Motif ID: EWSR1-FLI1.p2

Z-value: 0.784


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FLI1chr11_+_128068982,
chr11_+_128067598
0.184.9e-01Click!
EWSR1chr22_+_27993997-0.107.0e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_68071635 1.926 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr7_+_16759845 1.875 NM_014399
TSPAN13
tetraspanin 13
chr6_-_10520592 1.668 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_185064654 1.490 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr1_-_150276064 1.465 S100A11
S100 calcium binding protein A11
chr1_-_150276091 1.415 S100A11
S100 calcium binding protein A11
chr1_-_68470585 1.265 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr1_+_221955876 1.225 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chrX_+_107569671 1.168 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr6_-_134538762 1.093 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr6_-_134538526 1.066 SGK1
serum/glucocorticoid regulated kinase 1
chr3_-_42282665 0.992 NM_000729
CCK
cholecystokinin
chr1_-_150276114 0.966 NM_005620
S100A11
S100 calcium binding protein A11
chr2_+_37425240 0.919 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr2_-_24161033 0.847 NM_147184
NM_004881
TP53I3

tumor protein p53 inducible protein 3

chr6_-_132314004 0.750 NM_001901
CTGF
connective tissue growth factor
chr17_+_45488330 0.649 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr17_+_45488356 0.639 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr2_+_182464910 0.612 SSFA2
sperm specific antigen 2
chr17_+_2443983 0.604 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr1_-_93030538 0.526 NM_005665
EVI5
ecotropic viral integration site 5
chr1_-_223907283 0.517 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr17_+_2443652 0.512 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chrX_-_107569256 0.504 NM_001847
COL4A6
collagen, type IV, alpha 6
chr18_-_5620629 0.480 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr20_+_6696744 0.473 NM_001200
BMP2
bone morphogenetic protein 2
chr11_+_101485946 0.462 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr8_-_22982435 0.429 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chrX_-_148394570 0.414 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr19_-_242168 0.405 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr12_-_47637530 0.382


chr5_-_148422799 0.376 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr4_-_16509354 0.371 LDB2
LIM domain binding 2
chr4_-_86106567 0.366 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr12_-_115660017 0.363 NM_024738
C12orf49
chromosome 12 open reading frame 49
chr4_-_16509446 0.362 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr4_-_16509126 0.328 LDB2
LIM domain binding 2
chr2_+_113532685 0.309 NM_173170
IL1F5
interleukin 1 family, member 5 (delta)
chr9_-_83494198 0.296 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr12_-_47637396 0.287 ARF3
ADP-ribosylation factor 3
chr21_+_38550533 0.285 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_31146660 0.281 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr12_-_47637507 0.280 ARF3
ADP-ribosylation factor 3
chr10_+_70553983 0.263 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr12_-_47637564 0.255 ARF3
ADP-ribosylation factor 3
chr4_-_57216816 0.255 HOPX
HOP homeobox
chr19_-_1966628 0.254 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr19_-_242335 0.253 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr12_+_84198015 0.247 NM_006982
ALX1
ALX homeobox 1
chr12_-_47637512 0.245 ARF3
ADP-ribosylation factor 3
chr12_-_47637518 0.245 NM_001659
ARF3
ADP-ribosylation factor 3
chr2_+_182464713 0.244 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr1_-_20685314 0.243 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_-_224993498 0.236 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr7_-_106991941 0.229 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr1_+_151596953 0.226 NM_002965
S100A9
S100 calcium binding protein A9
chr21_+_38550739 0.225 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr10_+_70553993 0.223 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr5_+_86599350 0.222 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr8_+_30361485 0.214 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr4_+_154345039 0.204 NM_015271
TRIM2
tripartite motif containing 2
chr4_-_57217226 0.202 NM_001145459
NM_139211
HOPX

HOP homeobox

chr12_+_14409875 0.201 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr14_-_53493198 0.200 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr8_-_93177057 0.198 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr9_+_34169023 0.197 UBAP1
ubiquitin associated protein 1
chr10_-_103864651 0.187 NM_003893
LDB1
LIM domain binding 1
chr9_+_34169036 0.186 UBAP1
ubiquitin associated protein 1
chr9_-_129679760 0.184 NM_000476
AK1
adenylate kinase 1
chr10_+_106004457 0.175 NM_001191002
NM_004832
GSTO1

glutathione S-transferase omega 1

chr11_-_66897584 0.174 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr10_+_70553936 0.169 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chrX_-_78509662 0.163 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr1_+_44185005 0.158 NM_014652
IPO13
importin 13
chr13_-_74953873 0.157 NM_014832
TBC1D4
TBC1 domain family, member 4
chr10_+_70553862 0.156 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr1_-_154737189 0.154 MEF2D
myocyte enhancer factor 2D
chr8_-_29262240 0.149 NM_057158
DUSP4
dual specificity phosphatase 4
chr13_+_28131279 0.146 POMP
proteasome maturation protein
chr19_-_56178882 0.141 NM_139277
NM_005046
KLK7

