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• Activity deltas table
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Motif ID: EN1,2.p2

Z-value: 0.988

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr10_-_98021144	2.567	NM_001114094 NM_013314	BLNK	B-cell linker
chr4_+_74500748	2.466		ALB	albumin
chr11_+_22652894	2.424	NM_005256	GAS2	growth arrest-specific 2
chr11_+_59979857	1.516	NM_021950 NM_152866	MS4A1	membrane-spanning 4-domains, subfamily A, member 1
chr4_+_74488947	1.438		ALB	albumin
chr17_-_36928604	1.415	NM_002275	KRT15	keratin 15
chr14_-_105182025	1.169
chr6_+_32515596	1.106	NM_019111	HLA-DRA	major histocompatibility complex, class II, DR alpha
chr2_-_158008763	1.081	NM_004288	CYTIP	cytohesin 1 interacting protein
chr17_-_61655915	0.936	NM_000042	APOH	apolipoprotein H (beta-2-glycoprotein I)
chr14_-_105845570	0.930		IGHA1	immunoglobulin heavy constant alpha 1
chr2_-_88208650	0.913	NM_001443	FABP1	fatty acid binding protein 1, liver
chr10_+_114123828	0.903	NM_203379	ACSL5	acyl-CoA synthetase long-chain family member 5
chr15_-_78050515	0.877	NM_001114735 NM_004049	BCL2A1	BCL2-related protein A1
chr12_-_101115677	0.869	NM_002674	PMCH	pro-melanin-concentrating hormone
chr12_+_111829191	0.848		OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa
chr17_-_31441390	0.836	NM_002983	CCL3	chemokine (C-C motif) ligand 3
chr17_-_37181636	0.821		JUP	junction plakoglobin
chr12_+_6424293	0.818	NM_001242	CD27	CD27 molecule
chr14_-_64479198	0.784	NM_002083	GPX2	glutathione peroxidase 2 (gastrointestinal)
chr6_-_41811916	0.766	NM_001167827	TFEB	transcription factor EB
chr1_+_111217244	0.727	NM_000560	CD53	CD53 molecule
chr12_-_6356783	0.696	NM_001159575	SCNN1A	sodium channel, nonvoltage-gated 1 alpha
chr14_-_105182159	0.690		IGHG2	immunoglobulin heavy constant gamma 2 (G2m marker)
chr17_+_22996461	0.679		LGALS9	lectin, galactoside-binding, soluble, 9
chr3_-_184756101	0.670	NM_130446	KLHL6	kelch-like 6 (Drosophila)
chr4_+_39874921	0.658	NM_004310	RHOH	ras homolog gene family, member H
chr2_+_33592445	0.650	NM_015376	RASGRP3	RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_-_176769141	0.633	NM_000505	F12	coagulation factor XII (Hageman factor)
chr2_+_68855436	0.620	NM_001166276 NM_014882	ARHGAP25	Rho GTPase activating protein 25
chr6_+_30402203	0.608
chr14_+_87541220	0.603	NM_003608	GPR65	G protein-coupled receptor 65
chr22_+_38627031	0.602	NM_004810	GRAP2	GRB2-related adaptor protein 2
chr2_-_113310796	0.583	NM_000576	IL1B	interleukin 1, beta
chr20_-_45410033	0.583		ZMYND8	zinc finger, MYND-type containing 8
chr3_-_150422474	0.578	NM_000096	CP	ceruloplasmin (ferroxidase)
chr7_+_20653490	0.551	NM_001163942 NM_001163993 NM_178559	ABCB5	ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr6_+_32713160	0.548	NM_002122	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1
chr8_-_28403652	0.530	NM_172366	FBXO16 ZNF395	F-box protein 16 zinc finger protein 395
chr10_+_114123765	0.527		ACSL5	acyl-CoA synthetase long-chain family member 5
chr3_-_121884091	0.523	NM_000187	HGD	homogentisate 1,2-dioxygenase
