Motif ID: NKX2-2,8.p2

Z-value: 1.072


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-8chr14_-_36121536-0.136.3e-01Click!
NKX2-2chr20_-_214426630.049.0e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_122862447 5.292 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_122862391 5.238 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr17_-_26665144 4.583 EVI2B
ecotropic viral integration site 2B
chr17_-_26665220 2.936 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_-_26665213 2.822 EVI2B
ecotropic viral integration site 2B
chr17_-_26665194 2.462 EVI2B
ecotropic viral integration site 2B
chr4_-_71751070 2.274 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_-_71751205 2.065 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr12_+_25096755 1.795 LRMP
lymphoid-restricted membrane protein
chr21_-_14840506 1.771 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr10_+_97505398 1.757 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr17_-_35975227 1.736 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr14_-_106184988 1.685 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_+_54530485 1.635 NM_001040031
NM_001774
CD37

CD37 molecule

chr19_+_54530497 1.586 CD37
CD37 molecule
chr19_+_54530458 1.564 CD37
CD37 molecule
chr19_+_54530512 1.547 CD37
CD37 molecule
chr12_-_101115677 1.544 NM_002674
PMCH
pro-melanin-concentrating hormone
chr1_+_196874759 1.439 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_+_196874839 1.437 PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_+_25096472 1.404 NM_006152
LRMP
lymphoid-restricted membrane protein
chr19_+_54530546 1.337 CD37
CD37 molecule
chr11_-_110755112 1.310 POU2AF1
POU class 2 associating factor 1
chr13_-_45654327 1.289 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_239762179 1.267 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chrX_-_154216929 1.216 NM_001289
CLIC2
chloride intracellular channel 2
chr15_-_53350383 1.214 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr2_+_33514896 1.211 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_+_102320148 1.211 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr13_-_40454188 1.208 ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_+_143603368 1.107 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr1_+_196874867 1.078 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_-_205161821 1.046 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr4_-_153493133 1.004 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr22_+_38652555 1.002 GRAP2
GRB2-related adaptor protein 2
chr15_-_91078307 0.960 FAM174B
family with sequence similarity 174, member B
chr1_-_161379606 0.930 RGS5
regulator of G-protein signaling 5
chr22_+_21053972 0.928


chr3_+_153499883 0.863 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr5_+_156752739 0.859 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr15_-_53349775 0.809 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr18_+_30812205 0.809 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr17_+_65009986 0.803 MAP2K6
mitogen-activated protein kinase kinase 6
chrX_+_11687655 0.778 NM_006800
MSL3
male-specific lethal 3 homolog (Drosophila)
chr7_-_36991189 0.751 NM_001039459
ELMO1
engulfment and cell motility 1
chr2_-_158008763 0.736 NM_004288
CYTIP
cytohesin 1 interacting protein
chr3_+_88270951 0.723 NM_018293
ZNF654
zinc finger protein 654
chr1_+_111217244 0.699 NM_000560
CD53
CD53 molecule
chr11_+_22646229 0.698 NM_177553
GAS2
growth arrest-specific 2
chr14_-_22354457 0.688 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr10_+_35496449 0.688 NM_182771
NM_182772
CREM

cAMP responsive element modulator

chr10_-_121286034 0.683 NM_002925
RGS10
regulator of G-protein signaling 10
chr22_+_21079355 0.676


