Motif ID: IRF1,2,7.p3

Z-value: 5.024


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF7chr11_-_605998,
chr11_-_605649		0.926.2e-07Click!
IRF1chr5_-_1318543250.853.1e-05Click!
IRF2chr4_-_1856326100.774.6e-04Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_78858675 30.084 NM_006820
 IFI44L
interferon-induced protein 44-like
chr1_+_938709 24.137 NM_005101
 ISG15
ISG15 ubiquitin-like modifier
chr10_+_91142301 18.108 NM_001548
 IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr21_+_41714311 17.662 NM_001144925
 MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_-_27871306 16.573 NM_002038
NM_022872
NM_022873
 IFI6


interferon, alpha-inducible protein 6


chr1_-_27871245 16.018 IFI6
interferon, alpha-inducible protein 6
chr11_-_605920 16.016 IRF7
interferon regulatory factor 7
chr1_-_27871287 15.972 IFI6
interferon, alpha-inducible protein 6
chr11_-_605998 14.976 NM_001572
NM_004029
 IRF7

interferon regulatory factor 7

chr21_+_41655786 13.938 NM_002463
 LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr1_+_157246305 13.692 NM_005531
 IFI16
interferon, gamma-inducible protein 16
chr12_+_25096755 12.366 LRMP
lymphoid-restricted membrane protein
chr12_+_111900650 11.372 NM_001032731
NM_002535
NM_016817
 OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr4_+_89597257 11.293 NM_016323
 HERC5
hect domain and RLD 5
chr4_-_169476391 11.184 NM_017631
 DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr6_+_32929902 10.986 NM_002800
 PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr6_-_31432543 10.801 HLA-B
major histocompatibility complex, class I, B
chr1_+_78888064 10.538 NM_006417
 IFI44
interferon-induced protein 44
chr2_-_88946767 10.397


chr5_-_149772469 9.515 NM_001025159
NM_004355
NM_001025158
 CD74


CD74 molecule, major histocompatibility complex, class II invariant chain



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
14.45 1.01e-02 GO:0019883 antigen processing and presentation of endogenous antigen
12.45 6.25e-05 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
9.59 1.74e-04 GO:0048002 antigen processing and presentation of peptide antigen
8.96 1.65e-16 GO:0060337 type I interferon-mediated signaling pathway
8.96 1.65e-16 GO:0071357 cellular response to type I interferon
8.81 2.79e-16 GO:0034340 response to type I interferon
5.73 4.57e-06 GO:0060333 interferon-gamma-mediated signaling pathway
5.33 7.63e-07 GO:0034341 response to interferon-gamma
5.21 2.25e-05 GO:0071346 cellular response to interferon-gamma
5.06 1.19e-02 GO:0032479 regulation of type I interferon production
4.63 2.55e-13 GO:0019221 cytokine-mediated signaling pathway
4.31 1.23e-08 GO:0009615 response to virus
4.17 1.09e-11 GO:0071345 cellular response to cytokine stimulus
3.72 2.25e-15 GO:0045087 innate immune response
3.37 7.29e-10 GO:0034097 response to cytokine stimulus
3.22 1.73e-02 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
3.15 1.38e-02 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
3.00 5.58e-20 GO:0006955 immune response
2.65 4.67e-02 GO:0050867 positive regulation of cell activation
2.48 2.07e-11 GO:0006952 defense response

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
7.01 9.40e-04 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
5.06 6.87e-03 GO:0003823 antigen binding