chr11_+_7574992	0.510		PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr4_+_71096830	0.499	NM_017855	ODAM	odontogenic, ameloblast asssociated
chr15_-_53350383	0.486	NM_183236	RAB27A	RAB27A, member RAS oncogene family
chr19_+_45973139	0.481	NM_006533	MIA	melanoma inhibitory activity
chr6_+_14225836	0.480	NM_001040280 NM_004233	CD83	CD83 molecule
chr8_-_38577891	0.479
chr5_-_86739683	0.468		CCNH	cyclin H
chrX_+_128741578	0.466		SASH3	SAM and SH3 domain containing 3
chr12_+_111829121	0.463	NM_001032409 NM_002534 NM_016816	OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa
chr20_+_61838479	0.461		LIME1	Lck interacting transmembrane adaptor 1
chr2_+_68445936	0.456		PLEK	pleckstrin
chr14_-_23107106	0.454	NM_003917	AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr4_+_155703581	0.450	NM_001184741 NM_005141	FGB	fibrinogen beta chain
chr19_-_44518465	0.450		GMFG	glia maturation factor, gamma
chr6_+_6533932	0.449	NM_004271	LY86	lymphocyte antigen 86
chr4_+_74488835	0.446	NM_000477	ALB	albumin
chr3_-_152517204	0.441	NM_023915	GPR87	G protein-coupled receptor 87
chrX_+_128741562	0.439	NM_018990	SASH3	SAM and SH3 domain containing 3
chr22_+_38627129	0.433		GRAP2	GRB2-related adaptor protein 2
chr19_-_44518516	0.421	NM_004877	GMFG	glia maturation factor, gamma
chr6_-_123999640	0.419	NM_006073	TRDN	triadin
chr14_-_106149623	0.406
chr1_+_210275752	0.405		DTL	denticleless homolog (Drosophila)
chr1_+_154390939	0.402		SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr20_+_61838389	0.399	NM_017806	LIME1	Lck interacting transmembrane adaptor 1
chr12_-_121767272	0.395	NM_006018	GPR109B	G protein-coupled receptor 109B
chr19_+_47073029	0.384	NM_001783 NM_021601	CD79A	CD79a molecule, immunoglobulin-associated alpha
chr11_+_22316242	0.384	NM_020346	SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_-_24067347	0.383	NM_000147	FUCA1	fucosidase, alpha-L- 1, tissue
chr8_+_11702803	0.381		FDFT1	farnesyl-diphosphate farnesyltransferase 1
chr12_+_6925997	0.378	NM_080548	PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr14_+_94148466	0.376	NM_001085	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr1_-_229627412	0.374	NM_022051	EGLN1	egl nine homolog 1 (C. elegans)
chr3_+_99733432	0.374	NM_005290	GPR15	G protein-coupled receptor 15
chr7_-_25234582	0.373	NM_022150	NPVF	neuropeptide VF precursor
chr22_+_21053972	0.369
chr16_+_49288550	0.364	NM_022162	NOD2	nucleotide-binding oligomerization domain containing 2
chr12_-_101396459	0.362	NM_001111284	IGF1	insulin-like growth factor 1 (somatomedin C)
chr12_+_6926014	0.361		PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr7_+_50318801	0.356		IKZF1	IKAROS family zinc finger 1 (Ikaros)
chr18_-_28247186	0.354
chr19_+_39402167	0.351		LSM14A	LSM14A, SCD6 homolog A (S. cerevisiae)
chr1_-_152185764	0.350	NM_014856	DENND4B	DENN/MADD domain containing 4B
chr10_-_7722747	0.349		ITIH5	inter-alpha (globulin) inhibitor H5
chr14_-_106038573	0.347		IGHA1 IGHA2 IGHG1 IGHM	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant alpha 2 (A2m marker) immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant mu
