Motif ID: HNF4A_NR2F1,2.p2

Z-value: 4.018


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF4Achr20_+_424632790.467.3e-02Click!
NR2F1chr5_+_929463480.439.4e-02Click!
NR2F2chr15_+_94677572-0.312.4e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_24394281 14.155 PIPOX
pipecolic acid oxidase
chr14_-_93924873 13.509 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_31731647 10.530 NM_019101
APOM
apolipoprotein M
chr6_+_31731667 10.473 APOM
apolipoprotein M
chr1_-_167822248 10.262 F5
coagulation factor V (proaccelerin, labile factor)
chr12_+_51783540 9.920 NM_003578
SOAT2
sterol O-acyltransferase 2
chr12_+_51783554 9.131 SOAT2
sterol O-acyltransferase 2
chr10_-_101831579 8.743 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr6_+_32021793 8.670 CFB
complement factor B
chr6_+_32090516 8.509 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr5_-_42847716 8.438 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr10_+_102722275 8.226 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr1_-_167822334 8.175 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr1_-_159459814 7.740 APOA2
apolipoprotein A-II
chr11_+_46697345 7.540 F2
coagulation factor II (thrombin)
chr17_+_24394043 7.492 NM_016518
PIPOX
pipecolic acid oxidase
chr11_-_116213511 7.380 NM_000039
APOA1
apolipoprotein A-I
chr11_+_46697312 7.152 NM_000506
F2
coagulation factor II (thrombin)
chr17_-_31353196 7.106 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr14_-_23847024 7.031 CIDEB
cell death-inducing DFFA-like effector b
chr16_-_51138306 6.952 NM_001080430
TOX3
TOX high mobility group box family member 3
chr14_-_23846993 6.911 CIDEB
cell death-inducing DFFA-like effector b
chr2_-_21079145 6.861 APOB
apolipoprotein B (including Ag(x) antigen)
chr13_+_112825113 6.845 NM_000504
F10
coagulation factor X
chr14_-_23847000 6.678 CIDEB
cell death-inducing DFFA-like effector b
chr1_-_228916958 6.671 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_+_32021742 6.569 CFB
complement factor B
chr1_-_172153087 6.504 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr14_-_23846904 6.217 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_93924663 6.121 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_32021831 6.120 CFB
complement factor B
chr1_-_172153024 6.088 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_-_159459999 6.014 NM_001643
APOA2
apolipoprotein A-II
chr19_+_40321584 5.885 FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_40321567 5.755 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr17_-_7023378 5.670 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr10_+_114123828 5.665 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_238164042 5.660 RAB17
RAB17, member RAS oncogene family
chr6_+_32057779 5.549 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chrX_-_105169370 5.348 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr2_+_218992053 5.261 NM_007127
VIL1
villin 1
chr2_+_219354692 5.182 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr10_+_114123765 5.137 ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_29635456 5.044 UBD
ubiquitin D
chr2_-_238164452 4.873 NM_022449
RAB17
RAB17, member RAS oncogene family
chr3_-_52454082 4.749 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr19_+_5774817 4.731 NM_004558
NRTN
neurturin
chr4_+_100714995 4.669 MTTP
microsomal triglyceride transfer protein
chr17_+_4621924 4.587 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr17_-_6958773 4.548 NM_001181
NM_080912
NM_080913
ASGR2


asialoglycoprotein receptor 2


chr17_-_23721351 4.528 VTN
vitronectin
chr19_-_45888259 4.443 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr20_+_55569542 4.376 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_-_88208650 4.374 NM_001443
FABP1
fatty acid binding protein 1, liver
chr22_+_23333610 4.292 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr6_+_32021687 4.288 NM_001710
CFB
complement factor B
chr3_+_187813405 4.274 AHSG
alpha-2-HS-glycoprotein
chr17_+_38259620 4.265 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr2_+_47449951 4.215 EPCAM
epithelial cell adhesion molecule
chr4_+_69996780 4.141 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chrX_+_152565849 4.075 DUSP9
dual specificity phosphatase 9
chr17_-_6958695 4.067 ASGR2
asialoglycoprotein receptor 2
chr16_-_86527608 3.883 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr1_-_110108048 3.871 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr6_+_32003380 3.859 C2
complement component 2
chr17_+_1612092 3.850 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_73036241 3.813 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr17_+_1593040 3.809 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr4_-_9632192 3.752 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr12_-_109424260 3.738 NM_016226
NM_057180
VPS29

