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Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.693

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr10_+_53744043	5.774	NM_012242	DKK1	dickkopf homolog 1 (Xenopus laevis)
chr6_-_128883125	5.357	NM_002844 NM_001135648	PTPRK	protein tyrosine phosphatase, receptor type, K
chr10_+_7785347	3.761		ITIH2	inter-alpha (globulin) inhibitor H2
chr4_-_187114407	3.748		SORBS2	sorbin and SH3 domain containing 2
chr10_+_7785360	3.534		ITIH2	inter-alpha (globulin) inhibitor H2
chr10_+_7785331	3.490		ITIH2	inter-alpha (globulin) inhibitor H2
chr18_-_24011349	3.469	NM_001792	CDH2	cadherin 2, type 1, N-cadherin (neuronal)
chr11_+_69165119	2.985		CCND1	cyclin D1
chr11_+_69165018	2.943	NM_053056	CCND1	cyclin D1
chr10_+_7785235	2.787	NM_002216	ITIH2	inter-alpha (globulin) inhibitor H2
chr1_+_93686154	2.682	NM_001024948 NM_001164473 NM_017737	FNBP1L	formin binding protein 1-like
chr3_-_150858274	2.597	NM_001168280 NM_015472	WWTR1	WW domain containing transcription regulator 1
chr7_-_107430566	2.482	NM_002291	LAMB1	laminin, beta 1
chr5_-_16989371	2.479	NM_012334	MYO10	myosin X
chr10_+_7785290	2.444		ITIH2	inter-alpha (globulin) inhibitor H2
chr19_-_18578577	2.400		CRLF1	cytokine receptor-like factor 1
chr19_-_18578467	2.351		CRLF1	cytokine receptor-like factor 1
chr5_+_34720368	2.335	NM_001145521 NM_001145525	RAI14	retinoic acid induced 14
chr4_-_158111995	2.324	NM_016205	PDGFC	platelet derived growth factor C
chrX_-_105169370	2.297	NM_000354	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_-_39430180	2.246		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr19_-_18578631	2.219	NM_004750	CRLF1	cytokine receptor-like factor 1
chr5_-_16791346	2.168		MYO10	myosin X
chr12_-_120781002	2.165	NM_002150	HPD	4-hydroxyphenylpyruvate dioxygenase
chr2_+_101680594	2.079	NM_004834 NM_145686 NM_145687	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4
chr18_+_3439972	2.070	NM_173209 NM_173208 NM_003244	TGIF1	TGFB-induced factor homeobox 1
chr10_+_114699953	1.979	NM_001146274 NM_001146283 NM_001146284 NM_001146285 NM_001146286 NM_001198525 NM_001198526 NM_001198527 NM_001198528 NM_001198529 NM_001198530 NM_001198531 NM_030756	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)
chr10_+_4995453	1.950	NM_001353	AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr4_+_38740246	1.929	NM_015990 NM_199039	KLHL5	kelch-like 5 (Drosophila)
chr4_-_158111504	1.916		PDGFC	platelet derived growth factor C
chr2_+_228386800	1.852	NM_001130046 NM_004591	CCL20	chemokine (C-C motif) ligand 20
chr13_+_109935250	1.807		COL4A2	collagen, type IV, alpha 2
chr18_-_24010944	1.769		CDH2	cadherin 2, type 1, N-cadherin (neuronal)
chr10_-_118755077	1.730	NM_001127211 NM_018330	KIAA1598	KIAA1598
chr11_+_46697345	1.723		F2	coagulation factor II (thrombin)
chr11_+_69165159	1.680		CCND1	cyclin D1
chr11_+_46697312	1.663	NM_000506	F2	coagulation factor II (thrombin)
chr18_+_54039779	1.625		NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr3_-_150422474	1.578	NM_000096	CP	ceruloplasmin (ferroxidase)
chr14_-_64479198	1.577	NM_002083	GPX2	glutathione peroxidase 2 (gastrointestinal)
chr5_+_131621287	1.541		PDLIM4	PDZ and LIM domain 4
chr13_+_109932934	1.529		COL4A2	collagen, type IV, alpha 2
chr11_+_101488380	1.500	NM_001195045	YAP1	Yes-associated protein 1
chr18_+_54039818	1.483		NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr6_+_143971009	1.469	NM_001100166 NM_014721	PHACTR2	phosphatase and actin regulator 2
