Motif ID: NFATC1..3.p2

Z-value: 1.903


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
NFATC1 4772 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 4775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFATC3chr16_+_66676851-0.829.4e-05Click!
NFATC1chr18_+_75261231-0.457.9e-02Click!


Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_13240987 11.004 EMP1
epithelial membrane protein 1
chr12_+_13240868 9.940 NM_001423
EMP1
epithelial membrane protein 1
chr2_+_189547377 8.135 COL3A1
collagen, type III, alpha 1
chr2_-_237987579 7.306 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr2_+_189547323 7.007 NM_000090
COL3A1
collagen, type III, alpha 1
chr2_-_237987509 6.936 COL6A3
collagen, type VI, alpha 3
chr2_+_189547358 6.861 COL3A1
collagen, type III, alpha 1
chr2_-_237987554 6.184 COL6A3
collagen, type VI, alpha 3
chr4_+_169654742 5.454 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr12_-_90097384 4.964 NM_133503
DCN
decorin
chr3_+_161040439 4.901 SCHIP1
schwannomin interacting protein 1
chr6_-_169395847 4.499 THBS2
thrombospondin 2
chr6_-_128883125 4.499 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr22_-_34566210 4.472 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr22_-_34566367 4.471 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr8_+_26569709 4.376 DPYSL2
dihydropyrimidinase-like 2
chr6_-_169395972 4.305 NM_003247
THBS2
thrombospondin 2
chr7_+_115952074 4.142 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr17_-_45617899 4.074 COL1A1
collagen, type I, alpha 1
chr22_-_34566276 3.887 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chrX_-_10504852 3.646 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr1_-_149047329 3.539 NM_000396
CTSK
cathepsin K
chr3_+_158637273 3.504 NM_002852
PTX3
pentraxin 3, long
chr2_-_215967442 3.469 FN1
fibronectin 1
chr15_+_22652790 3.364 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_+_98899734 3.276 NM_015976
NM_152238
SNX7

