Motif ID: ZBTB16.p2

Z-value: 1.667


Transcription factors associated with ZBTB16.p2:

Gene SymbolEntrez IDGene Name
ZBTB16 7704 zinc finger and BTB domain containing 16

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZBTB16chr11_+_113436438,
chr11_+_113435506,
chr11_+_113435640
-0.009.9e-01Click!


Activity profile for motif ZBTB16.p2.

activity profile for motif ZBTB16.p2


Sorted Z-values histogram for motif ZBTB16.p2

Sorted Z-values for motif ZBTB16.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB16.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_51887318 6.796 ITGB7
integrin, beta 7
chr1_+_196874759 5.648 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr12_-_51887266 5.576 NM_000889
ITGB7
integrin, beta 7
chr1_+_196874839 4.821 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_196874867 3.720 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_-_53444733 3.621 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr8_-_81155564 3.611 NM_001025252
TPD52
tumor protein D52
chr19_-_53450953 3.596 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr13_-_98757634 3.515 NM_004951
GPR183
G protein-coupled receptor 183
chr13_-_98708549 3.244 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr6_-_44341296 3.207 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr13_-_45654292 3.190 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr16_+_80370400 3.008 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr14_-_105681377 2.557 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_+_12825022 2.543 PHACTR1
phosphatase and actin regulator 1
chr6_+_12825818 2.464 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr1_+_173111306 2.423 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr22_+_21053972 2.352


chr2_+_33514896 2.342 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr3_-_15357878 2.336 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr21_-_14840506 2.327 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_-_33149244 2.223 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr2_-_89073496 2.186 IGKC
immunoglobulin kappa constant
chr12_+_53178834 2.157 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr10_+_70517863 2.156 SRGN
serglycin
chr1_-_111544820 2.117 DENND2D
DENN/MADD domain containing 2D
chr12_+_25096755 2.116 LRMP
lymphoid-restricted membrane protein
chr10_+_35466715 2.037 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr11_-_67207112 2.008 RPL37
ribosomal protein L37
chr14_-_105804211 1.991 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_-_84254873 1.979 PLAC8
placenta-specific 8
chrX_+_12795111 1.918 NM_016562
TLR7
toll-like receptor 7
chr6_-_44341222 1.885 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr14_-_105796665 1.880 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr10_+_70517823 1.870 NM_002727
SRGN
serglycin
chr11_+_67107852 1.864 GSTP1
glutathione S-transferase pi 1
chr5_-_94250357 1.809 MCTP1
multiple C2 domains, transmembrane 1
chr2_-_38156769 1.798 CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr3_-_126412882 1.796 NM_001195483
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr4_-_84254912 1.782 PLAC8
placenta-specific 8
chr4_-_84254932 1.775 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr14_+_87541220 1.770 NM_003608
GPR65
G protein-coupled receptor 65
chr22_+_20880112 1.754


chr10_+_97505398 1.746 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chrX_-_78509662 1.729 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chrX_+_48427103 1.696 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr7_-_149960218 1.690 GIMAP6
GTPase, IMAP family member 6
chr1_+_111571803 1.670 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr19_-_20399601 1.667 ZNF826P
zinc finger protein 826, pseudogene
chr14_-_105762742 1.632


chr15_-_53349775 1.631 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr2_-_38156811 1.619 NM_000104
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr15_-_91078307 1.613 FAM174B
family with sequence similarity 174, member B
chr12_+_14429499 1.601 ATF7IP
activating transcription factor 7 interacting protein
chr13_-_45654296 1.591 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_20636152 1.559 NM_001076675
NM_145297
ZNF626