chr2_+_47449951	1.447		EPCAM	epithelial cell adhesion molecule
chr9_-_14388981	1.421	NM_001190738	NFIB	nuclear factor I/B
chr7_-_27186400	1.389	NM_153715	HOXA10	homeobox A10
chr14_+_105012106	1.383	NM_001312	CRIP2	cysteine-rich protein 2
chr22_-_34566367	1.377	NM_001031695 NM_001082576 NM_001082577 NM_014309	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2
chr12_-_15833383	1.372		EPS8	epidermal growth factor receptor pathway substrate 8
chr8_-_17624009	1.330	NM_001001931	MTUS1	microtubule associated tumor suppressor 1
chr4_-_139382672	1.308	NM_014331	SLC7A11	solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr19_-_6671585	1.300	NM_000064	C3	complement component 3
chr16_-_12805194	1.293	NM_001099455 NM_018340	CPPED1	calcineurin-like phosphoesterase domain containing 1
chr3_-_124822113	1.293	NM_053031 NM_053032	MYLK	myosin light chain kinase
chr1_-_95165089	1.269	NM_001839	CNN3	calponin 3, acidic
chr22_+_36928972	1.268	NM_001161573	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr7_+_94130673	1.256		PEG10	paternally expressed 10
chr12_+_19173669	1.229	NM_001143821 NM_001190860 NM_019012	PLEKHA5	pleckstrin homology domain containing, family A member 5
chr6_-_11340886	1.227		NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr6_-_2785682	1.225		SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1
chrX_+_54852217	1.212	NM_201222	MAGED2	melanoma antigen family D, 2
chr5_-_39460687	1.209		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr7_+_94130752	1.207		PEG10	paternally expressed 10
chr17_-_36347197	1.202	NM_015515	KRT23	keratin 23 (histone deacetylase inducible)
chr3_-_124821868	1.201		MYLK	myosin light chain kinase
chr13_+_109936080	1.196		COL4A2	collagen, type IV, alpha 2
chr11_+_69165065	1.191		CCND1	cyclin D1
chr17_-_61253122	1.168	NM_001037325	CCDC46	coiled-coil domain containing 46
chr20_-_43410437	1.165	NM_002999	SDC4	syndecan 4
chr4_-_7991992	1.129	NM_001134647 NM_198595	AFAP1	actin filament associated protein 1
chr18_+_54039730	1.122	NM_001144966	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr6_+_123151669	1.120	NM_006714	SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A
chr7_-_30032649	1.112	NM_017946	FKBP14	FK506 binding protein 14, 22 kDa
chr2_+_69093641	1.098	NM_018153 NM_032208 NM_053034	ANTXR1	anthrax toxin receptor 1
chr10_-_32385343	1.081	NM_004521	KIF5B	kinesin family member 5B
chr2_-_56003859	1.071	NM_004105	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1
chr14_-_93924663	1.067		SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_-_43196911	1.067		SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1
chr10_-_52315390	1.065		A1CF	APOBEC1 complementation factor
chr19_-_50506883	1.060		CKM	creatine kinase, muscle
chr1_+_99884018	1.052	NM_017734	PALMD	palmdelphin
chr10_-_99436889	1.034	NM_021732	AVPI1	arginine vasopressin-induced 1
chr5_+_131621276	1.034		PDLIM4	PDZ and LIM domain 4
chr17_+_69939806	1.028		GPRC5C	G protein-coupled receptor, family C, group 5, member C
chr3_-_79899748	1.022	NM_002941	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr17_-_23721468	1.022		VTN	vitronectin
chr5_+_102229425	1.022	NM_000919 NM_001177306 NM_138766 NM_138821 NM_138822	PAM	peptidylglycine alpha-amidating monooxygenase
chr6_-_11340869	1.013		NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr10_-_32385299	1.008		KIF5B	kinesin family member 5B
chr11_-_61415429	1.008	NM_021727	FADS3	fatty acid desaturase 3
chr8_-_17624304	1.007	NM_001166393	MTUS1	microtubule associated tumor suppressor 1
chr5_+_131621230	1.006	NM_001131027 NM_003687	PDLIM4	PDZ and LIM domain 4