kallikrein-related peptidase 7

chr19_-_47450991 0.141 ERF
Ets2 repressor factor
chrX_-_78509367 0.139 ITM2A
integral membrane protein 2A
chr16_-_73198515 0.136 NM_001145666
NM_001145667
NM_012201
GLG1


golgi glycoprotein 1


chr9_+_34169002 0.135 NM_001171201
NM_001171202
NM_001171203
NM_001171204
NM_016525
UBAP1




ubiquitin associated protein 1




chr10_-_14412813 0.133 NM_018027
FRMD4A
FERM domain containing 4A
chr2_+_113533155 0.133 NM_012275
IL1F5
interleukin 1 family, member 5 (delta)
chr19_-_56164628 0.132 NM_002774
KLK6
kallikrein-related peptidase 6
chr5_+_86599800 0.131 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr9_+_34169058 0.131 UBAP1
ubiquitin associated protein 1
chr11_+_58668827 0.129 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chrX_-_49851743 0.129 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr21_+_39099717 0.128 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr8_-_37943143 0.127 NM_000025
ADRB3
adrenergic, beta-3-, receptor
chr13_+_113193308 0.127 NM_017905
TMCO3
transmembrane and coiled-coil domains 3
chr11_+_9642226 0.127 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr13_+_28131140 0.126 NM_015932
POMP
proteasome maturation protein
chr9_+_124836666 0.125 NM_005294
GPR21
G protein-coupled receptor 21
chr20_+_41621119 0.125 SGK2
serum/glucocorticoid regulated kinase 2
chr10_-_103869923 0.123 NM_001113407
LDB1
LIM domain binding 1
chr11_-_31789168 0.123 PAX6
paired box 6
chr19_-_47451119 0.123 NM_006494
ERF
Ets2 repressor factor
chr15_+_39310693 0.120 NM_007236
CHP
calcium binding protein P22
chr15_+_39310757 0.114 CHP
calcium binding protein P22
chr3_-_109292444 0.114 NM_001777
NM_198793
CD47

CD47 molecule

chr8_-_93176819 0.111 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_171558143 0.110 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chrX_-_62891712 0.109 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr1_-_161379606 0.108 RGS5
regulator of G-protein signaling 5
chr8_-_111056099 0.101 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr10_+_70553949 0.100 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr9_+_77695334 0.093 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr19_-_11234117 0.092 NM_020812
DOCK6
dedicator of cytokinesis 6
chr1_-_21478571 0.092 NM_001113347
ECE1
endothelin converting enzyme 1
chr3_+_171558188 0.089 SKIL
SKI-like oncogene
chr3_-_193928038 0.088 NM_004113
FGF12
fibroblast growth factor 12
chr2_-_85490997 0.087 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr4_-_9650931 0.086 NM_001001290
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr16_-_73198416 0.086 GLG1
golgi glycoprotein 1
chr12_+_29193399 0.085 FAR2
fatty acyl CoA reductase 2
chr9_+_35528890 0.084 RUSC2
RUN and SH3 domain containing 2
chrX_+_67635593 0.082 YIPF6
Yip1 domain family, member 6
chr14_+_22845851 0.079 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr1_+_109036431 0.078 NM_018061
PRPF38B
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr10_+_23424383 0.077 NM_012228
MSRB2
methionine sulfoxide reductase B2
chr8_-_93176618 0.077 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr11_-_62231358 0.073 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr10_-_35143900 0.073 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr9_-_83493415 0.071 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr8_-_145530639 0.071 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr4_+_174326464 0.071 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chrY_+_1361570 0.071 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chrX_+_1361570 0.071 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr20_+_29656744 0.070 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr9_-_69669550 0.070 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr1_+_152460381 0.069 UBAP2L
ubiquitin associated protein 2-like
chr12_+_54838408 0.067 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr19_-_52243721 0.066 NM_017854
TMEM160
transmembrane protein 160
chr5_+_175041069 0.065 NM_022304
HRH2
histamine receptor H2
chr3_+_14141583 0.063 TMEM43
transmembrane protein 43
chr17_+_35372751 0.062 NM_178171
GSDMA
gasdermin A
chr10_-_102017327 0.062 NM_018294
CWF19L1
CWF19-like 1, cell cycle control (S. pombe)
chr11_+_2279812 0.062 NM_139022
TSPAN32
tetraspanin 32
chr16_-_73198498 0.062 GLG1
golgi glycoprotein 1
chr1_-_231498081 0.061 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr15_-_71712605 0.061 NPTN
neuroplastin
chr12_+_54838733 0.060 MYL6
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr1_+_153241665 0.058 NM_015872
ZBTB7B
zinc finger and BTB domain containing 7B
chr12_+_121803255 0.057 NM_003677
DENR
density-regulated protein
chr17_+_4784524 0.057 RNF167
ring finger protein 167
chr3_-_129852345 0.057 RPN1
ribophorin I
chrX_-_62891667 0.055 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr1_+_152459918 0.054 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr12_+_77781903 0.052 NM_001135805
SYT1
synaptotagmin I
chr8_+_22078622 0.052 BMP1
bone morphogenetic protein 1
chr12_+_47945132 0.052 TUBA1C
tubulin, alpha 1c
chr11_-_8789457 0.052 NM_139157
ST5
suppression of tumorigenicity 5
chr12_-_9651748 0.051 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr11_+_113435506 0.050 ZBTB16
zinc finger and BTB domain containing 16
chr8_-_27751462 0.049 PBK
PDZ binding kinase
chr11_-_62231386 0.049 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr16_-_74126568 0.047 NM_024533
CHST5
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
chr6_-_46091238 0.047 NM_016929
CLIC5
chloride intracellular channel 5
chr3_-_121295663 0.045 NM_001146156
NM_002093
GSK3B

