Motif ID: PAX2.p2

Z-value: 1.084


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX2chr10_+_1024953270.263.3e-01Click!


Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_61615124 1.705 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr14_+_100270222 1.621 DLK1
delta-like 1 homolog (Drosophila)
chr6_+_160310118 1.618 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr12_-_61614930 1.480 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr17_-_39556535 1.298 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr17_-_39556483 1.228 HDAC5
histone deacetylase 5
chr17_+_77529070 1.219 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr14_+_23653848 1.058 DCAF11
DDB1 and CUL4 associated factor 11
chrX_+_30581377 1.017 NM_000167
NM_001128127
NM_203391
GK


glycerol kinase


chr18_+_9126742 0.942 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr14_+_23654161 0.924 DCAF11
DDB1 and CUL4 associated factor 11
chr2_+_74914742 0.900 HK2
hexokinase 2
chr17_+_75689894 0.897 NM_000152
NM_001079803
NM_001079804
GAA


glucosidase, alpha; acid


chr1_-_152459667 0.890 C1orf43
chromosome 1 open reading frame 43
chr14_+_23653819 0.881 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr6_-_90178685 0.859 NM_021244
RRAGD
Ras-related GTP binding D
chr11_+_7574992 0.835 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr10_+_69314347 0.833 NM_012238
SIRT1
sirtuin 1
chr14_+_23653745 0.831 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr6_+_87921980 0.826 NM_015021
ZNF292
zinc finger protein 292
chr20_+_43953331 0.798 CTSA
cathepsin A
chr5_-_133734616 0.782 CDKL3
cyclin-dependent kinase-like 3
chr17_-_73636386 0.781 NM_001127198
TMC6
transmembrane channel-like 6
chr1_-_152459506 0.770 C1orf43
chromosome 1 open reading frame 43
chr16_+_23754822 0.766 PRKCB
protein kinase C, beta
chr2_+_42249896 0.751 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr17_+_50697355 0.745 HLF
hepatic leukemia factor
chr4_+_74498042 0.725 ALB
albumin
chr17_+_50697319 0.685 NM_002126
HLF
hepatic leukemia factor
chr20_+_43953372 0.685 CTSA
cathepsin A
chr20_+_43953428 0.682 CTSA
cathepsin A
chr6_+_138230045 0.681 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chrX_-_102205752 0.673 NM_018476
BEX1
brain expressed, X-linked 1
chrX_-_102205736 0.669 BEX1
brain expressed, X-linked 1
chr14_+_23654307 0.668 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr18_+_30875297 0.664 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr14_-_54438913 0.657 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr17_-_73636362 0.655 TMC6
transmembrane channel-like 6
chr19_-_50373294 0.654 NM_024108
TRAPPC6A
trafficking protein particle complex 6A
chr6_-_43135092 0.630 NM_015950
MRPL2
mitochondrial ribosomal protein L2
chr11_-_57039721 0.615 NM_003627
SLC43A1
solute carrier family 43, member 1
chr19_+_1018293 0.606 HMHA1
histocompatibility (minor) HA-1
chr4_+_74493918 0.588 ALB
albumin
chr9_+_130749812 0.583 NUP188
nucleoporin 188kDa
chr2_+_219751192 0.583 FAM134A
family with sequence similarity 134, member A
chr19_+_1018536 0.575 HMHA1
histocompatibility (minor) HA-1
chr2_+_219751230 0.574 FAM134A
family with sequence similarity 134, member A
chr17_+_77528782 0.572 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr2_+_170259195 0.559 NM_144711
NM_001008489
PHOSPHO2-KLHL23
KLHL23
PHOSPHO2
PHOSPHO2-KLHL23 read-through transcript
kelch-like 23 (Drosophila)
phosphatase, orphan 2
chr16_+_23754860 0.559 PRKCB
protein kinase C, beta
chr16_+_29726962 0.559 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_-_44076635 0.558 NM_133259
LRPPRC
leucine-rich PPR-motif containing
chr19_+_1018114 0.545 NM_012292
HMHA1
histocompatibility (minor) HA-1
chr11_+_7491789 0.545 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_+_120828058 0.543 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr5_-_175896829 0.543 NM_014901
RNF44
ring finger protein 44
chr19_-_52426055 0.542 NM_014417
BBC3
BCL2 binding component 3
chr7_+_94135384 0.537 PEG10
paternally expressed 10
chr6_-_90178630 0.534 RRAGD
Ras-related GTP binding D
chr2_-_44076616 0.532 LRPPRC
leucine-rich PPR-motif containing
chr4_+_100714995 0.527 MTTP
microsomal triglyceride transfer protein
chr17_+_75689985 0.526 GAA
glucosidase, alpha; acid
chr3_-_99724047 0.525 CLDND1
claudin domain containing 1
chr1_-_21868380 0.523 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr19_-_45948211 0.520 C19orf54
chromosome 19 open reading frame 54
chr20_+_43953606 0.517 CTSA
cathepsin A
chr17_+_77528699 0.514 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr9_-_19117494 0.513 NM_001122
PLIN2
perilipin 2
chr8_-_8788149 0.511 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr11_+_65236261 0.511 KAT5
K(lysine) acetyltransferase 5
chr2_-_64734544 0.509 NM_014755
SERTAD2
SERTA domain containing 2
chr7_-_29152597 0.509 NM_019029
NM_031311
CPVL

