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• Activity deltas table
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Motif ID: NFE2.p2

Z-value: 0.975

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_35975227	6.134	NM_001838	CCR7	chemokine (C-C motif) receptor 7
chr22_+_21495273	5.294
chr22_+_21370394	5.090		IGL@	immunoglobulin lambda locus
chr22_+_21053972	4.104
chr22_+_21011653	3.020
chr22_+_21116283	3.012
chr12_-_15005761	2.945	NM_001175	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr1_+_173111306	2.837	NM_001035230	RABGAP1L	RAB GTPase activating protein 1-like
chr13_-_98757634	2.825	NM_004951	GPR183	G protein-coupled receptor 183
chr22_+_21340757	2.687
chr22_+_20899155	2.600
chr22_+_21065134	2.411		LOC100290481	immunoglobulin lambda light chain-like
chr22_+_21079355	2.407
chr17_-_26665144	2.373		EVI2B	ecotropic viral integration site 2B
chr17_-_26665213	2.325		EVI2B	ecotropic viral integration site 2B
chrX_-_154216929	2.272	NM_001289	CLIC2	chloride intracellular channel 2
chr22_+_21065207	2.206		IGLJ3	immunoglobulin lambda joining 3
chr17_-_26665194	2.176		EVI2B	ecotropic viral integration site 2B
chr6_+_33151703	2.116	NM_002121	HLA-DPB1	major histocompatibility complex, class II, DP beta 1
chr22_+_21464980	1.989
chr11_+_67107641	1.926	NM_000852	GSTP1	glutathione S-transferase pi 1
chr11_+_67107852	1.903		GSTP1	glutathione S-transferase pi 1
chr9_-_122728173	1.858		TRAF1	TNF receptor-associated factor 1
chrX_+_12903145	1.855	NM_021109 NM_183049	TMSB4X TMSL3	thymosin beta 4, X-linked thymosin-like 3
chr11_+_20341806	1.800	NM_006410 NM_001098521	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr11_+_20341900	1.740	NM_001098522	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chrX_-_100527799	1.735	NM_000061	BTK	Bruton agammaglobulinemia tyrosine kinase
chr11_+_20341835	1.658	NM_001098520	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr17_-_26665220	1.605	NM_006495	EVI2B	ecotropic viral integration site 2B
chr6_-_84197477	1.556		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr22_+_21552897	1.521		LOC100290481	immunoglobulin lambda light chain-like
chr6_-_84197370	1.515		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr15_+_86983038	1.470	NM_002201	ISG20	interferon stimulated exonuclease gene 20kDa
chr22_+_21042091	1.411		IGLV1-44 IGL@	immunoglobulin lambda variable 1-44 immunoglobulin lambda locus
chr6_-_84197463	1.384		ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr14_-_105280425	1.329		IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_-_77163609	1.308	NM_001565	CXCL10	chemokine (C-X-C motif) ligand 10
chr12_+_6930694	1.267	NM_002831 NM_080549	PTPN6	protein tyrosine phosphatase, non-receptor type 6
chr1_+_12046020	1.162	NM_001243	TNFRSF8	tumor necrosis factor receptor superfamily, member 8
chr19_+_4180494	1.143	NM_005755	EBI3	Epstein-Barr virus induced 3
chr7_+_23252915	1.137		GPNMB	glycoprotein (transmembrane) nmb
chr5_+_150000394	1.126	NM_001109974 NM_007286	SYNPO	synaptopodin
chr11_+_20342262	1.124	NM_001098523	HTATIP2	HIV-1 Tat interactive protein 2, 30kDa
chr7_+_23252802	1.120	NM_001005340 NM_002510	GPNMB	glycoprotein (transmembrane) nmb
chr7_+_73262283	1.112		LAT2	linker for activation of T cells family, member 2
chr5_-_169657312	1.111		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr14_-_105308720	1.110		IGHM	immunoglobulin heavy constant mu
