Motif ID: GLI1..3.p2

Z-value: 0.939


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GLI3chr7_-_422431420.421.1e-01Click!
GLI1chr12_+_56140184-0.136.2e-01Click!
GLI2chr2_+_121271336-0.029.6e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_37660568 2.399 NM_003246
THBS1
thrombospondin 1
chr3_-_31998241 1.655 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chrX_+_55951280 1.490


chr10_+_53744043 1.303 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr19_-_54835162 1.302 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr7_+_100557098 1.288 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr6_-_3697244 1.287 NM_183373
C6orf145
chromosome 6 open reading frame 145
chr1_+_43837096 1.196 PTPRF
protein tyrosine phosphatase, receptor type, F
chr17_+_15788955 1.145 NM_000676
ADORA2B
adenosine A2b receptor
chr2_+_9264360 1.141 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr3_-_31997738 1.138 OSBPL10
oxysterol binding protein-like 10
chr3_-_187025501 1.081 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr5_-_121440704 1.067 NM_001178102
LOX
lysyl oxidase
chr16_+_31390567 1.050 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr8_-_17599438 1.021 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr11_+_44074322 1.010 NM_000401
EXT2
exostosin 2
chr2_+_9264327 0.990 NM_001135191
NM_003887
ASAP2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

chr5_+_52812165 0.985 FST
follistatin
chr21_+_17807167 0.948 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr10_-_46593923 0.945 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr22_+_36531246 0.937 H1F0
H1 histone family, member 0
chr1_-_151804929 0.928 NM_005978
S100A2
S100 calcium binding protein A2
chr10_+_47216925 0.924 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr20_-_36191623 0.877 TGM2
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr8_+_21972631 0.848 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr2_-_26058831 0.845 KIF3C
kinesin family member 3C
chr8_+_21972804 0.833 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr14_-_51605695 0.826 NM_007361
NID2
nidogen 2 (osteonidogen)
chr6_+_7486836 0.793 DSP
desmoplakin
chr2_-_20075889 0.788 MATN3
matrilin 3
chr9_-_98368913 0.787 NM_001077181
CDC14B
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr1_+_201862552 0.786 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr5_+_71438796 0.785 NM_005909
MAP1B
microtubule-associated protein 1B
chr4_+_166519392 0.780 NM_001873
CPE
carboxypeptidase E
chr20_-_6052056 0.779 NM_017671
FERMT1
fermitin family member 1
chr6_+_7486891 0.771 DSP
desmoplakin
chr8_+_31616809 0.760 NM_013962
NRG1
neuregulin 1
chr14_-_51605487 0.745 NID2
nidogen 2 (osteonidogen)
chr22_+_36531178 0.742 H1F0
H1 histone family, member 0
chr11_+_19691397 0.741 NM_145117
NM_182964
NAV2

neuron navigator 2

chrX_+_152608159 0.734 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr5_+_150380325 0.725 GPX3
glutathione peroxidase 3 (plasma)
chr12_-_51132129 0.718 NM_005555
KRT6B
keratin 6B
chr14_-_51605515 0.711 NID2
nidogen 2 (osteonidogen)
chr19_-_18910790 0.698 NM_001145724
HOMER3
homer homolog 3 (Drosophila)
chr7_-_47545717 0.692 NM_022748
TNS3
tensin 3
chr19_+_50109903 0.690 APOC1
apolipoprotein C-I
chr10_+_47875229 0.690 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr7_-_80386602 0.686 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chrX_-_140098941 0.676 LDOC1
leucine zipper, down-regulated in cancer 1
chr5_+_52812236 0.672 NM_006350
NM_013409
FST

follistatin

chr4_-_90977149 0.655 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr2_-_242096673 0.644 NM_006374
STK25
serine/threonine kinase 25
chr14_-_51605461 0.640 NID2
nidogen 2 (osteonidogen)
chr1_+_201862548 0.633 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chrX_-_140098959 0.630 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr1_-_12599934 0.629 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr1_+_19842309 0.609 NM_182744
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr19_-_56147971 0.607 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr1_+_181422016 0.606 LAMC2
laminin, gamma 2
chr11_-_2108035 0.598 IGF2
insulin-like growth factor 2 (somatomedin A)
chr11_-_65871592 0.595 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr10_-_118754549 0.587 KIAA1598
KIAA1598
chr20_+_61798446 0.581 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr2_-_242096122 0.580 STK25
serine/threonine kinase 25
chr7_-_80386258 0.576 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chrX_-_140099014 0.570 LDOC1
leucine zipper, down-regulated in cancer 1
chr17_-_6958695 0.557 ASGR2
asialoglycoprotein receptor 2
chr17_-_8474733 0.552 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr1_-_20682541 0.546


chr3_-_187025438 0.546 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chrX_+_51944658 0.545 NM_001098800
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B


melanoma antigen family D, 4
melanoma antigen family D, 4B


chr17_-_36996611 0.543 NM_000526
KRT14
keratin 14
chr7_+_129918408 0.540 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr16_+_67778441 0.536 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr7_-_94902149 0.530 NM_000305
NM_001018161
PON2

