Motif ID: GTF2I.p2

Z-value: 1.571


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_737099910.342.0e-01Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_20685314 5.211 NM_018584
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr2_-_227371698 3.435 NM_005544
 IRS1
insulin receptor substrate 1
chr2_-_218551786 3.051 TNS1
tensin 1
chr5_+_135392482 2.936 NM_000358
 TGFBI
transforming growth factor, beta-induced, 68kDa
chr8_+_97575317 2.781 SDC2
syndecan 2
chr8_+_97575196 2.768 SDC2
syndecan 2
chr8_+_97575244 2.764 SDC2
syndecan 2
chr2_-_39517934 2.540 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr19_+_50144267 2.510 APOC2
apolipoprotein C-II
chr12_-_113606322 2.435 NM_005996
NM_016569
 TBX3

T-box 3

chr2_-_39517795 2.413 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr3_-_187025501 2.296 NM_001007225
NM_006548
 IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr10_+_114699953 2.234 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
 TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr5_+_92944680 2.214 NM_005654
 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr14_-_53493198 2.060 NM_001202
NM_130850
 BMP4

bone morphogenetic protein 4

chr2_-_39517633 2.022 NM_003618
 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr22_-_34566276 2.011 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chrX_-_128485134 1.937 NM_003069
NM_139035
 SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr4_-_1156959 1.915 NM_001128325
 SPON2
spondin 2, extracellular matrix protein
chr22_-_34566210 1.892 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 61 entries
enrichment   p-value GO term description
1.89 3.25e-02 GO:0022612 gland morphogenesis
1.83 1.19e-02 GO:0030324 lung development
1.81 1.51e-02 GO:0030323 respiratory tube development
1.52 8.06e-04 GO:0051130 positive regulation of cellular component organization
1.49 3.46e-03 GO:0001944 vasculature development
1.47 8.85e-03 GO:0060284 regulation of cell development
1.47 2.14e-02 GO:0001568 blood vessel development
1.44 6.47e-05 GO:0000904 cell morphogenesis involved in differentiation
1.39 2.10e-04 GO:0000902 cell morphogenesis
1.38 1.88e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.38 3.67e-03 GO:0072358 cardiovascular system development
1.38 3.67e-03 GO:0072359 circulatory system development
1.38 9.57e-03 GO:0048812 neuron projection morphogenesis
1.38 1.09e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.38 2.35e-02 GO:0007409 axonogenesis
1.37 5.62e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.37 4.04e-03 GO:0051253 negative regulation of RNA metabolic process
1.37 8.86e-03 GO:0031175 neuron projection development
1.36 5.33e-04 GO:0030030 cell projection organization
1.36 6.58e-04 GO:0010558 negative regulation of macromolecule biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
2.21 4.59e-02 GO:0032432 actin filament bundle
1.80 1.47e-03 GO:0005925 focal adhesion
1.76 2.74e-03 GO:0005924 cell-substrate adherens junction
1.69 4.65e-04 GO:0005912 adherens junction
1.69 1.21e-02 GO:0030055 cell-substrate junction
1.59 4.66e-03 GO:0070161 anchoring junction
1.55 6.82e-03 GO:0031252 cell leading edge
1.48 8.27e-03 GO:0016323 basolateral plasma membrane
1.39 3.43e-03 GO:0043005 neuron projection
1.39 5.10e-03 GO:0045202 synapse
1.35 6.53e-04 GO:0030054 cell junction
1.30 1.47e-04 GO:0042995 cell projection
1.06 1.30e-03 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.06 3.85e-02 GO:0008013 beta-catenin binding
1.47 1.14e-03 GO:0003779 actin binding
1.32 1.06e-02 GO:0008092 cytoskeletal protein binding
1.29 1.00e-02 GO:0043565 sequence-specific DNA binding
1.25 2.88e-02 GO:0019899 enzyme binding
1.23 2.38e-02 GO:0001071 nucleic acid binding transcription factor activity
1.23 2.38e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.09 1.27e-06 GO:0005515 protein binding
1.04 1.52e-02 GO:0005488 binding