Motif ID: HES1.p2

Z-value: 2.007


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_1953366250.146.2e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_87535106 2.510 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr16_+_29725311 2.112 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr21_-_45786709 1.855 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr15_-_56145140 1.784 NM_003888
NM_170696
ALDH1A2

aldehyde dehydrogenase 1 family, member A2

chr1_-_32574185 1.731 NM_023009
MARCKSL1
MARCKS-like 1
chr7_+_106472243 1.718 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr5_+_665404 1.615 NM_018140
CEP72
centrosomal protein 72kDa
chr5_+_665454 1.601 CEP72
centrosomal protein 72kDa
chr7_+_154720547 1.591 INSIG1
insulin induced gene 1
chr3_-_47798279 1.557 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr15_+_39573363 1.500 NM_002220
ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr15_+_48261649 1.493 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr20_+_55399847 1.467 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chr3_-_47798341 1.455 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr3_-_47798308 1.454 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr3_-_47798347 1.449 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr6_+_37245860 1.416 NM_002648
PIM1
pim-1 oncogene
chr12_+_92295738 1.414 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr16_+_15397120 1.407 MPV17L
MPV17 mitochondrial membrane protein-like
chr3_-_47798337 1.405 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr4_+_57468847 1.404 REST
RE1-silencing transcription factor
chr21_+_34367678 1.390 NM_032476
NM_006933
MRPS6
SLC5A3
mitochondrial ribosomal protein S6
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr5_+_75734759 1.385 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr1_-_92124064 1.384 TGFBR3
transforming growth factor, beta receptor III
chr19_-_1603325 1.362 NM_003200
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr7_-_148212312 1.354 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr6_+_57145292 1.353 BAG2
BCL2-associated athanogene 2
chr3_-_47798381 1.350 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr7_-_148212230 1.308 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr22_+_18091065 1.308 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr14_+_100262916 1.291 DLK1
delta-like 1 homolog (Drosophila)
chr2_-_96174865 1.291 NM_004418
DUSP2
dual specificity phosphatase 2
chr9_+_130491340 1.281 SET
SET nuclear oncogene
chr19_+_34994701 1.249 NM_001238
CCNE1
cyclin E1
chr5_+_131657964 1.245 NM_003059
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr3_-_47798372 1.235 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr7_-_100068612 1.233 TFR2
transferrin receptor 2
chr6_-_13819463 1.231 RANBP9
RAN binding protein 9
chr7_-_148212310 1.227 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_148212336 1.224 NM_004456
NM_152998
EZH2

enhancer of zeste homolog 2 (Drosophila)

chr7_+_99865189 1.209 NM_019606
MEPCE
methylphosphate capping enzyme
chr6_-_13819931 1.183 RANBP9
RAN binding protein 9
chrX_-_153686923 1.182 NM_001166460
NM_001166461
NM_001166462
NM_002436
MPP1



membrane protein, palmitoylated 1, 55kDa



chr19_+_1022208 1.181 HMHA1
histocompatibility (minor) HA-1
chr10_-_99084417 1.177 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr6_+_157722467 1.155 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr16_+_15397087 1.141 NM_001128423
NM_173803
MPV17L

MPV17 mitochondrial membrane protein-like

chr21_-_43368963 1.139 NM_000071
CBS
cystathionine-beta-synthase
chr1_+_46485972 1.123 RAD54L
RAD54-like (S. cerevisiae)
chr7_+_99865340 1.118 MEPCE
methylphosphate capping enzyme
chr14_+_100262943 1.108 NM_003836
DLK1
delta-like 1 homolog (Drosophila)
chr1_-_52791309 1.105 NM_001009881
NM_015269
ZCCHC11

