Motif ID: ESR1.p2

Z-value: 1.185


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_152168500-0.175.2e-01Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_129445002 1.497 APLP2
amyloid beta (A4) precursor-like protein 2
chr11_+_129445017 1.492 APLP2
amyloid beta (A4) precursor-like protein 2
chr11_+_129444997 1.293 APLP2
amyloid beta (A4) precursor-like protein 2
chr22_-_18309447 1.271 TXNRD2
thioredoxin reductase 2
chr11_+_129444877 1.226 NM_001142276
NM_001142277
NM_001142278
NM_001642
APLP2



amyloid beta (A4) precursor-like protein 2



chr4_-_57671307 1.203 IGFBP7
insulin-like growth factor binding protein 7
chr6_+_31976754 1.132 NM_001178063
C2
complement component 2
chr6_+_148705646 1.109 SASH1
SAM and SH3 domain containing 1
chr6_+_148705421 1.082 NM_015278
SASH1
SAM and SH3 domain containing 1
chr15_-_50375143 1.065 NM_018728
MYO5C
myosin VC
chr22_-_18309333 1.027 NM_006440
TXNRD2
thioredoxin reductase 2
chr10_+_115428924 1.019 NM_033340
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr7_+_45894480 0.990 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr22_-_18309250 0.978 TXNRD2
thioredoxin reductase 2
chr6_+_7486836 0.960 DSP
desmoplakin
chr16_+_54072969 0.937 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr18_+_53862744 0.936 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_+_7486891 0.924 DSP
desmoplakin
chr11_-_116213511 0.924 NM_000039
APOA1
apolipoprotein A-I
chr6_+_7486862 0.920 NM_001008844
NM_004415
DSP

desmoplakin

chr17_-_72218535 0.901 NM_001008528
NM_001008529
NM_198530
MXRA7


matrix-remodelling associated 7


chr1_-_94475504 0.897 ARHGAP29
Rho GTPase activating protein 29
chr17_+_77261477 0.864 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr18_+_53862888 0.864 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_53862386 0.845 NM_001144967
NM_015277
NEDD4L

neural precursor cell expressed, developmentally down-regulated 4-like

chr1_-_94475840 0.826 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr6_-_47385313 0.825 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr16_+_64958025 0.823 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr9_-_73573121 0.793 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr21_+_41461924 0.790 BACE2
beta-site APP-cleaving enzyme 2
chr13_+_109757593 0.763 NM_001846
COL4A2
collagen, type IV, alpha 2
chr19_-_18578631 0.760 NM_004750
CRLF1
cytokine receptor-like factor 1
chr7_-_47588160 0.751 TNS3
tensin 3
chr7_-_47588266 0.728 TNS3
tensin 3
chr17_+_77261440 0.724 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr4_+_184257337 0.720 NM_024949
WWC2
WW and C2 domain containing 2
chr17_+_77261447 0.719 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr6_+_17501589 0.707 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr19_-_18578577 0.704 CRLF1
cytokine receptor-like factor 1
chr19_-_18578467 0.698 CRLF1
cytokine receptor-like factor 1
chr13_-_102249263 0.689 NM_024089
KDELC1
KDEL (Lys-Asp-Glu-Leu) containing 1
chrX_+_117745551 0.687 NM_001560
IL13RA1
interleukin 13 receptor, alpha 1
chr19_-_11234117 0.674 NM_020812
DOCK6
dedicator of cytokinesis 6
chr6_-_47385205 0.673 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_167342149 0.662 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_-_1727247 0.658 PXDN
peroxidasin homolog (Drosophila)
chr12_-_123023312 0.658 CCDC92
coiled-coil domain containing 92
chr2_-_1727324 0.656 PXDN
peroxidasin homolog (Drosophila)
chr17_+_77261401 0.654 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr11_-_82289006 0.654 NM_005040
NM_199418
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr2_+_236067424 0.645 NM_001037131
NM_014914
AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr19_+_54707739 0.638 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_-_2118916 0.637 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr22_-_36245155 0.636 NM_014550
CARD10
caspase recruitment domain family, member 10
chr2_+_187162969 0.636 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr17_+_71893014 0.621 SPHK1
sphingosine kinase 1
chr11_+_129445057 0.620 APLP2
amyloid beta (A4) precursor-like protein 2
chr21_+_41461962 0.616 BACE2
beta-site APP-cleaving enzyme 2
chr16_+_55217085 0.611 NM_175617
MT1E
metallothionein 1E
chr6_+_148705817 0.609 SASH1
SAM and SH3 domain containing 1
chr17_+_71892538 0.608 SPHK1
sphingosine kinase 1
chr17_+_71892271 0.605 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr9_+_136673464 0.601 NM_000093
COL5A1
collagen, type V, alpha 1
chr13_-_109757442 0.599 NM_001845
COL4A1
collagen, type IV, alpha 1
chr7_-_50828159 0.595 GRB10
growth factor receptor-bound protein 10
chr10_+_129595289 0.591 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr2_-_101134146 0.582 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr9_-_83493415 0.579 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr16_+_81218074 0.578 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr12_-_123023052 0.570 NM_025140
CCDC92
coiled-coil domain containing 92
chr4_-_122837501 0.562 ANXA5
annexin A5
chr3_+_52504391 0.561 NM_015136
STAB1
stabilin 1
chr21_+_45649719 0.560


chr10_-_126839546 0.558 NM_001083914
CTBP2
C-terminal binding protein 2
chr4_-_122837590 0.557 NM_001154
ANXA5
annexin A5
chr17_-_3518654 0.556 NM_014604
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr17_+_71892781 0.556 NM_001142602
SPHK1
sphingosine kinase 1
chr7_-_27190882 0.550 HOXA11
homeobox A11
chr11_+_822965 0.540 CD151
CD151 molecule (Raph blood group)
chr4_-_40911212 0.538 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr11_+_67836575 0.536 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr5_+_150380325 0.533 GPX3
glutathione peroxidase 3 (plasma)
chr4_+_4912272 0.532 NM_002448
MSX1
msh homeobox 1
chr3_+_52464657 0.532 NISCH
nischarin
chr4_-_122837579 0.532 ANXA5
annexin A5
chr5_+_150380270 0.529 GPX3
glutathione peroxidase 3 (plasma)
chr12_+_50631704 0.528 NM_004302
NM_020328
ACVR1B

activin A receptor, type IB

chr17_+_72648580 0.518 NM_001039573
NM_001143998
NM_001143999
NM_003003
SEC14L1



SEC14-like 1 (S. cerevisiae)



chr19_+_40242634 0.517 HPN
hepsin
chr22_+_42651007 0.501 PNPLA3
patatin-like phospholipase domain containing 3
chr5_+_150380173 0.501 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr22_+_42650951 0.501 NM_025225
PNPLA3
patatin-like phospholipase domain containing 3
chr16_+_8675904 0.496 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr11_-_63138516 0.494 NM_001128203
PLA2G16
phospholipase A2, group XVI
chr22_+_42651018 0.492 PNPLA3
patatin-like phospholipase domain containing 3
chr11_-_63138061 0.491 PLA2G16
phospholipase A2, group XVI
chr11_-_63138483 0.486 NM_007069
PLA2G16
phospholipase A2, group XVI
chr11_-_63138416 0.485 PLA2G16
phospholipase A2, group XVI
chr17_-_72218661 0.485 MXRA7
matrix-remodelling associated 7
chr2_-_1727292 0.483 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr19_+_54708247 0.482 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_-_120810899 0.478 NM_001171993
HPD
4-hydroxyphenylpyruvate dioxygenase
chr19_+_40224457 0.476 HPN
hepsin
chr7_+_93976927 0.476 NM_022900
CASD1
CAS1 domain containing 1
chr21_+_17807167 0.472 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr19_+_47521600 0.471 NM_001410
MEGF8
multiple EGF-like-domains 8
chr17_-_3518568 0.466 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr5_-_141041933 0.465 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr9_+_123003549 0.463 GSN
gelsolin
chr19_+_54708302 0.461 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr17_+_72648696 0.460 SEC14L1
SEC14-like 1 (S. cerevisiae)
chr5_-_141041982 0.454 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr7_-_29995809 0.453 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr1_-_27113018 0.450 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr5_+_176446425 0.448 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr6_+_7672009 0.447 NM_001718
BMP6
bone morphogenetic protein 6
chr17_-_3518628 0.444 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr20_-_61039672 0.441 DIDO1
death inducer-obliterator 1
chr2_+_219354692 0.441 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr2_+_218992053 0.433 NM_007127
VIL1
villin 1
chr7_-_50828608 0.428 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr19_+_40224480 0.421 HPN
hepsin
chr6_-_47385470 0.416 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_181259317 0.412


