Motif ID: HAND1,2.p2

Z-value: 1.312


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND1chr5_-_153838013-0.116.9e-01Click!
HAND2chr4_-_1746879310.048.9e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_105845570 5.269 IGHA1
immunoglobulin heavy constant alpha 1
chr5_-_149772563 3.925 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_+_6533932 2.802 NM_004271
LY86
lymphocyte antigen 86
chr14_-_106249999 2.775 IGHA1
immunoglobulin heavy constant alpha 1
chr22_+_21053972 2.712


chr19_+_55614006 2.651 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr5_-_149772469 2.572 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr14_-_106241445 2.394 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr1_-_158948176 1.988 NM_001778
CD48
CD48 molecule
chr11_+_22652894 1.870 NM_005256
GAS2
growth arrest-specific 2
chr4_-_40326603 1.835 NM_001098634
RBM47
RNA binding motif protein 47
chr7_+_99654806 1.818 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr14_+_75058591 1.684 BATF
basic leucine zipper transcription factor, ATF-like
chr14_+_75058518 1.622 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr1_+_26517045 1.602 CD52
CD52 molecule
chrX_+_128741562 1.580 NM_018990
SASH3
SAM and SH3 domain containing 3
chrX_+_128741578 1.550 SASH3
SAM and SH3 domain containing 3
chr12_-_51887318 1.535 ITGB7
integrin, beta 7
chr11_+_22646229 1.439 NM_177553
GAS2
growth arrest-specific 2
chr13_+_30207690 1.418 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr19_+_44886785 1.390 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr1_+_26516967 1.220 NM_001803
CD52
CD52 molecule
chr13_-_45640679 1.155 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_51887266 1.142 NM_000889
ITGB7
integrin, beta 7
chr14_-_63264445 1.136 NM_030791
SGPP1
sphingosine-1-phosphate phosphatase 1
chr14_-_105163301 1.102 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr13_+_30207668 1.101 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr6_+_88026338 1.094 ZNF292
zinc finger protein 292
chr1_+_154389945 1.064 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr22_+_23333610 1.018 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr2_+_228386800 1.009 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr6_+_33151703 0.974 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr3_+_99733432 0.948 NM_005290
GPR15
G protein-coupled receptor 15
chr12_+_53177806 0.931 NCKAP1L
NCK-associated protein 1-like
chr1_+_111215343 0.923 NM_001040033
CD53
CD53 molecule
chr1_+_116744992 0.897 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr3_-_13359746 0.874 NUP210
nucleoporin 210kDa
chr3_+_113534604 0.862 NM_001004196
NM_005944
CD200

CD200 molecule

chr21_-_45165204 0.823 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr12_+_53177789 0.819 NCKAP1L
NCK-associated protein 1-like
chr19_+_50144267 0.815 APOC2
apolipoprotein C-II
chr1_+_26728846 0.815 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr22_+_23329113 0.800 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr1_-_31003181 0.776 LAPTM5
lysosomal protein transmembrane 5
chr1_+_159899528 0.772 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr2_+_74913289 0.772 NM_000189
HK2
hexokinase 2
chr14_-_64479198 0.760 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chrX_-_32083506 0.759 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr14_-_105308720 0.758 IGHM
immunoglobulin heavy constant mu
chr21_-_45165249 0.750 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr3_+_113534710 0.748 CD200
CD200 molecule
chr14_-_106240998 0.736 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_-_90702490 0.733 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr19_-_10311262 0.725 NM_002162
ICAM3
intercellular adhesion molecule 3
chr4_+_74500748 0.721 ALB
albumin
chr14_-_105280425 0.702 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_-_36346240 0.695 KRT23
keratin 23 (histone deacetylase inducible)
chr8_-_103206310 0.679 NM_001040630
NCALD
neurocalcin delta
chr6_+_167445284 0.656 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr14_-_105589467 0.652 LOC100126583
IGHA1
IGHG1
IGHG2
IGHM
hypothetical LOC100126583
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr14_-_105712630 0.631 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106149623 0.615