zinc finger, CCHC domain containing 11

chr5_+_149526533 1.103 NM_001804
CDX1
caudal type homeobox 1
chr1_+_93317374 1.097 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr3_-_47798390 1.079 NM_003074
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr15_+_24799174 1.076 NM_033223
GABRG3
gamma-aminobutyric acid (GABA) A receptor, gamma 3
chr6_-_13922525 1.067 NM_001031713
CCDC90A
coiled-coil domain containing 90A
chr19_+_40451626 1.058 USF2
upstream transcription factor 2, c-fos interacting
chr22_+_27498679 1.052 CCDC117
coiled-coil domain containing 117
chr16_-_87244896 1.051 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr1_-_11042668 1.044 NM_003132
SRM
spermidine synthase
chr14_+_100263028 1.038 DLK1
delta-like 1 homolog (Drosophila)
chr16_+_83291097 1.033 USP10
ubiquitin specific peptidase 10
chr16_+_83291112 1.025 USP10
ubiquitin specific peptidase 10
chr7_-_65084668 1.024 NM_000181
GUSB
glucuronidase, beta
chr1_+_225194582 1.017 ADCK3
aarF domain containing kinase 3
chr16_+_83291055 1.016 NM_005153
USP10
ubiquitin specific peptidase 10
chr6_-_13819622 1.009 NM_005493
RANBP9
RAN binding protein 9
chr1_+_46485946 0.997 NM_001142548
NM_003579
RAD54L

RAD54-like (S. cerevisiae)

chr22_-_19686351 0.988 NM_001008695
NM_030573
THAP7

THAP domain containing 7

chr1_+_225194622 0.986 ADCK3
aarF domain containing kinase 3
chr11_-_67645246 0.986 CHKA
choline kinase alpha
chr10_-_23043449 0.985 NM_005028
PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr17_+_26060617 0.978


chr3_+_38470782 0.978 NM_001106
ACVR2B
activin A receptor, type IIB
chr20_+_36810510 0.970 NM_024855
ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr16_+_2593351 0.966 LOC652276
hypothetical LOC652276
chr3_-_129690056 0.964 NM_001145661
GATA2
GATA binding protein 2
chr1_+_23218515 0.962 NM_001009999
NM_015013
KDM1A

lysine (K)-specific demethylase 1A

chr19_-_8279157 0.959 NM_001165895
NM_016579
CD320

CD320 molecule

chr16_+_29725597 0.947


chrX_-_109447970 0.946 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr16_+_1979959 0.945 NM_004209
SYNGR3
synaptogyrin 3
chr9_+_115077752 0.941 PRPF4
PRP4 pre-mRNA processing factor 4 homolog (yeast)
chr14_+_102313585 0.938 TRAF3
TNF receptor-associated factor 3
chr1_+_165456572 0.936 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr22_+_16940755 0.932 PEX26
peroxisomal biogenesis factor 26
chr1_+_225194560 0.931 NM_020247
ADCK3
aarF domain containing kinase 3
chr6_-_125664913 0.900 NM_016063
HDDC2
HD domain containing 2
chr5_-_79986539 0.895 NM_000791
DHFR
dihydrofolate reductase
chr21_+_44109454 0.889 AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr19_+_10843244 0.888 NM_199141
CARM1
coactivator-associated arginine methyltransferase 1
chr1_+_65763945 0.883 NM_001198687
NM_001198688
NM_001198689
LEPR