glycogen synthase kinase 3 beta

chr3_-_129852400 0.044 NM_002950
RPN1
ribophorin I
chr17_+_53625084 0.043 NM_000502
EPX
eosinophil peroxidase
chr11_-_62231636 0.042 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_+_17714070 0.041 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr12_+_47945086 0.041 NM_032704
TUBA1C
tubulin, alpha 1c
chr3_+_33130451 0.041 NM_006371
CRTAP
cartilage associated protein
chr1_-_221604023 0.040 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr5_-_64100176 0.040 SREK1IP1
SREK1-interacting protein 1
chrX_+_80344253 0.040 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr1_+_153241858 0.039 ZBTB7B
zinc finger and BTB domain containing 7B
chr14_+_55654607 0.039 NM_021255
PELI2
pellino homolog 2 (Drosophila)
chr11_-_62231445 0.038 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr2_-_222867171 0.037 PAX3
paired box 3
chrX_-_62891730 0.037 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr9_+_35528628 0.036 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr12_+_107797985 0.035 NM_001917
DAO
D-amino-acid oxidase
chr7_+_65178369 0.035 ASL
argininosuccinate lyase
chr11_-_66898223 0.035 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr5_-_64100239 0.034 NM_173829
SREK1IP1
SREK1-interacting protein 1
chr11_-_8788765 0.034 NM_213618
ST5
suppression of tumorigenicity 5
chr19_-_11355882 0.033 NM_000121
EPOR
erythropoietin receptor
chr18_-_44189625 0.033 ZBTB7C
zinc finger and BTB domain containing 7C
chr8_+_22078589 0.032 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chrX_+_2994852 0.032 NM_004042
ARSF
arylsulfatase F
chr3_-_50353209 0.031 NM_007182
NM_170714
RASSF1

Ras association (RalGDS/AF-6) domain family member 1

chr14_+_55654900 0.030 PELI2
pellino homolog 2 (Drosophila)
chr11_+_2279932 0.030 TSPAN32
tetraspanin 32
chr19_+_57592913 0.029 NM_032423
ZNF528
zinc finger protein 528
chr11_-_62231242 0.029 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr3_+_33130563 0.029 CRTAP
cartilage associated protein
chr7_-_138133388 0.029 NM_020632
NM_130840
ATP6V0A4

ATPase, H+ transporting, lysosomal V0 subunit a4

chr10_+_114699953 0.028 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr14_-_20636568 0.028 NM_016423
ZNF219
zinc finger protein 219
chr11_-_62231565 0.027 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_62213946 0.027 NM_203422
LRRN4CL
LRRN4 C-terminal like
chrX_+_56606686 0.026 NM_013444
UBQLN2
ubiquilin 2
chr1_-_148166247 0.026 SF3B4
splicing factor 3b, subunit 4, 49kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.23 8.17e-04 GO:0009653 anatomical structure morphogenesis
2.66 2.33e-03 GO:0048699 generation of neurons
2.16 3.61e-03 GO:0007399 nervous system development
2.50 7.36e-03 GO:0022008 neurogenesis
2.68 1.75e-02 GO:0030182 neuron differentiation
38.44 3.87e-02 GO:0061036 positive regulation of cartilage development

Nothing significant found in compartment category.

Nothing significant found in function category.