chr6_-_84197573	1.096	NM_002395	ME1	malic enzyme 1, NADP(+)-dependent, cytosolic
chr14_-_105308639	1.093
chr1_-_181826292	1.069	NM_000433 NM_001190789 NM_001190794	NCF2	neutrophil cytosolic factor 2
chr10_+_30763056	1.063		MAP3K8	mitogen-activated protein kinase kinase kinase 8
chr5_-_169657395	1.042	NM_005565	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr10_-_6059460	1.041	NM_002189 NM_172200	IL15RA	interleukin 15 receptor, alpha
chrX_-_72351381	1.039		NAP1L2	nucleosome assembly protein 1-like 2
chr22_+_21065202	1.034
chr22_+_21006814	1.032
chr7_+_73262264	1.024		LAT2	linker for activation of T cells family, member 2
chr7_+_23252911	1.015		GPNMB	glycoprotein (transmembrane) nmb
chr3_+_48482213	1.013	NM_016381 NM_033629	TREX1	three prime repair exonuclease 1
chr4_-_35922288	1.007	NM_015230	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_72351348	0.993		NAP1L2	nucleosome assembly protein 1-like 2
chr19_+_40895669	0.987	NM_014383	ZBTB32	zinc finger and BTB domain containing 32
chr10_+_30762862	0.972	NM_005204	MAP3K8	mitogen-activated protein kinase kinase kinase 8
chr14_-_105163301	0.965		IGHG4	immunoglobulin heavy constant gamma 4 (G4m marker)
chr1_+_148388870	0.945		PLEKHO1	pleckstrin homology domain containing, family O member 1
chrX_-_72351392	0.943	NM_021963	NAP1L2	nucleosome assembly protein 1-like 2
chr17_+_27795633	0.937		PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr3_-_58175437	0.929	NM_004944	DNASE1L3	deoxyribonuclease I-like 3
chr7_+_90177082	0.928		CDK14	cyclin-dependent kinase 14
chr8_-_42742729	0.920	NM_004198	CHRNA6	cholinergic receptor, nicotinic, alpha 6
chr3_+_48482625	0.905		TREX1	three prime repair exonuclease 1
chr11_+_10433241	0.889	NM_001025389	AMPD3	adenosine monophosphate deaminase 3
chr5_-_169657360	0.886		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_-_159159242	0.883		EZR	ezrin
chr3_+_120799411	0.875	NM_015900	PLA1A	phospholipase A1 member A
chr10_+_17310263	0.869	NM_003380	VIM	vimentin
chr7_+_23252945	0.866		GPNMB	glycoprotein (transmembrane) nmb
chr10_+_17310475	0.857		VIM	vimentin
chr16_+_55950195	0.841	NM_002990	CCL22	chemokine (C-C motif) ligand 22
chr6_-_159159186	0.827		EZR	ezrin
chr1_+_148389039	0.824		PLEKHO1	pleckstrin homology domain containing, family O member 1
chr1_+_148388719	0.824	NM_016274	PLEKHO1	pleckstrin homology domain containing, family O member 1
chr11_+_35117226	0.821		CD44	CD44 molecule (Indian blood group)
chr1_-_157313179	0.820	NM_004833	AIM2	absent in melanoma 2
chr14_-_105182025	0.810
chr6_-_159159257	0.808	NM_003379	EZR	ezrin
chr1_+_151147646	0.805	NM_005547	IVL	involucrin
chr1_-_181826086	0.787		NCF2	neutrophil cytosolic factor 2
chr12_-_8656705	0.787	NM_020661	AICDA	activation-induced cytidine deaminase
chr22_+_21027538	0.769
chr7_+_23252909	0.767		GPNMB	glycoprotein (transmembrane) nmb
chr7_+_26298018	0.755	NM_013322	SNX10	sorting nexin 10
chr17_-_31231421	0.747	NM_002985	CCL5	chemokine (C-C motif) ligand 5
chr12_-_101115677	0.745	NM_002674	PMCH	pro-melanin-concentrating hormone
chr11_-_3818713	0.731		RHOG	ras homolog gene family, member G (rho G)
chr7_+_26298136	0.730		SNX10	sorting nexin 10
chr11_-_3818759	0.710	NM_001665	RHOG	ras homolog gene family, member G (rho G)
chr19_-_1989937	0.702		MKNK2	MAP kinase interacting serine/threonine kinase 2
chr6_+_106653429	0.697	NM_182907	PRDM1	PR domain containing 1, with ZNF domain
