Motif ID: NR1H4.p2

Z-value: 1.142


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
NR1H4 9971 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR1H4chr12_+_993918700.665.6e-03Click!


Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_31731667 3.536 APOM
apolipoprotein M
chr6_+_31731647 3.525 NM_019101
APOM
apolipoprotein M
chr10_-_95350949 3.246 NM_006744
RBP4
retinol binding protein 4, plasma
chr2_-_21079145 3.184 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_+_52803823 2.432 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr7_+_26298136 2.178 SNX10
sorting nexin 10
chr7_+_45899080 2.145 IGFBP1
insulin-like growth factor binding protein 1
chr5_-_149772469 2.134 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr6_-_29635680 2.017 NM_006398
UBD
ubiquitin D
chr12_+_68028407 1.880 LYZ
lysozyme
chr3_-_50315983 1.694 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr4_+_74500748 1.672 ALB
albumin
chrX_-_132947290 1.663 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr1_-_27113018 1.472 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr4_+_74497998 1.467 ALB
albumin
chr9_-_122877231 1.423 C5
complement component 5
chr16_+_23754822 1.318 PRKCB
protein kinase C, beta
chr9_-_115880366 1.308 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_-_101831579 1.214 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr3_+_134947940 1.196 TF
transferrin
chr16_+_23754772 1.184 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr22_+_23329113 1.179 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr17_-_7023283 1.159 ASGR1
asialoglycoprotein receptor 1
chr14_-_105163301 1.128 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr6_-_33016561 1.108 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr19_-_17377383 1.065 NM_004335
BST2
bone marrow stromal cell antigen 2
chr3_+_134947894 1.031 TF
transferrin
chr17_-_7023378 1.020 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr3_+_134947788 1.018 TF
transferrin
chrX_-_118711350 1.005 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chr4_-_40326603 1.004 NM_001098634
RBM47
RNA binding motif protein 47
chr6_-_29635456 0.992 UBD
ubiquitin D
chr4_-_69852090 0.974 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr14_-_105308720 0.940 IGHM
immunoglobulin heavy constant mu
chr12_-_120781002 0.938 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr16_+_23754860 0.927 PRKCB
protein kinase C, beta
chr19_+_40321567 0.922 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_40321584 0.904 FXYD1
FXYD domain containing ion transport regulator 1
chr8_-_124477639 0.903 ATAD2
ATPase family, AAA domain containing 2
chr5_+_133478252 0.895 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr20_-_22512893 0.889 FOXA2
forkhead box A2
chr9_-_115880281 0.875 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_+_219354692 0.866 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr11_-_71458739 0.849 NUMA1
nuclear mitotic apparatus protein 1
chr1_-_159459814 0.846 APOA2
apolipoprotein A-II
chr16_+_30102231 0.836 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr19_+_4180494 0.834 NM_005755
EBI3
Epstein-Barr virus induced 3
chr1_+_12046020 0.830 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chrX_-_118711088 0.828 SEPT6
septin 6
chr1_-_180622083 0.823 GLUL
glutamate-ammonia ligase
chr14_-_105182159 0.814 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr11_+_22646229 0.796 NM_177553
GAS2
growth arrest-specific 2
chr18_-_65775139 0.795 NM_006566
CD226
CD226 molecule
chr9_+_116413443 0.790 NM_153045
C9orf91
chromosome 9 open reading frame 91
chr17_+_73676219 0.787 NM_004710
SYNGR2
synaptogyrin 2
chr4_+_74498042 0.778 ALB
albumin
chr19_-_10311262 0.768 NM_002162
ICAM3
intercellular adhesion molecule 3
chr22_+_23309717 0.767 NM_013430
GGT1
gamma-glutamyltransferase 1
chr14_-_105280425 0.745 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_49701085 0.732 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr3_+_143858428 0.719 NM_001172312
PLS1
plastin 1
chr16_+_30102426 0.717 CORO1A
coronin, actin binding protein, 1A
chr11_+_67007155 0.712 AIP
aryl hydrocarbon receptor interacting protein
chr19_+_1022208 0.708 HMHA1
histocompatibility (minor) HA-1
chr2_+_241213334 0.701 NM_005301
GPR35
G protein-coupled receptor 35
chr4_+_74520796 0.693 NM_001134
AFP
alpha-fetoprotein
chr20_+_61839931 0.683 LIME1
Lck interacting transmembrane adaptor 1
chr9_-_115880372 0.676 AMBP
alpha-1-microglobulin/bikunin precursor
chr19_-_11550576 0.675 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr1_+_32512298 0.675 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr9_-_115880425 0.660 AMBP
alpha-1-microglobulin/bikunin precursor
chr20_+_30103642 0.659 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chr18_-_12367248 0.658 NM_006796
AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr17_-_71487038 0.658 ACOX1
acyl-CoA oxidase 1, palmitoyl
chr16_+_1979959 0.657 NM_004209
SYNGR3
synaptogyrin 3
chr18_-_12367168 0.656 AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr4_+_74488947 0.652 ALB
albumin
chr20_-_3097070 0.649 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr13_-_40735619 0.629 NM_004294
MTRF1
mitochondrial translational release factor 1
chr18_-_12367209 0.627 AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr11_+_67007080 0.626 NM_003977
AIP
aryl hydrocarbon receptor interacting protein
chr17_+_61729193 0.622 PRKCA
protein kinase C, alpha
chr4_-_71751205 0.614 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr19_-_44518465 0.602 GMFG
glia maturation factor, gamma
chr11_+_45825532 0.600 NM_021117
CRY2
cryptochrome 2 (photolyase-like)
chr2_+_73294852 0.599 NM_006062
SMYD5
SMYD family member 5
chr20_+_30192968 0.589 TM9SF4
transmembrane 9 superfamily protein member 4
chrX_-_71709335 0.588 HDAC8
histone deacetylase 8
chr12_+_55909622 0.587 NM_001166356
NM_005412
SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

