Motif ID: NR6A1.p2

Z-value: 0.547


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
NR6A1 2649 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR6A1chr9_-_126573349-0.533.3e-02Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_224611568 2.526 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr17_-_45619038 2.336 COL1A1
collagen, type I, alpha 1
chr7_+_100037817 1.342 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr6_+_146906520 1.142 NM_006834
RAB32
RAB32, member RAS oncogene family
chr16_+_55199978 0.963 NM_005953
MT2A
metallothionein 2A
chr9_+_123083540 0.942 GSN
gelsolin
chr10_+_89409332 0.915 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr16_-_68317945 0.707 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr9_-_14304036 0.667 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr1_+_19796044 0.641 NM_001032363
C1orf15-NBL1
C1orf151
C1ORF15-NBL1 read-through transcript
chromosome 1 open reading frame 151
chr19_-_6671585 0.639 NM_000064
C3
complement component 3
chr2_-_162638875 0.632 DPP4
dipeptidyl-peptidase 4
chr2_-_162638746 0.543 DPP4
dipeptidyl-peptidase 4
chr9_-_14303899 0.520 NFIB
nuclear factor I/B
chr7_-_149669622 0.434 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr10_+_123744131 0.429 TACC2
transforming, acidic coiled-coil containing protein 2
chr6_+_129245978 0.390 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr9_+_35782405 0.368 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr9_-_14303509 0.357 NFIB
nuclear factor I/B
chr2_-_162638790 0.326 DPP4
dipeptidyl-peptidase 4
chr19_-_48382398 0.303 NM_001130014
NM_002781
PSG5

pregnancy specific beta-1-glycoprotein 5

chrX_+_102727068 0.293 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr6_-_43592670 0.288 YIPF3
Yip1 domain family, member 3
chr19_-_14944729 0.244 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chrX_-_21686079 0.244 NM_014332
SMPX
small muscle protein, X-linked
chr1_+_224064365 0.214 NM_001136018
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr8_-_125648576 0.214 MTSS1
metastasis suppressor 1
chr14_+_92188546 0.212 RIN3
Ras and Rab interactor 3
chr12_+_7039453 0.196


chr3_-_52287297 0.175 WDR82
WD repeat domain 82
chr19_+_10057972 0.173 C19orf66
chromosome 19 open reading frame 66
chr2_-_162638174 0.173 DPP4
dipeptidyl-peptidase 4
chr8_-_57521702 0.150 NM_001135690
PENK
proenkephalin
chr19_+_10058023 0.147 C19orf66
chromosome 19 open reading frame 66
chr19_-_48401532 0.143 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr1_-_151873191 0.124 NM_001024210
S100A13
S100 calcium binding protein A13
chr17_+_72958330 0.124 SEPT9
septin 9
chr11_+_64946820 0.117 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr2_-_31215074 0.107 NM_024572
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr1_+_224064427 0.106 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr7_+_45899080 0.105 IGFBP1
insulin-like growth factor binding protein 1
chr12_+_107797985 0.101 NM_001917
DAO
D-amino-acid oxidase
chr2_-_97775300 0.098 TMEM131
transmembrane protein 131
chr1_+_143920424 0.095 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr8_-_53789544 0.084 NM_001083617
NM_014781
RB1CC1

RB1-inducible coiled-coil 1

chr1_+_234372454 0.082 NM_003272
GPR137B
G protein-coupled receptor 137B
chr6_-_133076873 0.080 NM_004666
VNN1
vanin 1
chr5_+_134237325 0.073 NM_024715
TXNDC15
thioredoxin domain containing 15
chr19_-_48133089 0.072 NM_002783
PSG7
pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
chr12_+_107480423 0.072 NM_014301
NM_213595
ISCU

iron-sulfur cluster scaffold homolog (E. coli)

chr12_-_6354650 0.068 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr7_+_28497272 0.067 CREB5
cAMP responsive element binding protein 5
chr8_-_93177057 0.066 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr6_-_43592481 0.065 YIPF3
Yip1 domain family, member 3
chr6_-_43592679 0.064 NM_015388
YIPF3
Yip1 domain family, member 3
chrX_-_104352005 0.064 NM_031274
TEX13A
testis expressed 13A
chr1_+_210805319 0.064 NM_001030287
ATF3
activating transcription factor 3
chr11_-_2113297 0.064 IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_+_134947894 0.064 TF
transferrin
chr17_-_24426752 0.060 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr1_+_19796119 0.058


