Motif ID: PRDM1.p3

Z-value: 1.967


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PRDM1chr6_+_1066534290.332.1e-01Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_210848763 4.146 ATF3
activating transcription factor 3
chr1_+_210848592 4.047 NM_001040619
NM_001674
ATF3

activating transcription factor 3

chr6_+_32929902 4.025 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr6_-_112682459 4.017 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr1_+_210848726 3.725 ATF3
activating transcription factor 3
chr11_+_32069183 3.718 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr1_-_111548440 3.549 DENND2D
DENN/MADD domain containing 2D
chr6_-_112682573 3.531 LAMA4
laminin, alpha 4
chr6_-_112682401 3.342 LAMA4
laminin, alpha 4
chr2_-_189752575 3.324 NM_000393
COL5A2
collagen, type V, alpha 2
chr3_+_8518508 3.147 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr11_-_104344473 2.926 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr5_-_142795269 2.822 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr10_-_44200458 2.782 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr4_+_142777172 2.747 NM_000585
NM_172174
IL15

interleukin 15

chr9_-_16717887 2.667 BNC2
basonuclin 2
chr3_-_115825742 2.513 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr6_-_29635456 2.439 UBD
ubiquitin D
chr6_-_32919751 2.421 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr8_+_97575196 2.317 SDC2
syndecan 2
chr6_-_29635680 2.271 NM_006398
UBD
ubiquitin D
chr3_+_8518539 2.267 LMCD1
LIM and cysteine-rich domains 1
chr10_+_114125927 2.111 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr10_+_114125955 2.111 ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_+_23675206 2.103 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr3_-_49826360 2.002 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr12_+_25096472 1.952 NM_006152
LRMP
lymphoid-restricted membrane protein
chr8_+_97575244 1.936 SDC2
syndecan 2
chr14_+_23675233 1.899 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr4_+_37569093 1.881 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr10_+_114126004 1.876 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_230989150 1.763 SP100
SP100 nuclear antigen
chr11_+_63060848 1.758 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr16_+_49333513 1.731 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr12_+_6431437 1.693 NM_018009
TAPBPL
TAP binding protein-like
chr16_+_49333461 1.647 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr6_-_112682038 1.576 LAMA4
laminin, alpha 4
chr12_+_25096755 1.551 LRMP
lymphoid-restricted membrane protein
chr1_+_160868932 1.537 DDR2
discoidin domain receptor tyrosine kinase 2
chr20_+_336963 1.499 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr8_+_144711619 1.468 NM_024736
GSDMD
gasdermin D
chr2_+_230989177 1.440 SP100
SP100 nuclear antigen
chr4_-_100461530 1.418 NM_000668
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr8_+_97575071 1.385 SDC2
syndecan 2
chr3_-_49826221 1.354 UBA7
ubiquitin-like modifier activating enzyme 7
chr9_+_136673464 1.342 NM_000093
COL5A1
collagen, type V, alpha 1
chr20_+_337346 1.341 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr8_-_29176490 1.293 NM_015254
KIF13B
kinesin family member 13B
chr4_+_146623405 1.292 NM_001003688
SMAD1
SMAD family member 1
chr8_+_97575052 1.279 NM_002998
SDC2
syndecan 2
chr22_+_20880112 1.272


chrX_-_118711088 1.270 SEPT6
septin 6
chr1_-_219982081 1.258 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr20_+_336693 1.250 NM_006462
NM_031229
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr8_-_79880095 1.241 NM_000880
IL7
interleukin 7
chr22_-_34886727 1.230 NM_145640
APOL3
apolipoprotein L, 3
chrX_-_118711350 1.198 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chr1_-_219982016 1.185 DUSP10
dual specificity phosphatase 10
chr17_+_6599879 1.175 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chrX_+_102770303 1.173 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr1_+_160868822 1.159 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr12_-_55791443 1.112 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr17_+_6600080 1.103 XAF1
XIAP associated factor 1
chr2_-_230792844 1.088 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr22_+_20880159 1.041 IGLV6-57
immunoglobulin lambda variable 6-57
chr11_+_5602782 0.996 NM_021616
TRIM34
tripartite motif containing 34
chr5_-_96169329 0.969 ERAP1
endoplasmic reticulum aminopeptidase 1
chr14_-_68329407 0.910 NM_004926
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr17_+_38412267 0.907 NM_005533
IFI35
interferon-induced protein 35
chr14_+_23771464 0.877 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chrX_+_102770547 0.863 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr19_-_23370066 0.850 NM_003430
ZNF91
zinc finger protein 91
chr12_+_100795213 0.842 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr5_-_96169445 0.834 NM_001040458
NM_016442
ERAP1

endoplasmic reticulum aminopeptidase 1

chr4_-_186815116 0.833 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr2_-_191587128 0.831 STAT1
signal transducer and activator of transcription 1, 91kDa
chr12_+_100795480 0.796 DRAM1
DNA-damage regulated autophagy modulator 1
chr2_+_230989114 0.791 NM_001080391
NM_003113
SP100