carboxypeptidase, vitellogenic-like

chr9_+_130749791 0.507 NM_015354
NUP188
nucleoporin 188kDa
chr14_+_54807855 0.507 FBXO34
F-box protein 34
chr20_-_47965474 0.505 NM_006038
SPATA2
spermatogenesis associated 2
chr6_+_32090516 0.504 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr1_-_11788666 0.500 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr6_-_90178544 0.499 RRAGD
Ras-related GTP binding D
chr11_+_61279436 0.498 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr14_-_35348086 0.489 NM_014990
NM_194301
RALGAPA1

Ral GTPase activating protein, alpha subunit 1 (catalytic)

chrX_+_30581523 0.489 GK
glycerol kinase
chr14_-_34943574 0.488 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr6_-_29703725 0.487 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr12_+_12761085 0.486 NM_004064
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr12_+_68028397 0.476 NM_000239
LYZ
lysozyme
chr4_-_155753272 0.471 FGG
fibrinogen gamma chain
chrX_-_39921525 0.469 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr15_-_63871598 0.467 NM_001144823
NM_005848
DENND4A

DENN/MADD domain containing 4A

chr17_-_45196516 0.460 NM_030802
FAM117A
family with sequence similarity 117, member A
chr15_+_50098700 0.460 NM_002748
MAPK6
mitogen-activated protein kinase 6
chr16_+_23754772 0.459 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr17_-_23928048 0.456 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr3_-_9895471 0.456 CIDEC
cell death-inducing DFFA-like effector c
chr6_+_64403631 0.455 PHF3
PHD finger protein 3
chr7_+_149696901 0.448 REPIN1
replication initiator 1
chr18_-_44729700 0.447 NM_001190822
SMAD7
SMAD family member 7
chr17_-_23928041 0.445 ALDOC
aldolase C, fructose-bisphosphate
chr2_+_177965617 0.445 NM_003659
AGPS
alkylglycerone phosphate synthase
chr3_-_151963607 0.444 SIAH2
seven in absentia homolog 2 (Drosophila)
chr20_+_46971618 0.443 NM_006420
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr9_+_6747919 0.443 KDM4C
lysine (K)-specific demethylase 4C
chr3_-_151963577 0.437 SIAH2
seven in absentia homolog 2 (Drosophila)
chr10_+_69314714 0.435 SIRT1
sirtuin 1
chr1_-_27834210 0.435 NM_005248
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr18_+_30810889 0.434 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr1_+_11788827 0.434 CLCN6
chloride channel 6
chr6_+_64403685 0.433 PHF3
PHD finger protein 3
chr2_+_74635354 0.431 DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr2_-_44076543 0.430 LRPPRC
leucine-rich PPR-motif containing
chr12_-_120715937 0.427 NM_019034
RHOF
ras homolog gene family, member F (in filopodia)
chr7_+_149699185 0.423 NM_014374
REPIN1
replication initiator 1
chr11_+_7491576 0.423 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr15_+_57696016 0.418 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr2_-_219750975 0.415 C2orf24
chromosome 2 open reading frame 24
chr1_+_40399642 0.414 RLF
rearranged L-myc fusion
chr15_-_63871492 0.414 DENND4A
DENN/MADD domain containing 4A
chr17_-_23927973 0.413 ALDOC
aldolase C, fructose-bisphosphate
chr9_-_19117462 0.411 PLIN2
perilipin 2
chr2_+_177965734 0.409 AGPS
alkylglycerone phosphate synthase
chr11_+_66915997 0.409 NM_004584
RAD9A
RAD9 homolog A (S. pombe)
chr1_-_149698516 0.409 NM_001194937
NM_001194938
NM_015100
NM_145796
POGZ