chr6_+_167624792	1.004	NM_001143947 NM_018974	UNC93A	unc-93 homolog A (C. elegans)
chr1_+_67923660	1.003		GADD45A	growth arrest and DNA-damage-inducible, alpha
chr2_+_47449790	0.994	NM_002354	EPCAM	epithelial cell adhesion molecule
chr6_-_11340887	0.989	NM_006403 NM_182966	NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr12_+_69046241	0.982	NM_014505	KCNMB4	potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr12_+_76749199	0.982	NM_014903	NAV3	neuron navigator 3
chr13_+_100902942	0.975	NM_004791	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)
chr10_-_88707299	0.948	NM_024756	MMRN2	multimerin 2
chr3_+_187813405	0.944		AHSG	alpha-2-HS-glycoprotein
chr10_-_30064600	0.944	NM_003174	SVIL	supervillin
chr5_-_39461054	0.925	NM_001343	DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr7_+_93862137	0.919		COL1A2 PLAG1	collagen, type I, alpha 2 pleiomorphic adenoma gene 1
chr16_+_70646008	0.868	NM_001126102 NM_005143	HP	haptoglobin
chr1_-_172153087	0.853	NM_000488	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1
chr10_-_101831579	0.849	NM_001308	CPN1	carboxypeptidase N, polypeptide 1
chr11_+_129484540	0.844		APLP2	amyloid beta (A4) precursor-like protein 2
chr7_-_27180398	0.833	NM_018951	HOXA10	homeobox A10
chr11_-_88864061	0.831	NM_001143836 NM_016931	NOX4	NADPH oxidase 4
chr17_-_53849929	0.828	NM_017763	RNF43	ring finger protein 43
chr10_-_32385129	0.815		KIF5B	kinesin family member 5B
chr3_-_115960807	0.815	NM_001164344 NM_001164345	ZBTB20	zinc finger and BTB domain containing 20
chr5_-_58370693	0.811	NM_001197221 NM_001197222	PDE4D	phosphodiesterase 4D, cAMP-specific
chr18_+_3437607	0.809	NM_173207	TGIF1	TGFB-induced factor homeobox 1
chr14_-_104515738	0.801	NM_138420	AHNAK2	AHNAK nucleoprotein 2
chr7_-_139523187	0.797	NM_030647	JHDM1D	jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr2_+_219354948	0.795		CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1
chr10_-_52315436	0.794	NM_001198818 NM_001198819 NM_001198820 NM_014576 NM_138932 NM_138933	A1CF	APOBEC1 complementation factor
chr15_+_22772545	0.777		SNRPN	small nuclear ribonucleoprotein polypeptide N
chr4_-_40911212	0.758	NM_001166050 NM_004307 NM_173075	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2
chr14_-_73555566	0.757	NM_001249	ENTPD5	ectonucleoside triphosphate diphosphohydrolase 5
chr9_-_98185815	0.746		SLC35D2	solute carrier family 35, member D2
chr5_+_36642424	0.746		SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr20_+_11846536	0.743	NM_014962	BTBD3	BTB (POZ) domain containing 3
chr7_+_29200636	0.740	NM_004067	CHN2	chimerin (chimaerin) 2
chr7_+_73506333	0.740	NM_005685	GTF2IRD1	GTF2I repeat domain containing 1
chr7_+_93861808	0.734	NM_000089	COL1A2	collagen, type I, alpha 2
chr15_-_88148538	0.730		ANPEP	alanyl (membrane) aminopeptidase
chr6_-_32253819	0.726	NM_032741	AGPAT1	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr3_+_161040343	0.723	NM_001197109	SCHIP1	schwannomin interacting protein 1
chr21_+_34112456	0.721		ITSN1	intersectin 1 (SH3 domain protein)
chr17_-_53849888	0.711		RNF43	ring finger protein 43
chr3_+_161040439	0.701		SCHIP1	schwannomin interacting protein 1
chr5_+_109053034	0.700	NM_002372	MAN2A1	mannosidase, alpha, class 2A, member 1
chr4_+_69996780	0.699	NM_001074	UGT2B7	UDP glucuronosyltransferase 2 family, polypeptide B7
chr7_+_73506172	0.691		GTF2IRD1	GTF2I repeat domain containing 1
chr12_-_15833617	0.689	NM_004447	EPS8	epidermal growth factor receptor pathway substrate 8
