Motif ID: SRY.p2

Z-value: 1.340


Transcription factors associated with SRY.p2:

Gene SymbolEntrez IDGene Name
SRY 6736 sex determining region Y

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRYchrY_-_2715478-0.116.9e-01Click!


Activity profile for motif SRY.p2.

activity profile for motif SRY.p2


Sorted Z-values histogram for motif SRY.p2

Sorted Z-values for motif SRY.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SRY.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_74956614 5.047 ANXA1
annexin A1
chr9_+_74956494 4.554 NM_000700
ANXA1
annexin A1
chr17_-_59817456 3.030 PECAM1
platelet/endothelial cell adhesion molecule
chr9_+_74956601 2.921 ANXA1
annexin A1
chr17_-_59817575 2.827 PECAM1
platelet/endothelial cell adhesion molecule
chr17_-_59817722 2.532 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr8_-_82557956 2.334 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr17_-_59817654 2.225 PECAM1
platelet/endothelial cell adhesion molecule
chr12_-_28016182 2.071 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr7_+_134114957 1.841 CALD1
caldesmon 1
chr11_+_129484540 1.809 APLP2
amyloid beta (A4) precursor-like protein 2
chr1_+_149299490 1.780 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr12_+_77963563 1.766 NM_001135806
SYT1
synaptotagmin I
chr4_-_101658094 1.669 NM_001159694
NM_016242
EMCN

endomucin

chr8_+_32623792 1.567 NM_013959
NRG1
neuregulin 1
chr1_+_66230977 1.543 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr2_-_215967442 1.532 FN1
fibronectin 1
chr2_+_101680594 1.472 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr1_+_149299307 1.472 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr12_-_6103945 1.453 NM_000552
VWF
von Willebrand factor
chrX_+_107569671 1.420 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr1_-_47468029 1.401 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chrX_-_99778340 1.379 NM_003270
TSPAN6
tetraspanin 6
chr9_-_14304036 1.374 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr2_-_192420168 1.364 NM_004657
SDPR
serum deprivation response
chr1_+_43539239 1.358 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr6_-_134540666 1.350 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr9_+_27099138 1.331 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr6_+_12398514 1.325 NM_001168319
NM_001955
EDN1

endothelin 1

chr5_+_34723420 1.322 NM_001145523
RAI14
retinoic acid induced 14
chr1_-_161380562 1.309 RGS5
regulator of G-protein signaling 5
chr18_+_3441589 1.303 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr1_+_149299530 1.300 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_149299504 1.294 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chrX_+_15435351 1.294 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr2_+_101874765 1.270 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr7_-_27171648 1.253 HOXA9
homeobox A9
chr20_+_19863716 1.250 RIN2
Ras and Rab interactor 2
chr7_-_27171673 1.239 NM_152739
HOXA9
homeobox A9
chr18_+_71051713 1.230 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr12_-_88270375 1.226 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr6_-_128883125 1.219 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr3_-_150569574 1.209 TM4SF1
transmembrane 4 L six family member 1
chr13_-_109600709 1.195 COL4A1
collagen, type IV, alpha 1
chr10_-_105835609 1.163 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr12_+_13240987 1.162 EMP1
epithelial membrane protein 1
chr12_-_10142779 1.157 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr9_-_32516164 1.123 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr4_+_86918870 1.115 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr12_-_69317441 1.090 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr20_+_19818209 1.080 NM_018993
RIN2
Ras and Rab interactor 2
chr18_+_45342398 1.070 NM_006033
LIPG
lipase, endothelial
chr12_-_51173238 1.066 NM_005554
KRT6A
keratin 6A
chr7_-_50740491 1.063 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr2_+_101874809 1.049 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr17_-_36996611 1.044 NM_000526
KRT14
keratin 14
chr2_-_165133239 1.042 GRB14
growth factor receptor-bound protein 14
chr5_+_71538456 1.025 MAP1B
microtubule-associated protein 1B
chr12_-_8706533 1.006 MFAP5
microfibrillar associated protein 5
chr4_-_186969041 0.984 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chrX_+_15428820 0.971 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr5_+_36642424 0.970 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_105835525 0.967 COL17A1
collagen, type XVII, alpha 1
chr6_-_47385313 0.957 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr22_-_34566367 0.955 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr1_+_185064654 0.951 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr5_+_34720368 0.941 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr1_-_171286634 0.940 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr5_+_36642213 0.939 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr22_-_34566276 0.923 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_+_84382529 0.917 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_-_88962426 0.913 NM_001143837
NOX4
NADPH oxidase 4
chr11_-_102174102 0.897 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr3_+_115099007 0.892 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr1_-_151873191 0.888 NM_001024210
S100A13
S100 calcium binding protein A13
chr11_+_129496792 0.885 APLP2
amyloid beta (A4) precursor-like protein 2
chr2_-_224974954 0.879 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr1_+_66570363 0.879 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr22_-_17892859 0.869 NM_001130861
NM_003277
CLDN5

