Motif ID: ATF2.p2

Z-value: 1.094


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF2chr2_-_175741096-0.146.2e-01Click!


Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74488947 4.280 ALB
albumin
chr4_+_74488910 3.984 ALB
albumin
chr4_+_74488835 3.632 NM_000477
ALB
albumin
chr11_+_12652427 3.450 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr10_-_95350949 2.383 NM_006744
RBP4
retinol binding protein 4, plasma
chr2_-_224611568 2.347 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr2_-_216009015 2.196 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr20_+_19863716 1.746 RIN2
Ras and Rab interactor 2
chr4_+_100704262 1.667 NM_000253
MTTP
microsomal triglyceride transfer protein
chr3_+_189354167 1.640 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_+_50697355 1.563 HLF
hepatic leukemia factor
chr4_+_75529716 1.487 NM_001657
AREG
amphiregulin
chr4_+_75699652 1.444 NM_001657
AREG
amphiregulin
chr16_-_4528739 1.426 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr21_-_42060266 1.413 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr21_-_42060334 1.383 RIPK4
receptor-interacting serine-threonine kinase 4
chr17_+_50697319 1.357 NM_002126
HLF
hepatic leukemia factor
chrX_-_13745108 1.356 GPM6B
glycoprotein M6B
chr11_+_116575249 1.353 NM_001001522
NM_003186
TAGLN

transgelin

chr6_-_47385605 1.344 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr10_+_4995597 1.308 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_-_101077605 1.298 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr21_-_26175068 1.295 APP
amyloid beta (A4) precursor protein
chrX_-_13744933 1.279 GPM6B
glycoprotein M6B
chr2_-_220116508 1.236 NM_024536
CHPF
chondroitin polymerizing factor
chrX_-_128485134 1.233 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chr6_-_47385470 1.232 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chrX_-_128485121 1.212 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr10_-_5035967 1.206 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr10_-_99436889 1.174 NM_021732
AVPI1
arginine vasopressin-induced 1
chr20_-_14266200 1.165 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr12_+_12935619 1.143 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr10_+_4995453 1.138 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr20_+_55569542 1.104 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr4_+_85723080 1.100 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr2_-_216008689 1.099 FN1
fibronectin 1
chr16_-_54424473 1.072 CES1
carboxylesterase 1
chr1_-_16355013 1.069 NM_004431
EPHA2
EPH receptor A2
chr17_+_38306339 1.040 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr9_+_102987137 1.035 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr20_+_4614796 1.031 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr8_+_26569709 1.027 DPYSL2
dihydropyrimidinase-like 2
chr10_+_4995685 1.026 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr6_-_47385313 1.015 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr13_+_47705493 0.998 ITM2B
integral membrane protein 2B
chr7_+_129918408 0.998 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr12_-_90029328 0.997 LUM
lumican
chr16_-_54424517 0.989 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr1_-_1283770 0.985 NM_032348
MXRA8
matrix-remodelling associated 8
chr11_-_8849485 0.956 ST5
suppression of tumorigenicity 5
chrX_-_13745234 0.955 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr3_-_188946168 0.953 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr19_-_62043867 0.944 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr2_-_237987509 0.934 COL6A3
collagen, type VI, alpha 3
chr9_+_96528764 0.930 NM_001193331
NM_032823
C9orf3

