Motif ID: HIF1A.p2

Z-value: 1.958


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_61231795-0.116.7e-01Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_13866451 4.909 GPM6B
glycoprotein M6B
chrX_-_13866565 3.347 NM_001001994
GPM6B
glycoprotein M6B
chr12_-_21702036 2.887 LDHB
lactate dehydrogenase B
chr12_-_21702021 2.857 LDHB
lactate dehydrogenase B
chr12_-_21701985 2.760 NM_001174097
LDHB
lactate dehydrogenase B
chr12_-_21702000 2.719 LDHB
lactate dehydrogenase B
chr12_-_21702046 2.591 NM_002300
LDHB
lactate dehydrogenase B
chrX_-_13866366 2.411


chr8_+_95722448 2.228 ESRP1
epithelial splicing regulatory protein 1
chr5_+_17270474 1.997 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr5_+_17270781 1.932 BASP1
brain abundant, membrane attached signal protein 1
chr11_+_69602055 1.884 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr10_+_3099708 1.701 NM_002627
PFKP
phosphofructokinase, platelet
chr1_+_231816372 1.684 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr3_+_157874898 1.647 NM_015508
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr11_+_20341806 1.601 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr2_-_96174865 1.553 NM_004418
DUSP2
dual specificity phosphatase 2
chr4_-_143987053 1.533 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr10_+_17312654 1.480 VIM
vimentin
chr17_-_3546047 1.470 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr12_-_48963505 1.461 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr7_+_156624424 1.458 UBE3C
ubiquitin protein ligase E3C
chr7_+_156624392 1.447 NM_014671
UBE3C
ubiquitin protein ligase E3C
chr11_+_20341835 1.447 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr11_-_63770716 1.445 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_+_64804235 1.437 NM_002444
MSN
moesin
chr5_+_49998677 1.431 PARP8
poly (ADP-ribose) polymerase family, member 8
chr11_+_20341900 1.376 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr8_+_31616809 1.336 NM_013962
NRG1
neuregulin 1
chr1_-_158161902 1.322 NM_003564
TAGLN2
transgelin 2
chr10_+_112247614 1.321 NM_004419
DUSP5
dual specificity phosphatase 5
chr3_-_16530132 1.285 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr2_-_235070431 1.256 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr17_+_38238938 1.247 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr1_-_158161877 1.233 TAGLN2
transgelin 2
chr3_-_129023850 1.223 NM_007283
MGLL
monoglyceride lipase
chr3_-_129024665 1.200 NM_001003794
MGLL
monoglyceride lipase
chrX_+_64804259 1.180 MSN
moesin
chr3_-_16529996 1.177 RFTN1
raftlin, lipid raft linker 1
chr11_-_63770983 1.146 NM_138689
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_+_78298326 1.142 CCNG2
cyclin G2
chr1_-_43410235 1.137 EBNA1BP2
EBNA1 binding protein 2
chr12_+_129922589 1.084 RAN
RAN, member RAS oncogene family
chr12_-_40918417 1.063 NM_001190979
NM_001190980
NM_005748
YAF2


YY1 associated factor 2


chr12_+_129922570 1.041 RAN
RAN, member RAS oncogene family
chr8_+_49083522 1.040 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr1_-_146398501 1.036 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr1_-_143232275 1.025 LOC728855
hypothetical LOC728855
chr1_-_143232344 1.023 LOC728855
hypothetical LOC728855
chr17_-_3546108 1.021 P2RX5-TAX1BP3
P2RX5
P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5
chr6_-_159160386 1.016 EZR
ezrin
chr1_-_146543102 1.000


chr1_-_142535878 0.998 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr19_+_44113187 0.993 NM_033362
MRPS12
mitochondrial ribosomal protein S12
chr8_+_97343282 0.974 PTDSS1
phosphatidylserine synthase 1
chr12_-_40918249 0.973 NM_001190977
YAF2
YY1 associated factor 2
chr10_+_73703682 0.972 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chrX_+_148430424 0.967 NM_001171907
NM_001171908
NM_178124
CXorf40A


chromosome X open reading frame 40A


chr11_+_32808045 0.964 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr1_-_142536082 0.964


chr5_-_142763418 0.947 NM_000176
NM_001020825
NM_001024094
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr1_-_43410556 0.945 NM_006824
NM_001159936
EBNA1BP2

