Motif ID: ESRRA.p2

Z-value: 1.446


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESRRAchr11_+_638296160.485.8e-02Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_44518516 3.358 NM_004877
 GMFG
glia maturation factor, gamma
chr19_-_44518465 2.915 GMFG
glia maturation factor, gamma
chr10_+_80777265 2.507 PPIF
peptidylprolyl isomerase F
chr10_+_80777248 2.330 PPIF
peptidylprolyl isomerase F
chr8_+_145221973 2.155 CYC1
cytochrome c-1
chr12_-_52980984 1.903 NM_001136023
 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr20_+_36867708 1.881 NM_001172735
NM_015568
 PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr6_-_97452416 1.867 NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr6_-_26393705 1.820 NM_003543
 HIST1H4H
histone cluster 1, H4h
chr12_-_52980914 1.811 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr8_-_131097856 1.691 FAM49B
family with sequence similarity 49, member B
chr3_-_50624085 1.554 CISH
cytokine inducible SH2-containing protein
chr11_-_56951167 1.421 NM_199329
 SLC43A3
solute carrier family 43, member 3
chr11_-_56951132 1.383 SLC43A3
solute carrier family 43, member 3
chr19_-_60360768 1.380 NM_000363
 TNNI3
troponin I type 3 (cardiac)
chr1_-_143706196 1.342 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_143706265 1.321 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_45224784 1.267 EIF2B3
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
chr12_-_21701985 1.243 NM_001174097
 LDHB
lactate dehydrogenase B
chr9_-_137992967 1.240 NM_016172
 UBAC1
UBA domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
16.75 2.44e-02 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
8.17 4.01e-11 GO:0042773 ATP synthesis coupled electron transport
8.17 4.01e-11 GO:0042775 mitochondrial ATP synthesis coupled electron transport
7.65 4.78e-11 GO:0006119 oxidative phosphorylation
7.62 2.74e-07 GO:0006120 mitochondrial electron transport, NADH to ubiquinone
7.04 1.93e-19 GO:0022904 respiratory electron transport chain
6.81 2.55e-05 GO:0009060 aerobic respiration
6.21 2.68e-20 GO:0045333 cellular respiration
5.78 7.37e-03 GO:0070585 protein localization in mitochondrion
5.58 3.12e-02 GO:0006626 protein targeting to mitochondrion
5.40 3.03e-15 GO:0022900 electron transport chain
5.39 4.36e-02 GO:0072655 establishment of protein localization in mitochondrion
4.01 1.22e-03 GO:0006839 mitochondrial transport
3.56 1.55e-12 GO:0015980 energy derivation by oxidation of organic compounds
3.05 4.59e-03 GO:0007005 mitochondrion organization
2.88 3.44e-10 GO:0006091 generation of precursor metabolites and energy
2.01 3.94e-07 GO:0055114 oxidation-reduction process
1.09 4.27e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
7.48 5.24e-14 GO:0005746 mitochondrial respiratory chain
7.42 4.16e-15 GO:0070469 respiratory chain
7.18 1.31e-07 GO:0005747 mitochondrial respiratory chain complex I
7.18 1.31e-07 GO:0030964 NADH dehydrogenase complex
7.18 1.31e-07 GO:0045271 respiratory chain complex I
6.24 3.96e-20 GO:0044455 mitochondrial membrane part
4.48 4.06e-25 GO:0005743 mitochondrial inner membrane
4.17 1.76e-23 GO:0019866 organelle inner membrane
3.89 8.84e-26 GO:0031966 mitochondrial membrane
3.75 6.61e-25 GO:0005740 mitochondrial envelope
3.31 2.45e-27 GO:0044429 mitochondrial part
2.75 9.19e-18 GO:0031967 organelle envelope
2.73 8.14e-18 GO:0031975 envelope
2.59 9.22e-05 GO:0005759 mitochondrial matrix
2.44 4.22e-24 GO:0005739 mitochondrion
1.24 5.28e-05 GO:0044444 cytoplasmic part
1.18 2.94e-02 GO:0044422 organelle part
1.18 4.35e-02 GO:0044446 intracellular organelle part
1.14 8.79e-03 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
7.98 5.28e-05 GO:0004129 cytochrome-c oxidase activity
7.98 5.28e-05 GO:0015002 heme-copper terminal oxidase activity
7.98 5.28e-05 GO:0016675 oxidoreductase activity, acting on a heme group of donors
7.98 5.28e-05 GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
7.33 5.60e-07 GO:0003954 NADH dehydrogenase activity
7.33 5.60e-07 GO:0008137 NADH dehydrogenase (ubiquinone) activity
7.33 5.60e-07 GO:0050136 NADH dehydrogenase (quinone) activity
6.34 5.48e-06 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
5.03 9.71e-09 GO:0015078 hydrogen ion transmembrane transporter activity
4.01 3.13e-02 GO:0051536 iron-sulfur cluster binding
4.01 3.13e-02 GO:0051540 metal cluster binding
3.96 3.96e-04 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
3.13 2.90e-05 GO:0015077 monovalent inorganic cation transmembrane transporter activity
2.95 5.15e-06 GO:0022890 inorganic cation transmembrane transporter activity
1.98 1.41e-05 GO:0016491 oxidoreductase activity
1.70 4.69e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.70 2.22e-02 GO:0015075 ion transmembrane transporter activity
1.59 1.69e-02 GO:0022892 substrate-specific transporter activity