chromosome 9 open reading frame 3

chr2_-_237987579 0.929 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr9_+_96528814 0.924 C9orf3
chromosome 9 open reading frame 3
chr1_+_154297588 0.910 NM_020387
RAB25
RAB25, member RAS oncogene family
chr11_-_66482366 0.910 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr6_-_47385205 0.905 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr10_+_123913094 0.902 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr17_+_64020155 0.886 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chrX_-_10605726 0.879 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr16_-_78192111 0.875 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr15_-_61461127 0.871 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr20_-_17897384 0.866 NM_152227
SNX5
sorting nexin 5
chr8_+_98857190 0.858 LAPTM4B
lysosomal protein transmembrane 4 beta
chr5_+_150380173 0.855 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chrX_-_13866565 0.850 NM_001001994
GPM6B
glycoprotein M6B
chr5_-_95323353 0.848 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr13_-_43908937 0.848 TSC22D1
TSC22 domain family, member 1
chr15_-_61460967 0.831 CA12
carbonic anhydrase XII
chr12_-_90029672 0.827 NM_002345
LUM
lumican
chr2_-_237987554 0.816 COL6A3
collagen, type VI, alpha 3
chr16_-_10581944 0.809 NM_001424
EMP2
epithelial membrane protein 2
chr5_-_172130766 0.800 NM_004417
DUSP1
dual specificity phosphatase 1
chr8_+_26296439 0.784 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chrX_-_128485062 0.781 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr14_-_93919305 0.750 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr5_+_150380270 0.737 GPX3
glutathione peroxidase 3 (plasma)
chr22_+_36927884 0.737 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr12_+_12935759 0.724 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr10_-_52315436 0.721 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr19_+_50041400 0.698 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr21_-_43671355 0.690 NM_173354
SIK1
salt-inducible kinase 1
chr21_+_46369617 0.689 COL6A2
collagen, type VI, alpha 2
chr19_-_56919032 0.686 NM_001523
HAS1
hyaluronan synthase 1
chr1_+_99502655 0.684 LPPR4
lipid phosphate phosphatase-related protein type 4
chr4_-_156517394 0.684 MAP9
microtubule-associated protein 9
chr3_+_8518508 0.681 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr9_-_128924819 0.672 NM_012098
ANGPTL2
angiopoietin-like 2
chr4_-_23500706 0.670 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr3_-_187309442 0.663 NM_004454
ETV5
ets variant 5
chr1_-_1274618 0.651 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr21_-_35343500 0.643 RUNX1
runt-related transcription factor 1
chr4_-_156517423 0.641 MAP9
microtubule-associated protein 9
chr10_+_124141808 0.641 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_+_29435534 0.633 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chrX_+_107569671 0.624 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr1_+_1994943 0.620 NM_001033581
PRKCZ
protein kinase C, zeta
chr16_+_70646008 0.620 NM_001126102
NM_005143
HP

haptoglobin

chr6_+_148705421 0.615 NM_015278
SASH1
SAM and SH3 domain containing 1
chr21_-_35343456 0.611 NM_001754
RUNX1
runt-related transcription factor 1
chr14_+_67156386 0.597 ARG2
arginase, type II
chr1_-_59022275 0.594 NM_002228
JUN
jun proto-oncogene
chr17_+_69939806 0.589 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr4_+_155707089 0.586 FGB
fibrinogen beta chain
chr7_-_41709191 0.584 NM_002192
INHBA
inhibin, beta A
chr14_+_23633101 0.581 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chrX_-_13866451 0.581 GPM6B
glycoprotein M6B
chrX_+_43399101 0.579 MAOA
monoamine oxidase A
chr19_+_50663089 0.576 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr4_-_156517544 0.576 NM_001039580
MAP9
microtubule-associated protein 9
chr6_+_39868126 0.575 DAAM2
dishevelled associated activator of morphogenesis 2
chrX_-_13745134 0.565 GPM6B
glycoprotein M6B
chr8_-_42184350 0.562 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr8_-_42184194 0.562 PLAT
plasminogen activator, tissue
chr11_-_8788765 0.556 NM_213618
ST5
suppression of tumorigenicity 5
chr2_+_148319033 0.551 NM_001616
ACVR2A
activin A receptor, type IIA
chr3_+_62279707 0.549 C3orf14
chromosome 3 open reading frame 14
chr17_-_38978772 0.549 NM_001986
ETV4
ets variant 4
chr19_+_50041387 0.544 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr14_+_67156323 0.543 NM_001172
ARG2
arginase, type II
chr17_+_38831874 0.542 NM_001661
ARL4D
ADP-ribosylation factor-like 4D
chr14_+_67156405 0.542 ARG2
arginase, type II
chr7_+_73506047 0.538 NM_016328
GTF2IRD1
GTF2I repeat domain containing 1
chr17_-_38979178 0.536 NM_001079675
ETV4
ets variant 4
chr17_+_77783432 0.533 NM_001042423
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr3_-_188945921 0.529 BCL6
B-cell CLL/lymphoma 6
chr12_-_100979923 0.526 NM_016053
CCDC53
coiled-coil domain containing 53
chr2_-_73170290 0.524 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr9_-_128924706 0.521 ANGPTL2
angiopoietin-like 2
chr22_+_36928011 0.509 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr5_+_36642213 0.493 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr3_+_160473729 0.491 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr9_+_96561750 0.491 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr4_-_186693574 0.490 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr16_+_70654625 0.486 NM_020995
HPR
haptoglobin-related protein
chr1_-_20682541 0.485