SP100 nuclear antigen

chr15_-_78050515 0.790 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr3_+_51951314 0.785 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr9_+_111582317 0.772 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr13_+_30207690 0.756 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr20_+_56904042 0.752 GNAS
GNAS complex locus
chr6_+_30018287 0.747 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr13_-_109600709 0.740 COL4A1
collagen, type IV, alpha 1
chr10_+_91051685 0.708 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr7_+_134483305 0.699 NM_018295
TMEM140
transmembrane protein 140
chr6_-_32920167 0.684 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr3_+_51952326 0.668 PARP3
poly (ADP-ribose) polymerase family, member 3
chr4_-_185632610 0.662 NM_002199
IRF2
interferon regulatory factor 2
chr12_-_55791388 0.653 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr5_+_49998528 0.642 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr13_+_30207668 0.608 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr22_-_28972683 0.605 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr16_-_66528235 0.551 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr12_-_56111054 0.534 R3HDM2
R3H domain containing 2
chr1_-_2486313 0.532 NM_003820
TNFRSF14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr7_+_5220342 0.509 NM_001033520
WIPI2
WD repeat domain, phosphoinositide interacting 2
chr7_-_86686754 0.505 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr11_-_104411065 0.501 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr11_-_5662762 0.494 NM_033034
NM_033092
NM_033093
TRIM5


tripartite motif containing 5


chr12_-_55791202 0.483 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr4_-_186814852 0.476 SORBS2
sorbin and SH3 domain containing 2
chr12_-_47605478 0.476 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr19_+_40931285 0.475 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr22_+_37802955 0.473 NM_021822
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr17_-_78000890 0.463 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr1_-_8406288 0.458 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chrM_-_5072 0.444


chr3_+_189354167 0.409 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_-_13789628 0.405 FRMD4A
FERM domain containing 4A
chr9_-_122716670 0.393 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr14_-_23685629 0.377 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_+_230798687 0.376 NM_001005176
NM_007237
SP140

SP140 nuclear body protein

chr20_+_56903595 0.368 GNAS
GNAS complex locus
chr9_+_122890394 0.364 NM_007018
CEP110
centrosomal protein 110kDa
chr10_+_123744131 0.358 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_-_157313179 0.356 NM_004833
AIM2
absent in melanoma 2
chr15_-_35180656 0.355 NM_002399
MEIS2
Meis homeobox 2
chr16_-_66528152 0.347 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr22_-_34892170 0.339 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr14_-_23981493 0.333 NM_020195
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr10_+_91082218 0.330 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chrX_-_100920493 0.327 GK
glycerol kinase
chr10_+_122600843 0.326 WDR11
WD repeat domain 11
chr1_-_219982049 0.326 DUSP10
dual specificity phosphatase 10
chr19_-_52427698 0.311 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr12_+_11694172 0.311 ETV6
ets variant 6
chr1_-_149004879 0.301 CTSS
cathepsin S
chr11_-_77730573 0.300 NM_012296
GAB2
GRB2-associated binding protein 2
chr1_+_17779528 0.291 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr3_-_11598829 0.291 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr1_-_9052253 0.287 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr2_-_174968595 0.275 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr11_-_58099884 0.271 NM_004811
LPXN
leupaxin
chr4_+_76868830 0.270 USO1
USO1 vesicle docking protein homolog (yeast)
chr22_+_17012704 0.269 NM_017414
USP18
ubiquitin specific peptidase 18
chr19_+_54669283 0.262 NM_001459
FLT3LG
fms-related tyrosine kinase 3 ligand
chr7_+_134114957 0.262 CALD1
caldesmon 1
chr1_-_149047329 0.261 NM_000396
CTSK
cathepsin K
chr8_-_93144366 0.252 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_+_109536214 0.249 NM_001082537
NM_001082538
NM_001173976
NM_024549
NM_001173975
TCTN1




tectonic family member 1




chr9_+_109085372 0.248 RAD23B
RAD23 homolog B (S. cerevisiae)
chr7_+_134114701 0.233 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr2_+_238634469 0.224 SCLY
selenocysteine lyase
chr22_-_30018329 0.221 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr4_+_76868850 0.220 NM_003715
USO1
USO1 vesicle docking protein homolog (yeast)
chr4_+_76868763 0.219 USO1
USO1 vesicle docking protein homolog (yeast)
chr15_-_35179614 0.217 MEIS2
Meis homeobox 2
chr14_-_23771401 0.214 NM_006156
NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr9_+_139633272 0.214 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr11_+_64946848 0.210


chr2_-_230798687 0.206 NM_001185015
SP110
SP110 nuclear body protein
chr19_+_12966970 0.205 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_+_230900121 0.201 NM_138402
SP140L
SP140 nuclear body protein-like
chr7_+_128367961 0.201 NM_001098627
IRF5
interferon regulatory factor 5
chr6_+_26070957 0.198 NM_006355
TRIM38
tripartite motif containing 38
chr2_-_144711375 0.195 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr11_+_77209807 0.191 NM_024684
C11orf67
chromosome 11 open reading frame 67
chr1_-_152847256 0.187 ADAR
adenosine deaminase, RNA-specific
chr22_+_37766554 0.185 NM_001006666
NM_145298
APOBEC3F

