Motif ID: EOMES.p2

Z-value: 0.643


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
EOMES 8320 eomesodermin

Activity-expression correlation:

GenePromoterPearsonP-valuePlot


Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_5227611 1.302 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr11_+_46358909 1.131 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr9_-_74757735 1.002 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr15_-_32875040 0.897 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr10_-_92670764 0.813 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_-_186969041 0.790 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr7_-_150283794 0.785 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr4_-_186969202 0.783 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr11_-_33870411 0.761 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_-_50740491 0.735 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr1_-_85703198 0.718 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr16_+_30293598 0.703 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr1_-_116112684 0.676 CASQ2
calsequestrin 2 (cardiac muscle)
chr11_-_5232480 0.655 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr10_+_4995685 0.634 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr4_-_186815116 0.589 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr2_-_192419896 0.587 SDPR
serum deprivation response
chrX_+_99785818 0.562 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chrX_+_99786044 0.560 SRPX2
sushi-repeat containing protein, X-linked 2
chr10_+_4995597 0.551 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_70517823 0.542 NM_002727
SRGN
serglycin
chr10_-_92671005 0.532 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr12_-_69434650 0.496 PTPRR
protein tyrosine phosphatase, receptor type, R
chr14_+_100270222 0.466 DLK1
delta-like 1 homolog (Drosophila)
chr10_+_70517863 0.458 SRGN
serglycin
chr21_+_39745649 0.437 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr12_-_69434330 0.436 PTPRR
protein tyrosine phosphatase, receptor type, R
chr4_-_186814852 0.425 SORBS2
sorbin and SH3 domain containing 2
chr12_-_69434598 0.422 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr2_+_152900076 0.405 FMNL2
formin-like 2
chr9_-_78710698 0.391 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr11_-_2108035 0.388 IGF2
insulin-like growth factor 2 (somatomedin A)
chr5_-_121440704 0.379 NM_001178102
LOX
lysyl oxidase
chr15_-_56145140 0.377 NM_003888
NM_170696
ALDH1A2

aldehyde dehydrogenase 1 family, member A2

chr15_-_56093477 0.369 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr2_-_200030944 0.349 NM_001172509
SATB2
SATB homeobox 2
chr3_+_114948591 0.332 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr16_+_84202515 0.322 NM_001134473
KIAA0182
KIAA0182
chr1_+_26973804 0.320 ARID1A
AT rich interactive domain 1A (SWI-like)
chr12_+_54760211 0.320 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr17_-_10393664 0.314 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr4_-_140280031 0.308 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr1_+_32889335 0.308 NM_001135255
NM_005610
NM_001135256
RBBP4


retinoblastoma binding protein 4


chr19_+_810658 0.304 NM_001928
CFD
complement factor D (adipsin)
chrX_-_11194015 0.304 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr11_-_27700180 0.303 NM_170731
BDNF
brain-derived neurotrophic factor
chr15_-_88143721 0.302 ANPEP
alanyl (membrane) aminopeptidase
chr13_-_35327798 0.300 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr5_+_128468785 0.298 ISOC1
isochorismatase domain containing 1
chr14_+_94148466 0.283 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr18_+_30812205 0.282 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr10_-_75080784 0.280 NM_024875
SYNPO2L
synaptopodin 2-like
chr21_-_46528594 0.277 MCM3AP
minichromosome maintenance complex component 3 associated protein
chr17_+_27795633 0.271 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr19_+_810673 0.271 CFD
complement factor D (adipsin)
chrX_-_15783015 0.262 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr2_-_192420168 0.261 NM_004657
SDPR
serum deprivation response
chr9_-_16717887 0.251 BNC2
basonuclin 2
chr6_-_31727460 0.249


chr8_-_38577891 0.247


chr5_-_132140786 0.246 NM_001098811
NM_001098812
NM_015146
SEPT8


septin 8


chr11_+_73036241 0.242 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr9_+_34642125 0.238 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr1_-_51198383 0.238 FAF1
Fas (TNFRSF6) associated factor 1
chr7_-_16471817 0.232 NM_015464
SOSTDC1
sclerostin domain containing 1
chr2_-_210888010 0.231 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr10_-_15453060 0.229 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr6_+_39868126 0.228 DAAM2
dishevelled associated activator of morphogenesis 2
chr2_+_228386800 0.218 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr17_+_27795632 0.217 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_-_51198052 0.217 FAF1
Fas (TNFRSF6) associated factor 1
chr6_-_31728121 0.217 NM_001098534
BAG6
BCL2-associated athanogene 6
chr16_-_87244896 0.215 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr1_-_51198417 0.212 FAF1
Fas (TNFRSF6) associated factor 1
chrX_-_137777382 0.212 NM_001139502
FGF13
fibroblast growth factor 13
chr1_+_144149794 0.211 NM_006472
TXNIP
thioredoxin interacting protein
chr11_-_2138984 0.208 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough transcript
chr17_+_27795598 0.207 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr12_-_109842736 0.206 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr7_+_142723340 0.203 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr11_-_2116048 0.199 IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_-_175578156 0.199 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr2_-_169455167 0.198 NM_020675
SPC25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr7_-_27191287 0.194 NM_005523
HOXA11
homeobox A11
chr2_-_179380301 0.192 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr17_+_27795645 0.192 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chrX_-_135577102 0.191 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_12599934 0.190 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr1_-_158579977 0.189 NM_001098398
NM_004371
COPA

coatomer protein complex, subunit alpha

chr3_-_115960807 0.188 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr8_+_31010319 0.184 NM_000553
WRN
Werner syndrome, RecQ helicase-like
chr7_+_99865340 0.183 MEPCE
methylphosphate capping enzyme
chr1_+_26609893 0.181 LIN28A
lin-28 homolog A (C. elegans)
chr2_-_156897286 0.177 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr2_-_96320185 0.176 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr6_-_46401363 0.175 NM_005822
RCAN2
regulator of calcineurin 2
chr16_-_28542366 0.174 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr4_+_124537334 0.173 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr7_+_99865189 0.173 NM_019606
MEPCE
methylphosphate capping enzyme
chr1_+_39229474 0.170 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr6_+_135544138 0.169 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr12_+_26239755 0.167 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr1_-_239865724 0.167 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr9_-_99001551 0.166 NM_199005
ZNF322B
ZNF322A
zinc finger protein 322B
zinc finger protein 322A
chr9_+_133368155 0.164 POMT1
protein-O-mannosyltransferase 1
chr22_-_20551953 0.164 NM_002745
NM_138957
MAPK1

mitogen-activated protein kinase 1

chr9_+_34980715 0.162 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr1_+_37795101 0.162 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chrX_-_15782859 0.159 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr17_+_27795635 0.156 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr11_+_63205444 0.155 NM_006054
NM_201428
NM_201429
NM_201430
RTN3



reticulon 3



chr12_+_73219826 0.152


chr6_+_135544170 0.151 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr2_-_189752575 0.151 NM_000393
COL5A2
collagen, type V, alpha 2
chr2_-_61551403 0.148 USP34
ubiquitin specific peptidase 34
chr2_-_27446670 0.147 EIF2B4
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
chr1_+_149165438 0.146 NM_001145415
NM_012432
SETDB1

SET domain, bifurcated 1

chr8_+_144802972 0.146 NM_014789
ZNF623
zinc finger protein 623
chr8_+_1980564 0.145 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr1_+_151867483 0.144 NM_006271
S100A1
S100 calcium binding protein A1
chr2_-_61551350 0.143 NM_014709
USP34
ubiquitin specific peptidase 34
chr6_-_26232109 0.143 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr11_-_111255354 0.142 NM_138378
ALG9
FDXACB1
asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae)
ferredoxin-fold anticodon binding domain containing 1
chr6_+_135544214 0.141 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr2_-_39517934 0.141 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr8_+_31010791 0.141 WRN
Werner syndrome, RecQ helicase-like
chr1_+_46151845 0.141 MAST2
microtubule associated serine/threonine kinase 2
chr3_-_188946168 0.140 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr2_-_210876560 0.139 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr5_-_78318112 0.139 NM_000046
ARSB
arylsulfatase B
chr3_-_12916547 0.138 IQSEC1
IQ motif and Sec7 domain 1
chr15_-_39412032 0.136 NM_007280
OIP5
Opa interacting protein 5
chr10_+_7785235 0.135 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr20_+_43943254 0.135 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr5_-_95184121 0.134 GLRX
glutaredoxin (thioltransferase)
chr1_+_26609819 0.133 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr6_+_34867794 0.133 UHRF1BP1
UHRF1 binding protein 1
chrX_-_70390704 0.132 NM_201599
ZMYM3
zinc finger, MYM-type 3
chr16_-_51139214 0.131 NM_001146188
TOX3
TOX high mobility group box family member 3
chr4_-_186970366 0.131 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr13_-_49554089 0.131 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chrY_+_21146998 0.130 NM_004681
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr9_+_109131814 0.129 RAD23B
RAD23 homolog B (S. cerevisiae)
chr5_+_139869819 0.129


chr9_+_133368174 0.129 POMT1
protein-O-mannosyltransferase 1
chr5_+_176446425 0.128 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr1_-_12830728 0.127 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr9_+_34980266 0.127 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr13_+_100902942 0.127 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr11_+_73037382 0.126 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr1_-_51198328 0.126 FAF1
Fas (TNFRSF6) associated factor 1
chr9_+_133368156 0.126 POMT1
protein-O-mannosyltransferase 1
chr1_-_51198506 0.125 NM_007051
FAF1
Fas (TNFRSF6) associated factor 1
chr1_-_201422450 0.124 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr1_-_151867338 0.123 NM_005979
S100A13
S100 calcium binding protein A13
chr20_-_2589476 0.122 IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
chr8_-_82557956 0.122 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr1_-_167822248 0.122 F5
coagulation factor V (proaccelerin, labile factor)
chr10_+_31647425 0.122 ZEB1
zinc finger E-box binding homeobox 1
chr12_-_7935010 0.121 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr13_+_108046500 0.121 NM_015011
MYO16
myosin XVI
chr1_-_159459814 0.121 APOA2
apolipoprotein A-II
chr17_+_55325224 0.121 NM_003161
RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr12_+_94776836 0.120 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr17_+_38247493 0.120 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr12_-_55134692 0.119 NM_012064
MIP
major intrinsic protein of lens fiber
chrX_-_154216929 0.119 NM_001289
CLIC2
chloride intracellular channel 2
chr12_+_32546243 0.119 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr11_-_86343859 0.118 NM_012193
FZD4
frizzled homolog 4 (Drosophila)
chr12_-_115199293 0.118 NM_015335
MED13L
mediator complex subunit 13-like
chr1_-_243092581 0.117 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr7_-_99604171 0.116 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr16_+_23754822 0.116 PRKCB
protein kinase C, beta
chr7_+_149696792 0.116 NM_001099695
NM_001099696
NM_013400
REPIN1


replication initiator 1


chr5_+_137542315 0.116 NM_005733
KIF20A
kinesin family member 20A
chr17_-_36232366 0.115 NM_000421
KRT10
keratin 10
chr6_+_131936057 0.115 NM_000045
ARG1
arginase, liver
chr17_+_8154864 0.114 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr1_+_181025494 0.114 NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr19_+_60589110 0.112 NM_000991
NM_001136134
NM_001136135
NM_001136136
NM_001136137
RPL28




ribosomal protein L28




chr9_-_129656413 0.112 ENG
endoglin
chr1_+_51208499 0.112 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr11_-_85457469 0.111 PICALM
phosphatidylinositol binding clathrin assembly protein
chr1_+_35317571 0.111 ZMYM1
zinc finger, MYM-type 1
chr9_-_36266930 0.110 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chrX_+_23595579 0.109 PRDX4
peroxiredoxin 4
chr15_+_61123327 0.107 TPM1
tropomyosin 1 (alpha)
chr17_+_22823151 0.107 NM_014238
KSR1
kinase suppressor of ras 1
chr4_+_86615275 0.106 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chrX_-_70391127 0.106 NM_001171163
NM_005096
ZMYM3

zinc finger, MYM-type 3

chr17_-_10265991 0.105 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr2_-_39517633 0.105 NM_003618
MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr7_-_99604127 0.105 GAL3ST4
galactose-3-O-sulfotransferase 4
chr8_-_13416554 0.105 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr15_+_38648801 0.104 RPUSD2
RNA pseudouridylate synthase domain containing 2
chr2_+_218954995 0.104 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr3_+_122109716 0.104 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr3_+_35696119 0.104 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr6_+_107917965 0.103 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chrX_+_16714452 0.103 NM_001168683
NM_018360
TXLNG

taxilin gamma


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 5.52e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 3.51e-04 GO:0005576 extracellular region
1.60 1.27e-02 GO:0005615 extracellular space
3.48 2.12e-02 GO:0016459 myosin complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.24 7.51e-03 GO:0008307 structural constituent of muscle
2.70 9.14e-03 GO:0046873 metal ion transmembrane transporter activity
1.50 4.14e-02 GO:0005102 receptor binding