chr9_-_14303509 0.412 NFIB
nuclear factor I/B
chr2_-_242096673 0.410 NM_006374
STK25
serine/threonine kinase 25
chr20_-_23566325 0.409 NM_000099
CST3
cystatin C
chr17_+_19377732 0.403 NM_018242
SLC47A1
solute carrier family 47, member 1
chr7_+_73506047 0.403 NM_016328
GTF2IRD1
GTF2I repeat domain containing 1
chr19_+_54708312 0.402 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_-_224612177 0.398 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr9_-_13269562 0.398 MPDZ
multiple PDZ domain protein
chr6_+_107917965 0.398 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr2_-_20714303 0.397 NM_022460
HS1BP3
HCLS1 binding protein 3
chr14_+_73073570 0.397 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr7_+_93977267 0.395 CASD1
CAS1 domain containing 1
chr17_-_75808680 0.393 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr1_+_149779384 0.392 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr22_-_18309312 0.384 TXNRD2
thioredoxin reductase 2
chr18_+_53967544 0.383 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr2_+_85213884 0.381 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr5_+_79739548 0.378 NM_001105251
NM_014733
ZFYVE16

zinc finger, FYVE domain containing 16

chr9_+_96528764 0.374 NM_001193331
NM_032823
C9orf3

chromosome 9 open reading frame 3

chr13_+_112670757 0.374 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr22_+_36632242 0.374 NM_033386
MICALL1
MICAL-like 1
chr9_+_96528814 0.370 C9orf3
chromosome 9 open reading frame 3
chr2_-_242096592 0.364 STK25
serine/threonine kinase 25
chr2_-_21079145 0.360 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_+_105012106 0.356 NM_001312
CRIP2
cysteine-rich protein 2
chr9_-_139202831 0.354 ANAPC2
anaphase promoting complex subunit 2
chr11_-_72031083 0.351 NM_001143839
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr4_-_89299034 0.350 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr2_-_242096122 0.350 STK25
serine/threonine kinase 25
chr6_-_47385605 0.344 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr9_-_139202855 0.342 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr19_-_4351357 0.342 SH3GL1
SH3-domain GRB2-like 1
chr12_-_69317441 0.341 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr12_-_105165805 0.339 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr19_+_15079141 0.337 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr13_+_112681626 0.337 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr6_-_33374678 0.335 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr7_+_73506172 0.334 GTF2IRD1
GTF2I repeat domain containing 1
chr8_+_38973681 0.325 ADAM9
ADAM metallopeptidase domain 9
chr5_-_1165106 0.324 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr13_+_97593411 0.323 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr21_-_45118037 0.321 NM_004339
PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr19_+_54707637 0.320 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr3_+_52504410 0.320 STAB1
stabilin 1
chr3_-_173010921 0.319 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr16_-_55876099 0.319 PLLP
plasmolipin
chr2_-_219802482 0.315 ATG9A
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr18_+_18003401 0.314 NM_005257
GATA6
GATA binding protein 6
chr16_-_55876075 0.313 NM_015993
PLLP
plasmolipin
chr22_+_36927884 0.312 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr13_+_112789669 0.312 MCF2L
MCF.2 cell line derived transforming sequence-like
chr17_+_50697355 0.312 HLF
hepatic leukemia factor
chr8_+_38973588 0.311 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr13_-_27967215 0.311 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr19_+_50041424 0.311 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr2_+_36436873 0.310 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr12_-_78608154 0.310 PAWR
PRKC, apoptosis, WT1, regulator
chr7_-_35044177 0.309 NM_015283
DPY19L1
dpy-19-like 1 (C. elegans)
chr16_+_3055313 0.308 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr16_+_55217180 0.307 MT1E
metallothionein 1E
chr2_+_182464713 0.307 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr8_+_123863224 0.306 ZHX2
zinc fingers and homeoboxes 2
chr10_-_52315390 0.306 A1CF
APOBEC1 complementation factor
chr6_-_2916280 0.304 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr17_-_34635446 0.301 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr8_+_61753793 0.299 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr9_-_110736143 0.297 IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr9_-_139202804 0.296 ANAPC2
anaphase promoting complex subunit 2
chr19_+_50041400 0.296 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr11_+_823007 0.294 CD151
CD151 molecule (Raph blood group)
chr6_-_52549673 0.294 TRAM2
translocation associated membrane protein 2
chr7_+_142789476 0.293 ZYX
zyxin
chr9_-_110736377 0.293 NM_003640
IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr8_-_11762918 0.289 CTSB
cathepsin B
chr19_-_18913011 0.288 HOMER3
homer homolog 3 (Drosophila)
chr6_-_52549774 0.282 NM_012288
TRAM2
translocation associated membrane protein 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.70 1.90e-02 GO:0019199 transmembrane receptor protein kinase activity
1.12 4.64e-02 GO:0005515 protein binding