sorting nexin 7

chr6_-_134680888 3.174 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr9_+_74956494 3.142 NM_000700
ANXA1
annexin A1
chr3_+_189425886 2.999 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_+_157246305 2.937 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr1_+_85819004 2.871 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr16_-_63713382 2.809 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr20_+_19863716 2.753 RIN2
Ras and Rab interactor 2
chr1_+_160868932 2.746 DDR2
discoidin domain receptor tyrosine kinase 2
chrX_+_100692071 2.736 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr8_-_18585721 2.714 PSD3
pleckstrin and Sec7 domain containing 3
chr13_-_37070862 2.646 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr1_-_94475504 2.638 ARHGAP29
Rho GTPase activating protein 29
chr1_+_160868822 2.579 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr3_-_124893875 2.559 MYLK
myosin light chain kinase
chr6_-_134537637 2.554 SGK1
serum/glucocorticoid regulated kinase 1
chr1_-_94475840 2.540 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr13_+_109932934 2.528 COL4A2
collagen, type IV, alpha 2
chr11_-_35503720 2.507 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr1_-_68470585 2.483 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr6_-_134537699 2.437 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr21_-_27261276 2.381 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr7_+_93388951 2.289 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr3_+_161040343 2.284 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr9_-_35679902 2.206 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr1_+_161305558 2.163 NM_001113381
RGS4
regulator of G-protein signaling 4
chr9_-_35679799 2.097 TPM2
tropomyosin 2 (beta)
chr2_-_189752575 2.086 NM_000393
COL5A2
collagen, type V, alpha 2
chr5_+_140742585 2.085 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr4_-_115120251 2.069 NM_024590
ARSJ
arylsulfatase family, member J
chr22_+_31526801 2.048 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chrX_+_135079120 2.027 NM_001159704
FHL1
four and a half LIM domains 1
chr18_+_3443771 1.975 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr1_+_169421011 1.956 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr19_+_46416938 1.952 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr12_+_118100977 1.919 NM_014365
HSPB8
heat shock 22kDa protein 8
chr20_+_42644633 1.876 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr4_+_40953698 1.809 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr16_-_63713485 1.798 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr18_+_64616296 1.796 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr3_-_150578207 1.774 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr1_+_100957883 1.770 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr8_+_70567581 1.764 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr4_+_40953666 1.753 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr16_-_63713466 1.728 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr7_+_23252909 1.726 GPNMB
glycoprotein (transmembrane) nmb
chr13_-_79810972 1.705 SPRY2
sprouty homolog 2 (Drosophila)
chr4_+_40953652 1.702 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr13_+_100902942 1.701 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr15_+_30721161 1.699 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr1_+_78243181 1.690 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr19_-_48401532 1.690 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr2_-_215949566 1.686 FN1
fibronectin 1
chr11_+_113672407 1.674 NNMT
nicotinamide N-methyltransferase
chr3_-_150578103 1.671 TM4SF1
transmembrane 4 L six family member 1
chr17_-_15104768 1.657 NM_153322
PMP22
peripheral myelin protein 22
chr12_-_90096275 1.647 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr6_+_39868770 1.647 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr10_-_126706442 1.638 NM_022802
CTBP2
C-terminal binding protein 2
chr11_+_130745580 1.636 NM_001048209
NTM
neurotrimin
chr7_+_93862137 1.594 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr3_-_150578023 1.589 TM4SF1
transmembrane 4 L six family member 1
chr7_+_23252915 1.562 GPNMB
glycoprotein (transmembrane) nmb
chr6_+_116798791 1.559 NM_013352
DSE
dermatan sulfate epimerase
chr5_+_140719773 1.559 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr8_+_70567634 1.541 SULF1
sulfatase 1
chrX_+_135057202 1.535 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr12_-_90029328 1.514 LUM
lumican
chrX_-_128485062 1.498 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr6_-_112682573 1.492 LAMA4
laminin, alpha 4
chr9_-_128924819 1.485 NM_012098
ANGPTL2
angiopoietin-like 2
chr11_-_11987198 1.476 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr6_-_112682459 1.473 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr7_+_23252911 1.471 GPNMB
glycoprotein (transmembrane) nmb
chr5_+_34720368 1.467 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr2_-_37727472 1.466 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr7_+_150044530 1.465 NM_130759
GIMAP1
GTPase, IMAP family member 1
chr3_-_150578148 1.464 TM4SF1
transmembrane 4 L six family member 1
chr5_-_172688024 1.451 STC2
stanniocalcin 2
chr2_+_36436873 1.438 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chrX_-_114158388 1.419 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr5_+_32824701 1.414 NM_024563
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr3_+_45042754 1.408 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chrX_-_128485121 1.398 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr1_-_79244948 1.397 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr12_-_48902692 1.380 NM_001113547
LIMA1
LIM domain and actin binding 1
chr8_-_49996353 1.372 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chrX_-_128485134 1.365 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr2_+_191818124 1.358 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr9_+_74956601 1.357 ANXA1
annexin A1
chr5_-_150517528 1.350 NM_001155
ANXA6
annexin A6
chr1_-_31942206 1.314 NM_001856
COL16A1
collagen, type XVI, alpha 1
chr8_-_93144366 1.296 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_-_116920232 1.292 NM_002160
