Motif ID: SPI1.p2

Z-value: 3.017


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPI1chr11_-_473566720.674.9e-03Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_26517032 5.730 CD52
CD52 molecule
chr5_-_88215034 5.612 NM_001193350
NM_002397
 MEF2C

myocyte enhancer factor 2C

chr1_+_26517045 5.294 CD52
CD52 molecule
chr1_-_31003260 5.272 NM_006762
 LAPTM5
lysosomal protein transmembrane 5
chr1_-_111544784 5.256 NM_024901
 DENND2D
DENN/MADD domain containing 2D
chr12_+_25096755 5.033 LRMP
lymphoid-restricted membrane protein
chr1_-_111544820 5.009 DENND2D
DENN/MADD domain containing 2D
chrX_+_48427103 4.727 NM_000377
 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr14_-_22354457 4.608 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr12_+_25096472 4.314 NM_006152
 LRMP
lymphoid-restricted membrane protein
chr17_-_26665220 4.272 NM_006495
 EVI2B
ecotropic viral integration site 2B
chr22_+_35586950 4.229 NM_000631
NM_013416
 NCF4

neutrophil cytosolic factor 4, 40kDa

chr14_-_22354389 4.086 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr17_-_26665213 4.077 EVI2B
ecotropic viral integration site 2B
chr17_-_26665144 3.999 EVI2B
ecotropic viral integration site 2B
chr5_+_118719591 3.738 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr1_+_111217314 3.694 CD53
CD53 molecule
chr1_+_111217244 3.663 NM_000560
 CD53
CD53 molecule
chr17_-_26665194 3.643 EVI2B
ecotropic viral integration site 2B
chr12_-_51887266 3.565 NM_000889
 ITGB7
integrin, beta 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 60 entries
enrichment   p-value GO term description
2.74 2.55e-02 GO:0031572 G2/M transition DNA damage checkpoint
2.40 4.49e-02 GO:0002285 lymphocyte activation involved in immune response
2.11 3.02e-02 GO:0002263 cell activation involved in immune response
2.11 3.02e-02 GO:0002366 leukocyte activation involved in immune response
1.94 1.74e-02 GO:0006302 double-strand break repair
1.77 1.65e-02 GO:0030098 lymphocyte differentiation
1.61 1.37e-03 GO:0046649 lymphocyte activation
1.56 8.18e-04 GO:0045321 leukocyte activation
1.56 2.42e-03 GO:0071156 regulation of cell cycle arrest
1.56 3.04e-03 GO:0000075 cell cycle checkpoint
1.56 1.51e-02 GO:0002757 immune response-activating signal transduction
1.53 3.53e-02 GO:0002764 immune response-regulating signaling pathway
1.51 1.32e-04 GO:0006281 DNA repair
1.50 9.25e-08 GO:0006974 response to DNA damage stimulus
1.46 4.00e-02 GO:0032446 protein modification by small protein conjugation
1.45 8.71e-03 GO:0070647 protein modification by small protein conjugation or removal
1.44 2.43e-02 GO:0008380 RNA splicing
1.39 1.18e-04 GO:0006259 DNA metabolic process
1.37 2.46e-03 GO:0016071 mRNA metabolic process
1.34 1.87e-02 GO:0001775 cell activation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
1.50 2.72e-02 GO:0030425 dendrite
1.43 4.41e-02 GO:0016604 nuclear body
1.40 1.14e-05 GO:0005694 chromosome
1.38 4.82e-04 GO:0044427 chromosomal part
1.32 9.07e-10 GO:0005654 nucleoplasm
1.29 1.24e-03 GO:0044451 nucleoplasm part
1.27 1.82e-12 GO:0044428 nuclear part
1.27 5.38e-10 GO:0031981 nuclear lumen
1.18 3.19e-05 GO:0070013 intracellular organelle lumen
1.18 4.08e-05 GO:0031974 membrane-enclosed lumen
1.18 5.28e-05 GO:0043233 organelle lumen
1.18 1.00e-04 GO:0005829 cytosol
1.17 1.16e-15 GO:0005634 nucleus
1.17 2.33e-05 GO:0043228 non-membrane-bounded organelle
1.17 2.33e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.16 1.22e-05 GO:0043234 protein complex
1.15 2.58e-06 GO:0032991 macromolecular complex
1.09 2.32e-03 GO:0044446 intracellular organelle part
1.08 6.66e-03 GO:0044422 organelle part
1.06 1.16e-04 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.85 2.50e-02 GO:0008094 DNA-dependent ATPase activity
1.58 1.90e-03 GO:0003682 chromatin binding
1.49 1.69e-02 GO:0019787 small conjugating protein ligase activity
1.46 1.75e-03 GO:0016564 transcription repressor activity
1.35 1.09e-04 GO:0043565 sequence-specific DNA binding
1.32 4.03e-06 GO:0030528 transcription regulator activity
1.23 2.44e-02 GO:0001071 nucleic acid binding transcription factor activity
1.23 2.44e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.18 4.64e-04 GO:0003677 DNA binding
1.14 3.40e-04 GO:0003676 nucleic acid binding
1.10 2.85e-09 GO:0005515 protein binding