EBNA1 binding protein 2

chr19_+_40337846 0.944 FXYD5
FXYD domain containing ion transport regulator 5
chr1_-_181871508 0.936 NM_005717
ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr1_-_143232526 0.935 FAM91A2
family with sequence similarity 91, member A2
chr8_+_98725505 0.934 NM_178812
MTDH
metadherin
chr15_-_40051979 0.924 EHD4
EH-domain containing 4
chr1_-_173428455 0.922 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chrX_+_48252290 0.919 NM_022825
NM_203473
PORCN

porcupine homolog (Drosophila)

chr17_-_3546236 0.917 NM_002561
NM_175080
NM_175081
P2RX5-TAX1BP3
P2RX5


P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5


chr8_-_54918389 0.911 NM_015941
NM_213619
ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr4_+_4439705 0.906 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr1_-_146543016 0.901


chr6_-_159160421 0.889 NM_001111077
EZR
ezrin
chr6_-_159160387 0.881 EZR
ezrin
chrX_-_148857299 0.872 NM_001013845
CXorf40B
chromosome X open reading frame 40B
chr1_+_191357843 0.865 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr15_+_46957556 0.864 NM_014335
EID1
EP300 interacting inhibitor of differentiation 1
chr2_-_10505902 0.862 NM_002539
ODC1
ornithine decarboxylase 1
chr1_+_191357680 0.860 NM_024529
CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr6_-_144371035 0.857 NM_001080952
NM_001080953
NM_001080954
NM_001080956
NM_002656
NM_006718
PLAGL1





HYMAI
pleiomorphic adenoma gene-like 1





hydatidiform mole associated and imprinted (non-protein coding)
chrX_+_77246368 0.852 PGK1
phosphoglycerate kinase 1
chr9_-_109291866 0.851 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chrX_+_77246321 0.849 NM_000291
PGK1
phosphoglycerate kinase 1
chr11_-_63770840 0.848 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr6_-_106879983 0.845 ATG5
ATG5 autophagy related 5 homolog (S. cerevisiae)
chr16_+_22733307 0.843 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr11_+_66580861 0.838 NM_014578
RHOD
ras homolog gene family, member D
chr1_+_191357906 0.829 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr16_+_67236730 0.824 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr11_-_124871258 0.817 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chrX_+_64804318 0.816 MSN
moesin
chr11_+_85633908 0.816 EED
embryonic ectoderm development
chr1_+_172395170 0.814 NM_014857
RABGAP1L
RAB GTPase activating protein 1-like
chr8_-_54918369 0.812 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr1_-_43606275 0.810 ELOVL1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr8_-_54918099 0.809 NM_213620
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr4_+_4439618 0.808 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr3_+_5204357 0.807 NM_014674
EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr18_+_32131628 0.805 NM_025135
FHOD3
formin homology 2 domain containing 3
chr3_+_157875063 0.802 TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr15_+_72006015 0.801 LOXL1
lysyl oxidase-like 1
chr22_-_16020153 0.801 CECR5
cat eye syndrome chromosome region, candidate 5
chr15_+_88732493 0.797 IQGAP1
IQ motif containing GTPase activating protein 1
chr11_-_63770957 0.794 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_+_191357788 0.794 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr1_+_231816540 0.790 KCNK1
potassium channel, subfamily K, member 1
chr17_+_32924110 0.787 DUSP14
dual specificity phosphatase 14
chrX_+_77246430 0.782 PGK1
phosphoglycerate kinase 1
chr8_-_54918325 0.780 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chrX_+_77246409 0.778 PGK1
phosphoglycerate kinase 1
chr12_+_52618815 0.772 NM_017410
HOXC13
homeobox C13
chr11_+_18372687 0.772 LDHA
lactate dehydrogenase A
chr11_+_18372689 0.768 LDHA
lactate dehydrogenase A
chr11_+_18372708 0.768 LDHA
lactate dehydrogenase A
chr22_-_16020076 0.762 CECR5
cat eye syndrome chromosome region, candidate 5
chr7_+_127883117 0.754 NM_001098786
NM_013332
C7orf68

