Motif ID: KLF4.p3

Z-value: 2.963


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_1092905280.674.7e-03Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_54835162 8.511 NM_006270
 RRAS
related RAS viral (r-ras) oncogene homolog
chr10_-_126839546 5.946 NM_001083914
 CTBP2
C-terminal binding protein 2
chr11_+_65443303 4.841 NM_006442
 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr11_+_65443452 4.808 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr10_-_126839056 4.779 NM_001329
 CTBP2
C-terminal binding protein 2
chr11_-_11987115 4.763 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr10_-_126839000 4.670 CTBP2
C-terminal binding protein 2
chrX_-_140098959 4.634 NM_012317
 LDOC1
leucine zipper, down-regulated in cancer 1
chrX_-_140098941 4.628 LDOC1
leucine zipper, down-regulated in cancer 1
chrX_-_140099014 4.547 LDOC1
leucine zipper, down-regulated in cancer 1
chr22_+_41877502 4.362 TSPO
translocator protein (18kDa)
chr12_-_45759691 4.336 NM_001143668
NM_181847
 AMIGO2

adhesion molecule with Ig-like domain 2

chr15_+_88732474 4.333 NM_003870
 IQGAP1
IQ motif containing GTPase activating protein 1
chr2_-_235070431 4.156 NM_005737
 ARL4C
ADP-ribosylation factor-like 4C
chr13_-_109236897 4.049 NM_003749
 IRS2
insulin receptor substrate 2
chr11_+_65443484 4.034 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr14_-_104515738 4.017 NM_138420
 AHNAK2
AHNAK nucleoprotein 2
chr17_+_45488330 3.978 NM_002204
NM_005501
 ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chrX_+_48915127 3.962 NM_002668
 PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr19_+_43447262 3.951 SPINT2
serine peptidase inhibitor, Kunitz type, 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
1.26 3.27e-02 GO:0034613 cellular protein localization
1.25 3.94e-02 GO:0070727 cellular macromolecule localization
1.24 1.12e-03 GO:0046907 intracellular transport
1.19 5.59e-04 GO:0051641 cellular localization
1.19 5.13e-03 GO:0051649 establishment of localization in cell
1.19 1.13e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.14 1.41e-03 GO:0048523 negative regulation of cellular process
1.12 3.57e-03 GO:0048519 negative regulation of biological process
1.09 2.28e-02 GO:0023052 signaling
1.08 4.55e-06 GO:0050794 regulation of cellular process
1.07 1.25e-05 GO:0050789 regulation of biological process
1.06 4.97e-05 GO:0065007 biological regulation
1.06 1.14e-02 GO:0044237 cellular metabolic process
1.05 1.44e-07 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.51 3.97e-02 GO:0019717 synaptosome
1.31 1.44e-02 GO:0015629 actin cytoskeleton
1.28 1.00e-02 GO:0045202 synapse
1.28 4.95e-02 GO:0005773 vacuole
1.26 1.72e-03 GO:0030054 cell junction
1.20 8.61e-04 GO:0044430 cytoskeletal part
1.17 1.59e-04 GO:0005856 cytoskeleton
1.16 1.17e-06 GO:0005829 cytosol
1.16 4.17e-02 GO:0005794 Golgi apparatus
1.13 2.58e-02 GO:0012505 endomembrane system
1.12 7.25e-05 GO:0043234 protein complex
1.11 2.71e-02 GO:0031090 organelle membrane
1.10 2.60e-02 GO:0043228 non-membrane-bounded organelle
1.10 2.60e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.09 1.14e-16 GO:0005737 cytoplasm
1.09 5.67e-09 GO:0044444 cytoplasmic part
1.09 1.04e-07 GO:0044446 intracellular organelle part
1.09 1.59e-07 GO:0044422 organelle part
1.08 1.60e-02 GO:0032991 macromolecular complex
1.07 4.40e-12 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.12 3.00e-02 GO:0017076 purine nucleotide binding
1.12 3.35e-02 GO:0032553 ribonucleotide binding
1.12 3.35e-02 GO:0032555 purine ribonucleotide binding
1.12 4.22e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.11 4.23e-02 GO:0000166 nucleotide binding
1.10 2.67e-15 GO:0005515 protein binding
1.03 1.24e-02 GO:0005488 binding