Motif ID: CEBPA,B_DDIT3.p2

Z-value: 0.933


Transcription factors associated with CEBPA,B_DDIT3.p2:

Gene SymbolEntrez IDGene Name
CEBPA 1050 CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB 1051 CCAAT/enhancer binding protein (C/EBP), beta
DDIT3 1649 DNA-damage-inducible transcript 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CEBPAchr19_-_384852690.821.2e-04Click!
CEBPBchr20_+_48241334,
chr20_+_48240705
0.504.6e-02Click!
DDIT3chr12_-_562005470.116.9e-01Click!


Activity profile for motif CEBPA,B_DDIT3.p2.

activity profile for motif CEBPA,B_DDIT3.p2


Sorted Z-values histogram for motif CEBPA,B_DDIT3.p2

Sorted Z-values for motif CEBPA,B_DDIT3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPA,B_DDIT3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_116125123 5.417 NM_000607
ORM1
orosomucoid 1
chr3_+_187813538 5.320 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr3_+_187813553 5.294 AHSG
alpha-2-HS-glycoprotein
chr3_+_187813405 4.769 AHSG
alpha-2-HS-glycoprotein
chr17_-_36346240 3.708 KRT23
keratin 23 (histone deacetylase inducible)
chr17_-_61655915 3.538 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_+_50144267 3.031 APOC2
apolipoprotein C-II
chr6_+_32003180 2.548 NM_000063
NM_001145903
C2

complement component 2

chr6_+_32003380 2.474 C2
complement component 2
chr10_-_116434102 2.257 ABLIM1
actin binding LIM protein 1
chr10_-_116434364 2.180 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr12_-_120781002 1.934 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr9_-_122852356 1.707 NM_001735
C5
complement component 5
chr1_+_149221122 1.490 NM_003568
ANXA9
annexin A9
chr8_-_17787342 1.448 FGL1
fibrinogen-like 1
chr6_+_167624792 1.415 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr4_-_9632192 1.383 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr12_-_61615124 1.382 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr17_+_1612056 1.339 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chrY_+_2769596 1.322 NM_001008
RPS4Y1
ribosomal protein S4, Y-linked 1
chr2_-_216009015 1.273 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr1_-_228916486 1.239 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_-_79899748 1.229 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr8_+_26569709 1.153 DPYSL2
dihydropyrimidinase-like 2
chr3_-_150422474 1.107 NM_000096
CP
ceruloplasmin (ferroxidase)
chr4_+_100704262 1.080 NM_000253
MTTP
microsomal triglyceride transfer protein
chr17_+_1612031 1.079 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr4_+_74499651 1.077 ALB
albumin
chr12_+_99391870 1.055 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr19_+_54707347 1.048 NM_001136019
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr10_-_92671005 1.029 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr17_+_1612092 0.996 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr1_-_228916470 0.972 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr10_-_92670764 0.939 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_+_12367993 0.932 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr19_+_11211282 0.896 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chrY_+_2769630 0.856 RPS4Y1
ribosomal protein S4, Y-linked 1
chr20_+_309272 0.829 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr6_+_32021831 0.741 CFB
complement factor B
chr17_+_1611983 0.709 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_-_8695974 0.698 ST5
suppression of tumorigenicity 5
chr2_-_63669085 0.682 WDPCP
WD repeat containing planar cell polarity effector
chr9_+_80101810 0.679 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr2_+_233961538 0.676 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr3_-_49701085 0.674 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr16_+_55523526 0.626 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr1_+_116744992 0.609 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr10_-_79459296 0.601 NM_007055
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chrX_+_9391314 0.595 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr3_-_131081910 0.593 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr4_+_184257337 0.592 NM_024949
WWC2
WW and C2 domain containing 2
chrX_-_131401319 0.583 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr20_+_309675 0.582 TRIB3
tribbles homolog 3 (Drosophila)
chr8_-_13018123 0.576 NM_001164271
DLC1
deleted in liver cancer 1
chr1_+_99884018 0.552 NM_017734
PALMD
palmdelphin
chr1_-_159543847 0.546 MPZ
myelin protein zero
chrX_-_15198509 0.538 NM_001168531
ASB9
ankyrin repeat and SOCS box containing 9
chr17_+_4621924 0.531 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr4_+_187424336 0.519 F11
coagulation factor XI
chr17_-_53335748 0.503 NM_017949
CUEDC1
CUE domain containing 1
chr15_+_80741827 0.502 LOC80154
hypothetical LOC80154
chr16_-_28457825 0.469 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr15_+_80741876 0.445 LOC80154
hypothetical LOC80154
chr18_-_53440012 0.443 NARS
asparaginyl-tRNA synthetase
chr18_-_53439949 0.440 NARS
asparaginyl-tRNA synthetase
chr3_+_9451506 0.427


