Motif ID: FEV.p2

Z-value: 1.576


Transcription factors associated with FEV.p2:

Gene SymbolEntrez IDGene Name
FEV 54738 FEV (ETS oncogene family)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FEVchr2_-_219558517-0.097.5e-01Click!


Activity profile for motif FEV.p2.

activity profile for motif FEV.p2


Sorted Z-values histogram for motif FEV.p2

Sorted Z-values for motif FEV.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FEV.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_122862447 3.071 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_122862391 2.913 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr8_-_82557956 2.157 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr19_-_44518465 1.971 GMFG
glia maturation factor, gamma
chr17_-_59437782 1.907 NM_000873
ICAM2
intercellular adhesion molecule 2
chr1_-_79244948 1.894 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr19_-_44518516 1.865 NM_004877
GMFG
glia maturation factor, gamma
chr2_+_33514896 1.849 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr4_-_101658094 1.648 NM_001159694
NM_016242
EMCN

endomucin

chr12_-_6103945 1.633 NM_000552
VWF
von Willebrand factor
chr5_-_54317102 1.513 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chrY_+_2769630 1.310 RPS4Y1
ribosomal protein S4, Y-linked 1
chr11_-_76059435 1.305 NM_001128922
LRRC32
leucine rich repeat containing 32
chrY_+_2769596 1.274 NM_001008
RPS4Y1
ribosomal protein S4, Y-linked 1
chr10_+_31650069 1.221 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr16_+_1523658 1.191 TMEM204
transmembrane protein 204
chr4_+_91035025 1.185 NM_007351
MMRN1
multimerin 1
chr21_-_14840506 1.124 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr8_+_75066117 1.113 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr17_-_59451662 1.080 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr11_-_33848061 1.074 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_-_31003260 1.017 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr11_-_33848013 1.001 LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_-_11490487 0.997 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_-_175207521 0.985 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr9_-_129656830 0.938 NM_000118
NM_001114753
ENG

endoglin

chr11_-_33847834 0.931 LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33847937 0.921 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr21_-_38792173 0.893 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr9_-_129656778 0.890 ENG
endoglin
chr8_+_40130143 0.882 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr22_-_17892859 0.857 NM_001130861
NM_003277
CLDN5

claudin 5

chr14_-_22354851 0.847 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chr1_+_43539239 0.844 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr9_-_129656581 0.839 ENG
endoglin
chr5_+_71538456 0.823 MAP1B
microtubule-associated protein 1B
chr11_-_92916161 0.813 NM_020179
C11orf75
chromosome 11 open reading frame 75
chr7_+_93388951 0.793 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr11_-_33847507 0.788 LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_103539895 0.785 PDGFD
platelet derived growth factor D
chr9_+_115396020 0.763 NM_144489
RGS3
regulator of G-protein signaling 3
chr11_-_103540275 0.742 PDGFD
platelet derived growth factor D
chr6_-_11340869 0.739 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_-_103540233 0.715 NM_025208
NM_033135
PDGFD

platelet derived growth factor D

chr6_+_153060722 0.710 NM_025107
MYCT1
myc target 1
chr4_+_54790020 0.707 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr7_-_149960612 0.700 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr17_+_64922420 0.695 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr12_+_68028407 0.694 LYZ
lysozyme
chr11_-_110755112 0.681 POU2AF1
POU class 2 associating factor 1
chr11_+_22644732 0.677 NM_001143830
GAS2
growth arrest-specific 2
chr17_+_29606408 0.673 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr17_-_59817722 0.659 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr10_+_70517863 0.640 SRGN
serglycin
chr1_-_149047329 0.639 NM_000396
CTSK
cathepsin K
chr13_+_110604039 0.633 NM_003899
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr10_+_70517823 0.626 NM_002727
SRGN
serglycin
chr13_+_110604071 0.618 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr3_+_52504391 0.617 NM_015136
STAB1
stabilin 1
chr12_-_6668680 0.614 ZNF384
zinc finger protein 384
chr4_+_39874921 0.610 NM_004310
RHOH
ras homolog gene family, member H
chr10_-_88707299 0.600 NM_024756
MMRN2
multimerin 2
chr9_-_129656413 0.598 ENG
endoglin
chr1_+_182040837 0.594 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr14_-_76993641 0.593 NM_001193314
NM_001193315
NM_001193316
NM_001193317
NM_022067
VIPAR




