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Motif ID: bHLH_family.p2

Z-value: 2.203

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr12_-_61615124	4.332		PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr12_-_61614930	3.751	NM_020700	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chrX_+_152562013	3.659		DUSP9	dual specificity phosphatase 9
chr1_-_113300138	3.285	NM_001166496	SLC16A1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr6_+_160310118	3.261	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chr1_-_159459999	3.253	NM_001643	APOA2	apolipoprotein A-II
chrX_+_130985316	3.185	NM_001042452	MST4	serine/threonine protein kinase MST4
chr19_+_10625987	3.042		ILF3	interleukin enhancer binding factor 3, 90kDa
chr6_+_37245860	3.035	NM_002648	PIM1	pim-1 oncogene
chr19_+_10626106	2.936		ILF3	interleukin enhancer binding factor 3, 90kDa
chr19_-_10625449	2.893		LOC147727	hypothetical LOC147727
chr2_-_208342296	2.855	NM_003468	FZD5	frizzled homolog 5 (Drosophila)
chr17_-_73636362	2.722		TMC6	transmembrane channel-like 6
chr14_-_54438913	2.632	NM_000161 NM_001024024 NM_001024070 NM_001024071	GCH1	GTP cyclohydrolase 1
chr16_-_66827449	2.628	NM_024939	ESRP2	epithelial splicing regulatory protein 2
chrX_-_132947141	2.594		GPC3	glypican 3
chr2_+_218992053	2.536	NM_007127	VIL1	villin 1
chr7_+_16759845	2.528	NM_014399	TSPAN13	tetraspanin 13
chr14_-_93919305	2.484		SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr17_+_77529070	2.475		ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1
chrX_-_132947290	2.443	NM_001164617 NM_001164618 NM_001164619 NM_004484	GPC3	glypican 3
chr11_-_66482366	2.362	NM_000920 NM_001040716	PC	pyruvate carboxylase
chr19_+_40431122	2.337		LSR	lipolysis stimulated lipoprotein receptor
chr19_+_10625896	2.288	NM_001137673 NM_004516 NM_012218 NM_017620 NM_153464	ILF3	interleukin enhancer binding factor 3, 90kDa
chr1_-_152459667	2.270		C1orf43	chromosome 1 open reading frame 43
chr1_-_113300351	2.264	NM_003051	SLC16A1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr12_-_56432292	2.236		CDK4	cyclin-dependent kinase 4
chr4_-_15694407	2.211		PROM1	prominin 1
chr3_+_50629604	2.180	NM_004635	MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3
chr8_-_145609737	2.111		SLC39A4	solute carrier family 39 (zinc transporter), member 4
chr1_-_152459506	2.075		C1orf43	chromosome 1 open reading frame 43
chrX_+_130984912	2.058	NM_001042453 NM_016542	MST4	serine/threonine protein kinase MST4
chr15_+_48261649	2.056	NM_001159629 NM_003645	SLC27A2	solute carrier family 27 (fatty acid transporter), member 2
chr14_+_100270222	2.054		DLK1	delta-like 1 homolog (Drosophila)
chr17_+_52518098	2.053		AKAP1	A kinase (PRKA) anchor protein 1
chr12_-_56432377	2.021		CDK4	cyclin-dependent kinase 4
chr6_+_32090516	1.978	NM_007293 NM_001002029	C4A C4B	complement component 4A (Rodgers blood group) complement component 4B (Chido blood group)
chr17_+_73676219	1.976	NM_004710	SYNGR2	synaptogyrin 2
chr3_+_51992339	1.938	NM_000666 NM_001198895 NM_001198896 NM_001198897 NM_001198898	ACY1	aminoacylase 1
chr12_-_56432385	1.935	NM_000075	CDK4	cyclin-dependent kinase 4
chr17_+_77528782	1.916		ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1
chr11_+_384199	1.903	NM_007183	PKP3	plakophilin 3
chr6_-_33493792	1.851		CUTA	cutA divalent cation tolerance homolog (E. coli)
chr12_-_56432375	1.825		CDK4	cyclin-dependent kinase 4