chr3_+_46386636 0.055 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr2_+_238265519 0.051 NM_001137551
NM_001137552
NM_001137553
NM_004735
LRRFIP1



leucine rich repeat (in FLII) interacting protein 1



chr7_-_97439500 0.050 MGC72080
MGC72080 pseudogene
chr22_-_22252376 0.050 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr9_-_21207303 0.046 NM_002173
IFNA16
interferon, alpha 16
chr3_+_134947788 0.046 TF
transferrin
chr3_+_46594079 0.042 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr9_+_139101235 0.042 NM_016219
MAN1B1
mannosidase, alpha, class 1B, member 1
chr17_-_9870292 0.041 NM_001130831
GAS7
growth arrest-specific 7
chr3_+_134947573 0.040 NM_001063
TF
transferrin
chr4_+_41309668 0.040 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_+_26376560 0.036 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr10_+_51507891 0.035 NM_018232
FAM21B
family with sequence similarity 21, member B
chrX_+_48505097 0.033 NM_001080489
GLOD5
glyoxalase domain containing 5
chr12_-_56422120 0.032 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr10_+_47414028 0.028 NM_018232
FAM21B
family with sequence similarity 21, member B
chr16_+_31274030 0.027 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr2_+_238265617 0.024 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr6_-_116706828 0.023 TSPYL1
TSPY-like 1
chr14_-_46190690 0.023 NM_080746
RPL10L
ribosomal protein L10-like
chr12_+_2792047 0.022 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr1_+_78284176 0.022 NM_017655
GIPC2
GIPC PDZ domain containing family, member 2
chr18_+_11741470 0.021 NM_001142339
NM_002071
GNAL

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

chr9_-_21218132 0.017 NM_021268
IFNA17
interferon, alpha 17
chr12_-_10453409 0.017 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr9_-_134219950 0.017 SETX
senataxin
chr14_-_63264445 0.016 NM_030791
SGPP1
sphingosine-1-phosphate phosphatase 1
chr19_-_5797465 0.014 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr12_+_119632213 0.014 NM_001080533
UNC119B
unc-119 homolog B (C. elegans)
chr17_-_40339919 0.013 GFAP
glial fibrillary acidic protein
chr11_+_36274300 0.012 NM_001160167
PRR5L
proline rich 5 like
chr10_+_106004457 0.010 NM_001191002
NM_004832
GSTO1

glutathione S-transferase omega 1

chr16_+_55553262 0.009 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr22_+_30340152 0.008 SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr4_-_47709717 0.007 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr11_-_73397929 0.007 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr6_+_30964441 0.007 NM_013994
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_-_40009513 0.006 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr9_-_38059082 0.005 SHB
Src homology 2 domain containing adaptor protein B
chr16_+_31273969 0.004 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr14_-_75517844 0.003 NM_003239
TGFB3
transforming growth factor, beta 3
chr19_+_47079089 0.002 NM_004706
NM_198977
ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1

chr5_-_41249270 0.002 NM_000065
C6
complement component 6
chr12_-_61832856 0.001 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr15_+_75074793 0.001 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr22_+_49388427 0.001 NM_016431
MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr21_-_36836767 0.001 NM_001146078
CLDN14
claudin 14
chr2_-_210798232 0.001 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr1_+_46151845 0.000 MAST2
microtubule associated serine/threonine kinase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
143.24 2.90e-02 GO:0001970 positive regulation of activation of membrane attack complex
143.24 2.90e-02 GO:0045917 positive regulation of complement activation
143.24 2.90e-02 GO:2000259 positive regulation of protein activation cascade
35.82 4.15e-02 GO:0010953 regulation of protein maturation by peptide bond cleavage
35.82 4.15e-02 GO:0070613 regulation of protein processing

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.50 9.58e-04 GO:0005576 extracellular region

Nothing significant found in function category.