Motif ID: NFKB1_REL_RELA.p2

Z-value: 3.028


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFKB1chr4_+_1036417620.853.4e-05Click!
RELchr2_+_609622060.656.2e-03Click!
RELAchr11_-_651867900.185.0e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_4180494 8.072 NM_005755
 EBI3
Epstein-Barr virus induced 3
chr19_-_6542012 7.085 CD70
CD70 molecule
chr5_-_149772469 6.386 NM_001025159
NM_004355
NM_001025158
 CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr11_+_101693403 6.099 NM_001165
NM_182962
 BIRC3

baculoviral IAP repeat containing 3

chr22_+_21543671 5.644 IGLV4-3
immunoglobulin lambda variable 4-3
chr14_-_95250155 5.532 NM_001098725
NM_021966
 TCL1A

T-cell leukemia/lymphoma 1A

chr6_+_14225932 5.244 CD83
CD83 molecule
chr6_+_32713160 5.066 NM_002122
 HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_-_162883062 4.793 NM_022168
 IFIH1
interferon induced with helicase C domain 1
chr14_-_34943574 4.728 NM_020529
 NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr6_+_116798791 4.687 NM_013352
 DSE
dermatan sulfate epimerase
chr22_-_35875890 4.660 NM_000878
 IL2RB
interleukin 2 receptor, beta
chr7_+_68702252 4.500 AUTS2
autism susceptibility candidate 2
chr21_+_25933459 4.382 NM_021219
 JAM2
junctional adhesion molecule 2
chr5_-_149772563 4.349 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_32659958 4.240 HLA-DRB1
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 5
chr6_-_31432934 4.164 HLA-B
major histocompatibility complex, class I, B
chr12_+_6925997 4.085 NM_080548
 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr16_+_84490267 3.982 NM_002163
 IRF8
interferon regulatory factor 8
chr1_+_111571803 3.975 NM_001025197
NM_004000
 CHI3L2

chitinase 3-like 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
5.14 1.61e-02 GO:0060603 mammary gland duct morphogenesis
5.14 4.82e-02 GO:0060330 regulation of response to interferon-gamma
5.14 4.82e-02 GO:0060334 regulation of interferon-gamma-mediated signaling pathway
3.12 7.74e-03 GO:0034130 toll-like receptor 1 signaling pathway
3.12 7.74e-03 GO:0034134 toll-like receptor 2 signaling pathway
3.03 3.66e-02 GO:0034138 toll-like receptor 3 signaling pathway
2.99 4.69e-02 GO:0002756 MyD88-independent toll-like receptor signaling pathway
2.98 1.65e-02 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
2.82 4.20e-02 GO:0008063 Toll signaling pathway
2.82 4.20e-02 GO:0034142 toll-like receptor 4 signaling pathway
2.79 1.86e-02 GO:0002224 toll-like receptor signaling pathway
2.69 2.33e-02 GO:0002758 innate immune response-activating signal transduction
2.66 2.86e-02 GO:0002218 activation of innate immune response
2.66 4.31e-02 GO:0002221 pattern recognition receptor signaling pathway
2.47 4.89e-04 GO:0051251 positive regulation of lymphocyte activation
2.45 2.08e-05 GO:0051249 regulation of lymphocyte activation
2.43 5.48e-04 GO:0045088 regulation of innate immune response
2.37 1.07e-03 GO:0002696 positive regulation of leukocyte activation
2.33 1.74e-03 GO:0050867 positive regulation of cell activation
2.33 3.52e-02 GO:0050870 positive regulation of T cell activation

Gene overrepresentation in compartment category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
10.28 3.71e-03 GO:0033256 I-kappaB/NF-kappaB complex
1.28 2.01e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
3.34 4.27e-02 GO:0003823 antigen binding