chr11_+_66915997	1.818	NM_004584	RAD9A	RAD9 homolog A (S. pombe)
chr8_-_8788149	1.813	NM_004225	MFHAS1	malignant fibrous histiocytoma amplified sequence 1
chr9_-_99994704	1.809	NM_052820	CORO2A	coronin, actin binding protein, 2A
chr4_-_15694691	1.789	NM_001145847 NM_001145848	PROM1	prominin 1
chr19_-_46595053	1.767	NM_020158	EXOSC5	exosome component 5
chr1_+_40399618	1.757	NM_012421	RLF	rearranged L-myc fusion
chr16_+_84204424	1.750	NM_014615	KIAA0182	KIAA0182
chr8_+_95722448	1.744		ESRP1	epithelial splicing regulatory protein 1
chr14_-_23106372	1.724		AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr19_+_40431359	1.723	NM_015925 NM_205834 NM_205835	LSR	lipolysis stimulated lipoprotein receptor
chr1_-_159459814	1.713		APOA2	apolipoprotein A-II
chr6_-_35804337	1.706	NM_001145775	FKBP5	FK506 binding protein 5
chr1_+_65385799	1.700	NM_203464 NM_001005353	AK4	adenylate kinase 4
chr1_+_148521852	1.688	NM_144697	C1orf51	chromosome 1 open reading frame 51
chr1_+_40399642	1.685		RLF	rearranged L-myc fusion
chr6_+_87921980	1.638	NM_015021	ZNF292	zinc finger protein 292
chr17_+_77528699	1.635	NM_024083	ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1
chr1_-_12599934	1.576	NM_004753	DHRS3	dehydrogenase/reductase (SDR family) member 3
chr2_-_171999473	1.574	NM_024770	METTL8	methyltransferase like 8
chr12_-_109424260	1.570	NM_016226 NM_057180	VPS29	vacuolar protein sorting 29 homolog (S. cerevisiae)
chr17_-_38979178	1.561	NM_001079675	ETV4	ets variant 4
chr1_+_152459918	1.555	NM_014847	UBAP2L	ubiquitin associated protein 2-like
chr17_-_7078446	1.539	NM_004422	DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr17_+_75689985	1.539		GAA	glucosidase, alpha; acid
chr19_+_10673105	1.535	NM_031209	QTRT1	queuine tRNA-ribosyltransferase 1
chr11_-_118477739	1.514		DPAGT1	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr3_+_50629593	1.503		MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3
chr19_+_18145578	1.499	NM_006332	IFI30	interferon, gamma-inducible protein 30
chr22_-_35233032	1.495	NM_024955 NM_001102371	FOXRED2	FAD-dependent oxidoreductase domain containing 2
chr20_+_46971618	1.489	NM_006420	ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr9_+_130749791	1.479	NM_015354	NUP188	nucleoporin 188kDa
chr12_+_51628921	1.465	NM_199187 NM_000224	KRT18	keratin 18
chr11_+_384238	1.460		PKP3	plakophilin 3
chr6_+_31891509	1.459		HSPA1A HSPA1B	heat shock 70kDa protein 1A heat shock 70kDa protein 1B
chr2_+_74610039	1.452	NM_013247 NM_145074	HTRA2	HtrA serine peptidase 2
chr7_-_1562272	1.452	NM_001097620	TMEM184A	transmembrane protein 184A
chr2_+_47449790	1.442	NM_002354	EPCAM	epithelial cell adhesion molecule
chr16_+_57106883	1.426	NM_001160305 NM_024860	SETD6	SET domain containing 6
chr2_+_219751230	1.405		FAM134A	family with sequence similarity 134, member A
chr19_-_45948211	1.402		C19orf54	chromosome 19 open reading frame 54
chr8_+_22280942	1.400	NM_001135153	SLC39A14	solute carrier family 39 (zinc transporter), member 14
chr17_-_7078399	1.352		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr6_+_7486862	1.352	NM_001008844 NM_004415	DSP	desmoplakin
chr19_+_40431618	1.351		LSR	lipolysis stimulated lipoprotein receptor
chr6_+_138230045	1.343	NM_006290	TNFAIP3	tumor necrosis factor, alpha-induced protein 3
chr8_+_22280703	1.338	NM_001128431 NM_001135154 NM_015359	SLC39A14	solute carrier family 39 (zinc transporter), member 14