chr19_-_48976852	0.691		KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr7_+_150065376	0.683	NM_018384	GIMAP5	GTPase, IMAP family member 5
chr6_-_24985432	0.680	NM_015864	FAM65B	family with sequence similarity 65, member B
chr2_-_85494639	0.675		CAPG	capping protein (actin filament), gelsolin-like
chr6_-_33016561	0.673	NM_002118	HLA-DMB	major histocompatibility complex, class II, DM beta
chr11_+_128068982	0.661	NM_002017	FLI1	Friend leukemia virus integration 1
chr3_-_99724047	0.657		CLDND1	claudin domain containing 1
chr2_-_85494664	0.657		CAPG	capping protein (actin filament), gelsolin-like
chr8_-_70908130	0.652	NM_001146008	SLCO5A1	solute carrier organic anion transporter family, member 5A1
chr6_-_31658044	0.645	NM_002341 NM_009588	LTB	lymphotoxin beta (TNF superfamily, member 3)
chr1_+_181421984	0.643		LAMC2	laminin, gamma 2
chr22_+_20880159	0.617		IGLV6-57	immunoglobulin lambda variable 6-57
chr11_+_10434056	0.614	NM_001025390	AMPD3	adenosine monophosphate deaminase 3
chr5_-_169657192	0.612		LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_-_43254132	0.604	NM_145798	OSBPL7	oxysterol binding protein-like 7
chr16_-_87570716	0.601	NM_005187	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr4_+_170817787	0.590		CLCN3	chloride channel 3
chr11_-_58099884	0.586	NM_004811	LPXN	leupaxin
chr22_+_20880112	0.581
chr2_+_151922350	0.580	NM_007115	TNFAIP6	tumor necrosis factor, alpha-induced protein 6
chr6_+_84626113	0.569		CYB5R4	cytochrome b5 reductase 4
chr11_+_35154775	0.569		CD44	CD44 molecule (Indian blood group)
chr19_-_48977247	0.568	NM_002250	KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr11_-_62231242	0.565		BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_110755112	0.561		POU2AF1	POU class 2 associating factor 1
chr17_-_25642962	0.561	NM_000386	BLMH	bleomycin hydrolase
chr3_-_99724373	0.560		CLDND1	claudin domain containing 1
chr8_-_70907957	0.556	NM_001146009	SLCO5A1	solute carrier organic anion transporter family, member 5A1
chr17_-_43254117	0.550		OSBPL7	oxysterol binding protein-like 7
chr7_+_139175420	0.544	NM_001061 NM_001166253 NM_030984	TBXAS1	thromboxane A synthase 1 (platelet)
chr9_+_4975082	0.543		JAK2	Janus kinase 2
chr14_-_105182159	0.542		IGHG2	immunoglobulin heavy constant gamma 2 (G2m marker)
chr5_-_137099361	0.541		KLHL3	kelch-like 3 (Drosophila)
chr11_+_128069203	0.540		FLI1	Friend leukemia virus integration 1
chr18_-_51219880	0.533		TCF4	transcription factor 4
chr7_+_150065594	0.530		GIMAP5	GTPase, IMAP family member 5
chr6_+_84626146	0.527		CYB5R4	cytochrome b5 reductase 4
chr6_+_107066422	0.520	NM_001624	AIM1	absent in melanoma 1
chr6_+_84626083	0.517	NM_016230	CYB5R4	cytochrome b5 reductase 4
chr3_+_142525744	0.514	NM_001080412	ZBTB38	zinc finger and BTB domain containing 38
chr2_-_175170674	0.513		WIPF1	WAS/WASL interacting protein family, member 1
chr3_-_99724438	0.513		CLDND1	claudin domain containing 1
chr5_-_137099602	0.511	NM_017415	KLHL3	kelch-like 3 (Drosophila)
chr10_+_70745615	0.511	NM_033496	HK1	hexokinase 1
chr19_-_61039939	0.502	NM_145007	NLRP11	NLR family, pyrin domain containing 11
chr10_-_94323808	0.501		IDE	insulin-degrading enzyme
chr9_+_2005218	0.500	NM_003070 NM_139045	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chrX_-_129072152	0.499	NM_001421	ELF4	E74-like factor 4 (ets domain transcription factor)
chr11_+_35117242	0.497		CD44	CD44 molecule (Indian blood group)
chr2_-_89400935	0.494		IGKC	immunoglobulin kappa constant