claudin 5

chr22_-_34566210 0.862 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr4_-_159312973 0.857 FAM198B
family with sequence similarity 198, member B
chr14_+_93646831 0.857 NM_001130080
NM_005532
IFI27

interferon, alpha-inducible protein 27

chr1_-_161379606 0.854 RGS5
regulator of G-protein signaling 5
chr2_+_207115060 0.845 ADAM23
ADAM metallopeptidase domain 23
chr6_+_151602787 0.840 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr15_+_41672543 0.837 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chrX_-_10504852 0.831 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr2_-_189752575 0.814 NM_000393
COL5A2
collagen, type V, alpha 2
chr6_+_151603201 0.814 AKAP12
A kinase (PRKA) anchor protein 12
chr21_+_34112456 0.814 ITSN1
intersectin 1 (SH3 domain protein)
chr11_-_102174032 0.811 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr1_-_20682541 0.800


chr1_+_153366928 0.793 NM_004428
NM_182685
EFNA1

ephrin-A1

chr21_+_38550739 0.791 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr10_-_118670968 0.789 KIAA1598
KIAA1598
chr18_+_3443771 0.784 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr13_-_98428244 0.782 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr10_-_126839000 0.782 CTBP2
C-terminal binding protein 2
chr6_-_134680888 0.779 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_188021117 0.778 NM_005795
CALCRL
calcitonin receptor-like
chr4_-_139382672 0.766 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr11_+_113436438 0.763 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr2_-_192419896 0.758 SDPR
serum deprivation response
chrX_+_102498035 0.756 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr10_+_124124083 0.756 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr7_-_107430566 0.744 NM_002291
LAMB1
laminin, beta 1
chr4_+_169654742 0.743 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr17_-_8364942 0.736 MYH10
myosin, heavy chain 10, non-muscle
chr2_+_102320148 0.732 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr3_-_170346760 0.725 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr10_-_126839056 0.721 NM_001329
CTBP2
C-terminal binding protein 2
chr21_-_38792173 0.703 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr18_+_3437607 0.694 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr11_+_57285809 0.692 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001331
CTNND1












catenin (cadherin-associated protein), delta 1












chr3_+_143824955 0.691 NM_002670
PLS1
plastin 1
chr4_-_186969202 0.690 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr9_-_14388981 0.689 NM_001190738
NFIB
nuclear factor I/B
chr9_-_14076901 0.688 NFIB
nuclear factor I/B
chr6_+_158653679 0.684 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr9_-_73573121 0.677 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr11_-_17147863 0.668 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr1_+_153366559 0.666 EFNA1
ephrin-A1
chr2_-_151052391 0.665 NM_005168
RND3
Rho family GTPase 3
chr11_-_72057755 0.655 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr12_-_94135154 0.653 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr3_+_62280435 0.653 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr10_+_124124196 0.651 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr4_+_91035025 0.644 NM_007351
MMRN1
multimerin 1
chr12_-_51132129 0.638 NM_005555
KRT6B
keratin 6B
chr2_-_218865451 0.634 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr16_+_54072969 0.634 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr8_-_13178399 0.633 DLC1
deleted in liver cancer 1
chr21_+_42492867 0.632 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr2_-_113310796 0.623 NM_000576
IL1B
interleukin 1, beta
chr14_+_85066265 0.620 FLRT2
fibronectin leucine rich transmembrane protein 2
chr9_+_33614214 0.619 ANXA2P2
annexin A2 pseudogene 2
chr12_+_76749199 0.614 NM_014903
NAV3
neuron navigator 3
chr4_-_186934059 0.614 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr2_+_183290912 0.610 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chrX_+_135079120 0.606 NM_001159704
FHL1
four and a half LIM domains 1
chr18_+_27281729 0.599 NM_001944
DSG3
desmoglein 3
chr7_-_27186400 0.598 NM_153715
HOXA10
homeobox A10
chr8_-_17624304 0.592 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr2_-_160181206 0.590 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr1_-_85703198 0.588 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr22_+_36928972 0.581 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr11_+_59279377 0.575 STX3
syntaxin 3
chr9_-_16717887 0.575 BNC2
basonuclin 2
chr7_-_41709191 0.559 NM_002192
INHBA
inhibin, beta A
chr10_-_116434364 0.558 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr19_-_18910790 0.549 NM_001145724
HOMER3
homer homolog 3 (Drosophila)
chr18_+_59405513 0.542 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr11_+_59279107 0.533 NM_001178040
NM_004177
STX3