paraoxonase 2

chr17_-_6958773 0.526 NM_001181
NM_080912
NM_080913
ASGR2


asialoglycoprotein receptor 2


chrX_-_119487164 0.521 LAMP2
lysosomal-associated membrane protein 2
chr12_+_77782648 0.518 SYT1
synaptotagmin I
chr16_-_66827449 0.516 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr16_+_55249355 0.515 NM_005949
MT1F
metallothionein 1F
chrX_-_119487096 0.515 LAMP2
lysosomal-associated membrane protein 2
chr2_+_101874765 0.508 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr7_-_100262971 0.507 NM_004444
EPHB4
EPH receptor B4
chr5_+_141468568 0.505 NDFIP1
Nedd4 family interacting protein 1
chr2_-_20075929 0.503 NM_002381
MATN3
matrilin 3
chr2_-_242096592 0.502 STK25
serine/threonine kinase 25
chr20_+_61798512 0.498 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr10_+_8137356 0.495 GATA3
GATA binding protein 3
chr10_+_8136778 0.490 GATA3
GATA binding protein 3
chr2_-_20288108 0.484 NM_002997
SDC1
syndecan 1
chr6_-_138470160 0.483 NM_022121
PERP
PERP, TP53 apoptosis effector
chr15_-_27901828 0.481 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr7_+_129919157 0.477 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chrX_+_151837064 0.476 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr4_+_74953971 0.473 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr8_-_142080169 0.471 NM_005607
NM_153831
PTK2

PTK2 protein tyrosine kinase 2

chr17_-_6958282 0.470 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr10_+_104493714 0.469 NM_001083913
C10orf26
chromosome 10 open reading frame 26
chr21_+_41461962 0.468 BACE2
beta-site APP-cleaving enzyme 2
chr11_-_72057755 0.466 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr1_+_31814672 0.463 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chrX_-_108863109 0.462 ACSL4
acyl-CoA synthetase long-chain family member 4
chr1_+_34993234 0.461 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr17_+_15789147 0.460 ADORA2B
adenosine A2b receptor
chr16_-_16224791 0.459 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr18_+_7557313 0.446 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr22_-_37969897 0.445 PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chrX_-_108863165 0.444 NM_004458
NM_022977
ACSL4

acyl-CoA synthetase long-chain family member 4

chr6_-_46811388 0.443 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr19_+_50109416 0.442 APOC1
apolipoprotein C-I
chrX_+_102518764 0.440 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr1_+_149779384 0.435 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr17_+_58058783 0.431 MRC2
mannose receptor, C type 2
chr2_+_101874809 0.428 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr19_+_50004134 0.428 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr6_+_32021687 0.424 NM_001710
CFB
complement factor B
chr20_+_43468617 0.421 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr12_+_6923441 0.421 NM_138425
C12orf57
chromosome 12 open reading frame 57
chr2_-_20288647 0.420 NM_001006946
SDC1
syndecan 1
chr13_+_112808102 0.415 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr5_+_71538456 0.412 MAP1B
microtubule-associated protein 1B
chr1_-_20685314 0.410 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_+_31814709 0.410 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr20_-_22512893 0.410 FOXA2
forkhead box A2
chr7_+_94130673 0.408 PEG10
paternally expressed 10
chr17_-_37022465 0.406 NM_005557
KRT16
keratin 16
chr9_-_112840064 0.403 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr3_-_130761967 0.402 PLXND1
plexin D1
chr13_+_109935250 0.402 COL4A2
collagen, type IV, alpha 2
chr7_-_107883929 0.399 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr5_+_92946348 0.399 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr9_+_123101926 0.396 GSN
gelsolin
chr12_+_77782719 0.395 SYT1
synaptotagmin I
chr6_+_7486862 0.394 NM_001008844
NM_004415
DSP

desmoplakin

chr18_+_54013575 0.394 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_-_74432800 0.392 TIMP2
TIMP metallopeptidase inhibitor 2
chr4_-_186934059 0.388 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr1_-_43005312 0.388 NM_001146289
NM_022356
LEPRE1

leucine proline-enriched proteoglycan (leprecan) 1

chr10_+_120853548 0.387 FAM45A
family with sequence similarity 45, member A
chr2_-_220116508 0.384 NM_024536
CHPF
chondroitin polymerizing factor
chr12_-_45052286 0.382 SLC38A2
solute carrier family 38, member 2
chr2_+_24126140 0.382 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr2_-_227372574 0.382 IRS1
insulin receptor substrate 1
chr7_+_116099648 0.381 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr5_-_168204430 0.376


chr5_+_176449156 0.375 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr15_+_88610181 0.374 NGRN
neugrin, neurite outgrowth associated
chr6_+_83130220 0.373 TPBG
trophoblast glycoprotein
chr3_+_187917791 0.373 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr1_+_20788027 0.372 NM_001785
CDA
cytidine deaminase
chr16_-_62573 0.372 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr2_+_24126087 0.372 NM_004116
NM_054033
FKBP1B