leptin receptor


chr6_+_36518778 0.880 KCTD20
potassium channel tetramerisation domain containing 20
chr1_+_225194616 0.880 ADCK3
aarF domain containing kinase 3
chrX_-_48661226 0.874 NM_006875
PIM2
pim-2 oncogene
chr7_+_154720416 0.872 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr1_+_210525490 0.870 NM_006243
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr5_+_44844724 0.870 NM_016640
MRPS30
mitochondrial ribosomal protein S30
chr1_+_23218572 0.869 KDM1A
lysine (K)-specific demethylase 1A
chr7_+_75515338 0.865 MDH2
malate dehydrogenase 2, NAD (mitochondrial)
chrX_-_153686818 0.855 MPP1
membrane protein, palmitoylated 1, 55kDa
chr1_+_65763978 0.854 LEPR
leptin receptor
chr16_-_34262262 0.853 UBE2MP1
ubiquitin-conjugating enzyme E2M pseudogene 1
chr22_-_20551937 0.853 MAPK1
mitogen-activated protein kinase 1
chr17_+_52517529 0.842 NM_003488
AKAP1
A kinase (PRKA) anchor protein 1
chr11_+_64785888 0.839 NM_002689
POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr19_+_4353658 0.834 NM_005483
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr19_-_12929008 0.833 GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr22_+_28206180 0.832 NM_021076
NEFH
neurofilament, heavy polypeptide
chr19_-_16443810 0.827 EPS15L1
epidermal growth factor receptor pathway substrate 15-like 1
chr7_+_87343479 0.824 NM_006716
DBF4
DBF4 homolog (S. cerevisiae)
chr16_+_84204424 0.821 NM_014615
KIAA0182
KIAA0182
chr14_+_100263066 0.817 DLK1
delta-like 1 homolog (Drosophila)
chr16_-_28542366 0.810 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr3_-_50515857 0.810 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr6_+_36518521 0.808 NM_173562
KCTD20
potassium channel tetramerisation domain containing 20
chr19_+_40451720 0.807 NM_003367
NM_207291
USF2

upstream transcription factor 2, c-fos interacting

chr1_+_11674365 0.804 NM_198545
C1orf187
chromosome 1 open reading frame 187
chr7_+_149696792 0.799 NM_001099695
NM_001099696
NM_013400
REPIN1


replication initiator 1


chr21_+_29593098 0.799 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr4_+_57469122 0.796 REST
RE1-silencing transcription factor
chr15_+_83092806 0.796 NM_014630
ZNF592
zinc finger protein 592
chr22_+_38183262 0.787 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr12_+_2938703 0.784 NM_003213
NM_201441
NM_201443
TEAD4


TEA domain family member 4


chr9_-_100510657 0.783 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr9_-_139100923 0.780 LOC100289341
similar to hCG2022304
chr18_-_12367248 0.777 NM_006796
AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr16_+_79598016 0.776 CENPN
centromere protein N
chr22_+_20101661 0.770 NM_015094
HIC2
hypermethylated in cancer 2
chrX_-_109447954 0.768 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr7_-_87343599 0.764 NM_018843
SLC25A40
solute carrier family 25, member 40
chr9_+_130491370 0.762 SET
SET nuclear oncogene
chr12_-_116021473 0.760 NM_001168325
NM_017899
TESC

tescalcin

chr1_+_32889335 0.759 NM_001135255
NM_005610
NM_001135256
RBBP4


retinoblastoma binding protein 4


chr1_-_218168548 0.758 NM_018713
SLC30A10
solute carrier family 30, member 10
chr5_+_118719448 0.757 NM_014350
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr5_+_70918888 0.757 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr2_-_27288518 0.754 NM_021095
SLC5A6
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
chr16_-_4341266 0.753 NM_016069
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr12_+_6893751 0.752 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr12_-_107479082 0.749 SART3
squamous cell carcinoma antigen recognized by T cells 3
chr10_-_23043042 0.748 PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr7_-_148212292 0.747 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr16_+_83291107 0.747 USP10
ubiquitin specific peptidase 10
chr11_+_67836575 0.745 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr8_+_56954953 0.744 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr5_+_70918935 0.743 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr6_-_43305156 0.741 NM_006443
NM_199184
C6orf108

chromosome 6 open reading frame 108

chr18_+_2645885 0.738 NM_015295
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
chr5_+_70918893 0.738 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr12_-_107479072 0.732 SART3
squamous cell carcinoma antigen recognized by T cells 3
chr22_+_18081968 0.731 NM_002688
SEPT5
septin 5
chr6_+_34312906 0.728 HMGA1
high mobility group AT-hook 1
chr1_-_159413833 0.723 NM_003779
B4GALT3
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chr7_-_150305933 0.721 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr12_-_107479059 0.719 SART3
squamous cell carcinoma antigen recognized by T cells 3
chr8_+_61753793 0.718 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr1_-_53566331 0.717 NM_033300
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chrX_-_137621492 0.716 NM_004114
FGF13
fibroblast growth factor 13
chr1_-_39111422 0.713 NM_012333
MYCBP
c-myc binding protein
chr7_+_99613282 0.711 STAG3
stromal antigen 3
chr10_+_30762862 0.710 NM_005204
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr19_-_12929033 0.709 NM_052850
GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr17_+_70769539 0.708 MRPS7
mitochondrial ribosomal protein S7
chr1_-_11042634 0.707 SRM
spermidine synthase
chr7_-_23476156 0.705


chr2_-_203444468 0.705 NM_138468
ICA1L
islet cell autoantigen 1,69kDa-like
chr10_+_28861705 0.704 WAC
WW domain containing adaptor with coiled-coil
chr17_-_3814334 0.702 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr12_-_6586811 0.700 NM_001273
CHD4
chromodomain helicase DNA binding protein 4
chr4_-_185892204 0.699 NM_024629
MLF1IP
MLF1 interacting protein
chr1_+_91739241 0.698 NM_001134420
CDC7
cell division cycle 7 homolog (S. cerevisiae)
chr19_-_10474767 0.695 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr10_+_22650145 0.695 BMI1
BMI1 polycomb ring finger oncogene
chr6_+_89912464 0.695 NM_001010853
PM20D2
peptidase M20 domain containing 2
chr19_+_10843369 0.694 CARM1
coactivator-associated arginine methyltransferase 1
chr3_+_73128771 0.691 NM_174907
PPP4R2
protein phosphatase 4, regulatory subunit 2
chr17_+_70769600 0.689 MRPS7
mitochondrial ribosomal protein S7
chr16_-_3707450 0.686 NM_016292
TRAP1
TNF receptor-associated protein 1
chr21_+_44109529 0.685 NM_020132
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr11_-_67645433 0.685 NM_001277
NM_212469
CHKA

choline kinase alpha

chr18_-_12367168 0.684 AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr6_+_96132064 0.683 NM_024641
MANEA
mannosidase, endo-alpha
chr6_-_125664770 0.683 HDDC2
HD domain containing 2
chr3_+_154035425 0.680 NM_002563
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr4_-_2934945 0.679 NOP14
NOP14 nucleolar protein homolog (yeast)
chr6_+_135544138 0.678 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr1_+_91738953 0.677 NM_001134419
NM_003503
CDC7

cell division cycle 7 homolog (S. cerevisiae)

chr2_-_10506033 0.675 ODC1
ornithine decarboxylase 1
chr17_-_73636386 0.667 NM_001127198
TMC6
transmembrane channel-like 6
chr12_-_6586736 0.665 CHD4
chromodomain helicase DNA binding protein 4
chr19_+_54314292 0.665 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr3_-_13436802 0.663 NM_024923
NUP210
nucleoporin 210kDa
chr10_-_28861465 0.662 LOC220906
hypothetical LOC220906
chr7_-_99536214 0.662 NM_182776
MCM7
minichromosome maintenance complex component 7
chr1_+_181075104 0.662 DHX9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
chr9_+_130491291 0.661 NM_003011
SET
SET nuclear oncogene
chr5_+_70918856 0.661 NM_022132
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr8_-_145609737 0.661 SLC39A4
solute carrier family 39 (zinc transporter), member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 2.32e-22 GO:0044237 cellular metabolic process
1.44 6.66e-20 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.40 1.39e-19 GO:0034641 cellular nitrogen compound metabolic process
1.38 3.99e-18 GO:0006807 nitrogen compound metabolic process
1.31 9.99e-18 GO:0044260 cellular macromolecule metabolic process
1.23 4.90e-17 GO:0044238 primary metabolic process
1.20 6.78e-16 GO:0008152 metabolic process
1.45 1.29e-15 GO:0090304 nucleic acid metabolic process
1.25 7.80e-13 GO:0043170 macromolecule metabolic process
1.79 7.74e-11 GO:0051276 chromosome organization
1.42 7.82e-10 GO:0016070 RNA metabolic process
1.99 1.99e-09 GO:0016568 chromatin modification
1.33 6.12e-09 GO:0044249 cellular biosynthetic process
1.82 2.13e-08 GO:0006325 chromatin organization
1.31 4.61e-08 GO:0009058 biosynthetic process
1.32 9.80e-08 GO:0010468 regulation of gene expression
1.32 2.30e-07 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.36 3.10e-07 GO:0010467 gene expression
1.25 6.13e-07 GO:0060255 regulation of macromolecule metabolic process
1.30 1.52e-06 GO:0010556 regulation of macromolecule biosynthetic process
1.32 2.51e-06 GO:0051252 regulation of RNA metabolic process
1.28 2.75e-06 GO:0031326 regulation of cellular biosynthetic process
1.28 3.29e-06 GO:0009889 regulation of biosynthetic process
1.08 4.16e-06 GO:0009987 cellular process
1.48 7.61e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.46 1.15e-05 GO:0007049 cell cycle
1.58 2.57e-05 GO:0006396 RNA processing
1.30 3.35e-05 GO:0006355 regulation of transcription, DNA-dependent
2.08 4.18e-05 GO:0016569 covalent chromatin modification
1.22 4.41e-05 GO:0031323 regulation of cellular metabolic process
1.59 4.88e-05 GO:0006259 DNA metabolic process
1.33 4.95e-05 GO:0034645 cellular macromolecule biosynthetic process
2.07 6.82e-05 GO:0016570 histone modification
1.30 8.66e-05 GO:0043412 macromolecule modification
1.20 9.37e-05 GO:0019222 regulation of metabolic process
1.21 1.00e-04 GO:0080090 regulation of primary metabolic process
1.32 1.29e-04 GO:0009059 macromolecule biosynthetic process
1.30 1.83e-04 GO:0006464 protein modification process
2.02 1.91e-04 GO:0006260 DNA replication
1.44 2.02e-04 GO:0006351 transcription, DNA-dependent
1.24 2.54e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.24 4.50e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.87 6.03e-04 GO:0032868 response to insulin stimulus
1.49 9.92e-04 GO:0022403 cell cycle phase
1.23 2.03e-03 GO:0044267 cellular protein metabolic process
1.50 2.41e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.51 3.14e-03 GO:0000278 mitotic cell cycle
1.50 3.54e-03 GO:0010629 negative regulation of gene expression
1.29 4.13e-03 GO:0006996 organelle organization
1.42 4.66e-03 GO:0022402 cell cycle process
1.48 5.05e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.48 6.58e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.46 7.52e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.65 8.37e-03 GO:0051325 interphase
1.38 9.89e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.64 1.51e-02 GO:0051329 interphase of mitotic cell cycle
