Motif ID: SOX5.p2

Z-value: 1.240


Transcription factors associated with SOX5.p2:

Gene SymbolEntrez IDGene Name
SOX5 6660 SRY (sex determining region Y)-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX5chr12_-_239951090.562.3e-02Click!


Activity profile for motif SOX5.p2.

activity profile for motif SOX5.p2


Sorted Z-values histogram for motif SOX5.p2

Sorted Z-values for motif SOX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_68028397 4.890 NM_000239
LYZ
lysozyme
chr12_+_68028407 4.489 LYZ
lysozyme
chr1_+_196874759 2.864 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_+_196874867 2.776 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_196874839 2.533 PTPRC
protein tyrosine phosphatase, receptor type, C
chr3_-_150422474 2.526 NM_000096
CP
ceruloplasmin (ferroxidase)
chr11_+_22652894 2.301 NM_005256
GAS2
growth arrest-specific 2
chr6_-_49712483 2.010 NM_000324
RHAG
Rh-associated glycoprotein
chr2_+_228386800 1.861 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr9_-_115880494 1.804 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_100714995 1.581 MTTP
microsomal triglyceride transfer protein
chr17_-_46479127 1.543 SPAG9
sperm associated antigen 9
chr4_+_71096830 1.521 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr17_+_63252704 1.510 BPTF
bromodomain PHD finger transcription factor
chr4_+_74491272 1.489 ALB
albumin
chr17_+_63252668 1.451 BPTF
bromodomain PHD finger transcription factor
chr2_+_143603368 1.437 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr16_+_68238460 1.381 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chrX_-_137649180 1.376 NM_033642
FGF13
fibroblast growth factor 13
chr1_+_116727514 1.353 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr2_+_143603439 1.350 ARHGAP15
Rho GTPase activating protein 15
chrX_+_152562013 1.347 DUSP9
dual specificity phosphatase 9
chr6_+_37245860 1.280 NM_002648
PIM1
pim-1 oncogene
chr9_-_97308687 1.240 PTCH1
patched 1
chr8_-_102872354 1.236 NCALD
neurocalcin delta
chrX_+_133952633 1.230 NM_001163438
LOC644538
hypothetical protein LOC644538
chr2_+_143351536 1.202 NM_001032998
NM_003937
KYNU

kynureninase

chr6_+_27885692 1.156 NM_003536
HIST1H3H
histone cluster 1, H3h
chrY_+_13525412 1.149 NM_001122665
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr8_-_102872372 1.143 NCALD
neurocalcin delta
chrX_+_123062143 1.135 STAG2
stromal antigen 2
chr12_-_101835183 1.123 PAH
phenylalanine hydroxylase
chr3_-_121884091 1.095 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr12_-_101835510 1.094 NM_000277
PAH
phenylalanine hydroxylase
chr4_+_89115825 1.064 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr6_+_64414389 1.064 NM_015153
PHF3
PHD finger protein 3
chr12_-_23995220 1.062 SOX5
SRY (sex determining region Y)-box 5
chr20_-_45418818 1.060 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr12_-_101835026 1.043 PAH
phenylalanine hydroxylase
chr13_-_47885653 1.043 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr7_+_111633878 1.033 NM_021994
ZNF277
zinc finger protein 277
chr16_+_68284252 1.022 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr12_-_24606616 0.986 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr11_-_35397090 0.982 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr9_-_129752687 0.980 NM_203305
FAM102A
family with sequence similarity 102, member A
chr7_-_100077072 0.974 NM_003227
TFR2
transferrin receptor 2
chr6_+_122762384 0.969 NM_001135564
NM_004506
HSF2

