Motif ID: EWSR1-FLI1.p2

Z-value: 0.784


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FLI1chr11_+_128068982,
chr11_+_128067598		0.184.9e-01Click!
EWSR1chr22_+_27993997-0.107.0e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_68071635 1.926 NM_018841
 GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr7_+_16759845 1.875 NM_014399
 TSPAN13
tetraspanin 13
chr6_-_10520592 1.668 NM_001032280
 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_185064654 1.490 NM_024420
 PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr1_-_150276064 1.465 S100A11
S100 calcium binding protein A11
chr1_-_150276091 1.415 S100A11
S100 calcium binding protein A11
chr1_-_68470585 1.265 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)


chr1_+_221955876 1.225 NM_001146068
 CAPN2
calpain 2, (m/II) large subunit
chrX_+_107569671 1.168 NM_000495
NM_033380
 COL4A5

collagen, type IV, alpha 5

chr6_-_134538762 1.093 NM_001143678
 SGK1
serum/glucocorticoid regulated kinase 1
chr6_-_134538526 1.066 SGK1
serum/glucocorticoid regulated kinase 1
chr3_-_42282665 0.992 NM_000729
 CCK
cholecystokinin
chr1_-_150276114 0.966 NM_005620
 S100A11
S100 calcium binding protein A11
chr2_+_37425240 0.919 NM_012413
 QPCT
glutaminyl-peptide cyclotransferase
chr2_-_24161033 0.847 NM_147184
NM_004881
 TP53I3

tumor protein p53 inducible protein 3

chr6_-_132314004 0.750 NM_001901
 CTGF
connective tissue growth factor
chr17_+_45488330 0.649 NM_002204
NM_005501
 ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr17_+_45488356 0.639 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr2_+_182464910 0.612 SSFA2
sperm specific antigen 2
chr17_+_2443983 0.604 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
38.44 3.87e-02 GO:0061036 positive regulation of cartilage development
2.68 1.75e-02 GO:0030182 neuron differentiation
2.66 2.33e-03 GO:0048699 generation of neurons
2.50 7.36e-03 GO:0022008 neurogenesis
2.23 8.17e-04 GO:0009653 anatomical structure morphogenesis
2.16 3.61e-03 GO:0007399 nervous system development

Nothing significant found in compartment category.

Nothing significant found in function category.