chrX_-_13745108 0.422 GPM6B
glycoprotein M6B
chr16_-_28457728 0.417 NUPR1
nuclear protein, transcriptional regulator, 1
chr11_+_22646229 0.416 NM_177553
GAS2
growth arrest-specific 2
chrX_-_105169370 0.410 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_-_16791346 0.403 MYO10
myosin X
chr1_+_17779528 0.401 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_-_53847937 0.398 RNF43
ring finger protein 43
chr1_-_172153024 0.394 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr19_-_52427698 0.388 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr6_+_151688327 0.380 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr5_-_139993469 0.372 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr20_+_56912146 0.366 GNAS
GNAS complex locus
chr16_-_88604029 0.365 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr1_-_92144146 0.357 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr9_-_129752687 0.344 NM_203305
FAM102A
family with sequence similarity 102, member A
chrM_+_12283 0.341


chrX_-_13745134 0.334 GPM6B
glycoprotein M6B
chr1_-_67292286 0.330 SLC35D1
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr15_+_56511466 0.330 NM_000236
LIPC
lipase, hepatic
chr15_+_83724743 0.328 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr12_-_55295628 0.318 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr6_+_131936057 0.312 NM_000045
ARG1
arginase, liver
chr18_-_53440024 0.311 NM_004539
NARS
asparaginyl-tRNA synthetase
chrX_+_114734074 0.283 NM_001136025
NM_001172335
PLS3

plastin 3

chr10_+_63331018 0.283 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr17_-_77488258 0.282 NM_006907
NM_153824
PYCR1

pyrroline-5-carboxylate reductase 1

chr6_-_29635456 0.275 UBD
ubiquitin D
chr14_-_94669547 0.249 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr20_+_31613800 0.249 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr6_+_32021899 0.248 CFB
complement factor B
chrX_-_15198093 0.244 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr1_+_159451685 0.236 FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr17_-_39556483 0.218 HDAC5
histone deacetylase 5
chr8_+_124263932 0.214 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr5_+_75734759 0.212 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr5_-_16795336 0.209 MYO10
myosin X
chr1_+_210848726 0.208 ATF3
activating transcription factor 3
chr15_-_74963246 0.207 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chrX_-_12972641 0.206 NM_174901
FAM9C
family with sequence similarity 9, member C
chr7_-_44496703 0.206 NM_015332
NUDCD3
NudC domain containing 3
chr20_+_42644633 0.204 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr16_+_65552600 0.202 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr2_+_74914742 0.201 HK2
hexokinase 2
chr16_-_66827449 0.201 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr3_+_188222337 0.199 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr6_-_109521969 0.187 NM_014454
SESN1
sestrin 1
chr4_+_187424111 0.186 NM_000128
F11
coagulation factor XI
chr15_-_31999815 0.183


chr3_+_57969127 0.180 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr6_+_64414389 0.179 NM_015153
PHF3
PHD finger protein 3
chr20_+_61842880 0.174 SLC2A4RG
SLC2A4 regulator
chr1_+_210848763 0.173 ATF3
activating transcription factor 3
chr7_-_156494741 0.172 NM_001165255
MNX1
motor neuron and pancreas homeobox 1
chr12_-_69837831 0.170 TSPAN8
tetraspanin 8
chr3_+_186563529 0.169 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr13_-_29067584 0.169 SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chrY_+_15145019 0.168 NM_014893
NLGN4Y
neuroligin 4, Y-linked
chr17_-_75427644 0.163 NM_003655
CBX4
chromobox homolog 4
chr17_-_39556535 0.159 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr11_+_73339011 0.159 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr19_+_52504914 0.157 NM_001736
C5AR1
complement component 5a receptor 1
chr1_+_149897334 0.156 SNX27
sorting nexin family member 27
chr11_+_47236072 0.155 NM_001130101
NM_005693
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr1_+_210848592 0.155 NM_001040619
NM_001674
ATF3

