Motif ID: KLF12.p2

Z-value: 1.934


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF12chr13_-_736059140.581.8e-02Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_45617899 3.073 COL1A1
collagen, type I, alpha 1
chr11_-_2108035 2.921 IGF2
insulin-like growth factor 2 (somatomedin A)
chr5_+_102229612 2.893 PAM
peptidylglycine alpha-amidating monooxygenase
chr9_+_696744 2.698 NM_153186
 KANK1
KN motif and ankyrin repeat domains 1
chr9_+_136673464 2.642 NM_000093
 COL5A1
collagen, type V, alpha 1
chr20_+_19818209 2.563 NM_018993
 RIN2
Ras and Rab interactor 2
chr3_-_101316038 2.419 NM_001042459
NM_182909
 FILIP1L

filamin A interacting protein 1-like

chr11_+_116575249 2.362 NM_001001522
NM_003186
 TAGLN

transgelin

chr15_-_88148177 2.262 ANPEP
alanyl (membrane) aminopeptidase
chr2_+_36436873 2.157 NM_016441
 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr10_-_125841840 2.148 NM_014863
NM_015892
 CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr5_+_52812165 2.126 FST
follistatin
chr1_-_68470585 2.052 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)


chr5_+_52812236 1.913 NM_006350
NM_013409
 FST

follistatin

chr12_-_88270375 1.868 NM_001946
NM_022652
 DUSP6

dual specificity phosphatase 6

chr3_-_147361626 1.841 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr10_+_124211353 1.801 HTRA1
HtrA serine peptidase 1
chr12_+_13240987 1.749 EMP1
epithelial membrane protein 1
chr12_-_74711474 1.744 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr6_-_11490487 1.737 NM_001142393
 NEDD9
neural precursor cell expressed, developmentally down-regulated 9

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 50 entries
enrichment   p-value GO term description
3.61 2.59e-04 GO:0003158 endothelium development
3.51 3.37e-03 GO:0045446 endothelial cell differentiation
2.74 4.96e-02 GO:0007044 cell-substrate junction assembly
1.84 8.72e-03 GO:0034330 cell junction organization
1.82 3.82e-02 GO:0034329 cell junction assembly
1.81 4.06e-07 GO:0001944 vasculature development
1.79 1.13e-04 GO:0048514 blood vessel morphogenesis
1.75 2.69e-05 GO:0001568 blood vessel development
1.73 1.65e-02 GO:0006936 muscle contraction
1.73 2.76e-02 GO:0001525 angiogenesis
1.69 1.18e-04 GO:0030029 actin filament-based process
1.69 1.82e-02 GO:0003012 muscle system process
1.64 1.65e-07 GO:0072358 cardiovascular system development
1.64 1.65e-07 GO:0072359 circulatory system development
1.63 1.31e-02 GO:0030036 actin cytoskeleton organization
1.59 1.15e-02 GO:0061061 muscle structure development
1.58 1.95e-03 GO:0007411 axon guidance
1.57 1.29e-05 GO:0000904 cell morphogenesis involved in differentiation
1.57 1.08e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.54 5.76e-04 GO:0007409 axonogenesis

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
3.69 2.58e-02 GO:0005583 fibrillar collagen
2.67 1.94e-02 GO:0001725 stress fiber
2.64 1.34e-02 GO:0032432 actin filament bundle
1.85 2.41e-02 GO:0005925 focal adhesion
1.62 3.21e-02 GO:0031252 cell leading edge
1.58 9.93e-03 GO:0016323 basolateral plasma membrane
1.51 8.26e-03 GO:0015629 actin cytoskeleton
1.16 7.71e-05 GO:0071944 cell periphery
1.16 1.21e-04 GO:0005886 plasma membrane
1.16 4.19e-02 GO:0044459 plasma membrane part
1.09 1.36e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
3.69 4.81e-02 GO:0048407 platelet-derived growth factor binding
1.61 2.40e-04 GO:0003779 actin binding
1.42 2.58e-03 GO:0008092 cytoskeletal protein binding