chrX_-_78509367 0.584 ITM2A
integral membrane protein 2A
chr18_+_54039730 0.583 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_-_106184988 0.578 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_-_11550765 0.575 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr13_-_74953873 0.566 NM_014832
TBC1D4
TBC1 domain family, member 4
chr19_-_47724365 0.560 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr15_+_88345612 0.555 NM_198526
ZNF710
zinc finger protein 710
chr18_-_44723116 0.553 NM_001190823
SMAD7
SMAD family member 7
chr1_+_116727514 0.552 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_+_26744893 0.547 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr19_+_40895669 0.547 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr1_-_172153024 0.539 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr17_+_71097147 0.535 MYO15B
myosin XVB pseudogene
chr9_+_35663852 0.532 NM_001216
CA9
carbonic anhydrase IX
chr9_-_115880494 0.530 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr22_+_21464980 0.528


chr18_-_12692631 0.526 NM_024899
CEP76
centrosomal protein 76kDa
chr7_+_56099463 0.525 SUMF2
sulfatase modifying factor 2
chr11_+_34894688 0.519 PDHX
pyruvate dehydrogenase complex, component X
chr7_+_94377145 0.519 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr1_+_26744929 0.516 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_25128951 0.512 RUNX3
runt-related transcription factor 3
chr19_+_810673 0.512 CFD
complement factor D (adipsin)
chr19_+_15644885 0.509 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr12_+_68028397 0.508 NM_000239
LYZ
lysozyme
chr22_+_20899155 0.508


chr12_+_68459015 0.505 NM_001024647
RAB3IP
RAB3A interacting protein (rabin3)
chr19_+_8415875 0.504 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr2_+_211129567 0.504 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr1_-_180621272 0.494 GLUL
glutamate-ammonia ligase
chr16_+_65552600 0.490 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr1_+_32489426 0.489 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chrX_+_128741562 0.488 NM_018990
SASH3
SAM and SH3 domain containing 3
chr2_+_108271526 0.483 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr4_+_74488835 0.482 NM_000477
ALB
albumin
chr14_-_34001164 0.480 NM_138288
C14orf147
chromosome 14 open reading frame 147
chr1_-_25129354 0.477 NM_004350
RUNX3
runt-related transcription factor 3
chr17_+_1612056 0.477 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr4_-_176970407 0.477 GPM6A
glycoprotein M6A
chr4_-_71751070 0.475 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr7_+_93977267 0.473 CASD1
CAS1 domain containing 1
chr3_-_13359746 0.472 NUP210
nucleoporin 210kDa
chr20_+_5055393 0.463 NM_003818
CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr3_-_180460372 0.463 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr6_+_42822664 0.458 KIAA0240
KIAA0240
chr6_-_2190654 0.456 NM_001500
GMDS
GDP-mannose 4,6-dehydratase
chrX_-_118711144 0.453 SEPT6
septin 6
chr4_-_100359353 0.451 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr17_+_1612092 0.451 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chrX_-_151653756 0.450 NM_001166386
NM_001166387
NM_005367
MAGEA12