chr19_+_40465249 0.615 NM_021175
HAMP
hepcidin antimicrobial peptide
chr17_+_69974361 0.601 CD300A
CD300a molecule
chr5_+_157090900 0.599 NM_017872
THG1L
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr12_+_53177758 0.584 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr1_-_31003260 0.582 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr8_-_28403652 0.582 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr17_+_69974116 0.580 NM_007261
CD300A
CD300a molecule
chr7_-_1562272 0.575 NM_001097620
TMEM184A
transmembrane protein 184A
chr22_-_35875890 0.566 NM_000878
IL2RB
interleukin 2 receptor, beta
chr1_+_87153025 0.558 HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr12_+_111900650 0.553 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr17_+_16259812 0.550 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chrX_+_1415508 0.519 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chrY_+_1415508 0.519 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr13_-_45910325 0.510 C13orf18
chromosome 13 open reading frame 18
chr8_+_28230567 0.509 NM_006228
PNOC
prepronociceptin
chr5_-_176769094 0.505 F12
coagulation factor XII (Hageman factor)
chr10_-_121286034 0.465 NM_002925
RGS10
regulator of G-protein signaling 10
chr21_-_45165302 0.464 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_+_26744929 0.458 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr14_-_106184988 0.456 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_-_175170674 0.447 WIPF1
WAS/WASL interacting protein family, member 1
chr8_-_38577891 0.440


chr19_-_8548309 0.438 NM_012335
MYO1F
myosin IF
chr17_+_16259636 0.437 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr19_-_45888259 0.430 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr14_-_105182025 0.429


chrX_-_105169370 0.425 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr19_+_40511909 0.409 NM_001185099
NM_001185100
NM_001185101
NM_001771
CD22



CD22 molecule



chr11_+_118463906 0.406 NM_001024382
HMBS
hydroxymethylbilane synthase
chr7_-_140361199 0.403 MRPS33
mitochondrial ribosomal protein S33
chr5_-_138753443 0.402 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr1_+_205328834 0.400 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr14_-_105523735 0.399 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_+_16259573 0.397 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr2_+_74610395 0.397 HTRA2
HtrA serine peptidase 2
chr19_-_63715135 0.393 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr1_+_26744893 0.388 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_158815850 0.385 CD84
CD84 molecule
chr13_-_40491491 0.382 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr17_-_10313600 0.380 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr21_+_33524143 0.380 IFNAR2
interferon (alpha, beta and omega) receptor 2
chr14_+_64948332 0.376 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr8_-_102872372 0.375 NCALD
neurocalcin delta
chr3_+_134976965 0.375 TF
transferrin
chr12_-_9804682 0.373 NM_001781
CD69
CD69 molecule
chr5_-_176769141 0.370 NM_000505
F12
coagulation factor XII (Hageman factor)
chr19_-_8548337 0.369 MYO1F
myosin IF
chr13_-_40491405 0.365 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_-_45654327 0.363 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_-_105182159 0.358 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr11_+_22316242 0.357 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr5_-_171814026 0.356 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr2_-_42441798 0.354 NM_004718
COX7A2L
cytochrome c oxidase subunit VIIa polypeptide 2 like
chr21_+_33524174 0.352 IFNAR2
interferon (alpha, beta and omega) receptor 2
chr4_-_103464491 0.350 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr11_+_120966280 0.347 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr19_-_8548297 0.343 MYO1F
myosin IF
chr6_-_112301123 0.342 NM_002037
FYN
FYN oncogene related to SRC, FGR, YES
chr1_+_179269689 0.338 MR1
major histocompatibility complex, class I-related
chr16_-_28515868 0.330 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr1_-_146543016 0.330


chr1_-_203868622 0.323 NM_001973
NM_021795
ELK4

ELK4, ETS-domain protein (SRF accessory protein 1)

chr18_+_27425727 0.322 NM_000371
TTR
transthyretin
chr4_+_69996780 0.319 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr16_-_29817841 0.317 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr19_-_59542197 0.314 NM_012276
LILRA4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr8_+_11388918 0.305 NM_001715
BLK
B lymphoid tyrosine kinase
chr12_+_119617060 0.303


chrX_+_48978923 0.301 CCDC22
coiled-coil domain containing 22
chr19_-_9556166 0.300 NM_001008727
ZNF121
zinc finger protein 121
chr19_+_40224480 0.299 HPN
hepsin
chr22_+_21393107 0.297 IGLJ3
immunoglobulin lambda joining 3
chr6_+_31651319 0.295 NM_000594
TNF
tumor necrosis factor
chr17_+_72958330 0.294 SEPT9
septin 9
chr14_+_70209807 0.294 TTC9
tetratricopeptide repeat domain 9
chr17_-_37590910 0.288 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr15_-_43457916 0.285 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr19_+_60850765 0.284 NM_013301
CCDC106
coiled-coil domain containing 106
chr15_+_72687765 0.284 NM_003992
CLK3
CDC-like kinase 3
chr1_-_30977931 0.275 LAPTM5
lysosomal protein transmembrane 5
chr1_-_159099090 0.272 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr3_-_143230124 0.267 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr1_+_111571803 0.266 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr21_+_33524075 0.265 NM_000874
NM_207584
NM_207585
IFNAR2