chr16_+_28850760	0.342	NM_001178098 NM_001770	CD19	CD19 molecule
chr2_+_102401580	0.342	NM_003853	IL18RAP	interleukin 18 receptor accessory protein
chr1_+_31823097	0.341		TINAGL1	tubulointerstitial nephritis antigen-like 1
chr17_-_36347197	0.341	NM_015515	KRT23	keratin 23 (histone deacetylase inducible)
chr11_+_22646229	0.339	NM_177553	GAS2	growth arrest-specific 2
chr1_-_108032645	0.333	NM_001079874	VAV3	vav 3 guanine nucleotide exchange factor
chr6_-_79732391	0.332		PHIP	pleckstrin homology domain interacting protein
chr19_-_56164628	0.331	NM_002774	KLK6	kallikrein-related peptidase 6
chr17_-_53946899	0.331		MTMR4	myotubularin related protein 4
chr2_+_171316462	0.329		EIF2S2	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr4_-_77147625	0.324	NM_002416	CXCL9	chemokine (C-X-C motif) ligand 9
chr10_-_105835525	0.323		COL17A1	collagen, type XVII, alpha 1
chr6_+_106653429	0.321	NM_182907	PRDM1	PR domain containing 1, with ZNF domain
chr4_+_74493266	0.320		ALB	albumin
chr15_-_50375143	0.317	NM_018728	MYO5C	myosin VC
chr14_-_93924873	0.316	NM_000295	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_-_23998515	0.313	NM_001127621	GALE	UDP-galactose-4-epimerase
chrX_-_48655978	0.308		PIM2	pim-2 oncogene
chr16_+_55950195	0.308	NM_002990	CCL22	chemokine (C-C motif) ligand 22
chr7_+_106897737	0.305	NM_005295	GPR22	G protein-coupled receptor 22
chr6_+_32021831	0.304		CFB	complement factor B
chr5_-_176769094	0.304		F12	coagulation factor XII (Hageman factor)
chr3_-_122862391	0.303		HCLS1	hematopoietic cell-specific Lyn substrate 1
chr12_-_101036407	0.303	NM_024057	NUP37	nucleoporin 37kDa
chr4_-_17415918	0.302		DCAF16	DDB1 and CUL4 associated factor 16
chr12_+_84792203	0.299	NM_006183	NTS	neurotensin
chr1_-_159459999	0.294	NM_001643	APOA2	apolipoprotein A-II
chr17_-_24491521	0.293		MYO18A	myosin XVIIIA
chr15_+_41672543	0.292	NM_020990	CKMT1B CKMT1A	creatine kinase, mitochondrial 1B creatine kinase, mitochondrial 1A
chr1_+_20788027	0.288	NM_001785	CDA	cytidine deaminase
chr5_-_169749215	0.288	NM_004137	KCNMB1	potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr14_-_94669547	0.288	NM_001195573	DICER1	dicer 1, ribonuclease type III
chr9_-_103185621	0.287	NM_001127610	BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr4_+_74499651	0.282		ALB	albumin
chr1_+_210275541	0.275	NM_016448	DTL	denticleless homolog (Drosophila)
chr3_-_122862447	0.275	NM_005335	HCLS1	hematopoietic cell-specific Lyn substrate 1
chr6_-_133126278	0.275	NM_078488	VNN2	vanin 2
chr1_+_111571803	0.272	NM_001025197 NM_004000	CHI3L2	chitinase 3-like 2
chr7_+_115650240	0.272	NM_152829	TES	testis derived transcript (3 LIM domains)
chr5_+_68703036	0.269	NM_133339	RAD17	RAD17 homolog (S. pombe)
chr13_-_45654296	0.269		LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_51585004	0.267	NM_002273	KRT8	keratin 8
chr7_+_94130752	0.266		PEG10	paternally expressed 10
chr13_-_45577144	0.266	NM_001872 NM_016413	CPB2	carboxypeptidase B2 (plasma)
chr3_-_121883647	0.261		HGD	homogentisate 1,2-dioxygenase
