Motif ID: HSF1,2.p2

Z-value: 1.717


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HSF2chr6_+_122762384-0.476.8e-02Click!
HSF1chr8_+_145486052,
chr8_+_145486087
-0.078.1e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_224611568 5.721 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr6_+_151688327 4.238 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chrX_+_135058402 4.218 NM_001159700
FHL1
four and a half LIM domains 1
chr7_+_134114957 4.146 CALD1
caldesmon 1
chr7_+_134114701 3.700 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr16_+_69060325 3.643 FUK
fucokinase
chr14_-_51605487 3.571 NID2
nidogen 2 (osteonidogen)
chr14_-_51605695 3.452 NM_007361
NID2
nidogen 2 (osteonidogen)
chr20_+_19818209 3.426 NM_018993
RIN2
Ras and Rab interactor 2
chr2_-_105421661 3.247 NM_201557
FHL2
four and a half LIM domains 2
chr8_-_13018123 3.229 NM_001164271
DLC1
deleted in liver cancer 1
chr14_-_51605515 3.125 NID2
nidogen 2 (osteonidogen)
chr14_-_51605461 3.040 NID2
nidogen 2 (osteonidogen)
chr2_-_188127430 3.025 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr3_+_160269734 2.959 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr11_-_118799452 2.907 NM_006288
THY1
Thy-1 cell surface antigen
chr12_+_118100977 2.860 NM_014365
HSPB8
heat shock 22kDa protein 8
chr2_-_188127294 2.478 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr6_+_146906520 2.262 NM_006834
RAB32
RAB32, member RAS oncogene family
chr2_-_189752575 2.260 NM_000393
COL5A2
collagen, type V, alpha 2
chrX_+_135106578 2.231 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr11_-_111287657 2.211 NM_001885
CRYAB
crystallin, alpha B
chr11_-_6298284 2.179 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr3_-_124893875 2.131 MYLK
myosin light chain kinase
chrX_-_10495476 2.125 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr2_-_158439868 2.104 NM_001105
ACVR1
activin A receptor, type I
chr7_-_80386258 2.074 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr7_-_80386602 2.009 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr12_+_74160779 1.933 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr11_+_69176391 1.879 CCND1
cyclin D1
chr7_+_129913271 1.840 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr9_-_87904280 1.782 GOLM1
golgi membrane protein 1
chr2_-_224612177 1.760 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr1_+_148747110 1.757 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr10_+_124210980 1.713 NM_002775
HTRA1
HtrA serine peptidase 1
chr1_+_148747208 1.648 ECM1
extracellular matrix protein 1
chr2_-_210876560 1.619 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr10_+_121400741 1.579 NM_004281
BAG3
BCL2-associated athanogene 3
chr12_+_13240868 1.578 NM_001423
EMP1
epithelial membrane protein 1
chr20_+_9146036 1.553 NM_182797
PLCB4
phospholipase C, beta 4
chr10_+_75343352 1.539 PLAU
plasminogen activator, urokinase
chr10_+_53744043 1.535 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr10_+_121401061 1.507 BAG3
BCL2-associated athanogene 3
chr1_-_108536885 1.464 NM_213651
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr9_-_87904306 1.459 NM_016548
GOLM1
golgi membrane protein 1
chr13_+_109932934 1.450 COL4A2
collagen, type IV, alpha 2
chr16_+_31391998 1.429 NM_015927
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chrX_+_135079461 1.410 NM_001167819
FHL1
four and a half LIM domains 1
chr11_+_12652427 1.400 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr12_-_119172339 1.398 NM_025157
PXN
paxillin
chrX_+_135079120 1.386 NM_001159704
FHL1
four and a half LIM domains 1
chr11_-_35503720 1.380 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr3_+_137224266 1.362 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr18_+_3441589 1.334 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr9_-_87904844 1.325 NM_177937
GOLM1
golgi membrane protein 1
chr2_-_192419896 1.315 SDPR
serum deprivation response
chr14_-_69953433 1.298 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr10_-_75080784 1.288 NM_024875
SYNPO2L
synaptopodin 2-like
chr9_-_32516164 1.287 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_134538526 1.279 SGK1
serum/glucocorticoid regulated kinase 1
chr19_+_15079141 1.248 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr9_+_494661 1.241 NM_015158
KANK1
KN motif and ankyrin repeat domains 1
chr15_+_94670160 1.235 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr7_+_129919157 1.218 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr6_-_109521969 1.216 NM_014454
SESN1
sestrin 1
chr15_+_22772545 1.203 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr7_+_142790047 1.203 ZYX
zyxin
chr10_+_121401032 1.197 BAG3
BCL2-associated athanogene 3
chr1_-_148175383 1.196 NM_001145862
MTMR11
myotubularin related protein 11
chr3_-_115585178 1.193 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chrX_-_102828238 1.184 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr6_-_134538762 1.182 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr4_-_22126437 1.177 NM_145290
GPR125
G protein-coupled receptor 125
chr21_+_29374743 1.171 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr9_-_74757735 1.171 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr20_+_4614796 1.165 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr16_+_55217180 1.136 MT1E
metallothionein 1E
chr7_+_102340579 1.135 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr2_-_158440587 1.127 NM_001111067
ACVR1
activin A receptor, type I
chr22_-_35011703 1.089 MYH9
myosin, heavy chain 9, non-muscle
chr17_-_59817456 1.089 PECAM1
platelet/endothelial cell adhesion molecule
chr9_-_87904215 1.087 GOLM1
golgi membrane protein 1
chr15_-_53996597 1.077 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr10_+_121400881 1.069 BAG3
BCL2-associated athanogene 3
chr19_+_52973653 1.053 NM_003009
SEPW1
selenoprotein W, 1
chr5_-_131590833 1.049 NM_001017973
NM_004199
P4HA2