interferon (alpha, beta and omega) receptor 2


chr6_-_55848346 0.263 BMP5
bone morphogenetic protein 5
chr1_+_15858950 0.263 NM_006511
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr17_+_69974375 0.262 CD300A
CD300a molecule
chr1_+_179269761 0.262 MR1
major histocompatibility complex, class I-related
chr6_-_109795925 0.261 CD164
CD164 molecule, sialomucin
chr1_-_232681471 0.260 NM_005646
TARBP1
TAR (HIV-1) RNA binding protein 1
chr6_-_55848317 0.258 NM_021073
BMP5
bone morphogenetic protein 5
chr18_+_9092618 0.254 NM_021074
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr5_-_176763789 0.253 F12
coagulation factor XII (Hageman factor)
chr22_+_35586950 0.251 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_-_146543102 0.250


chr17_-_24426752 0.249 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chrX_-_47374187 0.249 NM_001145252
CFP
complement factor properdin
chr1_-_52642646 0.248 NM_001190818
NM_001190819
NM_004153
ORC1


origin recognition complex, subunit 1


chr2_+_169021039 0.246 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr12_+_117067214 0.246 PEBP1
phosphatidylethanolamine binding protein 1
chr1_+_13609493 0.245 NM_001099852
PRAMEF20
PRAME family member 20
chr1_+_179269766 0.239 MR1
major histocompatibility complex, class I-related
chr1_-_158815895 0.239 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr1_-_92724181 0.238 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr11_-_27450808 0.237 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr16_+_55553262 0.237 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr13_-_45654292 0.236 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr16_+_29582065 0.234 SPN
sialophorin
chr14_-_22947320 0.234 NM_002471
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr5_+_59819761 0.233 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr3_-_120761092 0.232 NM_005191
CD80
CD80 molecule
chr19_-_40996040 0.232 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr1_-_114215768 0.230 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr21_+_33524124 0.226 IFNAR2
interferon (alpha, beta and omega) receptor 2
chr14_-_23846993 0.226 CIDEB
cell death-inducing DFFA-like effector b
chr20_-_1113116 0.225 NM_018354
C20orf46
chromosome 20 open reading frame 46
chr11_-_33139449 0.225 NM_001033505
NM_001033506
NM_001326
CSTF3


cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa


chr3_-_197643701 0.224 NM_015562
UBXN7
UBX domain protein 7
chrX_-_33267646 0.224 NM_000109
DMD
dystrophin
chr1_+_13388652 0.221 NM_001099852
PRAMEF20
PRAME family member 20
chr19_-_56567602 0.221 NM_005601
NKG7
natural killer cell group 7 sequence
chr7_+_63763916 0.219 NM_001013746
NM_016220
ZNF107

zinc finger protein 107

chr7_+_142270634 0.217 EPHB6
EPH receptor B6
chr12_+_27377034 0.217 NM_020183
ARNTL2
aryl hydrocarbon receptor nuclear translocator-like 2
chr9_+_35819208 0.216 NM_016446
NM_001042589
TMEM8B

transmembrane protein 8B

chr5_-_142795269 0.215 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr6_-_41823056 0.215 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr1_-_154170825 0.212 KIAA0907
KIAA0907
chr5_+_159558625 0.211 NM_001040442
FABP6
fatty acid binding protein 6, ileal
chr19_-_56163815 0.207 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr7_+_94135384 0.201 PEG10
paternally expressed 10
chr15_-_41346346 0.198 NM_004245
NM_201631
TGM5

transglutaminase 5

chr19_+_6690697 0.197 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr20_-_48686832 0.196 NM_080829
FAM65C
family with sequence similarity 65, member C
chr14_-_105565211 0.196 IGHV4-31
IGHA1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
chr19_-_47623340 0.195 NM_005357
LIPE
lipase, hormone-sensitive
chr1_+_159817752 0.194 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 4.62e-04 GO:0044459 plasma membrane part
1.48 3.40e-03 GO:0005576 extracellular region
1.30 4.55e-03 GO:0071944 cell periphery
1.28 1.15e-02 GO:0005886 plasma membrane
1.20 3.35e-02 GO:0044425 membrane part
12.52 3.35e-02 GO:0001891 phagocytic cup
1.49 3.68e-02 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.98 1.89e-04 GO:0005179 hormone activity
4.69 1.60e-02 GO:0003823 antigen binding