melanoma antigen family A, 12


chr6_+_43846155 0.449 VEGFA
vascular endothelial growth factor A
chr5_-_32424352 0.447 ZFR
zinc finger RNA binding protein
chr19_-_53081326 0.446 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr17_+_1611983 0.444 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_+_11211282 0.443 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr14_-_22496196 0.440 HAUS4
HAUS augmin-like complex, subunit 4
chr19_+_40242634 0.439 HPN
hepsin
chr17_+_1612031 0.438 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_94669547 0.433 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr12_-_31370351 0.431 FAM60A
family with sequence similarity 60, member A
chr8_-_38577891 0.427


chr2_+_58127419 0.426 VRK2
vaccinia related kinase 2
chr14_-_22496098 0.424 NM_001166269
NM_001166270
NM_017815
HAUS4


HAUS augmin-like complex, subunit 4


chr11_+_61276576 0.424 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr17_+_45858606 0.423 ACSF2
acyl-CoA synthetase family member 2
chr17_+_45858517 0.419 NM_025149
ACSF2
acyl-CoA synthetase family member 2
chr18_-_26935883 0.417 NM_004949
NM_024422
DSC2

desmocollin 2

chr4_-_40212670 0.416 NM_019027
RBM47
RNA binding motif protein 47
chr19_-_40995564 0.413 PRODH2
proline dehydrogenase (oxidase) 2
chr18_-_50004458 0.412 MBD2
methyl-CpG binding domain protein 2
chr1_+_144439069 0.410 NM_002614
PDZK1
PDZ domain containing 1
chr19_+_810658 0.410 NM_001928
CFD
complement factor D (adipsin)
chr16_+_8722068 0.402 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr19_-_9790502 0.402 FBXL12
F-box and leucine-rich repeat protein 12
chr12_-_31370387 0.398 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr4_+_155707089 0.397 FGB
fibrinogen beta chain
chr11_+_45825244 0.397 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chrX_-_118711183 0.392 SEPT6
septin 6
chr6_-_133126278 0.392 NM_078488
VNN2
vanin 2
chrX_-_48661226 0.387 NM_006875
PIM2
pim-2 oncogene
chr20_+_5055653 0.386 CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr20_-_45360903 0.386 ZMYND8
zinc finger, MYND-type containing 8
chr19_-_9790473 0.381 FBXL12
F-box and leucine-rich repeat protein 12
chr6_+_43846735 0.381 VEGFA
vascular endothelial growth factor A
chr14_+_94117545 0.380 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr16_+_69115227 0.378 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr15_+_72695248 0.378 CLK3
CDC-like kinase 3
chr17_-_6958282 0.374 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr15_+_78232395 0.372 NM_000137
FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr14_+_99601498 0.372 NM_016337
EVL
Enah/Vasp-like
chr6_-_32268267 0.368 GPSM3
G-protein signaling modulator 3
chr19_-_10474266 0.363 NM_012289
KEAP1
kelch-like ECH-associated protein 1
chr19_+_55398680 0.362 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr12_-_31370305 0.359 FAM60A
family with sequence similarity 60, member A
chr17_-_9880729 0.358 NM_201432
GAS7
growth arrest-specific 7
chr4_-_186934059 0.357 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr16_-_29797172 0.354 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr6_+_43845915 0.352 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_003376
VEGFA















vascular endothelial growth factor A















chr19_-_6671585 0.349 NM_000064
C3
complement component 3
chr2_-_219791902 0.346 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr19_+_59064471 0.344 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr19_-_16497213 0.342 CHERP
calcium homeostasis endoplasmic reticulum protein
chr1_+_150902495 0.340 NM_178430
LCE2D
late cornified envelope 2D
chr3_+_134947573 0.340 NM_001063
TF
transferrin
chr7_-_37454933 0.337 NM_014800
ELMO1
engulfment and cell motility 1
chr1_-_211031727 0.337 NM_001042549
NM_015471
NSL1

NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr11_+_7491789 0.336 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_-_74292800 0.331 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr16_-_23559978 0.331 NM_024675
PALB2
partner and localizer of BRCA2
chr4_+_74488910 0.328 ALB
albumin
chr16_-_1369613 0.327 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.17 1.51e-03 GO:0003823 antigen binding