vacuolar protein sorting 29 homolog (S. cerevisiae)

chr7_+_137411717 3.734 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr3_-_195553297 3.716 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr17_-_31352720 3.684 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr6_+_32003180 3.642 NM_000063
NM_001145903
C2

complement component 2

chr13_+_112808102 3.581 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr17_+_1592879 3.554 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr8_+_21972631 3.486 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr12_-_7935010 3.484 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr19_+_18357966 3.461 NM_004864
GDF15
growth differentiation factor 15
chr12_-_120781002 3.446 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr10_+_101532544 3.381 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr12_+_7039453 3.380


chr16_+_8722068 3.368 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr14_-_64479198 3.332 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr20_-_3097070 3.295 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr16_-_54424517 3.262 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr16_+_29597965 3.189 QPRT
quinolinate phosphoribosyltransferase
chr2_+_241193492 3.188 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr17_+_38306339 3.180 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr19_+_876984 3.163 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr8_-_17787342 3.154 FGL1
fibrinogen-like 1
chr10_+_101532450 3.147 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr8_+_21972804 3.092 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr17_-_31352643 3.024 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr4_+_140806536 3.024 MGST2
microsomal glutathione S-transferase 2
chr9_-_98368913 3.014 NM_001077181
CDC14B
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr4_+_140806371 2.968 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr3_-_58497913 2.946 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr17_+_69950782 2.920 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr16_+_8675904 2.920 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr1_+_153366928 2.872 NM_004428
NM_182685
EFNA1

ephrin-A1

chr17_-_23721420 2.857 VTN
vitronectin
chr3_-_121883647 2.811 HGD
homogentisate 1,2-dioxygenase
chr19_-_56561444 2.799 NM_001985
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr16_-_54424473 2.783 CES1
carboxylesterase 1
chr19_-_56561391 2.780 ETFB
electron-transfer-flavoprotein, beta polypeptide
chr3_+_38470782 2.772 NM_001106
ACVR2B
activin A receptor, type IIB
chr6_-_29635680 2.767 NM_006398
UBD
ubiquitin D
chr1_+_219026661 2.756 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr6_+_30238961 2.713 NM_033229
TRIM15
tripartite motif containing 15
chr2_+_74502364 2.651 NM_032118
WDR54
WD repeat domain 54
chr17_+_19377732 2.638 NM_018242
SLC47A1
solute carrier family 47, member 1
chr14_+_73073570 2.637 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr16_-_30032330 2.618 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr16_+_30118036 2.594 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr17_-_23721468 2.576 VTN
vitronectin
chrX_+_115481774 2.520 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr19_-_6671585 2.491 NM_000064
C3
complement component 3
chr3_-_50315983 2.470 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr17_-_23721430 2.470 VTN
vitronectin
chr14_+_20226762 2.453 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr2_+_42249896 2.446 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr14_+_38805251 2.439 NM_203356
CTAGE5
CTAGE family, member 5
chr16_-_16224791 2.406 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr9_-_129752687 2.375 NM_203305
FAM102A
family with sequence similarity 102, member A
chr17_+_35147697 2.368 NM_005310
GRB7
growth factor receptor-bound protein 7
chr14_+_73105515 2.364 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr2_+_159021653 2.351 PKP4
plakophilin 4
chr19_-_40996040 2.347 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr2_+_11591692 2.337 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr22_+_19458378 2.321 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr12_+_110688728 2.313 NM_000690
ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
chr1_+_43837096 2.295 PTPRF
protein tyrosine phosphatase, receptor type, F
chr12_-_55295628 2.295 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr3_+_52787478 2.270 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chrX_-_130250880 2.264 IGSF1
immunoglobulin superfamily, member 1
chr7_-_86942910 2.260 NM_000443
NM_018849
NM_018850
ABCB4