heat shock transcription factor 2

chrX_-_39921525 0.953 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr17_-_23721420 0.952 VTN
vitronectin
chr11_+_46358909 0.949 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr4_+_100704262 0.927 NM_000253
MTTP
microsomal triglyceride transfer protein
chr4_+_89115862 0.912 SPP1
secreted phosphoprotein 1
chr17_-_23721351 0.898 VTN
vitronectin
chr20_+_31613800 0.893 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr10_-_101831579 0.887 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr5_+_102493155 0.880 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr10_+_114123828 0.843 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_+_111633972 0.838 ZNF277
zinc finger protein 277
chr4_+_89115892 0.823 SPP1
secreted phosphoprotein 1
chr14_-_88953059 0.820 NM_005197
FOXN3
forkhead box N3
chrX_-_71709335 0.811 HDAC8
histone deacetylase 8
chr11_+_22644732 0.807 NM_001143830
GAS2
growth arrest-specific 2
chr4_-_83566246 0.796 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr2_+_86521999 0.791 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr2_-_200033445 0.788 SATB2
SATB homeobox 2
chr10_+_114123765 0.777 ACSL5
acyl-CoA synthetase long-chain family member 5
chr10_+_11246934 0.774 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr6_+_122762449 0.771 HSF2
heat shock transcription factor 2
chr9_-_85773899 0.755 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr3_-_121883647 0.753 HGD
homogentisate 1,2-dioxygenase
chr1_+_148603769 0.743 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr8_-_57286381 0.734 PLAG1
pleiomorphic adenoma gene 1
chr11_+_73037382 0.734 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr11_-_35397675 0.726 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_-_32665409 0.722 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr1_+_165564904 0.719 NM_001198783
POU2F1
POU class 2 homeobox 1
chr8_-_57286412 0.715 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr3_+_52803823 0.712 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr2_-_20375497 0.706 PUM2
pumilio homolog 2 (Drosophila)
chr12_-_101115677 0.699 NM_002674
PMCH
pro-melanin-concentrating hormone
chrX_+_107174855 0.683 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr14_-_19871267 0.676 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr2_+_86521939 0.669 KDM3A
lysine (K)-specific demethylase 3A
chr1_-_52791218 0.665 ZCCHC11
zinc finger, CCHC domain containing 11
chr7_+_29486010 0.659 NM_001039936
CHN2
chimerin (chimaerin) 2
chr4_-_155731288 0.658 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr20_+_254205 0.655 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr12_-_23995109 0.644 SOX5
SRY (sex determining region Y)-box 5
chr4_-_140280031 0.641 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr1_-_52791309 0.635 NM_001009881
NM_015269
ZCCHC11

zinc finger, CCHC domain containing 11

chr22_+_38652555 0.633 GRAP2
GRB2-related adaptor protein 2
chr1_+_165565006 0.633 POU2F1
POU class 2 homeobox 1
chr1_+_11674365 0.632 NM_198545
C1orf187
chromosome 1 open reading frame 187
chr6_-_79732391 0.630 PHIP
pleckstrin homology domain interacting protein
chr14_-_106184988 0.629 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_+_50314801 0.620 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr14_+_38653177 0.618 NM_001009182
NM_001009183
NM_003616
SIP1


survival of motor neuron protein interacting protein 1


chr4_+_89115923 0.613 SPP1
secreted phosphoprotein 1
chr5_-_88155360 0.610 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr2_+_74914742 0.610 HK2
hexokinase 2
chr3_+_46591048 0.608 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr6_-_43135092 0.607 NM_015950
MRPL2
mitochondrial ribosomal protein L2
chr6_+_88026338 0.605 ZNF292
zinc finger protein 292
chr6_-_32605898 0.603 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr4_-_71751070 0.599 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_-_20390601 0.596 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr8_-_102872614 0.596 NM_032041
NCALD
neurocalcin delta
chr9_+_136358145 0.582 RXRA
retinoid X receptor, alpha
chr17_-_44058612 0.581 NM_024017
HOXB9
homeobox B9
chr17_+_56032271 0.581 NM_003620
PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr2_-_162638875 0.573 DPP4
dipeptidyl-peptidase 4
chr9_-_115877104 0.571 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_-_84254873 0.570 PLAC8
placenta-specific 8
chr17_-_36346240 0.569 KRT23
keratin 23 (histone deacetylase inducible)
chr12_-_101396459 0.567 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr15_+_72861767 0.567 CSK
c-src tyrosine kinase
chr9_-_122728173 0.566 TRAF1
TNF receptor-associated factor 1
chr4_-_105635499 0.566 CXXC4
CXXC finger protein 4
chr4_+_124537334 0.564 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr17_-_77488258 0.553 NM_006907
NM_153824
PYCR1

pyrroline-5-carboxylate reductase 1

chr10_-_99084417 0.550 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr15_+_72861470 0.550 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr1_-_51660328 0.549 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr11_-_101828563 0.549 NM_052932
TMEM123
transmembrane protein 123
chrX_+_49047068 0.542 NM_001098413
GAGE10
G antigen 10
chr6_-_138862273 0.539


chr2_+_86800898 0.538 NM_022780
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr11_-_72530605 0.536 NM_014824
FCHSD2
FCH and double SH3 domains 2
chr3_-_57209319 0.534 NM_003865
HESX1
HESX homeobox 1
chr4_-_71751205 0.531 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr14_-_90953883 0.527 NM_001080414
CCDC88C
coiled-coil domain containing 88C
chr1_-_74971679 0.525 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chr1_-_229627412 0.523 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr2_+_86521781 0.522 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr4_+_170817787 0.521 CLCN3
chloride channel 3
chr1_+_50344550 0.520 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_+_9392980 0.520 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr12_-_110410730 0.516 ATXN2
ataxin 2
chr5_-_71838875 0.508 NM_152625
ZNF366
zinc finger protein 366
chr2_-_162639297 0.507 NM_001935
DPP4
dipeptidyl-peptidase 4
chr1_-_180627023 0.505 NM_001033056
GLUL
glutamate-ammonia ligase
chr4_-_187114407 0.503 SORBS2
sorbin and SH3 domain containing 2
chr5_-_175896829 0.501 NM_014901
RNF44
ring finger protein 44
chr2_-_174475528 0.498