pogo transposable element with ZNF domain



chr5_+_172415891 0.408 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr22_-_35232979 0.408 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr2_+_105320247 0.408 C2orf49
chromosome 2 open reading frame 49
chr6_-_119712596 0.407 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr10_-_64246129 0.405 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr6_+_64403668 0.403 PHF3
PHD finger protein 3
chr11_+_60858611 0.403 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr1_+_40399618 0.402 NM_012421
RLF
rearranged L-myc fusion
chr20_-_47965393 0.402 SPATA2
spermatogenesis associated 2
chr4_-_155753249 0.398 FGG
fibrinogen gamma chain
chr6_+_89847183 0.395 PNRC1
proline-rich nuclear receptor coactivator 1
chr12_+_68028407 0.390 LYZ
lysozyme
chr19_+_10626106 0.390 ILF3
interleukin enhancer binding factor 3, 90kDa
chr2_-_208342296 0.386 NM_003468
FZD5
frizzled homolog 5 (Drosophila)
chr21_-_42689192 0.383 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr11_+_65236064 0.383 NM_006388
NM_182709
NM_182710
KAT5


K(lysine) acetyltransferase 5


chr6_+_89847019 0.382 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr10_+_76256305 0.382 NM_012330
MYST4
MYST histone acetyltransferase (monocytic leukemia) 4
chr11_-_118757574 0.381 NM_004205
USP2
ubiquitin specific peptidase 2
chr17_+_69939130 0.379 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr14_-_64040072 0.378 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr4_+_74497998 0.377 ALB
albumin
chr20_+_33667160 0.377 NM_003116
SPAG4
sperm associated antigen 4
chr1_-_113300351 0.376 NM_003051
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr16_-_23429304 0.375 NM_015044
GGA2
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr6_+_30632464 0.375 NM_001077497
NM_025263
PRR3

proline rich 3

chr4_-_155753287 0.374 FGG
fibrinogen gamma chain
chr5_+_133479196 0.372 NM_001134851
NM_201632
NM_201634
NM_213648
TCF7



transcription factor 7 (T-cell specific, HMG-box)



chr17_-_7078446 0.370 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr16_+_29726931 0.368 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr12_+_28234657 0.366


chr22_-_35233032 0.365 NM_024955
NM_001102371
FOXRED2

FAD-dependent oxidoreductase domain containing 2

chr7_-_97339616 0.364 ASNS
asparagine synthetase (glutamine-hydrolyzing)
chr16_+_29725665 0.363


chr2_+_228045053 0.361 AGFG1
ArfGAP with FG repeats 1
chr18_+_53862888 0.357 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_+_219751145 0.355 NM_024293
FAM134A
family with sequence similarity 134, member A
chr1_-_11788550 0.354 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr4_+_38341982 0.354 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr11_-_118757477 0.351 USP2
ubiquitin specific peptidase 2
chr6_-_31938530 0.351 NEU1
sialidase 1 (lysosomal sialidase)
chr5_+_94916533 0.351 NM_198150
ARSK
arylsulfatase family, member K
chr18_+_58533597 0.350 NM_194449
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1
chr2_-_240613357 0.348 NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr17_+_50699965 0.347 HLF
hepatic leukemia factor
chr16_-_5023914 0.347 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr16_-_5023934 0.347 NM_016256
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr2_+_86800898 0.346 NM_022780
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr17_+_52518098 0.345 AKAP1
A kinase (PRKA) anchor protein 1
chr2_-_196744546 0.345 NM_004226
STK17B
serine/threonine kinase 17b
chr5_+_137829065 0.345 EGR1
early growth response 1
chr10_-_64246080 0.344 EGR2
early growth response 2
chr6_-_109810354 0.341 CD164
CD164 molecule, sialomucin
chr5_-_167938991 0.341 NM_024594
PANK3
pantothenate kinase 3
chr3_+_187813405 0.340 AHSG
alpha-2-HS-glycoprotein
chr14_+_67156405 0.338 ARG2
arginase, type II
chr8_+_11599119 0.338 NM_002052
GATA4
GATA binding protein 4
chr6_-_90178375 0.337 RRAGD
Ras-related GTP binding D
chr1_+_1994943 0.337 NM_001033581
PRKCZ
protein kinase C, zeta
chrX_+_128741578 0.333 SASH3
SAM and SH3 domain containing 3
chr3_-_151963653 0.332 NM_005067
SIAH2
seven in absentia homolog 2 (Drosophila)
chr4_-_23500706 0.332 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr10_+_104145421 0.330 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr10_+_104144218 0.330 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr14_+_22860511 0.329 PABPN1
poly(A) binding protein, nuclear 1
chr13_-_31900218 0.328 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr17_-_45196465 0.328 FAM117A
family with sequence similarity 117, member A
chr11_+_73036241 0.327 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_+_11788793 0.325 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr12_+_115660468 0.325 NM_001109903
NM_032814
RNFT2