chr14_+_95740768 0.479 NM_000623
BDKRB2
bradykinin receptor B2
chr2_+_101874765 0.475 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr5_-_95323180 0.475 ELL2
elongation factor, RNA polymerase II, 2
chr17_+_64020159 0.475 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr17_-_77824849 0.474 NM_001893
NM_139062
CSNK1D

casein kinase 1, delta

chr1_+_227506751 0.461 NM_006542
SPHAR
S-phase response (cyclin related)
chr16_-_4528380 0.460 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr11_-_35397675 0.457 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_+_61204392 0.455 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr6_+_89848229 0.450 PNRC1
proline-rich nuclear receptor coactivator 1
chr3_-_101316038 0.449 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr3_+_134976965 0.443 TF
transferrin
chr3_+_23962518 0.442 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr6_+_32021687 0.442 NM_001710
CFB
complement factor B
chr14_-_68424653 0.442 ACTN1
actinin, alpha 1
chr5_+_34723420 0.442 NM_001145523
RAI14
retinoic acid induced 14
chr5_+_36642424 0.436 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_65385799 0.435 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr5_+_150380325 0.435 GPX3
glutathione peroxidase 3 (plasma)
chr6_-_47385599 0.434 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr11_-_2118916 0.427 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_+_35148084 0.427 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr1_+_181380837 0.422 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr2_-_188127430 0.417 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr14_-_35348086 0.415 NM_014990
NM_194301
RALGAPA1

Ral GTPase activating protein, alpha subunit 1 (catalytic)

chr8_-_145097031 0.410 NM_201380
PLEC
plectin
chr8_+_40130143 0.410 NM_020130
C8orf4
chromosome 8 open reading frame 4
chrX_-_131375217 0.407 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr8_+_132985521 0.402 NM_015137
EFR3A
EFR3 homolog A (S. cerevisiae)
chr9_-_32542550 0.402 TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr12_+_70120028 0.401 NM_003667
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr2_+_54638957 0.400 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr2_+_5750229 0.398 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr5_-_121441910 0.398 NM_002317
LOX
lysyl oxidase
chr5_-_121441866 0.396 LOX
lysyl oxidase
chr14_-_68329407 0.391 NM_004926
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr6_+_148705646 0.391 SASH1
SAM and SH3 domain containing 1
chr4_-_111777651 0.389 PITX2
paired-like homeodomain 2
chr3_+_8518539 0.387 LMCD1
LIM and cysteine-rich domains 1
chr4_-_111777584 0.387 PITX2
paired-like homeodomain 2
chr2_+_101874809 0.379 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr9_-_32542573 0.378 NM_001195622
NM_005802
TOPORS

topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

chr5_-_133734616 0.376 CDKL3
cyclin-dependent kinase-like 3
chr20_-_17897067 0.367 NM_014426
SNX5
sorting nexin 5
chr6_-_46566969 0.366 RCAN2
regulator of calcineurin 2
chr9_-_128924782 0.365 ANGPTL2
angiopoietin-like 2
chr1_+_110328850 0.365 AHCYL1
adenosylhomocysteinase-like 1
chr3_-_78749633 0.363 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr17_-_75385371 0.362 NM_020649
CBX8
chromobox homolog 8
chr12_+_70119785 0.361 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr5_+_32747194 0.359 NM_000908
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chrX_-_10495476 0.355 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr17_+_71033339 0.354 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr8_-_95343696 0.354 GEM
GTP binding protein overexpressed in skeletal muscle
chr20_+_43236953 0.349 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr3_-_126257425 0.349 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr8_-_49996353 0.349 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr16_+_415606 0.348 RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr3_-_55496370 0.346 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr10_-_73953699 0.346 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr5_-_78318112 0.345 NM_000046
ARSB
arylsulfatase B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 4.93e-03 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.18 5.73e-03 GO:0031091 platelet alpha granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 9.74e-03 GO:0005515 protein binding