prolyl 4-hydroxylase, alpha polypeptide II

chr18_-_802268 1.048 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr2_+_66516196 1.042 MEIS1
Meis homeobox 1
chr3_+_45042754 1.021 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr6_+_129245978 1.017 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr8_+_70541412 1.016 NM_001128204
NM_015170
SULF1

sulfatase 1

chr3_+_189425886 1.012 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr5_+_17270781 0.981 BASP1
brain abundant, membrane attached signal protein 1
chr3_+_161040439 0.979 SCHIP1
schwannomin interacting protein 1
chr2_-_151052391 0.979 NM_005168
RND3
Rho family GTPase 3
chr17_-_59817654 0.977 PECAM1
platelet/endothelial cell adhesion molecule
chr8_-_93181091 0.967 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_161040343 0.967 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr17_-_59817575 0.959 PECAM1
platelet/endothelial cell adhesion molecule
chr7_+_134114912 0.958 CALD1
caldesmon 1
chr7_+_134226727 0.948 CALD1
caldesmon 1
chr1_-_148174722 0.948 NM_181873
MTMR11
myotubularin related protein 11
chr11_-_27637771 0.936 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr1_-_148175345 0.932 MTMR11
myotubularin related protein 11
chr7_+_93862137 0.931 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr1_-_199657468 0.904 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr6_-_134540666 0.902 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr4_+_40953652 0.891 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr20_+_29656744 0.886 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr2_-_162808123 0.882 NM_004460
FAP
fibroblast activation protein, alpha
chr2_+_108604111 0.879 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr13_+_113574925 0.879 NM_001143945
GAS6
growth arrest-specific 6
chrX_-_10605726 0.872 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr13_+_47705493 0.865 ITM2B
integral membrane protein 2B
chr17_-_59817722 0.848 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chrX_-_106130098 0.842 NM_001085354
NM_024657
MORC4

MORC family CW-type zinc finger 4

chr4_+_40953698 0.832 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr8_+_136539290 0.829 KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr10_+_121401076 0.825 BAG3
BCL2-associated athanogene 3
chr4_+_40953666 0.822 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr1_+_78217510 0.820 DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr12_-_8706533 0.818 MFAP5
microfibrillar associated protein 5
chr5_+_36644187 0.814 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_+_75769765 0.812 NM_001540
HSPB1
heat shock 27kDa protein 1
chr7_+_134226690 0.811 NM_033139
NM_033140
CALD1

caldesmon 1

chr2_-_192420168 0.809 NM_004657
SDPR
serum deprivation response
chr9_+_123126652 0.808 GSN
gelsolin
chr16_+_55273879 0.796 NM_005952
MT1X
metallothionein 1X
chr14_+_54104383 0.792 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr4_-_101658094 0.791 NM_001159694
NM_016242
EMCN

endomucin

chr5_-_146813343 0.790 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr21_+_34112456 0.790 ITSN1
intersectin 1 (SH3 domain protein)
chr11_-_27700180 0.787 NM_170731
BDNF
brain-derived neurotrophic factor
chr2_-_217268492 0.776 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr11_-_63138516 0.774 NM_001128203
PLA2G16
phospholipase A2, group XVI
chr7_+_75769927 0.771 HSPB1
heat shock 27kDa protein 1
chr13_-_32658215 0.767 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chrX_-_21686079 0.760 NM_014332
SMPX
small muscle protein, X-linked
chr9_-_13269562 0.760 MPDZ
multiple PDZ domain protein
chr8_-_131483395 0.759 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr2_+_28469850 0.752 FOSL2
FOS-like antigen 2
chr15_+_22652790 0.739 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr12_-_6321417 0.729 NM_001065
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr4_-_187114407 0.717 SORBS2
sorbin and SH3 domain containing 2
chr7_+_142789476 0.715 ZYX
zyxin
chr8_-_82557956 0.713 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr7_+_32963486 0.713 NM_007270
FKBP9
FK506 binding protein 9, 63 kDa
chr11_-_63138483 0.712 NM_007069
PLA2G16
phospholipase A2, group XVI
chr1_-_171442937 0.712 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr9_-_35679799 0.712 TPM2
tropomyosin 2 (beta)
chr2_+_210152399 0.711 MAP2
microtubule-associated protein 2
chr13_+_47705251 0.710 NM_021999
ITM2B
integral membrane protein 2B
chr11_-_63138416 0.710 PLA2G16
phospholipase A2, group XVI
chr20_+_9406460 0.704 PLCB4
phospholipase C, beta 4
chr3_-_124822113 0.701 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr19_+_50041424 0.699 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr12_+_1596482 0.697 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chr11_+_74950766 0.691 NM_001235
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr9_-_34700062 0.691 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr19_+_3073560 0.690