activating transcription factor 3

chrX_-_108863165 0.152 NM_004458
NM_022977
ACSL4

acyl-CoA synthetase long-chain family member 4

chr5_-_139992621 0.151 NM_000591
CD14
CD14 molecule
chr8_-_28403652 0.145 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr16_-_68880908 0.138 NM_001605
AARS
alanyl-tRNA synthetase
chr12_+_117067214 0.138 PEBP1
phosphatidylethanolamine binding protein 1
chr13_-_44812246 0.138 TPT1
tumor protein, translationally-controlled 1
chr19_+_1401117 0.136 NM_005883
APC2
adenomatosis polyposis coli 2
chr7_-_100645032 0.134 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr14_+_34583863 0.132 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr19_+_5774817 0.131 NM_004558
NRTN
neurturin
chr20_+_11846536 0.131 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr5_+_154115046 0.130 LARP1
La ribonucleoprotein domain family, member 1
chr6_-_11887265 0.125 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr13_-_97972252 0.125 NM_003576
STK24
serine/threonine kinase 24
chr15_-_70838703 0.125


chr17_+_45979518 0.124 NM_022827
SPATA20
spermatogenesis associated 20
chrX_-_13745234 0.121 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr14_-_67232172 0.120 NM_016026
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr7_+_129634935 0.119 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr3_+_187917791 0.118 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr16_-_68880844 0.114 AARS
alanyl-tRNA synthetase
chr19_+_60838170 0.109


chr20_+_43425153 0.107 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 read-through transcript
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr20_-_4938913 0.106 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr7_-_1562272 0.106 NM_001097620
TMEM184A
transmembrane protein 184A
chr1_-_67292616 0.105 NM_015139
SLC35D1
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr14_+_38805251 0.104 NM_203356
CTAGE5
CTAGE family, member 5
chr19_+_53450743 0.101


chr1_+_26376560 0.101 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr8_+_144802972 0.100 NM_014789
ZNF623
zinc finger protein 623
chr17_-_31281843 0.095 NM_001034836
NM_001163120
NM_001163121
NM_145654
RDM1



RAD52 motif 1



chr7_-_91601613 0.091 CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr17_-_7519535 0.091 NM_001126115
NM_001126116
NM_001126117
TP53


tumor protein p53


chr12_+_54910086 0.091 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr6_+_35418377 0.090 PPARD
peroxisome proliferator-activated receptor delta
chr17_+_53670785 0.087 NM_001160102
NM_006151
LPO

lactoperoxidase

chr1_+_114298021 0.087 NM_181358
HIPK1
homeodomain interacting protein kinase 1
chr3_-_121295202 0.086 GSK3B
glycogen synthase kinase 3 beta
chr8_-_110726921 0.084 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr20_+_2851852 0.083 NM_080841
PTPRA
protein tyrosine phosphatase, receptor type, A
chr3_+_173240136 0.082 FNDC3B
fibronectin type III domain containing 3B
chr3_-_47932479 0.082


chr18_-_76106221 0.082 NM_032510
PARD6G
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr8_-_18585721 0.081 PSD3
pleckstrin and Sec7 domain containing 3
chr7_-_91601764 0.080 NM_000786
CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr3_+_143824955 0.080 NM_002670
PLS1
plastin 1
chr18_-_3001944 0.079 NM_014646
LPIN2
lipin 2
chr21_-_42689192 0.078 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr16_-_18705578 0.077


chr14_-_20642629 0.077 NM_001102454
ZNF219
zinc finger protein 219
chr11_-_8789457 0.077 NM_139157
ST5
suppression of tumorigenicity 5
chr6_-_122807439 0.075 SERINC1
serine incorporator 1
chr22_-_41685827 0.074 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr1_+_50348052 0.073 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_-_91601972 0.073 NM_001146152
CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr9_+_134927185 0.072 NM_001807
CEL
carboxyl ester lipase (bile salt-stimulated lipase)
chr17_+_4784097 0.070 RNF167
ring finger protein 167
chr15_+_75500284 0.070 NM_018200
HMG20A
high-mobility group 20A
chr17_+_41457394 0.069 MAPT
microtubule-associated protein tau
chr15_-_49174107 0.069 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr2_-_74395657 0.069 NM_021196
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr1_+_234748187 0.069 NM_201545
LGALS8
lectin, galactoside-binding, soluble, 8
chr17_-_18118441 0.066 TOP3A
topoisomerase (DNA) III alpha
chr8_-_110730183 0.065 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chrX_-_13744933 0.065 GPM6B
glycoprotein M6B
chr17_+_46176105 0.065 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr14_+_23508922 0.063 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr6_+_28601767 0.063 NM_001509
NM_003996
GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr2_-_96314148 0.063 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr11_+_2279932 0.063 TSPAN32
tetraspanin 32

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.27 1.43e-03 GO:0071702 organic substance transport
4.75 4.50e-03 GO:0046942 carboxylic acid transport
4.72 4.88e-03 GO:0015849 organic acid transport
3.61 2.37e-02 GO:0032101 regulation of response to external stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.12 2.93e-02 GO:0005615 extracellular space

Nothing significant found in function category.