VPS33B interacting protein, apical-basolateral polarity regulator




chr4_-_5071996 0.586 NM_018659
CYTL1
cytokine-like 1
chr6_-_32268267 0.584 GPSM3
G-protein signaling modulator 3
chr15_-_35179614 0.578 MEIS2
Meis homeobox 2
chr7_+_149895390 0.574 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr13_-_45654296 0.566 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr18_+_30875297 0.564 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr1_-_167969802 0.559 NM_000450
SELE
selectin E
chr5_-_121440704 0.557 NM_001178102
LOX
lysyl oxidase
chr12_+_12829807 0.557 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr3_-_173010921 0.556 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr1_+_210805319 0.555 NM_001030287
ATF3
activating transcription factor 3
chr13_-_27967215 0.548 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr17_-_31441390 0.547 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr13_-_45654327 0.540 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_149004879 0.536 CTSS
cathepsin S
chr17_-_59817654 0.535 PECAM1
platelet/endothelial cell adhesion molecule
chr3_+_52504410 0.534 STAB1
stabilin 1
chr6_-_11340887 0.533 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr19_+_14412087 0.531 PKN1
protein kinase N1
chr17_-_35975227 0.520 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr12_-_10142779 0.516 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr11_-_110755366 0.514 NM_006235
POU2AF1
POU class 2 associating factor 1
chr1_-_148936123 0.513 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr1_+_82038669 0.511 NM_012302
LPHN2
latrophilin 2
chr2_+_37425240 0.507 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr12_+_110688728 0.505 NM_000690
ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
chr17_-_59817456 0.501 PECAM1
platelet/endothelial cell adhesion molecule
chr9_+_139292094 0.499 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr2_-_98646367 0.498 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr11_+_60886407 0.498 TMEM138
transmembrane protein 138
chr19_-_4510713 0.496 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr20_-_23014828 0.496 NM_012072
CD93
CD93 molecule
chr3_-_53356573 0.494 NM_018403
DCP1A
DCP1 decapping enzyme homolog A (S. cerevisiae)
chr1_-_171441234 0.492 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr9_+_76893232 0.491 OSTF1
osteoclast stimulating factor 1
chr17_-_76883677 0.490 NM_001037984
NM_138570
SLC38A10

solute carrier family 38, member 10

chr20_+_44180296 0.489 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr6_-_32268615 0.487 GPSM3
G-protein signaling modulator 3
chr1_+_148511806 0.483 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr5_-_88235624 0.482 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr2_-_188127430 0.480 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr6_-_31728405 0.477 BAG6
BCL2-associated athanogene 6
chr17_-_59817575 0.476 PECAM1
platelet/endothelial cell adhesion molecule
chr17_-_31337798 0.472 NM_032962
NM_032963
CCL14

chemokine (C-C motif) ligand 14

chr2_-_174538197 0.471 SP3
Sp3 transcription factor
chr2_-_224974954 0.469 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr9_+_115367122 0.465 NM_134427
RGS3
regulator of G-protein signaling 3
chr7_-_149960218 0.463 GIMAP6
GTPase, IMAP family member 6
chr5_-_88214720 0.463 MEF2C
myocyte enhancer factor 2C
chr15_-_88148177 0.461 ANPEP
alanyl (membrane) aminopeptidase
chr1_-_31003181 0.459 LAPTM5
lysosomal protein transmembrane 5
chr14_-_52487386 0.457 FERMT2
fermitin family member 2
chr1_+_111217244 0.450 NM_000560
CD53
CD53 molecule
chr14_-_53491019 0.448 NM_130851
BMP4
bone morphogenetic protein 4
chr4_-_16509354 0.448 LDB2
LIM domain binding 2
chr4_-_16509446 0.447 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr16_+_29373365 0.447 NM_001014999
NM_001015000
NM_024044
NM_178044
SLX1A-SULT1A3
SLX1A

SLX1B

SLX1A-SULT1A3 read-through transcript
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

chr16_+_64958025 0.444 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr6_-_31728363 0.439 BAG6
BCL2-associated athanogene 6
chr5_+_95092384 0.436 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr13_+_57103944 0.434 PCDH17
protocadherin 17
chr2_-_136590210 0.434 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr1_+_111217314 0.433 CD53
CD53 molecule
chr8_+_38704860 0.430 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr6_+_107917965 0.429 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr4_-_16509126 0.427 LDB2
LIM domain binding 2
chr3_+_134976965 0.426 TF
transferrin
chr1_+_196874839 0.424 PTPRC
protein tyrosine phosphatase, receptor type, C
chr6_-_7855125 0.423 NM_001145549
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr11_-_404975 0.422 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr1_-_36562341 0.415 NM_018166
FAM176B
family with sequence similarity 176, member B
chr15_+_79376295 0.415 NM_004513
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr1_-_149004852 0.414 CTSS
cathepsin S
chr11_-_88864061 0.414 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr13_+_30089829 0.414 NM_005800
USPL1
ubiquitin specific peptidase like 1
chr16_+_75782608 0.413 MON1B
MON1 homolog B (yeast)
chr12_-_9123126 0.412 A2M
alpha-2-macroglobulin
chr22_+_27498679 0.412 CCDC117
coiled-coil domain containing 117
chr7_-_115458064 0.408 TFEC
transcription factor EC
chr1_+_32512298 0.407 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chrX_+_12795111 0.403 NM_016562
TLR7
toll-like receptor 7
chr14_-_52487558 0.401 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr5_-_93472993 0.399 NM_001163417
NM_001163418
NM_032042
FAM172A


family with sequence similarity 172, member A


chr1_-_161439248 0.397 NM_001195303
RGS5
regulator of G-protein signaling 5
chr7_-_115458010 0.395 NM_001018058
NM_012252
TFEC

transcription factor EC

chr15_-_35179650 0.388 NM_170674
NM_170675
NM_170676
NM_170677
MEIS2



Meis homeobox 2



chr12_+_68028397 0.387 NM_000239
LYZ
lysozyme
chr6_-_112682573 0.386 LAMA4
laminin, alpha 4
chr19_-_10311262 0.386 NM_002162
ICAM3
intercellular adhesion molecule 3
chr6_-_31728447 0.385 NM_004639
NM_080702
NM_080703
BAG6


BCL2-associated athanogene 6


chr11_+_64620183 0.383 NM_013265
C11orf2
chromosome 11 open reading frame 2
chr11_-_124175493 0.382 NM_024631
C11orf61
chromosome 11 open reading frame 61
chr3_-_184756101 0.382 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr6_-_31728121 0.382 NM_001098534
BAG6
BCL2-associated athanogene 6
chr3_-_46224791 0.381 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr12_-_91063441 0.381 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr1_+_196874759 0.381 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr11_+_64620276 0.380 C11orf2
chromosome 11 open reading frame 2
chr17_-_53950191 0.377 NM_004687
MTMR4
myotubularin related protein 4
chr10_+_114123765 0.377 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_+_11242666 0.374 NM_001098211
HRH1
histamine receptor H1
chr11_+_64620287 0.373 C11orf2
chromosome 11 open reading frame 2
chrX_+_15428820 0.370 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr10_+_114123828 0.369 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_+_20319049 0.367 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr17_-_26665144 0.365 EVI2B
ecotropic viral integration site 2B
chr7_-_135312734 0.363 NM_145808
NM_001128619
MTPN
LUZP6
myotrophin
leucine zipper protein 6
chrX_-_44945025 0.363 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chrX_-_15783015 0.362 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr2_-_188127294 0.361 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr5_-_121441910 0.359 NM_002317
LOX
lysyl oxidase
chr4_+_86615275 0.358 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr1_-_111544784 0.358 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr5_-_149515613 0.358 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr5_-_111121150 0.357 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chrX_-_135691168 0.357 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr19_+_54530546 0.357 CD37
CD37 molecule
chr6_+_122834760 0.355 NM_181794
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr2_+_102320148 0.354 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr17_+_37694007 0.353 STAT5A
signal transducer and activator of transcription 5A
chr17_-_26665220 0.351 NM_006495
EVI2B
ecotropic viral integration site 2B
chr5_-_149515331 0.350 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr19_+_52940610 0.349 GLTSCR2
glioma tumor suppressor candidate region gene 2
chr18_-_51219880 0.349 TCF4
transcription factor 4
chr14_-_22354457 0.347 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr19_-_40928131 0.347 NM_001040425
NM_144987
U2AF1L4

U2 small nuclear RNA auxiliary factor 1-like 4

chr4_-_70661018 0.347 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr17_-_44042924 0.345 HOXB7
homeobox B7
chrX_+_128741562 0.344 NM_018990
SASH3
SAM and SH3 domain containing 3
chr11_-_74818685 0.343 KLHL35
kelch-like 35 (Drosophila)
chr6_-_47030492 0.342 NM_015234
GPR116
G protein-coupled receptor 116
chr19_-_17377383 0.337 NM_004335
BST2
bone marrow stromal cell antigen 2
chr9_+_102244005 0.335 NM_001198812
C9orf3-TMEFF1
C9orf30
C9orf3-TMEFF1 readthrough
chromosome 9 open reading frame 30
chr16_-_24850163 0.334 ARHGAP17
Rho GTPase activating protein 17
chr20_+_44180355 0.332 CD40
CD40 molecule, TNF receptor superfamily member 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 9.03e-07 GO:0090304 nucleic acid metabolic process
1.16 8.32e-06 GO:0044260 cellular macromolecule metabolic process
1.37 1.41e-05 GO:0032774 RNA biosynthetic process
1.27 2.48e-05 GO:0009059 macromolecule biosynthetic process
1.76 2.69e-05 GO:0045321 leukocyte activation
1.27 3.05e-05 GO:0034645 cellular macromolecule biosynthetic process
2.18 4.56e-05 GO:0050851 antigen receptor-mediated signaling pathway
1.27 4.77e-05 GO:0016070 RNA metabolic process
1.53 1.12e-04 GO:0002684 positive regulation of immune system process
1.50 1.35e-04 GO:0001775 cell activation
1.19 5.67e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.13 6.08e-04 GO:0043170 macromolecule metabolic process
2.00 1.22e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.99 1.26e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.16 1.60e-03 GO:0050852 T cell receptor signaling pathway
1.21 6.35e-03 GO:0010467 gene expression
1.47 6.60e-03 GO:0016032 viral reproduction
1.32 8.10e-03 GO:0006351 transcription, DNA-dependent
1.69 1.04e-02 GO:0002764 immune response-regulating signaling pathway
1.69 1.10e-02 GO:0002757 immune response-activating signal transduction
1.67 1.68e-02 GO:0046649 lymphocyte activation
1.59 1.69e-02 GO:0002694 regulation of leukocyte activation
1.43 1.73e-02 GO:0050776 regulation of immune response
1.56 2.68e-02 GO:0050865 regulation of cell activation
1.32 4.73e-02 GO:0002682 regulation of immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 4.75e-05 GO:0005654 nucleoplasm
1.20 2.20e-03 GO:0031981 nuclear lumen
1.18 2.62e-03 GO:0043233 organelle lumen
1.17 3.91e-03 GO:0031974 membrane-enclosed lumen
1.18 4.53e-03 GO:0044428 nuclear part
1.10 4.56e-03 GO:0005634 nucleus
2.04 4.95e-03 GO:0071013 catalytic step 2 spliceosome
1.10 9.36e-03 GO:0044446 intracellular organelle part
1.10 1.01e-02 GO:0044422 organelle part
1.37 1.95e-02 GO:0030529 ribonucleoprotein complex
1.04 2.13e-02 GO:0005622 intracellular
1.16 2.24e-02 GO:0070013 intracellular organelle lumen
1.04 2.49e-02 GO:0044424 intracellular part
1.12 3.14e-02 GO:0032991 macromolecular complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 8.07e-03 GO:0003676 nucleic acid binding
1.07 1.59e-02 GO:0005515 protein binding