ATP-binding cassette, sub-family B (MDR/TAP), member 4


chr18_-_19420376 2.244 NPC1
Niemann-Pick disease, type C1
chr18_-_19420438 2.188 NM_000271
NPC1
Niemann-Pick disease, type C1
chr19_-_45947667 2.174 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr11_-_71458739 2.163 NUMA1
nuclear mitotic apparatus protein 1
chr1_+_203740391 2.157 CDK18
cyclin-dependent kinase 18
chr11_+_120966280 2.137 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr11_+_22644732 2.132 NM_001143830
GAS2
growth arrest-specific 2
chr17_+_1612031 2.125 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr1_+_144439069 2.112 NM_002614
PDZK1
PDZ domain containing 1
chr17_+_1612056 2.104 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_-_584526 2.090 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr17_+_50699965 2.087 HLF
hepatic leukemia factor
chr10_+_102096761 2.013 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr3_-_9896933 1.980 CIDEC
cell death-inducing DFFA-like effector c
chr17_+_69939130 1.971 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr4_+_113372287 1.961 NM_001128426
NM_018569
AP1AR

adaptor-related protein complex 1 associated regulatory protein

chr17_+_38256710 1.954 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr16_-_28528780 1.952 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr3_+_143797895 1.950 NM_001145319
PLS1
plastin 1
chr5_-_74198370 1.940 NM_015566
FAM169A
family with sequence similarity 169, member A
chr2_+_47449790 1.930 NM_002354
EPCAM
epithelial cell adhesion molecule
chr19_-_584563 1.910 NM_005035
POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr10_+_102096991 1.896 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr16_+_29597829 1.881 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr17_+_1611983 1.826 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_60858611 1.820 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chrX_+_38305634 1.812 NM_004615
TSPAN7
tetraspanin 7
chr3_-_9895633 1.809 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr16_+_29819647 1.806 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr17_+_35147738 1.801 GRB7
growth factor receptor-bound protein 7
chr11_-_2127368 1.797 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr19_-_4293718 1.795 STAP2
signal transducing adaptor family member 2
chr3_-_49434874 1.782 AMT
aminomethyltransferase
chr6_+_43845915 1.775 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_003376
VEGFA















vascular endothelial growth factor A















chr9_-_94936319 1.768 NM_004148
NINJ1
ninjurin 1
chr20_+_34143983 1.753 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr6_-_47362102 1.743 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_224083047 1.742 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr20_+_35406497 1.737 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr22_-_36305883 1.733 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr7_+_149201962 1.730 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr19_-_60412624 1.726 NM_001161440
NM_002842
PTPRH

protein tyrosine phosphatase, receptor type, H

chr4_-_1156959 1.712 NM_001128325
SPON2
spondin 2, extracellular matrix protein
chr11_-_1549719 1.710 NM_004420
DUSP8
dual specificity phosphatase 8
chr1_+_39229474 1.707 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr3_+_134947894 1.701 TF
transferrin
chr16_+_3055313 1.699 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr17_+_76133337 1.686 RPTOR
regulatory associated protein of MTOR, complex 1
chr12_-_49706190 1.677 NM_001174129
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr19_+_50137334 1.674 NM_001646
APOC4-APOC2
APOC4
APOC4-APOC2 read-through transcript
apolipoprotein C-IV
chr19_-_40995606 1.673 PRODH2
proline dehydrogenase (oxidase) 2
chr2_+_211129567 1.667 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr20_-_22514092 1.661 NM_153675
FOXA2
forkhead box A2
chr1_-_180622083 1.652 GLUL
glutamate-ammonia ligase
chr17_-_33179118 1.649 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr12_-_46684551 1.647 NM_001844
NM_033150
COL2A1

collagen, type II, alpha 1

chr17_+_67628749 1.646 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr2_+_211166323 1.626 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr19_+_54708302 1.620 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr8_+_22280703 1.618 NM_001128431
NM_001135154
NM_015359
SLC39A14


solute carrier family 39 (zinc transporter), member 14


chr1_-_228916470 1.613 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chrX_-_100920493 1.607 GK
glycerol kinase
chr10_+_102096948 1.600 SCD
stearoyl-CoA desaturase (delta-9-desaturase)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.36 1.59e-04 GO:0044281 small molecule metabolic process
1.14 4.76e-04 GO:0008152 metabolic process
1.54 3.18e-03 GO:0006082 organic acid metabolic process
1.53 4.71e-03 GO:0019752 carboxylic acid metabolic process
1.53 4.71e-03 GO:0043436 oxoacid metabolic process
1.50 1.47e-02 GO:0042180 cellular ketone metabolic process
1.76 1.53e-02 GO:0032787 monocarboxylic acid metabolic process
1.13 3.00e-02 GO:0044238 primary metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 2.53e-02 GO:0044432 endoplasmic reticulum part
1.09 2.90e-02 GO:0005737 cytoplasm
1.12 4.83e-02 GO:0044444 cytoplasmic part

Nothing significant found in function category.