chrX_-_51256035 0.689 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr11_+_74950893 0.687 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr17_+_9686572 0.677 GLP2R
glucagon-like peptide 2 receptor
chr12_-_14887648 0.677 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr11_+_101488380 0.675 NM_001195045
YAP1
Yes-associated protein 1
chr15_-_88143721 0.668 ANPEP
alanyl (membrane) aminopeptidase
chr3_-_131081910 0.660 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr14_-_52487558 0.657 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr10_+_82268433 0.655 TSPAN14
tetraspanin 14
chr8_-_18710575 0.650 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr11_-_63138061 0.647 PLA2G16
phospholipase A2, group XVI
chr16_+_29739256 0.643 MVP
major vault protein
chr5_-_122400312 0.631 NM_000943
PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr12_+_47494882 0.621 CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr10_-_116434102 0.612 ABLIM1
actin binding LIM protein 1
chr9_-_35679902 0.611 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr8_-_18585721 0.602 PSD3
pleckstrin and Sec7 domain containing 3
chr1_+_160868822 0.601 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr11_-_118799058 0.599 THY1
Thy-1 cell surface antigen
chr12_-_51298599 0.598 NM_175068
KRT73
keratin 73
chr17_+_35853177 0.597 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr10_+_123738678 0.594 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr6_-_40003295 0.593 NM_005943
MOCS1
molybdenum cofactor synthesis 1
chr17_+_65677255 0.591 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr10_+_71231649 0.589 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr9_+_74956494 0.588 NM_000700
ANXA1
annexin A1
chr2_+_69093641 0.584 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr2_+_189547323 0.583 NM_000090
COL3A1
collagen, type III, alpha 1
chr8_+_40130143 0.581 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr18_+_54013575 0.576 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_+_95838801 0.576 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr10_-_125841840 0.575 NM_014863
NM_015892
CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr19_+_40298571 0.574 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr2_-_113259441 0.573 NM_000575
IL1A
interleukin 1, alpha
chr15_+_66711380 0.571 NM_001190457
CORO2B
coronin, actin binding protein, 2B
chr16_+_29739215 0.567 NM_005115
NM_017458
MVP

major vault protein

chr12_-_6321241 0.565 TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr19_-_59383944 0.563 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr5_-_55326358 0.561 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr12_-_48902692 0.559 NM_001113547
LIMA1
LIM domain and actin binding 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.78 2.51e-06 GO:0007155 cell adhesion
1.78 2.51e-06 GO:0022610 biological adhesion
1.86 8.95e-06 GO:0006928 cellular component movement
9.53 4.22e-05 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
7.80 1.99e-04 GO:0060600 dichotomous subdivision of an epithelial terminal unit
6.81 3.10e-04 GO:0048484 enteric nervous system development
8.47 3.44e-04 GO:0048880 sensory system development
8.47 3.44e-04 GO:0048892 lateral line nerve development
8.47 3.44e-04 GO:0048895 lateral line nerve glial cell differentiation
8.47 3.44e-04 GO:0048925 lateral line system development
8.47 3.44e-04 GO:0048937 lateral line nerve glial cell development
8.47 3.44e-04 GO:0050935 iridophore differentiation
6.35 8.42e-04 GO:0030513 positive regulation of BMP signaling pathway
1.54 4.69e-03 GO:0040011 locomotion
6.93 5.19e-03 GO:0090184 positive regulation of kidney development
1.73 1.18e-02 GO:0048870 cell motility
1.73 1.18e-02 GO:0051674 localization of cell
6.35 1.41e-02 GO:0048846 axon extension involved in axon guidance
1.18 1.48e-02 GO:0032501 multicellular organismal process
1.37 3.10e-02 GO:0009653 anatomical structure morphogenesis
2.92 3.37e-02 GO:0048762 mesenchymal cell differentiation
3.75 3.97e-02 GO:0014033 neural crest cell differentiation
1.37 4.06e-02 GO:0009966 regulation of signal transduction
2.96 4.70e-02 GO:0014031 mesenchymal cell development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.65 1.67e-07 GO:0044421 extracellular region part
1.45 1.56e-06 GO:0005576 extracellular region
1.61 8.04e-05 GO:0005615 extracellular space
1.96 8.06e-05 GO:0031012 extracellular matrix
2.63 7.74e-04 GO:0044420 extracellular matrix part
1.95 1.22e-03 GO:0005578 proteinaceous extracellular matrix
3.47 3.09e-02 GO:0005581 collagen

Nothing significant found in function category.