TNC
tenascin C
chr6_-_112682401 1.290 LAMA4
laminin, alpha 4
chr7_-_136678815 1.282 PTN
pleiotrophin
chr9_-_13269562 1.270 MPDZ
multiple PDZ domain protein
chr12_-_48963505 1.262 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr1_+_163084934 1.251 PBX1
pre-B-cell leukemia homeobox 1
chr9_+_74956614 1.239 ANXA1
annexin A1
chr3_-_18455207 1.231 NM_001131010
SATB1
SATB homeobox 1
chr11_+_101488380 1.229 NM_001195045
YAP1
Yes-associated protein 1
chr5_-_111121691 1.227 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr5_+_140709907 1.226 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr2_-_231697999 1.221 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr10_+_124141808 1.220 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr3_+_69216747 1.210 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr11_-_11986704 1.198 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr12_-_90029672 1.196 NM_002345
LUM
lumican
chr5_-_146813343 1.181 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr16_+_81218074 1.173 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr15_+_22772545 1.167 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr13_+_113546912 1.167 GAS6
growth arrest-specific 6
chr7_-_41709191 1.165 NM_002192
INHBA
inhibin, beta A
chr11_-_11987115 1.162 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr20_+_9146036 1.159 NM_182797
PLCB4
phospholipase C, beta 4
chr1_-_151804929 1.159 NM_005978
S100A2
S100 calcium binding protein A2
chr1_-_31942142 1.143 COL16A1
collagen, type XVI, alpha 1
chr19_-_48465422 1.143 NM_002784
PSG9
pregnancy specific beta-1-glycoprotein 9
chrX_-_13745108 1.128 GPM6B
glycoprotein M6B
chr7_-_136678973 1.120 PTN
pleiotrophin
chr5_+_140848905 1.112 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr5_-_111119846 1.110 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr22_+_36401558 1.106 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr5_-_42847716 1.104 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr13_+_113587674 1.097 GAS6
growth arrest-specific 6
chr7_+_23252802 1.093 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr14_-_68424653 1.089 ACTN1
actinin, alpha 1
chr8_+_97575317 1.082 SDC2
syndecan 2
chr5_+_140714951 1.078 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr4_-_100461530 1.077 NM_000668
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr8_+_17478214 1.058 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr17_+_29606408 1.055 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chrX_+_133993984 1.054 NM_001078171
FAM127A
family with sequence similarity 127, member A
chr18_+_3402071 1.052 NM_174886
TGIF1
TGFB-induced factor homeobox 1
chr13_+_113546943 1.049 GAS6
growth arrest-specific 6
chr12_+_26239535 1.045 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chrX_-_13744933 1.045 GPM6B
glycoprotein M6B
chr10_+_123738678 1.040 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr7_+_23252945 1.029 GPNMB
glycoprotein (transmembrane) nmb
chr2_+_66516196 1.029 MEIS1
Meis homeobox 1
chr4_+_47181987 1.028 NM_020453
ATP10D
ATPase, class V, type 10D
chr16_-_10581944 1.020 NM_001424
EMP2
epithelial membrane protein 2
chr12_-_54392328 1.016 NM_001144997
ITGA7
integrin, alpha 7
chr2_-_55090759 1.011 NM_007008
RTN4
reticulon 4
chr5_+_140730014 0.996 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr12_-_90100710 0.992 DCN
decorin
chr12_-_90100679 0.989 DCN
decorin
chr22_-_35494019 0.988 NM_001177702
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr14_-_60818263 0.988 NM_001017970
TMEM30B
transmembrane protein 30B
chrX_+_102518764 0.983 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr1_+_163084707 0.982 PBX1
pre-B-cell leukemia homeobox 1
chr9_-_94338072 0.980 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr5_+_140790365 0.979 PCDHGA12
protocadherin gamma subfamily A, 12
chr5_+_140790310 0.978 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr18_+_59571256 0.976 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr8_-_95343696 0.971 GEM
GTP binding protein overexpressed in skeletal muscle
chr11_-_76059435 0.968 NM_001128922
LRRC32
leucine rich repeat containing 32
chr16_+_1524162 0.968 NM_024600
TMEM204
transmembrane protein 204
chr12_+_12656022 0.959 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr11_-_8849485 0.954 ST5
suppression of tumorigenicity 5
chr12_-_9159780 0.939 A2M
alpha-2-macroglobulin
chr6_+_123151669 0.934 NM_006714
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr3_+_160269734 0.930 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr3_-_147361912 0.930 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr7_-_136679045 0.927 NM_002825
PTN
pleiotrophin
chr5_+_140733664 0.926 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr13_+_113546897 0.926 GAS6
growth arrest-specific 6
chr1_+_224083047 0.924 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr13_-_33148899 0.924 STARD13
StAR-related lipid transfer (START) domain containing 13
chr8_-_95343716 0.919 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr10_-_90702490 0.914 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr19_+_43447262 0.913 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr9_+_111582317 0.907 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr22_+_29808845 0.893 SMTN
smoothelin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.83 3.43e-06 GO:0007156 homophilic cell adhesion
1.70 1.21e-05 GO:0007155 cell adhesion
1.70 1.21e-05 GO:0022610 biological adhesion
2.34 2.13e-03 GO:0043062 extracellular structure organization
1.91 6.04e-03 GO:0016337 cell-cell adhesion
2.58 1.01e-02 GO:0030198 extracellular matrix organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.56 6.47e-12 GO:0005576 extracellular region
1.65 1.60e-08 GO:0044421 extracellular region part
1.61 1.26e-05 GO:0005615 extracellular space
1.98 1.58e-04 GO:0005578 proteinaceous extracellular matrix
3.93 4.86e-04 GO:0005581 collagen
1.80 1.04e-03 GO:0031012 extracellular matrix
2.88 5.12e-03 GO:0031091 platelet alpha granule
1.85 4.09e-02 GO:0030141 stored secretory granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.76 1.49e-06 GO:0005509 calcium ion binding
2.08 3.70e-02 GO:0005539 glycosaminoglycan binding
2.54 3.95e-02 GO:0005201 extracellular matrix structural constituent