chromosome 7 open reading frame 68

chr17_+_50333021 0.753 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr16_+_30102231 0.747 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr17_+_38238960 0.740 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr16_+_162845 0.734 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr15_-_81744469 0.733 NM_001717
BNC1
basonuclin 1
chr1_-_158161898 0.730 TAGLN2
transgelin 2
chr1_+_207915617 0.715 G0S2
G0/G1switch 2
chr7_+_55054416 0.710 EGFR
epidermal growth factor receptor
chr20_-_57015698 0.706 NM_001336
CTSZ
cathepsin Z
chr5_+_133889584 0.705 NM_015288
PHF15
PHD finger protein 15
chr13_+_35903966 0.703 NM_001111046
NM_001111047
CCNA1

cyclin A1

chrX_+_135057202 0.701 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr15_+_72005864 0.700 LOXL1
lysyl oxidase-like 1
chr14_+_64041257 0.699 ZBTB1
zinc finger and BTB domain containing 1
chr6_-_159160355 0.696 EZR
ezrin
chr3_+_50629593 0.694 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr15_+_72005875 0.693 LOXL1
lysyl oxidase-like 1
chr1_-_181871490 0.692 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr4_-_24195113 0.688 DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr6_-_144427340 0.684 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr1_-_8861374 0.684 ENO1
enolase 1, (alpha)
chr8_+_94998258 0.683 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr9_-_109291575 0.683 KLF4
Kruppel-like factor 4 (gut)
chr5_+_110102639 0.681 NM_138773
SLC25A46
solute carrier family 25, member 46
chr1_-_8861332 0.680 NM_001428
ENO1
enolase 1, (alpha)
chr1_+_41217989 0.680 CTPS
CTP synthase
chr10_+_35455986 0.680 CREM
cAMP responsive element modulator
chr5_+_110102607 0.679 SLC25A46
solute carrier family 25, member 46
chr1_-_8861314 0.676 ENO1
enolase 1, (alpha)
chr22_+_43476755 0.674 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr8_+_99198664 0.674 NM_001145860
NM_001145861
POP1

processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)

chr1_+_12046020 0.672 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr1_-_181871416 0.670 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr7_-_87687302 0.662 NM_003130
SRI
sorcin
chr1_+_172395277 0.657 RABGAP1L
RAB GTPase activating protein 1-like
chr11_+_64785888 0.651 NM_002689
POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr10_-_64248932 0.651 NM_001136178
EGR2
early growth response 2
chr3_-_49424404 0.651 RHOA
ras homolog gene family, member A
chr6_-_106880229 0.649 ATG5
ATG5 autophagy related 5 homolog (S. cerevisiae)
chr7_-_87687276 0.648 SRI
sorcin
chr1_-_181871473 0.647 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr3_+_50629604 0.646 NM_004635
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr3_+_5204430 0.645 EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr4_+_89597257 0.641 NM_016323
HERC5
hect domain and RLD 5
chr2_-_10505724 0.641 ODC1
ornithine decarboxylase 1
chr7_-_27102049 0.641 NM_005522
NM_153620
HOXA1

homeobox A1

chr15_+_61356801 0.641 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr10_+_105716925 0.640 SLK
STE20-like kinase
chrX_-_152804731 0.639 L1CAM
L1 cell adhesion molecule
chr3_-_157755603 0.636 NM_007107
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr1_-_43606254 0.634 ELOVL1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr5_+_61637822 0.631 KIF2A
kinesin heavy chain member 2A
chr4_+_4439750 0.628 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr5_+_49998528 0.625 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr9_-_21984414 0.625 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr10_+_35455806 0.624 NM_001881
NM_182850
NM_182853
NM_183013
CREM