chr12_-_61615124	0.260		PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr17_-_26665144	0.260		EVI2B	ecotropic viral integration site 2B
chr14_+_59782222	0.257	NM_177952	PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr12_+_68028407	0.256		LYZ	lysozyme
chr3_+_42176662	0.255	NM_014965	TRAK1	trafficking protein, kinesin binding 1
chr9_-_122852356	0.253	NM_001735	C5	complement component 5
chr6_-_154692906	0.251	NM_001130699	IPCEF1	interaction protein for cytohesin exchange factors 1
chr1_+_86662356	0.250	NM_006536	CLCA2	chloride channel accessory 2
chrX_-_47374647	0.250	NM_002621	CFP	complement factor properdin
chr14_-_105280425	0.248		IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_2593351	0.248		LOC652276	hypothetical LOC652276
chr6_+_12825818	0.248	NM_030948	PHACTR1	phosphatase and actin regulator 1
chr18_+_27425727	0.247	NM_000371	TTR	transthyretin
chr9_-_122728993	0.246	NM_005658	TRAF1	TNF receptor-associated factor 1
chr15_-_32416336	0.245	NM_001042497 NM_133647	SLC12A6	solute carrier family 12 (potassium/chloride transporters), member 6
chr15_-_63199228	0.242		PDCD7	programmed cell death 7
chr12_-_51253875	0.241	NM_175053	KRT74	keratin 74
chr14_-_93924663	0.240		SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_105610144	0.239		IGHA1 IGHG1 IGHG3	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker)
chr16_+_29734785	0.238		C16orf53	chromosome 16 open reading frame 53
chr10_-_104168890	0.237	NM_002779	PSD	pleckstrin and Sec7 domain containing
chrX_-_7855400	0.237	NM_004650	PNPLA4	patatin-like phospholipase domain containing 4
chr4_+_74493174	0.236		ALB	albumin
chr13_+_52114565	0.234		HNRNPA1L2	heterogeneous nuclear ribonucleoprotein A1-like 2
chr1_+_57093030	0.234	NM_000562	C8A	complement component 8, alpha polypeptide
chr4_+_74493218	0.234		ALB	albumin
chr1_-_27604656	0.230		WASF2	WAS protein family, member 2
chr19_+_61151009	0.230	NM_176811	NLRP8	NLR family, pyrin domain containing 8
chr18_-_29882555	0.230	NM_001198549	NOL4	nucleolar protein 4
chr1_+_240078655	0.229	NM_003686 NM_006027	EXO1	exonuclease 1
chr20_-_23915431	0.229	NM_178312	GGTLC1	gamma-glutamyltransferase light chain 1
chr2_+_88966170	0.229
chr1_+_173111306	0.228	NM_001035230	RABGAP1L	RAB GTPase activating protein 1-like
chr10_+_104169560	0.228	NM_024326	FBXL15	F-box and leucine-rich repeat protein 15
chr2_-_89073496	0.226		IGKC	immunoglobulin kappa constant
chr13_-_45654327	0.226	NM_002298	LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_70539922	0.225	NM_001105677	UGT2A2	UDP glucuronosyltransferase 2 family, polypeptide A2
chr12_+_21059896	0.224	NM_001009562	LST-3TM12	organic anion transporter LST-3b
chr2_-_74235860	0.223
chr1_-_202726068	0.220	NM_002646	PIK3C2B	phosphoinositide-3-kinase, class 2, beta polypeptide
chr5_+_180399830	0.219	NM_152547	BTNL9	butyrophilin-like 9
chr4_+_74488910	0.219		ALB	albumin
chr9_+_33016482	0.219		DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1
chr3_+_195336625	0.218	NM_005524	HES1	hairy and enhancer of split 1, (Drosophila)
chr5_+_67558217	0.218	NM_181523	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_24342158	0.216	NM_021258	IL22RA1	interleukin 22 receptor, alpha 1
chr10_+_17891348	0.215	NM_001009567 NM_002438	MRC1L1 MRC1	mannose receptor, C type 1-like 1 mannose receptor, C type 1
chr14_+_94117483	0.214	NM_000624	SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_+_74496575	0.213		ALB	albumin
chr17_+_31562577	0.212	NM_207007 NM_001001435	CCL4L2 CCL4L1	chemokine (C-C motif) ligand 4-like 2 chemokine (C-C motif) ligand 4-like 1
chr18_-_56190980	0.211	NM_005912	MC4R	melanocortin 4 receptor
chr12_-_89922888	0.211	NM_004950	EPYC	epiphycan
chr8_+_22900863	0.208	NM_001160036	RHOBTB2	Rho-related BTB domain containing 2
chr12_+_51783554	0.206		SOAT2	sterol O-acyltransferase 2
chr10_-_116408046	0.203	NM_002313	ABLIM1	actin binding LIM protein 1
chr3_+_48239865	0.202	NM_004345	CAMP	cathelicidin antimicrobial peptide
chr8_+_28230567	0.202	NM_006228	PNOC	prepronociceptin
chr6_-_119512035	0.202	NM_001100411	FAM184A	family with sequence similarity 184, member A
chr14_-_94677807	0.200	NM_030621	DICER1	dicer 1, ribonuclease type III
chr12_-_642786	0.200	NM_016533	NINJ2	ninjurin 2
chr12_+_119617060	0.200
chr5_-_150583808	0.197		CCDC69	coiled-coil domain containing 69
chr18_-_58005268	0.196	NM_012327 NM_176787	PIGN	phosphatidylinositol glycan anchor biosynthesis, class N
chr12_-_66933492	0.196	NM_020525	IL22	interleukin 22
chr3_-_137395966	0.195	NM_001145417	MSL2	male-specific lethal 2 homolog (Drosophila)
chr10_-_52315436	0.195	NM_001198818 NM_001198819 NM_001198820 NM_014576 NM_138932 NM_138933	A1CF	APOBEC1 complementation factor
chr17_+_43165608	0.195	NM_013351	TBX21	T-box 21
chr1_-_28392966	0.193	NM_001164722 NM_001164721	PTAFR	platelet-activating factor receptor
chr10_-_105835609	0.190	NM_000494	COL17A1	collagen, type XVII, alpha 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
2.18	2.58e-10	GO:0006955	immune response
1.79	4.15e-08	GO:0002376	immune system process
1.89	1.15e-05	GO:0006952	defense response
2.30	1.82e-03	GO:0006954	inflammatory response
1.21	2.04e-03	GO:0050896	response to stimulus
3.17	1.28e-02	GO:0007586	digestion
1.98	2.15e-02	GO:0051707	response to other organism
1.98	3.01e-02	GO:0045087	innate immune response
1.85	3.99e-02	GO:0009607	response to biotic stimulus

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.66	4.28e-09	GO:0005576	extracellular region
1.84	7.30e-06	GO:0005615	extracellular space
1.72	1.24e-05	GO:0044421	extracellular region part
1.26	2.31e-03	GO:0071944	cell periphery
1.26	3.00e-03	GO:0005886	plasma membrane
1.32	2.18e-02	GO:0044459	plasma membrane part
1.42	4.24e-02	GO:0005887	integral to plasma membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
3.23	3.88e-08	GO:0005125	cytokine activity
5.28	8.01e-06	GO:0008009	chemokine activity
4.74	4.64e-05	GO:0042379	chemokine receptor binding
1.69	6.03e-05	GO:0005102	receptor binding
2.69	1.25e-04	GO:0005126	cytokine receptor binding
3.08	8.13e-03	GO:0005179	hormone activity
1.60	8.17e-03	GO:0004888	transmembrane receptor activity
1.45	3.10e-02	GO:0004872	receptor activity