chr11_-_102174102	0.491	NM_001145938 NM_002421	MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr10_-_94323701	0.490		IDE	insulin-degrading enzyme
chr1_+_13948448	0.489	NM_001007257	PRDM2	PR domain containing 2, with ZNF domain
chr22_-_30388165	0.487		PISD	phosphatidylserine decarboxylase
chr15_-_73818013	0.485
chr4_-_87500201	0.482		MAPK10	mitogen-activated protein kinase 10
chr4_-_151990061	0.480		LRBA	LPS-responsive vesicle trafficking, beach and anchor containing
chr11_-_62231445	0.478		BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_+_181421796	0.475	NM_005562 NM_018891	LAMC2	laminin, gamma 2
chr7_+_90176647	0.455	NM_012395	CDK14	cyclin-dependent kinase 14
chr3_-_99724412	0.452		CLDND1	claudin domain containing 1
chr7_+_68701704	0.446	NM_001127231 NM_001127232 NM_015570	AUTS2	autism susceptibility candidate 2
chr1_-_146543016	0.445
chr18_+_59705918	0.440	NM_001143818 NM_002575	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr1_+_40508336	0.439		ZMPSTE24	zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr22_+_20715340	0.438
chr17_-_70662364	0.431	NM_001002032 NM_001002033 NM_016185	HN1	hematological and neurological expressed 1
chr10_-_101759630	0.430	NM_015221	DNMBP	dynamin binding protein
chr22_+_21094094	0.429
chr9_+_4975243	0.425	NM_004972	JAK2	Janus kinase 2
chr4_+_40953698	0.422		UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr22_-_37858871	0.420		CBX7	chromobox homolog 7
chr3_+_49002285	0.419	NM_177938 NM_177939	P4HTM	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr11_-_102174032	0.412		MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr22_-_35875890	0.411	NM_000878	IL2RB	interleukin 2 receptor, beta
chr19_-_6542012	0.407		CD70	CD70 molecule
chr15_+_99276982	0.406	NM_024652	LRRK1	leucine-rich repeat kinase 1
chr1_-_223683141	0.405	NM_194442	LBR	lamin B receptor
chrX_-_16640590	0.405	NM_175859 NM_019857	CTPS2	CTP synthase II
chr19_-_40939756	0.405	NM_144617	HSPB6	heat shock protein, alpha-crystallin-related, B6
chr17_+_69974116	0.403	NM_007261	CD300A	CD300a molecule
chr19_+_59820413	0.398	NM_006669	LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr12_+_67489063	0.397		MDM2	Mdm2 p53 binding protein homolog (mouse)
chr11_+_118463906	0.394	NM_001024382	HMBS	hydroxymethylbilane synthase
chr3_+_133855979	0.393	NM_198329	UBA5	ubiquitin-like modifier activating enzyme 5
chr11_-_102219450	0.390	NM_002422	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr11_+_35116961	0.388	NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392	CD44	CD44 molecule (Indian blood group)
chr5_-_142795269	0.387	NM_001018074 NM_001018075 NM_001018077	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr20_+_44180355	0.380		CD40	CD40 molecule, TNF receptor superfamily member 5
chr19_+_6482009	0.376	NM_003811	TNFSF9	tumor necrosis factor (ligand) superfamily, member 9
chr17_-_37022465	0.376	NM_005557	KRT16	keratin 16
chrX_-_129072103	0.373		ELF4	E74-like factor 4 (ets domain transcription factor)
chr10_-_94323827	0.373	NM_004969	IDE	insulin-degrading enzyme
chr4_-_38710376	0.371	NM_024943	TMEM156	transmembrane protein 156
chr19_-_6621078	0.371		TNFSF14	tumor necrosis factor (ligand) superfamily, member 14
chr9_-_73715666	0.367		FAM108B1	family with sequence similarity 108, member B1
chr9_-_34652629	0.364	NM_006664	CCL27	chemokine (C-C motif) ligand 27