chr4_-_84254932 0.666 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chrX_-_70248022 0.646 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr14_-_22354389 0.645 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr2_+_143603439 0.634 ARHGAP15
Rho GTPase activating protein 15
chr22_-_16070778 0.624 NM_017424
CECR1
cat eye syndrome chromosome region, candidate 1
chr18_+_27925859 0.623 RNF138
ring finger protein 138
chr1_+_185064654 0.614 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chrX_-_118610880 0.604 NM_001173488
NKRF
NFKB repressing factor
chr8_-_81155564 0.591 NM_001025252
TPD52
tumor protein D52
chr9_+_99303282 0.586 NM_001166116
TMOD1
tropomodulin 1
chr1_+_111217314 0.582 CD53
CD53 molecule
chr22_+_38627031 0.575 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr3_+_63928459 0.553 NM_001128149
ATXN7
ataxin 7
chrX_+_108665665 0.546 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr1_+_100099353 0.545 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chrX_+_99726445 0.534 NM_022144
TNMD
tenomodulin
chr22_+_38627129 0.533 GRAP2
GRB2-related adaptor protein 2
chr11_-_47467094 0.531 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr1_-_224993498 0.529 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr18_-_65775139 0.525 NM_006566
CD226
CD226 molecule
chr10_+_57028755 0.521 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr4_+_88147107 0.520 NM_005935
AFF1
AF4/FMR2 family, member 1
chr5_-_98290117 0.515 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr1_-_180840016 0.510 NM_002928
RGS16
regulator of G-protein signaling 16
chr4_-_84254912 0.503 PLAC8
placenta-specific 8
chr5_-_88155360 0.502 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr2_-_61566477 0.501 XPO1
exportin 1 (CRM1 homolog, yeast)
chr13_+_57103789 0.499 NM_001040429
PCDH17
protocadherin 17
chr7_+_115650240 0.490 NM_152829
TES
testis derived transcript (3 LIM domains)
chr1_+_66230977 0.487 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr14_+_20319049 0.481 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr14_+_66901237 0.479 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr1_+_173111306 0.469 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr2_-_191580567 0.462 STAT1
signal transducer and activator of transcription 1, 91kDa
chrX_-_30505804 0.462 NM_025159
CXorf21
chromosome X open reading frame 21
chr1_-_111544784 0.457 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr14_+_87541220 0.456 NM_003608
GPR65
G protein-coupled receptor 65
chr9_+_115303527 0.455 NM_130795
RGS3
regulator of G-protein signaling 3
chr14_-_19871267 0.454 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr14_-_99911528 0.453 WARS
tryptophanyl-tRNA synthetase
chr6_-_32271277 0.451 NM_022107
GPSM3
G-protein signaling modulator 3
chr11_+_33520348 0.451 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr14_-_99911679 0.445 NM_004184
NM_213646
WARS

tryptophanyl-tRNA synthetase

chr3_-_33675484 0.443 CLASP2
cytoplasmic linker associated protein 2
chr8_+_17866373 0.443 PCM1
pericentriolar material 1
chr5_+_128468785 0.435 ISOC1
isochorismatase domain containing 1
chr5_+_159781413 0.419 NM_004219
PTTG1
pituitary tumor-transforming 1
chr5_+_159781454 0.417 PTTG1
pituitary tumor-transforming 1
chr14_-_105542441 0.407 IGLJ3
IGHA1
IGHG1
IGHM
immunoglobulin lambda joining 3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr4_-_35922288 0.400 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_165564904 0.399 NM_001198783
POU2F1
POU class 2 homeobox 1
chr10_+_91488704 0.397 KIF20B
kinesin family member 20B
chr18_+_27925815 0.397 NM_016271
RNF138
ring finger protein 138
chr21_+_41655786 0.385 NM_002463
LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr4_-_103464491 0.381 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr16_-_21197138 0.379 CRYM
crystallin, mu
chr1_+_15862887 0.378


chr9_-_20612476 0.377 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr3_-_56673113 0.372 NM_015224
C3orf63
chromosome 3 open reading frame 63
chr6_-_55848346 0.366 BMP5
bone morphogenetic protein 5
chr13_-_47885018 0.366 LPAR6
lysophosphatidic acid receptor 6
chr13_-_40454360 0.366 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_+_58127155 0.365 NM_001130480
NM_001130482
NM_001130483
NM_006296
NM_001130481
VRK2




vaccinia related kinase 2




chr6_-_55848317 0.362 NM_021073
BMP5
bone morphogenetic protein 5
chr12_-_642786 0.361 NM_016533
NINJ2
ninjurin 2
chr2_+_85658124 0.360 NM_003761
VAMP8
vesicle-associated membrane protein 8 (endobrevin)
chr10_+_35524060 0.355 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr17_+_7532391 0.354 NM_001143992
NM_018081
WRAP53

WD repeat containing, antisense to TP53

chr1_+_165565006 0.353 POU2F1
POU class 2 homeobox 1
chr9_-_20612433 0.349 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chrX_+_107174855 0.348 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr2_+_161980865 0.343 NM_006593
TBR1
T-box, brain, 1
chrX_+_48978875 0.343 CCDC22
coiled-coil domain containing 22
chr4_+_114433551 0.337 ANK2
ankyrin 2, neuronal
chr8_+_26206648 0.334 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr7_+_5609416 0.333 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr2_+_161981138 0.333 TBR1
T-box, brain, 1
chr2_+_88966170 0.330