zinc finger protein 626

chr1_-_149004916 1.553 NM_004079
CTSS
cathepsin S
chr17_-_26672757 1.542 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr5_-_88235624 1.511 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr19_-_44518516 1.471 NM_004877
GMFG
glia maturation factor, gamma
chr6_+_32713160 1.429 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr4_+_106851415 1.400 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr8_+_86287161 1.399 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr10_+_35524060 1.385 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr3_+_123256902 1.367 NM_175862
CD86
CD86 molecule
chr21_+_41719847 1.344 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr10_+_62208094 1.338 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr13_-_40454360 1.329 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr8_-_102872614 1.281 NM_032041
NCALD
neurocalcin delta
chr7_+_26298136 1.271 SNX10
sorting nexin 10
chr1_+_239762179 1.246 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_+_100099353 1.232 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr17_+_65009986 1.202 MAP2K6
mitogen-activated protein kinase kinase 6
chr1_+_158975662 1.185 NM_021181
SLAMF7
SLAM family member 7
chr13_-_40735619 1.179 NM_004294
MTRF1
mitochondrial translational release factor 1
chr13_-_40491405 1.158 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_-_45654327 1.157 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_149004879 1.129 CTSS
cathepsin S
chr15_+_79276273 1.124 NM_001172128
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr7_+_7573074 1.102 NM_019005
MIOS
missing oocyte, meiosis regulator, homolog (Drosophila)
chr5_-_94443300 1.101 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr2_-_136590210 1.100 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr14_-_105549177 1.097 IGHV4-31
IGHD
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr3_+_99733432 1.087 NM_005290
GPR15
G protein-coupled receptor 15
chr3_+_138132006 1.078 NM_001190796
NCK1
NCK adaptor protein 1
chr5_+_49997489 1.058 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr4_+_39874921 1.056 NM_004310
RHOH
ras homolog gene family, member H
chr22_+_20880159 1.049 IGLV6-57
immunoglobulin lambda variable 6-57
chr7_+_7573159 1.040 MIOS
missing oocyte, meiosis regulator, homolog (Drosophila)
chr12_-_55432348 1.040 NM_000946
PRIM1
primase, DNA, polypeptide 1 (49kDa)
chr20_-_51633042 1.039 NM_006526
ZNF217
zinc finger protein 217
chr18_+_27925859 1.031 RNF138
ring finger protein 138
chr13_-_40491491 0.998 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr11_+_67107641 0.995 NM_000852
GSTP1
glutathione S-transferase pi 1
chr13_-_40454188 0.988 ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_-_124357272 0.986 NM_001042594
NM_015450
POT1

protection of telomeres 1 homolog (S. pombe)

chr22_+_21384862 0.985 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr5_+_68703036 0.972 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr5_+_159589014 0.960 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr19_-_20540380 0.954 NM_001159293
ZNF737
zinc finger protein 737
chr8_-_30704984 0.948 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr8_-_102029997 0.946 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr10_-_99042381 0.943 NM_032900
ARHGAP19-SLIT1
ARHGAP19
ARHGAP19-SLIT1 read-through transcript
Rho GTPase activating protein 19
chr7_+_26298018 0.935 NM_013322
SNX10
sorting nexin 10
chr19_+_20138991 0.919 NM_052852
ZNF486
zinc finger protein 486
chr7_+_116447499 0.909 ST7
suppression of tumorigenicity 7
chr5_-_88155360 0.909 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr7_+_116447527 0.899 ST7
suppression of tumorigenicity 7
chr10_-_99042419 0.899 ARHGAP19
Rho GTPase activating protein 19
chr6_-_154692906 0.896 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chr3_-_191321367 0.877 LEPREL1
leprecan-like 1
chr17_-_39094787 0.876 NM_001040002
MEOX1
mesenchyme homeobox 1
chr1_+_100089118 0.869 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr12_+_116938888 0.859 NM_001130112
NM_001130113
NM_007370
NM_181578
RFC5



replication factor C (activator 1) 5, 36.5kDa



chr14_+_64947592 0.857 NM_178155
NM_178156
FUT8

fucosyltransferase 8 (alpha (1,6) fucosyltransferase)

chr11_+_5597749 0.856 NM_001003827
TRIM34
tripartite motif containing 34
chr22_+_27498679 0.848 CCDC117
coiled-coil domain containing 117
chr3_+_142175329 0.845 SLC25A36
solute carrier family 25, member 36
chr14_+_69306019 0.845 SRSF5
serine/arginine-rich splicing factor 5
chr7_+_149895390 0.837 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr17_-_3546047 0.831 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr10_-_11614279 0.824 NM_001080491
USP6NL
USP6 N-terminal like
chr16_-_84280004 0.822 GINS2
GINS complex subunit 2 (Psf2 homolog)
chr2_+_172530120 0.817 HAT1
histone acetyltransferase 1
chr10_-_64698831 0.803 NM_004241
JMJD1C
jumonji domain containing 1C
chr10_+_97461525 0.797 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr14_-_105542441 0.779 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr16_-_21221872 0.769 NM_001014444
NM_001888
CRYM