2.24 1.60e-02 GO:0040029 regulation of gene expression, epigenetic
1.76 1.65e-02 GO:0071375 cellular response to peptide hormone stimulus
1.60 1.97e-02 GO:0043434 response to peptide hormone stimulus
1.98 1.98e-02 GO:0008286 insulin receptor signaling pathway
1.43 2.12e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.49 2.36e-02 GO:0006974 response to DNA damage stimulus
1.34 2.58e-02 GO:0009892 negative regulation of metabolic process
1.42 2.71e-02 GO:0009890 negative regulation of biosynthetic process
1.48 2.85e-02 GO:0016071 mRNA metabolic process
1.83 3.48e-02 GO:0032869 cellular response to insulin stimulus
1.73 3.54e-02 GO:0051186 cofactor metabolic process
1.47 4.50e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.46 4.81e-02 GO:0051253 negative regulation of RNA metabolic process
1.33 4.97e-02 GO:0032774 RNA biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 8.24e-29 GO:0005634 nucleus
1.20 4.69e-26 GO:0043231 intracellular membrane-bounded organelle
1.20 6.25e-26 GO:0043227 membrane-bounded organelle
1.14 7.83e-26 GO:0044424 intracellular part
1.13 1.68e-24 GO:0005622 intracellular
1.50 1.72e-20 GO:0044428 nuclear part
1.55 2.36e-20 GO:0031981 nuclear lumen
1.47 5.77e-20 GO:0031974 membrane-enclosed lumen
1.48 1.21e-19 GO:0070013 intracellular organelle lumen
1.16 1.61e-19 GO:0043229 intracellular organelle
1.16 3.58e-19 GO:0043226 organelle
1.46 1.89e-18 GO:0043233 organelle lumen
1.59 2.94e-16 GO:0005654 nucleoplasm
1.20 9.98e-11 GO:0044446 intracellular organelle part
1.19 8.11e-10 GO:0044422 organelle part
1.05 5.63e-07 GO:0044464 cell part
1.05 6.06e-07 GO:0005623 cell
1.39 3.35e-06 GO:0005739 mitochondrion
1.51 9.69e-06 GO:0044451 nucleoplasm part
1.56 4.49e-05 GO:0005694 chromosome
1.55 2.57e-04 GO:0005730 nucleolus
1.09 9.68e-04 GO:0005737 cytoplasm
1.73 2.52e-03 GO:0000785 chromatin
1.49 8.09e-03 GO:0044427 chromosomal part
1.15 1.81e-02 GO:0032991 macromolecular complex
1.18 1.96e-02 GO:0043228 non-membrane-bounded organelle
1.18 1.96e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.65 3.97e-02 GO:0000228 nuclear chromosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.32 3.39e-12 GO:0003676 nucleic acid binding
1.36 1.41e-10 GO:0000166 nucleotide binding
1.14 1.16e-08 GO:0005515 protein binding
1.41 3.47e-08 GO:0032559 adenyl ribonucleotide binding
1.41 3.89e-08 GO:0030554 adenyl nucleotide binding
1.33 4.63e-08 GO:0003677 DNA binding
1.36 2.43e-07 GO:0016740 transferase activity
1.39 2.72e-07 GO:0005524 ATP binding
1.49 5.61e-07 GO:0030528 transcription regulator activity
1.33 1.11e-06 GO:0032553 ribonucleotide binding
1.33 1.11e-06 GO:0032555 purine ribonucleotide binding
1.33 1.42e-06 GO:0017076 purine nucleotide binding
1.87 2.03e-06 GO:0016564 transcription repressor activity
1.32 3.83e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.17 6.76e-06 GO:0003824 catalytic activity
1.06 1.10e-04 GO:0005488 binding
1.95 2.18e-04 GO:0003682 chromatin binding
1.39 5.98e-04 GO:0001071 nucleic acid binding transcription factor activity
1.39 5.98e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.70 7.29e-04 GO:0008134 transcription factor binding
1.55 2.08e-03 GO:0019904 protein domain specific binding
1.37 3.36e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.89 5.27e-03 GO:0016741 transferase activity, transferring one-carbon groups
2.17 6.38e-03 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
1.87 1.03e-02 GO:0008168 methyltransferase activity
2.32 1.20e-02 GO:0042393 histone binding
1.59 1.23e-02 GO:0016563 transcription activator activity
1.36 1.74e-02 GO:0003723 RNA binding
1.52 2.19e-02 GO:0003712 transcription cofactor activity
1.51 2.48e-02 GO:0000988 protein binding transcription factor activity
1.51 2.48e-02 GO:0000989 transcription factor binding transcription factor activity
2.00 3.34e-02 GO:0051427 hormone receptor binding
4.99 3.35e-02 GO:0070742 C2H2 zinc finger domain binding