FK506 binding protein 1B, 12.6 kDa

chr13_+_113574925 0.368 NM_001143945
GAS6
growth arrest-specific 6
chr17_-_77634455 0.367 FASN
fatty acid synthase
chrX_-_119487183 0.364 NM_001122606
NM_002294
NM_013995
LAMP2


lysosomal-associated membrane protein 2


chr21_-_43903755 0.363 NM_007031
HSF2BP
heat shock transcription factor 2 binding protein
chr12_-_51200347 0.362 NM_000424
KRT5
keratin 5
chr12_-_45052830 0.361 NM_018976
SLC38A2
solute carrier family 38, member 2
chr1_-_180621272 0.359 GLUL
glutamate-ammonia ligase
chr1_+_31814712 0.359 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr22_-_36998889 0.359 TMEM184B
transmembrane protein 184B
chr22_-_17891777 0.356 CLDN5
claudin 5
chr4_+_1764802 0.355 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr18_+_19706979 0.354 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr14_-_34169047 0.353 NM_021249
NM_152233
SNX6

sorting nexin 6

chr10_+_5556923 0.353 NM_005185
CALML3
calmodulin-like 3
chr11_+_46359781 0.349 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr13_+_112789669 0.348 MCF2L
MCF.2 cell line derived transforming sequence-like
chr16_+_27232745 0.348 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr3_-_10042989 0.347 CIDECP
cell death-inducing DFFA-like effector c pseudogene
chr1_+_36462583 0.346 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr20_+_3399615 0.346 NM_139321
NM_139322
ATRN

attractin

chr1_-_55125469 0.345 DHCR24
24-dehydrocholesterol reductase
chr2_-_220144427 0.344 OBSL1
obscurin-like 1
chr22_-_36998912 0.343 NM_001195072
NM_012264
TMEM184B

transmembrane protein 184B

chr17_+_37372222 0.343 NM_033133
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr2_-_175578156 0.340 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr9_+_123101701 0.339 NM_000177
GSN
gelsolin
chr14_-_104515738 0.339 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr5_-_175776137 0.338 NM_001834
NM_007097
CLTB

clathrin, light chain B

chrX_+_43400350 0.335 NM_000240
MAOA
monoamine oxidase A
chr2_+_188865796 0.334 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr6_-_2785682 0.334 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr2_+_188865634 0.333 NM_016315
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr11_+_46359836 0.333 MDK
midkine (neurite growth-promoting factor 2)
chr2_+_10361276 0.331 NM_134421
HPCAL1
hippocalcin-like 1
chr9_+_35663852 0.328 NM_001216
CA9
carbonic anhydrase IX
chr8_-_134653194 0.327 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr10_+_121401061 0.324 BAG3
BCL2-associated athanogene 3
chr2_+_241023703 0.322 NM_002081
GPC1
glypican 1
chr17_-_1342700 0.321 NM_001080779
MYO1C
myosin IC
chr2_-_26058941 0.319 NM_002254
KIF3C
kinesin family member 3C
chr16_+_56259657 0.319 NM_170776
GPR97
G protein-coupled receptor 97
chr16_+_54072969 0.319 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_-_43005243 0.318 LEPRE1
leucine proline-enriched proteoglycan (leprecan) 1
chr12_-_51173238 0.318 NM_005554
KRT6A
keratin 6A
chr1_+_218930542 0.317 C1orf115
chromosome 1 open reading frame 115
chr21_+_41461597 0.316 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr6_-_166960690 0.315 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.32 5.08e-07 GO:0048856 anatomical structure development
1.32 2.59e-06 GO:0048731 system development
1.47 4.69e-06 GO:0009653 anatomical structure morphogenesis
1.26 8.64e-06 GO:0032502 developmental process
1.26 8.28e-05 GO:0007275 multicellular organismal development
1.20 1.53e-04 GO:0032501 multicellular organismal process
1.38 9.31e-04 GO:0023051 regulation of signaling
1.39 2.09e-03 GO:0009966 regulation of signal transduction
1.31 4.33e-03 GO:0048869 cellular developmental process
1.31 6.31e-03 GO:0030154 cell differentiation
1.36 8.12e-03 GO:0007399 nervous system development
1.45 2.44e-02 GO:0048468 cell development
1.39 4.46e-02 GO:0010646 regulation of cell communication

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.20 3.87e-04 GO:0070161 anchoring junction
2.21 1.27e-03 GO:0005912 adherens junction
2.43 3.20e-03 GO:0005925 focal adhesion
2.33 7.76e-03 GO:0005924 cell-substrate adherens junction
1.53 1.39e-02 GO:0030054 cell junction
2.23 1.76e-02 GO:0030055 cell-substrate junction
1.09 2.19e-02 GO:0005737 cytoplasm
1.77 4.06e-02 GO:0016323 basolateral plasma membrane
1.30 4.42e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 5.56e-03 GO:0005515 protein binding
1.44 8.28e-03 GO:0030234 enzyme regulator activity
1.95 1.33e-02 GO:0005543 phospholipid binding
1.76 3.04e-02 GO:0005083 small GTPase regulator activity