Motif ID: EN1,2.p2

Z-value: 0.988


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_154943466-0.533.3e-02Click!
EN1chr2_-_119322228-0.523.9e-02Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_98021144 2.567 NM_001114094
NM_013314
 BLNK

B-cell linker

chr4_+_74500748 2.466 ALB
albumin
chr11_+_22652894 2.424 NM_005256
 GAS2
growth arrest-specific 2
chr11_+_59979857 1.516 NM_021950
NM_152866
 MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr4_+_74488947 1.438 ALB
albumin
chr17_-_36928604 1.415 NM_002275
 KRT15
keratin 15
chr14_-_105182025 1.169


chr6_+_32515596 1.106 NM_019111
 HLA-DRA
major histocompatibility complex, class II, DR alpha
chr2_-_158008763 1.081 NM_004288
 CYTIP
cytohesin 1 interacting protein
chr17_-_61655915 0.936 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr14_-_105845570 0.930 IGHA1
immunoglobulin heavy constant alpha 1
chr2_-_88208650 0.913 NM_001443
 FABP1
fatty acid binding protein 1, liver
chr10_+_114123828 0.903 NM_203379
 ACSL5
acyl-CoA synthetase long-chain family member 5
chr15_-_78050515 0.877 NM_001114735
NM_004049
 BCL2A1

BCL2-related protein A1

chr12_-_101115677 0.869 NM_002674
 PMCH
pro-melanin-concentrating hormone
chr12_+_111829191 0.848 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr17_-_31441390 0.836 NM_002983
 CCL3
chemokine (C-C motif) ligand 3
chr17_-_37181636 0.821 JUP
junction plakoglobin
chr12_+_6424293 0.818 NM_001242
 CD27
CD27 molecule
chr14_-_64479198 0.784 NM_002083
 GPX2
glutathione peroxidase 2 (gastrointestinal)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
3.17 1.28e-02 GO:0007586 digestion
2.30 1.82e-03 GO:0006954 inflammatory response
2.18 2.58e-10 GO:0006955 immune response
1.98 2.15e-02 GO:0051707 response to other organism
1.98 3.01e-02 GO:0045087 innate immune response
1.89 1.15e-05 GO:0006952 defense response
1.85 3.99e-02 GO:0009607 response to biotic stimulus
1.79 4.15e-08 GO:0002376 immune system process
1.21 2.04e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.84 7.30e-06 GO:0005615 extracellular space
1.72 1.24e-05 GO:0044421 extracellular region part
1.66 4.28e-09 GO:0005576 extracellular region
1.42 4.24e-02 GO:0005887 integral to plasma membrane
1.32 2.18e-02 GO:0044459 plasma membrane part
1.26 2.31e-03 GO:0071944 cell periphery
1.26 3.00e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
5.28 8.01e-06 GO:0008009 chemokine activity
4.74 4.64e-05 GO:0042379 chemokine receptor binding
3.23 3.88e-08 GO:0005125 cytokine activity
3.08 8.13e-03 GO:0005179 hormone activity
2.69 1.25e-04 GO:0005126 cytokine receptor binding
1.69 6.03e-05 GO:0005102 receptor binding
1.60 8.17e-03 GO:0004888 transmembrane receptor activity
1.45 3.10e-02 GO:0004872 receptor activity