chr1_+_103961476 0.321 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr3_-_57209319 0.319 NM_003865
HESX1
HESX homeobox 1
chr1_+_242281199 0.318 ZNF238
zinc finger protein 238
chr14_-_105523735 0.317 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_+_139175420 0.316 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chrX_+_48978923 0.309 CCDC22
coiled-coil domain containing 22
chr11_+_93916653 0.306 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr12_-_44877769 0.306 SLC38A1
solute carrier family 38, member 1
chr13_+_81162030 0.298


chr10_-_64698831 0.298 NM_004241
JMJD1C
jumonji domain containing 1C
chr6_-_99957253 0.295 SFRS18
splicing factor, arginine/serine-rich 18
chr4_-_153523113 0.295 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr5_+_169713458 0.289 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr2_-_215605054 0.288 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr6_-_47030492 0.288 NM_015234
GPR116
G protein-coupled receptor 116
chr1_-_111544820 0.287 DENND2D
DENN/MADD domain containing 2D
chr3_+_150065732 0.287 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr1_-_181826086 0.286 NCF2
neutrophil cytosolic factor 2
chr5_+_70980724 0.275 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr1_-_118123033 0.274


chrX_-_70391771 0.271 NM_001171162
ZMYM3
zinc finger, MYM-type 3
chr11_-_102001259 0.271 NM_004771
MMP20
matrix metallopeptidase 20
chr2_+_161981046 0.268 TBR1
T-box, brain, 1
chr7_-_120285364 0.266 NM_012338
TSPAN12
tetraspanin 12
chr6_+_4835224 0.264 NM_001143971
CDYL
chromodomain protein, Y-like
chr8_+_17874128 0.264 PCM1
pericentriolar material 1
chr5_-_150501393 0.264 NM_001193544
ANXA6
annexin A6
chr5_+_102493155 0.264 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr3_-_168674502 0.261 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr4_+_88939725 0.255 NM_004967
IBSP
integrin-binding sialoprotein
chr1_+_242281175 0.252 NM_205768
ZNF238
zinc finger protein 238
chr2_-_20375497 0.251 PUM2
pumilio homolog 2 (Drosophila)
chr4_-_140280031 0.251 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr2_-_225086564 0.250 CUL3
cullin 3
chr21_-_42689192 0.250 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr3_+_120799411 0.249 NM_015900
PLA1A
phospholipase A1 member A
chr5_+_162862808 0.245 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr9_-_15500209 0.241 NM_021144
PSIP1
PC4 and SFRS1 interacting protein 1
chr10_+_13668944 0.241 NM_003675
PRPF18
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
chrX_-_32083506 0.240 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr1_-_74971679 0.240 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chr22_-_22426551 0.239 NM_013378
VPREB3
pre-B lymphocyte 3
chr16_-_1761504 0.239 NME3
non-metastatic cells 3, protein expressed in
chr1_-_26266571 0.236 NM_032588
TRIM63
tripartite motif containing 63
chr8_+_107807415 0.232 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr13_+_110653407 0.231 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr12_-_52975823 0.229 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr1_+_103840900 0.229 RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr12_+_61645361 0.228 RPL14
ribosomal protein L14
chr5_+_43645018 0.228 NNT
nicotinamide nucleotide transhydrogenase
chr11_-_5657947 0.227 TRIM5
tripartite motif containing 5
chr6_-_123999640 0.227 NM_006073
TRDN
triadin
chrX_+_122923279 0.226 STAG2
stromal antigen 2
chr10_-_101680645 0.226 DNMBP
dynamin binding protein
chr14_-_99911409 0.223 WARS
tryptophanyl-tRNA synthetase
chr1_-_51660328 0.219 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr17_+_22982372 0.217 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_+_149299307 0.217 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr7_+_90177082 0.215 CDK14
cyclin-dependent kinase 14
chrX_+_37524190 0.214 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr2_-_89400935 0.213 IGKC
immunoglobulin kappa constant
chr4_+_129021514 0.213 NM_001190801
PLK4
polo-like kinase 4
chr20_+_20296744 0.212 NM_002196
INSM1
insulinoma-associated 1
chr22_+_21384862 0.210 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr2_-_98646367 0.209 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chrX_+_90977115 0.209 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr4_-_84254873 0.209 PLAC8
placenta-specific 8
chrX_+_48978870 0.209 NM_014008
CCDC22
coiled-coil domain containing 22
chr10_+_13668964 0.207 PRPF18
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.