Motif ID: HLF.p2

Z-value: 1.590


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HLFchr17_+_506973190.821.0e-04Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_116125123 5.619 NM_000607
ORM1
orosomucoid 1
chr1_-_228916486 5.257 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr10_-_52315436 4.940 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr2_+_113601608 4.770 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr9_+_116131889 4.735 NM_000608
ORM2
orosomucoid 2
chr1_-_228916470 4.598 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr7_+_45899621 4.099


chr3_+_134976965 4.084 TF
transferrin
chr16_+_70646008 3.963 NM_001126102
NM_005143
HP

haptoglobin

chr3_+_187813538 3.552 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr10_-_95350949 3.478 NM_006744
RBP4
retinol binding protein 4, plasma
chr3_-_49701085 3.037 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr19_+_40465249 3.030 NM_021175
HAMP
hepcidin antimicrobial peptide
chr2_-_98646367 2.689 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr2_+_113601616 2.627 IL1RN
interleukin 1 receptor antagonist
chr3_+_187813553 2.612 AHSG
alpha-2-HS-glycoprotein
chr4_+_100704262 2.579 NM_000253
MTTP
microsomal triglyceride transfer protein
chr13_-_45577144 2.394 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr10_-_116434364 2.340 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr1_+_205328834 2.267 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr18_+_54039779 2.123 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_-_12561962 2.110 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr16_+_55963899 2.046 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr17_-_36346240 1.941 KRT23
keratin 23 (histone deacetylase inducible)
chr10_-_116434102 1.922 ABLIM1
actin binding LIM protein 1
chr6_+_32003180 1.863 NM_000063
NM_001145903
C2

complement component 2

chr16_+_70654625 1.845 NM_020995
HPR
haptoglobin-related protein
chr3_-_121883647 1.844 HGD
homogentisate 1,2-dioxygenase
chr6_+_131936057 1.819 NM_000045
ARG1
arginase, liver
chr17_-_38978772 1.819 NM_001986
ETV4
ets variant 4
chr18_+_53967544 1.776 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr16_-_54424517 1.748 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr2_-_113310796 1.711 NM_000576
IL1B
interleukin 1, beta
chr9_+_102987137 1.694 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr3_+_46591048 1.614 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr17_-_31352720 1.582 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr16_-_54424473 1.546 CES1
carboxylesterase 1
chr12_-_28016182 1.544 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr3_+_187813405 1.473 AHSG
alpha-2-HS-glycoprotein
chr8_+_124263932 1.465 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr12_-_51132129 1.462 NM_005555
KRT6B
keratin 6B
chr10_+_114123765 1.454 ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_-_61655915 1.443 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr17_-_31352643 1.430 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr1_-_228916958 1.382 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr17_-_31353196 1.381 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr6_+_32003380 1.378 C2
complement component 2
chr4_+_74488835 1.374 NM_000477
ALB
albumin
chr15_-_40628202 1.373 LRRC57
leucine rich repeat containing 57
chr12_-_121767272 1.328 NM_006018
GPR109B
G protein-coupled receptor 109B
chr18_+_54039730 1.326 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_+_150380173 1.319 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr4_+_71096830 1.318 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr10_+_124141808 1.302 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr4_+_155703581 1.285 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr14_+_23633101 1.264 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr16_-_4528739 1.238 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr3_+_123526700 1.231 NM_005213
CSTA
cystatin A (stefin A)
chr8_+_26569709 1.227 DPYSL2
dihydropyrimidinase-like 2
chr4_+_74488910 1.182 ALB
albumin
chr8_+_40130143 1.157 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr2_+_101974737 1.145 NM_004633
IL1R2
interleukin 1 receptor, type II
chr10_-_82039158 1.140 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr9_-_129752687 1.131 NM_203305
FAM102A
family with sequence similarity 102, member A
chr3_+_143824955 1.084 NM_002670
PLS1
plastin 1
chr18_+_75967902 1.077 NM_014913
ADNP2
ADNP homeobox 2
chr7_+_129634935 1.053 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr2_-_114230666 1.005 NM_025181
SLC35F5
solute carrier family 35, member F5
chr22_+_23333610 0.998 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr9_-_98421894 0.988 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr9_+_71009746 0.962 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr22_+_23309717 0.954 NM_013430
GGT1
gamma-glutamyltransferase 1
chr4_+_187424336 0.942 F11
coagulation factor XI
chr18_+_54039818 0.938 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_114230455 0.914 SLC35F5
solute carrier family 35, member F5
chr1_+_149221122 0.906 NM_003568
ANXA9
annexin A9
chr12_-_121753795 0.901 NM_177551
GPR109A
G protein-coupled receptor 109A
chr15_+_40628283 0.870 NM_001130447
NM_018097
HAUS2

HAUS augmin-like complex, subunit 2

chr3_-_172227152 0.856 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr4_-_110942783 0.855 NM_000204
CFI
complement factor I
chr12_-_51360439 0.845 NM_006121
KRT1
keratin 1
chr14_-_19871267 0.843 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr19_+_38556414 0.835 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr11_-_66431910 0.820 NM_022172
PC
pyruvate carboxylase
chr15_-_40628284 0.811 NM_153260
LRRC57
leucine rich repeat containing 57
chrM_+_1670 0.809 USP47
ubiquitin specific peptidase 47
chr7_+_20621769 0.777 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr3_-_101077605 0.759 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr19_+_50663089 0.736 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr19_-_4491078 0.722 LRG1
leucine-rich alpha-2-glycoprotein 1
chr1_+_239762179 0.721 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr6_+_144654565 0.720 NM_007124
UTRN
utrophin
chr2_+_228386800 0.719 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr9_-_93225961 0.716 NM_005384
NFIL3
nuclear factor, interleukin 3 regulated
chr6_-_133076873 0.710 NM_004666
VNN1
vanin 1
chr10_+_114123828 0.710 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_-_1993022 0.697 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr19_-_411995 0.681 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr6_-_41810712 0.680 NM_007162
TFEB
transcription factor EB
chr3_-_150422474 0.672 NM_000096
CP
ceruloplasmin (ferroxidase)
chr16_+_2593351 0.659 LOC652276
hypothetical LOC652276
chr5_+_150380270 0.648 GPX3
glutathione peroxidase 3 (plasma)
chr21_-_43671355 0.646 NM_173354
SIK1
salt-inducible kinase 1
chr3_+_120984246 0.641 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr17_-_53849888 0.623 RNF43
ring finger protein 43
chr2_+_113119985 0.619 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr2_-_31491102 0.609 NM_000379
XDH
xanthine dehydrogenase
chr17_-_53849929 0.609 NM_017763
RNF43
ring finger protein 43
chr18_+_75968133 0.607 ADNP2
ADNP homeobox 2
chrX_+_43399101 0.605 MAOA
monoamine oxidase A
chr1_-_245161282 0.599 NM_015446
AHCTF1
AHCTF1P1
AT hook containing transcription factor 1
AT hook containing transcription factor 1 pseudogene 1
chr8_+_117847922 0.584 NM_032334
UTP23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr1_+_166414839 0.579 TIPRL
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr5_+_150612805 0.576 NM_000405
NM_001167607
GM2A

GM2 ganglioside activator

chr7_+_143511480 0.571 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr12_+_55910094 0.569 NM_001166358
NM_001166359
NM_001166357
SHMT2


serine hydroxymethyltransferase 2 (mitochondrial)


chr1_-_152867007 0.565 ADAR
adenosine deaminase, RNA-specific
chr21_+_43903803 0.563 NM_015056
RRP1B
ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr19_+_50109903 0.561 APOC1
apolipoprotein C-I
chr17_+_31562577 0.558 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr19_-_4491024 0.555 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr7_+_94135384 0.551 PEG10
paternally expressed 10
chr3_+_171167243 0.549 NM_003262
SEC62
SEC62 homolog (S. cerevisiae)
chr11_-_70350292 0.543 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_-_152867070 0.527 NM_001025107
ADAR
adenosine deaminase, RNA-specific
chr3_+_187917791 0.526 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chrX_-_131375217 0.519 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr1_+_227506751 0.518 NM_006542
SPHAR
S-phase response (cyclin related)
chr10_-_101180191 0.511 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr3_+_42107711 0.508 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr21_-_42060266 0.506 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr4_-_23500706 0.505 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr19_-_56147971 0.504 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr20_+_30161173 0.498 TM9SF4
transmembrane 9 superfamily protein member 4
chr6_-_30151526 0.496 NM_170769
NM_025236
RNF39

ring finger protein 39

chr7_-_143597313 0.494 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr20_+_31613800 0.493 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr5_-_42847716 0.487 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr18_-_72857665 0.485 MBP
myelin basic protein
chr11_+_22644732 0.478 NM_001143830
GAS2
growth arrest-specific 2
chr4_-_153493133 0.461 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr19_+_50109760 0.448 NM_001645
APOC1
apolipoprotein C-I
chr21_-_42659671 0.446 NM_003225
TFF1
trefoil factor 1
chr2_-_73723001 0.443 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr16_+_3447957 0.441 NM_001083600
NM_024845
NAT15

N-acetyltransferase 15 (GCN5-related, putative)

chr17_+_31455332 0.434 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr10_+_123913094 0.434 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr4_-_100704156 0.425 NM_001134665
NM_001134666
RG9MTD2

RNA (guanine-9-) methyltransferase domain containing 2

chr1_+_210805319 0.424 NM_001030287
ATF3
activating transcription factor 3
chr17_-_23965305 0.423 NM_001174103
SGK494
uncharacterized serine/threonine-protein kinase SgK494
chr17_-_75427644 0.415 NM_003655
CBX4
chromobox homolog 4
chr19_-_52308848 0.413 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr13_-_74799898 0.406 TBC1D4
TBC1 domain family, member 4
chr12_+_55909622 0.405 NM_001166356
NM_005412
SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

chr2_-_213723298 0.402 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr9_-_111230926 0.400 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr2_-_43676603 0.399 NM_001083953
NM_022065
THADA

thyroid adenoma associated

chr8_-_145187553 0.395 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr17_-_68819713 0.395 NM_012121
CDC42EP4
CDC42 effector protein (Rho GTPase binding) 4
chr16_-_4528380 0.391 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr6_-_2785682 0.389 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr20_+_61842880 0.385 SLC2A4RG
SLC2A4 regulator
chr14_+_38805251 0.385 NM_203356
CTAGE5
CTAGE family, member 5
chr19_-_6410735 0.384 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr6_-_132073849 0.383 NM_001145659
CTAGE9
CTAGE family, member 9
chr19_-_50779924 0.383 NM_001017989
NM_025136
OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr6_+_33047952 0.379 BRD2
bromodomain containing 2
chr17_-_4554163 0.379 PELP1
proline, glutamate and leucine rich protein 1
chr12_-_121946635 0.378 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr8_+_21972804 0.375 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr16_+_31036474 0.375 NM_032188
NM_182958
MYST1

MYST histone acetyltransferase 1

chr2_-_68547893 0.372 NM_001024680
FBXO48
F-box protein 48
chr18_+_59705918 0.369 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chrX_-_40391610 0.367 CXorf38
chromosome X open reading frame 38
chr11_+_28086373 0.367 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr7_+_142978994 0.366 NM_001008747
CTAGE6P
CTAGE15P
CTAGE family, member 6, pseudogene
CTAGE family, member 15, pseudogene
chr3_+_9950513 0.363 NM_015513
NM_001031717
NM_001077415
CRELD1


cysteine-rich with EGF-like domains 1


chr4_-_110942576 0.360 CFI
complement factor I
chr6_-_47362102 0.360 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr22_+_33792125 0.360 NM_001008494
ISX
intestine-specific homeobox
chr17_+_59205289 0.358 NM_007372
NM_203499
DDX42

DEAD (Asp-Glu-Ala-Asp) box polypeptide 42

chr20_+_35445350 0.357 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr17_-_4553947 0.350 PELP1
proline, glutamate and leucine rich protein 1
chr1_-_62557655 0.348 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr2_-_31491057 0.334 XDH
xanthine dehydrogenase
chr1_+_157067729 0.327 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr17_+_38575939 0.327 NM_031862
NM_031858
NBR1

neighbor of BRCA1 gene 1

chr3_+_9950474 0.326 CRELD1
cysteine-rich with EGF-like domains 1
chr11_+_43622348 0.325


chr12_-_121946581 0.325 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr3_-_40469668 0.321 FLJ36665
hypothetical protein FLJ36665
chr10_+_103901922 0.319 NM_004741
NOLC1
nucleolar and coiled-body phosphoprotein 1
chr4_-_77147625 0.316 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr16_-_30364698 0.316 NM_012248
SEPHS2
selenophosphate synthetase 2
chr15_-_81412354 0.313 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr10_-_46593923 0.313 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chrX_-_40391744 0.312 NM_144970
CXorf38
chromosome X open reading frame 38
chr7_-_15568099 0.311 NM_001004320
AGMO
alkylglycerol monooxygenase
chr17_-_4554171 0.308 PELP1
proline, glutamate and leucine rich protein 1
chr14_+_67156405 0.308 ARG2
arginase, type II

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.13 4.60e-04 GO:0006955 immune response
2.74 8.46e-03 GO:0006954 inflammatory response
5.51 4.69e-02 GO:0009064 glutamine family amino acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.93 2.43e-03 GO:0005615 extracellular space
1.73 1.53e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
6.13 1.36e-03 GO:0008009 chemokine activity
5.50 3.83e-03 GO:0042379 chemokine receptor binding