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

chr15_+_68971835 0.179 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr9_+_109085337 0.177 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr1_-_152847301 0.171 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr8_-_23768242 0.170 NM_003155
STC1
stanniocalcin 1
chr3_+_108724472 0.167 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr3_+_133619193 0.167 NM_015268
DNAJC13
DnaJ (Hsp40) homolog, subfamily C, member 13
chr15_+_65245546 0.166 NM_001145104
SMAD3
SMAD family member 3
chrX_-_106248706 0.165 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr21_+_42807052 0.160 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr9_+_139633264 0.159 NM_001145527
NM_024757
EHMT1

euchromatic histone-lysine N-methyltransferase 1

chr12_-_9804682 0.157 NM_001781
CD69
CD69 molecule
chr1_+_220884257 0.155 MIA3
melanoma inhibitory activity family, member 3
chr3_-_69212192 0.154 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr17_-_15914485 0.151 NCOR1
nuclear receptor corepressor 1
chr1_+_110254979 0.151 CSF1
colony stimulating factor 1 (macrophage)
chr4_+_88075176 0.148 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr10_-_6059460 0.147 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr3_-_8518327 0.145 LOC100288428
hypothetical LOC100288428
chr9_+_109085386 0.142 RAD23B
RAD23 homolog B (S. cerevisiae)
chr3_+_9809776 0.142 NM_001198780
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr22_-_34965498 0.130 APOL2
apolipoprotein L, 2
chr4_+_152240182 0.128 NM_001006
RPS3A
ribosomal protein S3A
chr14_+_101297887 0.127 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr1_+_219119468 0.126 HLX
H2.0-like homeobox
chr1_-_143232526 0.125 FAM91A2
family with sequence similarity 91, member A2
chr20_+_336941 0.120 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_+_224079597 0.117 NM_000120
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr9_+_99214000 0.115 NM_014290
TDRD7
tudor domain containing 7
chr8_+_97726757 0.113 PGCP
plasma glutamate carboxypeptidase
chr14_-_23771312 0.101 NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr1_+_219119358 0.101 NM_021958
HLX
H2.0-like homeobox
chr20_-_18395622 0.100 NM_001099407
C20orf12
chromosome 20 open reading frame 12
chrX_-_118711183 0.095 SEPT6
septin 6
chr1_+_219119430 0.090 HLX
H2.0-like homeobox
chr7_+_99459019 0.089 ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr18_+_46659424 0.088 NM_001168335
NM_002396
ME2

malic enzyme 2, NAD(+)-dependent, mitochondrial

chr6_-_25044156 0.081 FAM65B
family with sequence similarity 65, member B
chr3_+_115099007 0.080 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr11_-_77209398 0.077 NM_016578
RSF1
remodeling and spacing factor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
14.02 2.16e-07 GO:0060337 type I interferon-mediated signaling pathway
14.02 2.16e-07 GO:0071357 cellular response to type I interferon
13.80 2.60e-07 GO:0034340 response to type I interferon
6.22 4.38e-05 GO:0019221 cytokine-mediated signaling pathway
62.19 1.02e-04 GO:0002483 antigen processing and presentation of endogenous peptide antigen
62.19 1.02e-04 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
5.62 1.58e-04 GO:0071345 cellular response to cytokine stimulus
3.01 6.08e-04 GO:0006955 immune response
44.42 7.02e-04 GO:0019883 antigen processing and presentation of endogenous antigen
2.46 8.73e-04 GO:0002376 immune system process
4.32 1.63e-03 GO:0034097 response to cytokine stimulus
7.50 8.65e-03 GO:0030330 DNA damage response, signal transduction by p53 class mediator
3.70 1.10e-02 GO:0045087 innate immune response
23.92 1.35e-02 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
2.67 3.09e-02 GO:0006508 proteolysis
38.87 3.18e-02 GO:0016553 base conversion or substitution editing
6.04 4.20e-02 GO:0042770 signal transduction in response to DNA damage

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
7.91 1.36e-02 GO:0000502 proteasome complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.32 2.16e-02 GO:0001071 nucleic acid binding transcription factor activity
2.32 2.16e-02 GO:0003700 sequence-specific DNA binding transcription factor activity