Motif ID: bHLH_family.p2

Z-value: 2.203


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MXD4chr4_-_2233504-0.665.5e-03Click!
MLXIPLchr7_-_726767500.591.6e-02Click!
ID1chr20_+_296567440.523.9e-02Click!
TFE3chrX_-_48787696-0.514.5e-02Click!
NPAS2chr2_+_1008029230.485.9e-02Click!
OLIG2chr21_+_33320080-0.401.2e-01Click!
ARNTL2chr12_+_27377034-0.302.6e-01Click!
MITFchr3_+_69895651-0.292.7e-01Click!
HEY1chr8_-_808424520.292.8e-01Click!
MXI1chr10_+_111959978,
chr10_+_111975618		0.282.9e-01Click!
ARNTLchr11_+_13255952-0.263.3e-01Click!
HEY2chr6_+_126112417,
chr6_+_126112506		0.175.2e-01Click!
MXD3chr5_-_176671437-0.175.4e-01Click!
HEYLchr1_-_39877928,
chr1_-_39877883,
chr1_-_39871226		0.107.1e-01Click!
MNTchr17_-_22509670.058.6e-01Click!
CLOCKchr4_-_561077250.048.7e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_61615124 4.332 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr12_-_61614930 3.751 NM_020700
 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chrX_+_152562013 3.659 DUSP9
dual specificity phosphatase 9
chr1_-_113300138 3.285 NM_001166496
 SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr6_+_160310118 3.261 NM_000876
 IGF2R
insulin-like growth factor 2 receptor
chr1_-_159459999 3.253 NM_001643
 APOA2
apolipoprotein A-II
chrX_+_130985316 3.185 NM_001042452
 MST4
serine/threonine protein kinase MST4
chr19_+_10625987 3.042 ILF3
interleukin enhancer binding factor 3, 90kDa
chr6_+_37245860 3.035 NM_002648
 PIM1
pim-1 oncogene
chr19_+_10626106 2.936 ILF3
interleukin enhancer binding factor 3, 90kDa
chr19_-_10625449 2.893 LOC147727
hypothetical LOC147727
chr2_-_208342296 2.855 NM_003468
 FZD5
frizzled homolog 5 (Drosophila)
chr17_-_73636362 2.722 TMC6
transmembrane channel-like 6
chr14_-_54438913 2.632 NM_000161
NM_001024024
NM_001024070
NM_001024071
 GCH1



GTP cyclohydrolase 1



chr16_-_66827449 2.628 NM_024939
 ESRP2
epithelial splicing regulatory protein 2
chrX_-_132947141 2.594 GPC3
glypican 3
chr2_+_218992053 2.536 NM_007127
 VIL1
villin 1
chr7_+_16759845 2.528 NM_014399
 TSPAN13
tetraspanin 13
chr14_-_93919305 2.484 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr17_+_77529070 2.475 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
2.09 1.90e-03 GO:0042254 ribosome biogenesis
1.86 7.53e-03 GO:0034470 ncRNA processing
1.78 1.83e-02 GO:0022613 ribonucleoprotein complex biogenesis
1.76 2.52e-03 GO:0034660 ncRNA metabolic process
1.72 4.81e-02 GO:0071843 cellular component biogenesis at cellular level
1.53 1.47e-04 GO:0006396 RNA processing
1.41 5.44e-03 GO:0055085 transmembrane transport
1.31 3.12e-05 GO:0016070 RNA metabolic process
1.30 4.68e-05 GO:0010467 gene expression
1.27 2.76e-05 GO:0090304 nucleic acid metabolic process
1.22 1.15e-05 GO:0034641 cellular nitrogen compound metabolic process
1.22 2.50e-05 GO:0006807 nitrogen compound metabolic process
1.21 9.75e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.20 1.88e-02 GO:0044249 cellular biosynthetic process
1.19 3.25e-02 GO:0009058 biosynthetic process
1.16 1.01e-03 GO:0044260 cellular macromolecule metabolic process
1.13 7.71e-05 GO:0044237 cellular metabolic process
1.13 2.42e-04 GO:0044238 primary metabolic process
1.12 4.85e-02 GO:0043170 macromolecule metabolic process
1.11 1.11e-03 GO:0008152 metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
1.69 8.00e-08 GO:0005730 nucleolus
1.36 4.28e-09 GO:0031981 nuclear lumen
1.33 1.34e-09 GO:0044428 nuclear part
1.32 6.09e-10 GO:0031974 membrane-enclosed lumen
1.32 3.22e-09 GO:0043233 organelle lumen
1.32 3.57e-09 GO:0070013 intracellular organelle lumen
1.32 8.43e-05 GO:0005654 nucleoplasm
1.18 3.31e-08 GO:0005634 nucleus
1.17 2.90e-02 GO:0043228 non-membrane-bounded organelle
1.17 2.90e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.13 4.66e-04 GO:0044422 organelle part
1.12 1.34e-03 GO:0044446 intracellular organelle part
1.11 3.54e-08 GO:0043227 membrane-bounded organelle
1.11 5.31e-08 GO:0043231 intracellular membrane-bounded organelle
1.10 5.21e-07 GO:0043226 organelle
1.10 7.16e-07 GO:0043229 intracellular organelle
1.08 1.51e-07 GO:0005622 intracellular
1.08 3.42e-07 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
2.18 2.79e-02 GO:0005275 amine transmembrane transporter activity
1.42 2.11e-04 GO:0003723 RNA binding