crystallin, mu

chr6_-_29635456 0.762 UBD
ubiquitin D
chr18_-_49944986 0.761 MBD2
methyl-CpG binding domain protein 2
chr16_-_84280088 0.751 NM_016095
GINS2
GINS complex subunit 2 (Psf2 homolog)
chr17_-_3546108 0.748 P2RX5-TAX1BP3
P2RX5
P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5
chr14_-_106064887 0.739 LOC100126583
IGHV3-48
IGHA1
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 3-48
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr1_+_165565006 0.737 POU2F1
POU class 2 homeobox 1
chr2_+_88966170 0.725


chr5_+_102493155 0.720 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr2_-_20375497 0.719 PUM2
pumilio homolog 2 (Drosophila)
chr5_+_67622242 0.715 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_167947301 0.714 NM_000655
SELL
selectin L
chr2_+_24660849 0.708 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr1_-_51660328 0.700 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr18_+_27925815 0.699 NM_016271
RNF138
ring finger protein 138
chr7_-_63660766 0.699 ZNF680
zinc finger protein 680
chr14_-_105763152 0.690 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG3
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr5_+_159546951 0.681 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr16_+_20682812 0.674 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr2_-_73860609 0.673 NM_003584
DUSP11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr3_+_39484073 0.673 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr3_+_113534604 0.671 NM_001004196
NM_005944
CD200

CD200 molecule

chr18_-_46068689 0.667 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr7_-_104696678 0.662 NM_182691
SRPK2
SRSF protein kinase 2
chr3_-_198784590 0.661 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr22_-_40666168 0.656 NM_001110215
CENPM
centromere protein M
chrX_+_118486390 0.654 NM_001152
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr2_+_132196533 0.650 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr8_+_98772537 0.642 MTDH
metadherin
chr17_-_18207416 0.640 NM_004169
NM_148918
SHMT1

serine hydroxymethyltransferase 1 (soluble)

chr3_-_47073910 0.639 SETD2
SET domain containing 2
chr4_+_68107039 0.638 NM_012108
STAP1
signal transducing adaptor family member 1
chr14_+_38719462 0.637 PNN
pinin, desmosome associated protein
chrX_-_153903963 0.636 NM_000132
F8
coagulation factor VIII, procoagulant component
chr14_-_44792082 0.631 MIS18BP1
MIS18 binding protein 1
chr7_+_38984133 0.631 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr12_+_12829807 0.625 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr8_+_104900591 0.618 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr12_+_9713472 0.613 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr15_-_58706934 0.613 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr1_-_9052207 0.611 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr2_-_89400935 0.609 IGKC
immunoglobulin kappa constant
chr14_-_19867372 0.608 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chrX_-_23835868 0.608 NM_024122
APOO
apolipoprotein O
chr17_-_38087366 0.607 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr1_-_9052253 0.604 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr5_+_70980724 0.604 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr17_+_31195760 0.596 TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr7_-_63660889 0.592 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr4_-_176970895 0.592 GPM6A
glycoprotein M6A
chr13_-_45910325 0.586 C13orf18
chromosome 13 open reading frame 18
chr6_+_10629550 0.585 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr17_-_18118441 0.584 TOP3A
topoisomerase (DNA) III alpha
chr17_-_64823368 0.571 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr1_-_167969802 0.569 NM_000450
SELE
selectin E
chr14_+_69305265 0.569 SRSF5
serine/arginine-rich splicing factor 5
chr10_+_111755715 0.568 NM_019903
ADD3
adducin 3 (gamma)
chrX_+_118486419 0.568 SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr6_-_32920689 0.559 NM_004159
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr11_-_104411065 0.558 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr3_-_166278969 0.554 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr10_-_27097782 0.554 ABI1
abl-interactor 1
chr4_+_53986759 0.550 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr20_-_18425811 0.539 NM_006606
RBBP9
retinoblastoma binding protein 9
chr6_-_22405708 0.531 NM_000948
PRL
prolactin
chr5_-_24680841 0.529 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr3_-_191321601 0.526 NM_018192
LEPREL1
leprecan-like 1
chr3_-_187124290 0.526 TRA2B
transformer 2 beta homolog (Drosophila)
chrX_+_48427137 0.526 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr6_+_27885692 0.515 NM_003536
HIST1H3H
histone cluster 1, H3h
chr7_-_107558021 0.513 NM_007356
LAMB4
laminin, beta 4
chr1_+_157246305 0.508 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr8_+_75066117 0.504 NM_001195797
NM_015364
LY96

lymphocyte antigen 96


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.68 4.87e-03 GO:0006955 immune response
1.51 5.10e-03 GO:0002376 immune system process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.15 1.60e-02 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds