Motif ID: VSX1,2.p2

Z-value: 0.321


Transcription factors associated with VSX1,2.p2:

Gene SymbolEntrez IDGene Name
VSX1 30813 visual system homeobox 1
VSX2 338917 visual system homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
VSX1chr20_-_250107560.381.5e-01Click!


Activity profile for motif VSX1,2.p2.

activity profile for motif VSX1,2.p2


Sorted Z-values histogram for motif VSX1,2.p2

Sorted Z-values for motif VSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of VSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_169654742 0.997 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chrX_+_43400385 0.937 MAOA
monoamine oxidase A
chrX_+_43400350 0.929 NM_000240
MAOA
monoamine oxidase A
chrX_+_43400475 0.815 MAOA
monoamine oxidase A
chr11_-_117640407 0.633 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr16_+_54072969 0.378 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr18_+_59705918 0.368 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr6_-_47361921 0.317 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr3_-_127810087 0.235 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr6_-_112033752 0.231 TRAF3IP2
TRAF3 interacting protein 2
chr4_-_169476391 0.228 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr6_+_121798443 0.207 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr12_+_28301399 0.191 NM_018318
CCDC91
coiled-coil domain containing 91
chr18_+_3437607 0.184 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr11_-_4371463 0.141 NM_003141
TRIM21
tripartite motif containing 21
chr6_-_166960690 0.140 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr5_-_39430180 0.128 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr4_-_57242492 0.127 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr8_+_54926920 0.115 NM_170587
RGS20
regulator of G-protein signaling 20
chr11_-_128399218 0.112 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr3_+_161040343 0.110 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr6_-_112034166 0.094 NM_001164281
NM_147686
TRAF3IP2

TRAF3 interacting protein 2

chr3_+_113200696 0.088 NM_001008273
TAGLN3
transgelin 3
chr9_+_130428519 0.075 SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
chr4_+_70831387 0.075 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr11_-_117640166 0.067 MPZL2
myelin protein zero-like 2
chr14_-_77152862 0.065 NM_004863
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr11_-_17147863 0.061 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr10_+_96433240 0.055 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr8_+_9450800 0.055 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr1_+_28134090 0.052 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr6_+_151688327 0.050 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr8_+_9990471 0.048 NM_001135671
MSRA
methionine sulfoxide reductase A
chr8_-_62764839 0.048 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr7_+_2524022 0.048 NM_002304
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chrX_+_55951280 0.046


chr3_+_113200275 0.045 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr5_+_36642424 0.044 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_+_115396020 0.038 NM_144489
RGS3
regulator of G-protein signaling 3
chr10_+_5126613 0.032 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_+_158426908 0.031 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr2_-_217268492 0.029 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr7_+_37689903 0.029


chr3_-_166278969 0.027 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr7_-_30032649 0.027 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr7_-_83662152 0.027 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr10_+_32896656 0.026 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr9_+_131937163 0.026 GPR107
G protein-coupled receptor 107
chr4_+_78651929 0.025 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr15_-_70350609 0.025 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chr2_-_218739891 0.023 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr10_+_5126589 0.023 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr4_-_66218777 0.023 EPHA5
EPH receptor A5
chr6_+_29187565 0.023 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr11_-_128567302 0.023 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr3_+_110024234 0.021 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr4_-_39655944 0.020 NM_001100399
NM_001100400
PDS5A

PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)

chr4_+_88790477 0.020 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr17_-_26648375 0.019 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr10_+_18729518 0.019 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr1_+_117345894 0.019 NM_004258
CD101
CD101 molecule
chr12_+_18305740 0.019 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr1_-_108032645 0.018 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr16_-_20246309 0.017 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr1_-_203592538 0.015 NM_018203
KLHDC8A
kelch domain containing 8A
chr8_-_86477585 0.014 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr8_+_39911630 0.014 NM_194294
IDO2
indoleamine 2,3-dioxygenase 2
chr10_+_18589589 0.013 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr7_+_128795280 0.012 AHCYL2
adenosylhomocysteinase-like 2
chr11_+_89403921 0.012 NM_001195234
TRIM49
TRIM49L2
tripartite motif containing 49
tripartite motif containing 49-like 2
chr4_-_122357104 0.011 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr5_-_9683462 0.010 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr12_+_15590552 0.010 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chrX_-_138617994 0.009 NM_001099855
NM_001171876
MCF2

MCF.2 cell line derived transforming sequence

chr6_+_160462852 0.009 NM_003057
NM_153187
SLC22A1

solute carrier family 22 (organic cation transporter), member 1

chr14_+_31868229 0.009 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr2_+_201755865 0.009 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr12_-_14740694 0.009 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr10_-_98311813 0.009 TM9SF3
transmembrane 9 superfamily member 3
chr4_+_5577783 0.009 NM_005750
C4orf6
chromosome 4 open reading frame 6
chr6_-_87861492 0.008 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr3_+_196933422 0.008 NM_152673
MUC20
mucin 20, cell surface associated
chrX_+_48978870 0.008 NM_014008
CCDC22
coiled-coil domain containing 22
chr11_-_89181390 0.007 NM_020358
TRIM49
tripartite motif containing 49
chr4_+_70928718 0.006 NM_000200
HTN3
histatin 3
chr1_+_22835684 0.006 NM_015991
C1QA
complement component 1, q subcomponent, A chain
chr8_-_87824996 0.006 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr12_-_4358968 0.005 NM_020638
FGF23
fibroblast growth factor 23
chr17_+_7732759 0.005 NM_001005273
NM_005852
CHD3

chromodomain helicase DNA binding protein 3

chr4_-_90197140 0.005 NM_014883
FAM13A
family with sequence similarity 13, member A
chr1_-_23998515 0.004 NM_001127621
GALE
UDP-galactose-4-epimerase
chr1_-_77457664 0.004 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr1_+_145892190 0.004 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr7_+_141457977 0.004 LOC93432
maltase-glucoamylase-like pseudogene
chr10_-_48036698 0.004 NM_016204
GDF2
growth differentiation factor 2
chr5_-_24535386 0.003 NM_001190450
CDH10
cadherin 10, type 2 (T2-cadherin)
chr19_-_45611110 0.003 NM_020956
NM_181882
PRX

periaxin

chr11_-_36576352 0.002 NM_000536
RAG2
recombination activating gene 2
chr1_-_156013487 0.002 NM_030764
FCRL2
Fc receptor-like 2
chr1_-_150653351 0.002 NM_016190
CRNN
cornulin
chr10_+_95362334 0.001 NM_006204
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr1_-_198643885 0.001 ZNF281
zinc finger protein 281
chrY_+_18756722 0.001 NM_001002906
NM_004677
XKRY2
XKRY
XK, Kell blood group complex subunit-related, Y-linked 2
XK, Kell blood group complex subunit-related, Y-linked
chr1_+_175406685 0.001 FAM5B
family with sequence similarity 5, member B
chr18_+_44319365 0.001 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr7_-_44547382 0.001 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr3_-_168674502 0.001 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr1_+_198263352 0.000 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
34.65 9.75e-03 GO:0035004 phosphatidylinositol 3-kinase activity
92.38 1.97e-02 GO:0035005 phosphatidylinositol-4-phosphate 3-kinase activity