chr2_+_86800940 0.492 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr2_+_232281470 0.491 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr6_+_17708483 0.491 NM_016255
FAM8A1
family with sequence similarity 8, member A1
chr16_-_45562840 0.490 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr16_+_2593351 0.489 LOC652276
hypothetical LOC652276
chr19_+_3958690 0.488 NM_015897
PIAS4
protein inhibitor of activated STAT, 4
chr1_-_148508030 0.484 NM_001077628
NM_016022
APH1A

anterior pharynx defective 1 homolog A (C. elegans)

chr5_-_32424352 0.481 ZFR
zinc finger RNA binding protein
chr17_+_65009986 0.476 MAP2K6
mitogen-activated protein kinase kinase 6
chr7_-_16471817 0.475 NM_015464
SOSTDC1
sclerostin domain containing 1
chr19_-_46595053 0.474 NM_020158
EXOSC5
exosome component 5
chr5_+_36912656 0.472 NIPBL
Nipped-B homolog (Drosophila)
chr1_-_180626804 0.470 GLUL
glutamate-ammonia ligase
chr9_-_74757735 0.469 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr17_-_59817722 0.467 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr4_-_73653331 0.467 NM_014243
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr17_+_56032385 0.464 PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr3_-_47909001 0.463 MAP4
microtubule-associated protein 4
chr1_-_12599934 0.462 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr2_+_232281491 0.461 PTMA
prothymosin, alpha
chrX_+_70419766 0.456 NM_001145408
NM_001145409
NM_001145410
NM_007363
NONO



non-POU domain containing, octamer-binding



chr10_+_101532450 0.456 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr13_-_47885248 0.453 LPAR6
lysophosphatidic acid receptor 6
chr7_+_116447499 0.453 ST7
suppression of tumorigenicity 7
chr4_+_74500748 0.450 ALB
albumin
chr13_-_45577144 0.450 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr15_+_80741876 0.448 LOC80154
hypothetical LOC80154
chr3_+_173043832 0.446 NM_001164436
TMEM212
transmembrane protein 212
chr1_-_148507779 0.445 APH1A
anterior pharynx defective 1 homolog A (C. elegans)
chr20_-_45410033 0.444 ZMYND8
zinc finger, MYND-type containing 8
chr6_+_32090516 0.443 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr1_-_31003181 0.442 LAPTM5
lysosomal protein transmembrane 5
chr12_-_31635089 0.442 NM_144973
DENND5B
DENN/MADD domain containing 5B
chr4_-_84254932 0.441 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr7_+_96583840 0.440 NM_020186
ACN9
ACN9 homolog (S. cerevisiae)
chr19_-_51909416 0.440 NM_001079882
PRKD2
protein kinase D2
chr19_-_52426055 0.439 NM_014417
BBC3
BCL2 binding component 3
chr18_+_27425727 0.438 NM_000371
TTR
transthyretin
chr8_-_70907957 0.435 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr6_+_155579788 0.434 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr17_-_36074812 0.434 NM_152349
KRT222
keratin 222
chr10_+_35455986 0.434 CREM
cAMP responsive element modulator
chr12_-_101398451 0.433 IGF1
insulin-like growth factor 1 (somatomedin C)
chr3_-_12916547 0.433 IQSEC1
IQ motif and Sec7 domain 1
chr4_+_69996780 0.431 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr10_+_35455806 0.427 NM_001881
NM_182850
NM_182853
NM_183013
CREM



cAMP responsive element modulator



chrX_-_78509662 0.427 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr1_+_50347188 0.425 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr8_-_108579270 0.424 NM_001146
ANGPT1
angiopoietin 1
chr8_+_126511739 0.422 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr3_-_143230124 0.414 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr16_-_66535457 0.412 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr16_-_30841938 0.411 NCRNA00095
non-protein coding RNA 95
chr8_-_70908130 0.411 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr10_-_5050191 0.410 NM_001354
NM_205845
AKR1C2

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

chr17_-_53847937 0.409 RNF43
ring finger protein 43

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 3.00e-02 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.28 6.67e-04 GO:0003676 nucleic acid binding
3.51 2.45e-02 GO:0003823 antigen binding