chr7_-_95789204	1.332	NM_001160210 NM_014251	SLC25A13	solute carrier family 25, member 13 (citrin)
chr8_+_98857190	1.326		LAPTM4B	lysosomal protein transmembrane 4 beta
chr6_+_7486836	1.316		DSP	desmoplakin
chr6_+_7052985	1.316	NM_001003698 NM_001003699 NM_001003700	RREB1	ras responsive element binding protein 1
chr8_+_22280731	1.311		SLC39A14	solute carrier family 39 (zinc transporter), member 14
chr2_+_219751192	1.309		FAM134A	family with sequence similarity 134, member A
chr6_-_33493898	1.302		CUTA	cutA divalent cation tolerance homolog (E. coli)
chr19_+_18145619	1.297		IFI30	interferon, gamma-inducible protein 30
chr7_+_150390566	1.296		SLC4A2	solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr8_+_61753793	1.290	NM_017780	CHD7	chromodomain helicase DNA binding protein 7
chr17_+_2627099	1.280		RAP1GAP2	RAP1 GTPase activating protein 2
chr6_+_32230172	1.273		PPT2	palmitoyl-protein thioesterase 2
chr17_-_73636386	1.272	NM_001127198	TMC6	transmembrane channel-like 6
chr6_+_32229771	1.271		PPT2-EGFL8 PPT2	PPT2-EGFL8 read-through transcript palmitoyl-protein thioesterase 2
chr17_+_46692908	1.267		UTP18	UTP18, small subunit (SSU) processome component, homolog (yeast)
chr1_+_1971762	1.266	NM_002744	PRKCZ	protein kinase C, zeta
chr6_-_47385313	1.266		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr2_+_169021039	1.262	NM_203463	LASS6	LAG1 homolog, ceramide synthase 6
chr4_+_74491272	1.261		ALB	albumin
chr9_+_696744	1.258	NM_153186	KANK1	KN motif and ankyrin repeat domains 1
chr11_+_118463906	1.257	NM_001024382	HMBS	hydroxymethylbilane synthase
chr6_+_31891293	1.254		HSPA1A	heat shock 70kDa protein 1A
chr6_-_53517466	1.251		GCLC	glutamate-cysteine ligase, catalytic subunit
chr3_-_4483939	1.237		SUMF1	sulfatase modifying factor 1
chr1_-_27113018	1.235	NM_021969	NR0B2	nuclear receptor subfamily 0, group B, member 2
chr17_+_70256397	1.231		SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr16_-_2037819	1.228	NM_002528	NTHL1	nth endonuclease III-like 1 (E. coli)
chr1_-_21868380	1.227	NM_001145657 NM_002885	RAP1GAP	RAP1 GTPase activating protein
chr7_-_23476497	1.227	NM_006547	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3
chr17_-_7078304	1.224		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr19_+_7608010	1.220		STXBP2	syntaxin binding protein 2
chr8_+_95722516	1.219	NM_001034915 NM_001122825 NM_001122826 NM_001122827 NM_017697	ESRP1	epithelial splicing regulatory protein 1
chr4_-_56996400	1.218	NM_002703	PPAT	phosphoribosyl pyrophosphate amidotransferase
chr17_-_2561676	1.215	NM_015229	KIAA0664	KIAA0664
chr6_-_47385205	1.211		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr16_+_67236699	1.210		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr2_+_215885063	1.208		ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr14_-_23727826	1.199		IPO4	importin 4
chr12_-_101835026	1.189		PAH	phenylalanine hydroxylase
chr1_-_159257567	1.187		F11R	F11 receptor
chr11_+_120828058	1.181	NM_003105	SORL1	sortilin-related receptor, L(DLR class) A repeats containing
chr10_+_69314347	1.173	NM_012238	SIRT1	sirtuin 1
chr2_+_215885053	1.169		ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr8_+_95722575	1.166		ESRP1	epithelial splicing regulatory protein 1
chr19_-_38485269	1.165	NM_004364	CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha
chr9_+_130749812	1.161		NUP188	nucleoporin 188kDa
