 0.399 AMBP
alpha-1-microglobulin/bikunin precursor
chr16_-_30032330 0.398 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr16_+_55523248 0.397 NM_001010989
NM_001010990
NM_014685
HERPUD1


homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1


chr15_+_65205107 0.394 NM_001145102
SMAD3
SMAD family member 3
chr2_-_162808123 0.392 NM_004460
FAP
fibroblast activation protein, alpha
chr4_+_74497998 0.392 ALB
albumin
chr17_+_72827185 0.391 NM_006640
SEPT9
septin 9
chr1_-_153209625 0.390 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr17_+_77261401 0.389 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr1_+_154351162 0.389 LMNA
lamin A/C
chr3_-_167037946 0.388 NM_000055
BCHE
butyrylcholinesterase
chr18_-_72336133 0.387 NM_014643
ZNF516
zinc finger protein 516
chr14_+_54291255 0.383 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr10_-_101831579 0.379 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr3_-_121883647 0.379 HGD
homogentisate 1,2-dioxygenase
chr5_-_121441805 0.378 LOX
lysyl oxidase
chr12_-_131915023 0.378 GOLGA3
golgin A3
chr6_-_46401363 0.378 NM_005822
RCAN2
regulator of calcineurin 2
chr2_-_152538694 0.376 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr20_+_30480848 0.374 ASXL1
additional sex combs like 1 (Drosophila)
chr14_-_23847000 0.371 CIDEB
cell death-inducing DFFA-like effector b
chr21_-_26464931 0.369 APP
amyloid beta (A4) precursor protein
chr5_-_121441866 0.368 LOX
lysyl oxidase
chr21_+_29374743 0.367 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr8_+_26296439 0.366 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr7_+_72883128 0.366 NM_001305
CLDN4
claudin 4
chr7_-_136678973 0.365 PTN
pleiotrophin
chr15_+_20444140 0.365 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr13_+_96592051 0.361 MBNL2
muscleblind-like 2 (Drosophila)
chr20_+_10147455 0.359 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr5_-_138561925 0.359 NM_001037633
NM_022464
SIL1

SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)

chr7_+_90176647 0.356 NM_012395
CDK14
cyclin-dependent kinase 14
chr10_+_7785347 0.356 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_+_154120170 0.356 SYT11
synaptotagmin XI
chr3_-_11585264 0.344 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr22_-_43986896 0.342 KIAA0930
KIAA0930
chr3_+_36396948 0.338 NM_003149
STAC
SH3 and cysteine rich domain
chr11_-_71458739 0.337 NUMA1
nuclear mitotic apparatus protein 1
chrX_+_133952633 0.337 NM_001163438
LOC644538
hypothetical protein LOC644538
chr7_+_80105858 0.336 CD36
CD36 molecule (thrombospondin receptor)
chr3_-_167037861 0.334 BCHE
butyrylcholinesterase
chr18_+_54489658 0.331 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr22_-_37044034 0.331 NM_001894
CSNK1E
casein kinase 1, epsilon
chr16_+_31274030 0.330 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr8_-_103735194 0.329 NM_001032282
KLF10
Kruppel-like factor 10
chr2_+_69055208 0.328 NM_019617
GKN1
gastrokine 1
chr15_+_78858763 0.327 NM_018689
KIAA1199
KIAA1199

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
14.31 8.34e-03 GO:0034993 SUN-KASH complex
1.36 4.23e-02 GO:0005576 extracellular region

Nothing significant found in function category.