chr19_+_43971689	0.361	NM_001042507	LGALS7B	lectin, galactoside-binding, soluble, 7B
chrX_-_47374187	0.361	NM_001145252	CFP	complement factor properdin
chr1_-_156923111	0.360	NM_003126	SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr20_+_44180296	0.360	NM_001250 NM_152854	CD40	CD40 molecule, TNF receptor superfamily member 5

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.27	1.03e-04	GO:0050896	response to stimulus
1.40	1.12e-04	GO:0007165	signal transduction
1.37	1.38e-04	GO:0023052	signaling
1.33	2.56e-04	GO:0051716	cellular response to stimulus
4.63	4.32e-04	GO:0071158	positive regulation of cell cycle arrest
4.56	1.27e-03	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.56	1.27e-03	GO:0072395	signal transduction involved in cell cycle checkpoint
4.56	1.27e-03	GO:0072401	signal transduction involved in DNA integrity checkpoint
4.56	1.27e-03	GO:0072404	signal transduction involved in G1/S transition checkpoint
4.56	1.27e-03	GO:0072413	signal transduction involved in mitotic cell cycle checkpoint
4.56	1.27e-03	GO:0072422	signal transduction involved in DNA damage checkpoint
4.56	1.27e-03	GO:0072431	signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.56	1.27e-03	GO:0072474	signal transduction involved in mitotic cell cycle G1/S checkpoint
1.64	1.81e-03	GO:0002376	immune system process
3.95	2.13e-03	GO:2000045	regulation of G1/S transition of mitotic cell cycle
2.19	3.59e-03	GO:0051247	positive regulation of protein metabolic process
2.37	4.45e-03	GO:0031401	positive regulation of protein modification process
3.92	4.87e-03	GO:0031575	mitotic cell cycle G1/S transition checkpoint
3.92	4.87e-03	GO:0071779	G1/S transition checkpoint
4.13	4.96e-03	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint
2.19	5.96e-03	GO:0032270	positive regulation of cellular protein metabolic process
1.64	6.55e-03	GO:0010604	positive regulation of macromolecule metabolic process
1.61	6.80e-03	GO:0009893	positive regulation of metabolic process
1.66	8.31e-03	GO:0051246	regulation of protein metabolic process
4.50	8.67e-03	GO:0006521	regulation of cellular amino acid metabolic process
1.58	8.85e-03	GO:0035556	intracellular signal transduction
1.20	9.04e-03	GO:0050794	regulation of cellular process
1.17	9.79e-03	GO:0065007	biological regulation
1.66	1.17e-02	GO:0043067	regulation of programmed cell death
4.05	1.41e-02	GO:0033238	regulation of cellular amine metabolic process
1.71	1.50e-02	GO:0051704	multi-organism process
1.65	1.65e-02	GO:0042981	regulation of apoptosis
1.63	1.97e-02	GO:0010941	regulation of cell death
1.75	2.15e-02	GO:0006955	immune response
3.17	2.75e-02	GO:0000077	DNA damage checkpoint
1.98	2.93e-02	GO:0009607	response to biotic stimulus
1.58	2.93e-02	GO:0031325	positive regulation of cellular metabolic process
3.80	3.09e-02	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.41	3.25e-02	GO:0048523	negative regulation of cellular process
1.35	3.29e-02	GO:0048518	positive regulation of biological process
3.40	3.41e-02	GO:0030330	DNA damage response, signal transduction by p53 class mediator
1.38	4.46e-02	GO:0048519	negative regulation of biological process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
4.48	2.39e-04	GO:0000502	proteasome complex
7.26	7.52e-03	GO:0001533	cornified envelope
1.57	2.26e-02	GO:0044421	extracellular region part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
2.65	2.59e-03	GO:0005126	cytokine receptor binding