chr19_+_7608015	1.160		STXBP2	syntaxin binding protein 2
chr12_+_51629164	1.158		KRT18	keratin 18
chrX_-_100549561	1.155	NM_000169	GLA	galactosidase, alpha
chr5_-_131160541	1.151		FNIP1	folliculin interacting protein 1
chr7_-_103417198	1.140	NM_005045 NM_173054	RELN	reelin
chr2_+_17585462	1.139		VSNL1	visinin-like 1
chr1_-_27689129	1.135		WASF2	WAS protein family, member 2
chr6_-_47385605	1.133	NM_014452	TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr19_+_7607976	1.133	NM_001127396 NM_006949	STXBP2	syntaxin binding protein 2
chr2_+_17585287	1.129	NM_003385	VSNL1	visinin-like 1
chr12_-_101835183	1.129		PAH	phenylalanine hydroxylase
chr17_-_31964723	1.128		MYO19	myosin XIX
chr6_+_32057779	1.128	NM_007293 NM_001002029	C4A C4B	complement component 4A (Rodgers blood group) complement component 4B (Chido blood group)
chr2_+_215884923	1.126	NM_004044	ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr16_+_29726962	1.124		MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)
chr17_+_70256389	1.120		SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr20_+_60744231	1.117	NM_016354	SLCO4A1	solute carrier organic anion transporter family, member 4A1
chr11_-_118477994	1.114	NM_001382	DPAGT1	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr11_-_107234733	1.112		SLC35F2	solute carrier family 35, member F2
chr6_+_7486891	1.110		DSP	desmoplakin
chr3_-_12983959	1.108	NM_014869	IQSEC1	IQ motif and Sec7 domain 1
chr1_-_159257486	1.102		F11R	F11 receptor
chr11_-_118757477	1.098		USP2	ubiquitin specific peptidase 2
chr12_-_121316907	1.095		VPS33A	vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr16_-_28410580	1.090	NM_000086	CLN3	ceroid-lipofuscinosis, neuronal 3
chr17_+_70256341	1.071	NM_004252	SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr6_-_47385470	1.068		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr12_-_121316997	1.067	NM_022916	VPS33A	vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr17_-_44058612	1.065	NM_024017	HOXB9	homeobox B9
chr22_-_35232979	1.059		FOXRED2	FAD-dependent oxidoreductase domain containing 2
chr17_-_77478835	1.058	NM_002359	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr20_+_60744268	1.056		SLCO4A1	solute carrier organic anion transporter family, member 4A1
chr9_-_132444639	1.051		LOC100272217	hypothetical LOC100272217
chr5_-_133734616	1.050		CDKL3	cyclin-dependent kinase-like 3
chr14_-_23727850	1.049	NM_024658	IPO4	importin 4
chr5_+_149717489	1.049		TCOF1	Treacher Collins-Franceschetti syndrome 1
chr1_+_11255831	1.048	NM_013319	UBIAD1	UbiA prenyltransferase domain containing 1
chr16_+_67236730	1.048		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr2_-_172675480	1.048	NM_004405	DLX2	distal-less homeobox 2
chr17_-_32730804	1.044	NM_198837 NM_198838	ACACA	acetyl-CoA carboxylase alpha
chr3_+_53855603	1.041	NM_018725	IL17RB	interleukin 17 receptor B
chr6_-_33494042	1.040	NM_001014433 NM_001014837 NM_001014838 NM_001014840 NM_015921	CUTA	cutA divalent cation tolerance homolog (E. coli)
chr2_-_219750975	1.031		C2orf24	chromosome 2 open reading frame 24
chrX_+_152608159	1.028	NM_001142806	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr1_+_44213229	1.028		ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chrX_-_131401319	1.027	NM_018388 NM_133486	MBNL3	muscleblind-like 3 (Drosophila)
chrX_-_100549444	1.016		GLA	galactosidase, alpha
chr1_+_116717552	1.009		ATP1A1	ATPase, Na+/K+ transporting, alpha 1 polypeptide
chrX_-_100490329	1.009	NM_001145951	TIMM8A	translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr1_+_10015577	1.002	NM_001105562 NM_006048	UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)
chr1_+_44213200	0.998		ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr20_+_47986342	0.996		RNF114	ring finger protein 114
chr6_-_43305156	0.996	NM_006443 NM_199184	C6orf108	chromosome 6 open reading frame 108
chr20_+_37024383	0.995	NM_001190809 NM_021931	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr2_+_28971007	0.993	NM_015131	WDR43	WD repeat domain 43
chrX_+_105823723	0.991	NM_024539	RNF128	ring finger protein 128
chr2_-_220116508	0.985	NM_024536	CHPF	chondroitin polymerizing factor
chr11_+_34083784	0.984		NAT10	N-acetyltransferase 10 (GCN5-related)
chr16_-_1465007	0.983		CLCN7	chloride channel 7
chr3_+_185515013	0.983		EIF4G1	eukaryotic translation initiation factor 4 gamma, 1
chr6_-_35996915	0.983	NM_003137	SRPK1	SRSF protein kinase 1
chr17_+_70256370	0.983		SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr7_-_99536966	0.980		MCM7	minichromosome maintenance complex component 7
chr22_-_17798998	0.979		HIRA	HIR histone cell cycle regulation defective homolog A (S. cerevisiae)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.22	1.15e-05	GO:0034641	cellular nitrogen compound metabolic process
1.22	2.50e-05	GO:0006807	nitrogen compound metabolic process
1.27	2.76e-05	GO:0090304	nucleic acid metabolic process
1.31	3.12e-05	GO:0016070	RNA metabolic process
1.30	4.68e-05	GO:0010467	gene expression
1.13	7.71e-05	GO:0044237	cellular metabolic process
1.53	1.47e-04	GO:0006396	RNA processing
1.13	2.42e-04	GO:0044238	primary metabolic process
1.21	9.75e-04	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.16	1.01e-03	GO:0044260	cellular macromolecule metabolic process
1.11	1.11e-03	GO:0008152	metabolic process
2.09	1.90e-03	GO:0042254	ribosome biogenesis
1.76	2.52e-03	GO:0034660	ncRNA metabolic process
1.41	5.44e-03	GO:0055085	transmembrane transport
1.86	7.53e-03	GO:0034470	ncRNA processing
1.06	8.74e-03	GO:0009987	cellular process
1.78	1.83e-02	GO:0022613	ribonucleoprotein complex biogenesis
1.20	1.88e-02	GO:0044249	cellular biosynthetic process
1.19	3.25e-02	GO:0009058	biosynthetic process
1.72	4.81e-02	GO:0071843	cellular component biogenesis at cellular level
1.12	4.85e-02	GO:0043170	macromolecule metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.32	6.09e-10	GO:0031974	membrane-enclosed lumen
1.33	1.34e-09	GO:0044428	nuclear part
1.32	3.22e-09	GO:0043233	organelle lumen
1.32	3.57e-09	GO:0070013	intracellular organelle lumen
1.36	4.28e-09	GO:0031981	nuclear lumen
1.18	3.31e-08	GO:0005634	nucleus
1.11	3.54e-08	GO:0043227	membrane-bounded organelle
1.11	5.31e-08	GO:0043231	intracellular membrane-bounded organelle
1.69	8.00e-08	GO:0005730	nucleolus
1.08	1.51e-07	GO:0005622	intracellular
1.08	3.42e-07	GO:0044424	intracellular part
1.10	5.21e-07	GO:0043226	organelle
1.10	7.16e-07	GO:0043229	intracellular organelle
1.32	8.43e-05	GO:0005654	nucleoplasm
1.13	4.66e-04	GO:0044422	organelle part
1.12	1.34e-03	GO:0044446	intracellular organelle part
1.17	2.90e-02	GO:0043228	non-membrane-bounded organelle
1.17	2.90e-02	GO:0043232	intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.42	2.11e-04	GO:0003723	RNA binding
2.18	2.79e-02	GO:0005275	amine transmembrane transporter activity