cAMP responsive element modulator



chr3_-_50349865 0.624 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr1_-_143232464 0.622


chr16_+_166678 0.620 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr17_+_38238942 0.619 NM_005789
NM_176863
PSME3

proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)

chr9_+_92603884 0.616 SYK
spleen tyrosine kinase
chr7_+_115637795 0.615 NM_015641
TES
testis derived transcript (3 LIM domains)
chr1_-_43410545 0.614 EBNA1BP2
EBNA1 binding protein 2
chr10_+_75580914 0.614 NM_006721
ADK
adenosine kinase
chr21_-_29179482 0.612 NM_013240
NM_182749
N6AMT1

N-6 adenine-specific DNA methyltransferase 1 (putative)

chr17_+_38238951 0.609 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr3_+_134775247 0.606 CDV3
CDV3 homolog (mouse)
chr6_+_30402203 0.603


chr1_+_170017383 0.603 NM_001007239
NM_014955
NM_015935
METTL13


methyltransferase like 13


chr8_+_28407613 0.599 NM_017412
FZD3
frizzled homolog 3 (Drosophila)
chr5_-_88215034 0.598 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr1_+_170017430 0.595 METTL13
methyltransferase like 13
chr22_-_16020168 0.591 NM_033070
CECR5
cat eye syndrome chromosome region, candidate 5
chr8_-_124123707 0.585 DERL1
Der1-like domain family, member 1
chr19_-_12747263 0.584 HOOK2
hook homolog 2 (Drosophila)
chr13_+_113287048 0.583 NM_007111
TFDP1
transcription factor Dp-1
chr1_+_170017452 0.582 METTL13
methyltransferase like 13
chr11_-_8942577 0.580 TMEM9B
TMEM9 domain family, member B
chr11_-_8942426 0.579 TMEM9B
TMEM9 domain family, member B
chr1_-_35957030 0.577 C1orf216
chromosome 1 open reading frame 216
chr16_+_67236699 0.577 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr4_-_24195276 0.569 NM_001358
DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr3_+_157875408 0.568 NM_001184717
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 6.51e-04 GO:0044237 cellular metabolic process
1.20 8.30e-03 GO:0044260 cellular macromolecule metabolic process
2.45 2.26e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.97 2.60e-02 GO:0050770 regulation of axonogenesis
2.43 2.74e-02 GO:0022604 regulation of cell morphogenesis
1.08 2.78e-02 GO:0009987 cellular process
2.38 3.96e-02 GO:0010975 regulation of neuron projection development
1.97 4.56e-02 GO:0048011 nerve growth factor receptor signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 3.03e-11 GO:0044424 intracellular part
1.12 6.76e-11 GO:0005622 intracellular
1.16 1.84e-07 GO:0005737 cytoplasm
1.12 6.80e-06 GO:0043226 organelle
1.12 1.08e-05 GO:0043229 intracellular organelle
1.13 6.23e-05 GO:0043231 intracellular membrane-bounded organelle
1.13 8.32e-05 GO:0043227 membrane-bounded organelle
1.32 5.51e-04 GO:0005829 cytosol
1.18 8.62e-04 GO:0005634 nucleus
1.15 2.18e-03 GO:0044444 cytoplasmic part
1.97 3.72e-03 GO:0005635 nuclear envelope
1.04 1.87e-02 GO:0044464 cell part
2.18 1.88e-02 GO:0031965 nuclear membrane
1.04 1.94e-02 GO:0005623 cell
1.14 2.82e-02 GO:0044446 intracellular organelle part
1.25 4.93e-02 GO:0044428 nuclear part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 9.33e-04 GO:0005515 protein binding