Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.693


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF7L2chr10_+_1146999530.811.3e-04Click!
LEF1chr4_-_109307325-0.639.1e-03Click!
TCF7L1chr2_+_852138840.514.6e-02Click!
TCF7chr5_+_133479196-0.411.2e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_53744043 5.774 NM_012242
 DKK1
dickkopf homolog 1 (Xenopus laevis)
chr6_-_128883125 5.357 NM_002844
NM_001135648
 PTPRK

protein tyrosine phosphatase, receptor type, K

chr10_+_7785347 3.761 ITIH2
inter-alpha (globulin) inhibitor H2
chr4_-_187114407 3.748 SORBS2
sorbin and SH3 domain containing 2
chr10_+_7785360 3.534 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785331 3.490 ITIH2
inter-alpha (globulin) inhibitor H2
chr18_-_24011349 3.469 NM_001792
 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr11_+_69165119 2.985 CCND1
cyclin D1
chr11_+_69165018 2.943 NM_053056
 CCND1
cyclin D1
chr10_+_7785235 2.787 NM_002216
 ITIH2
inter-alpha (globulin) inhibitor H2
chr1_+_93686154 2.682 NM_001024948
NM_001164473
NM_017737
 FNBP1L


formin binding protein 1-like


chr3_-_150858274 2.597 NM_001168280
NM_015472
 WWTR1

WW domain containing transcription regulator 1

chr7_-_107430566 2.482 NM_002291
 LAMB1
laminin, beta 1
chr5_-_16989371 2.479 NM_012334
 MYO10
myosin X
chr10_+_7785290 2.444 ITIH2
inter-alpha (globulin) inhibitor H2
chr19_-_18578577 2.400 CRLF1
cytokine receptor-like factor 1
chr19_-_18578467 2.351 CRLF1
cytokine receptor-like factor 1
chr5_+_34720368 2.335 NM_001145521
NM_001145525
 RAI14

retinoic acid induced 14

chr4_-_158111995 2.324 NM_016205
 PDGFC
platelet derived growth factor C
chrX_-_105169370 2.297 NM_000354
 SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.82 4.71e-02 GO:0048812 neuron projection morphogenesis
1.81 2.53e-02 GO:0048858 cell projection morphogenesis
1.79 3.38e-02 GO:0032990 cell part morphogenesis
1.78 7.56e-03 GO:0000902 cell morphogenesis
1.71 2.44e-02 GO:0032989 cellular component morphogenesis
1.67 3.67e-03 GO:0048699 generation of neurons
1.67 3.49e-02 GO:0030182 neuron differentiation
1.62 7.14e-03 GO:0022008 neurogenesis

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
3.16 3.26e-02 GO:0005604 basement membrane
2.87 3.66e-02 GO:0030027 lamellipodium
2.54 4.94e-02 GO:0044420 extracellular matrix part
1.58 6.63e-04 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
6.11 3.15e-02 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity