Motif ID: HES1.p2

Z-value: 2.007


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_1953366250.146.2e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_87535106 2.510 NM_175931
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr16_+_29725311 2.112 NM_001042539
NM_002383
 MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr21_-_45786709 1.855 NM_194255
 SLC19A1
solute carrier family 19 (folate transporter), member 1
chr15_-_56145140 1.784 NM_003888
NM_170696
 ALDH1A2

aldehyde dehydrogenase 1 family, member A2

chr1_-_32574185 1.731 NM_023009
 MARCKSL1
MARCKS-like 1
chr7_+_106472243 1.718 NM_002736
 PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr5_+_665404 1.615 NM_018140
 CEP72
centrosomal protein 72kDa
chr5_+_665454 1.601 CEP72
centrosomal protein 72kDa
chr7_+_154720547 1.591 INSIG1
insulin induced gene 1
chr3_-_47798279 1.557 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr15_+_39573363 1.500 NM_002220
 ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr15_+_48261649 1.493 NM_001159629
NM_003645
 SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr20_+_55399847 1.467 NM_017495
NM_183425
 RBM38

RNA binding motif protein 38

chr3_-_47798341 1.455 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr3_-_47798308 1.454 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr3_-_47798347 1.449 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr6_+_37245860 1.416 NM_002648
 PIM1
pim-1 oncogene
chr12_+_92295738 1.414 NM_019094
NM_199040
 NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr16_+_15397120 1.407 MPV17L
MPV17 mitochondrial membrane protein-like
chr3_-_47798337 1.405 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 70 entries
enrichment   p-value GO term description
2.24 1.60e-02 GO:0040029 regulation of gene expression, epigenetic
2.08 4.18e-05 GO:0016569 covalent chromatin modification
2.07 6.82e-05 GO:0016570 histone modification
2.02 1.91e-04 GO:0006260 DNA replication
1.99 1.99e-09 GO:0016568 chromatin modification
1.98 1.98e-02 GO:0008286 insulin receptor signaling pathway
1.87 6.03e-04 GO:0032868 response to insulin stimulus
1.83 3.48e-02 GO:0032869 cellular response to insulin stimulus
1.82 2.13e-08 GO:0006325 chromatin organization
1.79 7.74e-11 GO:0051276 chromosome organization
1.76 1.65e-02 GO:0071375 cellular response to peptide hormone stimulus
1.73 3.54e-02 GO:0051186 cofactor metabolic process
1.65 8.37e-03 GO:0051325 interphase
1.64 1.51e-02 GO:0051329 interphase of mitotic cell cycle
1.60 1.97e-02 GO:0043434 response to peptide hormone stimulus
1.59 4.88e-05 GO:0006259 DNA metabolic process
1.58 2.57e-05 GO:0006396 RNA processing
1.51 3.14e-03 GO:0000278 mitotic cell cycle
1.50 2.41e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.50 3.54e-03 GO:0010629 negative regulation of gene expression

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.73 2.52e-03 GO:0000785 chromatin
1.65 3.97e-02 GO:0000228 nuclear chromosome
1.59 2.94e-16 GO:0005654 nucleoplasm
1.56 4.49e-05 GO:0005694 chromosome
1.55 2.36e-20 GO:0031981 nuclear lumen
1.55 2.57e-04 GO:0005730 nucleolus
1.51 9.69e-06 GO:0044451 nucleoplasm part
1.50 1.72e-20 GO:0044428 nuclear part
1.49 8.09e-03 GO:0044427 chromosomal part
1.48 1.21e-19 GO:0070013 intracellular organelle lumen
1.47 5.77e-20 GO:0031974 membrane-enclosed lumen
1.46 1.89e-18 GO:0043233 organelle lumen
1.39 3.35e-06 GO:0005739 mitochondrion
1.33 8.24e-29 GO:0005634 nucleus
1.20 4.69e-26 GO:0043231 intracellular membrane-bounded organelle
1.20 6.25e-26 GO:0043227 membrane-bounded organelle
1.20 9.98e-11 GO:0044446 intracellular organelle part
1.19 8.11e-10 GO:0044422 organelle part
1.18 1.96e-02 GO:0043228 non-membrane-bounded organelle
1.18 1.96e-02 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
4.99 3.35e-02 GO:0070742 C2H2 zinc finger domain binding
2.32 1.20e-02 GO:0042393 histone binding
2.17 6.38e-03 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
2.00 3.34e-02 GO:0051427 hormone receptor binding
1.95 2.18e-04 GO:0003682 chromatin binding
1.89 5.27e-03 GO:0016741 transferase activity, transferring one-carbon groups
1.87 2.03e-06 GO:0016564 transcription repressor activity
1.87 1.03e-02 GO:0008168 methyltransferase activity
1.70 7.29e-04 GO:0008134 transcription factor binding
1.59 1.23e-02 GO:0016563 transcription activator activity
1.55 2.08e-03 GO:0019904 protein domain specific binding
1.52 2.19e-02 GO:0003712 transcription cofactor activity
1.51 2.48e-02 GO:0000988 protein binding transcription factor activity
1.51 2.48e-02 GO:0000989 transcription factor binding transcription factor activity
1.49 5.61e-07 GO:0030528 transcription regulator activity
1.41 3.47e-08 GO:0032559 adenyl ribonucleotide binding
1.41 3.89e-08 GO:0030554 adenyl nucleotide binding
1.39 2.72e-07 GO:0005524 ATP binding
1.39 5.98e-04 GO:0001071 nucleic acid binding transcription factor activity
1.39 5.98e-04 GO:0003700 sequence-specific DNA binding transcription factor activity