ring finger protein, transmembrane 2

chr15_+_38843535 0.325 NM_005258
GCHFR
GTP cyclohydrolase I feedback regulator
chr14_-_90953883 0.325 NM_001080414
CCDC88C
coiled-coil domain containing 88C
chr4_-_155753207 0.325 FGG
fibrinogen gamma chain
chr15_-_68781662 0.324 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_-_98646367 0.323 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr19_+_54707787 0.322 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr16_+_23476334 0.321 NM_019116
UBFD1
ubiquitin family domain containing 1
chr7_+_149201962 0.321 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr6_+_64403936 0.320 PHF3
PHD finger protein 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 8.26e-06 GO:0090304 nucleic acid metabolic process
1.33 2.81e-05 GO:0010467 gene expression
1.26 5.58e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.33 1.76e-04 GO:0016070 RNA metabolic process
1.21 4.94e-04 GO:0006807 nitrogen compound metabolic process
1.22 6.58e-04 GO:0034641 cellular nitrogen compound metabolic process
1.31 1.25e-03 GO:0009059 macromolecule biosynthetic process
1.30 1.78e-03 GO:0034645 cellular macromolecule biosynthetic process
1.16 3.50e-03 GO:0044260 cellular macromolecule metabolic process
1.13 3.79e-03 GO:0044237 cellular metabolic process
1.23 4.97e-03 GO:0044249 cellular biosynthetic process
1.15 7.98e-03 GO:0043170 macromolecule metabolic process
1.22 9.22e-03 GO:0009058 biosynthetic process
1.11 1.85e-02 GO:0008152 metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 3.48e-09 GO:0043231 intracellular membrane-bounded organelle
1.13 4.00e-09 GO:0043227 membrane-bounded organelle
1.09 1.91e-08 GO:0044424 intracellular part
1.09 2.42e-08 GO:0005622 intracellular
1.19 3.15e-08 GO:0005634 nucleus
1.11 6.46e-08 GO:0043226 organelle
1.11 7.64e-08 GO:0043229 intracellular organelle
1.40 2.76e-06 GO:0005654 nucleoplasm
1.29 3.00e-06 GO:0031974 membrane-enclosed lumen
1.29 4.32e-06 GO:0043233 organelle lumen
1.28 1.12e-05 GO:0070013 intracellular organelle lumen
1.28 3.64e-04 GO:0031981 nuclear lumen
1.14 6.30e-04 GO:0044422 organelle part
1.25 7.48e-04 GO:0044428 nuclear part
1.14 1.06e-03 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.27 3.18e-07 GO:0003676 nucleic acid binding
1.28 1.41e-04 GO:0003677 DNA binding
1.59 4.29e-03 GO:0003712 transcription cofactor activity
1.59 4.86e-03 GO:0000988 protein binding transcription factor activity
1.59 4.86e-03 GO:0000989 transcription factor binding transcription factor activity
1.10 6.87e-03 GO:0005515 protein binding
1.39 8.24e-03 GO:0003723 RNA binding
1.05 2.25e-02 GO:0005488 binding
1.33 4.82e-02 GO:0001071 nucleic acid binding transcription factor activity
1.33 4.82e-02 GO:0003700 sequence-specific DNA binding transcription factor activity