syntaxin 3

chr2_+_234286376 0.531 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr2_-_55090759 0.528 NM_007008
RTN4
reticulon 4
chr4_-_159313167 0.528 NM_016613
FAM198B
family with sequence similarity 198, member B
chr7_+_134114912 0.527 CALD1
caldesmon 1
chr13_-_47885018 0.525 LPAR6
lysophosphatidic acid receptor 6
chr2_-_133144094 0.523 LYPD1
LY6/PLAUR domain containing 1
chr5_+_140719773 0.520 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr4_+_74491272 0.518 ALB
albumin
chr9_-_74757735 0.515 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr3_+_137224266 0.515 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr3_+_195336631 0.513 HES1
hairy and enhancer of split 1, (Drosophila)
chr13_-_47885653 0.503 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr13_-_47885248 0.502 LPAR6
lysophosphatidic acid receptor 6
chr6_-_46997579 0.500 NM_001098518
GPR116
G protein-coupled receptor 116
chr7_-_115458010 0.500 NM_001018058
NM_012252
TFEC

transcription factor EC

chr9_+_138677197 0.499 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr2_+_108571336 0.497 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_12599934 0.494 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr17_-_59451662 0.491 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr5_-_39460687 0.490 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr5_-_64813459 0.486 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr1_+_84402962 0.482 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_+_74493918 0.482 ALB
albumin
chr22_+_36928011 0.482 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr11_+_101488380 0.478 NM_001195045
YAP1
Yes-associated protein 1
chr1_-_167969802 0.478 NM_000450
SELE
selectin E
chr14_-_68424653 0.472 ACTN1
actinin, alpha 1
chr11_+_19328846 0.469 NM_001111018
NAV2
neuron navigator 2
chr9_+_115382990 0.466 RGS3
regulator of G-protein signaling 3
chr3_-_130761967 0.466 PLXND1
plexin D1
chr12_-_8706746 0.464 MFAP5
microfibrillar associated protein 5
chr8_+_79591074 0.463 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr3_-_170347019 0.458 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr9_-_74735669 0.457 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chrX_-_71709335 0.454 HDAC8
histone deacetylase 8
chr10_-_116434102 0.453 ABLIM1
actin binding LIM protein 1
chr14_-_64479198 0.448 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr19_+_35555158 0.447 NM_014717
ZNF536
zinc finger protein 536
chr9_+_115382760 0.446 NM_021106
RGS3
regulator of G-protein signaling 3
chr8_+_104900591 0.446 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr10_-_123346148 0.443 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chrX_+_135079461 0.438 NM_001167819
FHL1
four and a half LIM domains 1
chr12_+_50592379 0.436 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr3_+_190990142 0.436 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr6_-_105734535 0.435 NM_022361
POPDC3
popeye domain containing 3
chr3_-_112796855 0.433 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr2_-_113259441 0.432 NM_000575
IL1A
interleukin 1, alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 2.12e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 1.08e-02 GO:0005886 plasma membrane
1.16 2.99e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.73 3.31e-07 GO:0005509 calcium ion binding
1.36 2.63e-03 GO:0004872 receptor activity
1.28 1.70e-02 GO:0004871 signal transducer activity
1.28 1.70e-02 GO:0060089 molecular transducer activity