chr6_-_47361921	0.686		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr11_+_86189138	0.682	NM_007173	PRSS23	protease, serine, 23
chr7_-_133794404	0.676	NM_001628	AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)
chr14_-_20340830	0.673	NM_002933 NM_198234 NM_198235	RNASE1	ribonuclease, RNase A family, 1 (pancreatic)
chr6_-_134680888	0.672	NM_001143676	SGK1	serum/glucocorticoid regulated kinase 1
chr9_-_98185613	0.668	NM_007001	SLC35D2	solute carrier family 35, member D2
chr2_-_39517795	0.668		MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3
chr1_-_43197123	0.665		SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1
chr8_-_11763037	0.648	NM_001908 NM_147780 NM_147781 NM_147782 NM_147783	CTSB	cathepsin B
chr5_+_66160359	0.646	NM_015183	MAST4	microtubule associated serine/threonine kinase family member 4
chr7_+_73506047	0.640	NM_016328	GTF2IRD1	GTF2I repeat domain containing 1
chr3_-_135575925	0.639	NM_016201	AMOTL2	angiomotin like 2
chr11_-_88962426	0.638	NM_001143837	NOX4	NADPH oxidase 4
chr10_-_116434364	0.636	NM_001003407 NM_001003408	ABLIM1	actin binding LIM protein 1
chr17_-_60088637	0.628		SMURF2	SMAD specific E3 ubiquitin protein ligase 2
chr5_-_114543632	0.627	NM_001017397 NM_001017398 NM_018700	TRIM36	tripartite motif containing 36
chr5_-_39460787	0.627		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr11_-_65138217	0.625	NM_002419	MAP3K11	mitogen-activated protein kinase kinase kinase 11
chr14_+_85066207	0.616	NM_013231	FLRT2	fibronectin leucine rich transmembrane protein 2
chrX_+_135057202	0.614	NM_001159702 NM_001159703 NM_001449	FHL1	four and a half LIM domains 1
chr6_+_123152044	0.614		SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A
chr11_+_44073674	0.612	NM_001178083 NM_207122	EXT2	exostosin 2
chr11_-_72063059	0.612	NM_002599	PDE2A	phosphodiesterase 2A, cGMP-stimulated
chr20_+_9146036	0.609	NM_182797	PLCB4	phospholipase C, beta 4
chr10_+_73393998	0.608	NM_004273	CHST3	carbohydrate (chondroitin 6) sulfotransferase 3
chrX_-_13744933	0.605		GPM6B	glycoprotein M6B
chr10_+_102722275	0.604	NM_017893	SEMA4G	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr15_-_86890796	0.601	NM_001144074 NM_017996	DET1	de-etiolated homolog 1 (Arabidopsis)
chr5_+_36642213	0.600	NM_001166696 NM_004172	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_+_4995685	0.584		AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr8_+_32698892	0.583	NM_001159996	NRG1	neuregulin 1
chr10_-_5035967	0.581	NM_001135241	AKR1C1 AKR1C2	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chrX_+_55951280	0.581
chr16_-_18720192	0.576	NM_015161	ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1
chr13_-_32658215	0.573	NM_178007	STARD13	StAR-related lipid transfer (START) domain containing 13
chr17_-_36346240	0.571		KRT23	keratin 23 (histone deacetylase inducible)
chr6_-_11887265	0.570	NM_001143948 NM_032744	C6orf105	chromosome 6 open reading frame 105
chr12_-_88573949	0.566	NM_001001323 NM_001682	ATP2B1	ATPase, Ca++ transporting, plasma membrane 1
chr1_+_170768914	0.565	NM_016227	C1orf9	chromosome 1 open reading frame 9
chr12_-_120810899	0.565	NM_001171993	HPD	4-hydroxyphenylpyruvate dioxygenase
chr16_+_56259657	0.564	NM_170776	GPR97	G protein-coupled receptor 97
chr4_-_111777956	0.563	NM_153426 NM_153427	PITX2	paired-like homeodomain 2
chr4_+_146622154	0.562	NM_005900	SMAD1	SMAD family member 1
chr17_+_19377732	0.559	NM_018242	SLC47A1	solute carrier family 47, member 1
chr2_+_9264360	0.556		ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chrX_+_46822751	0.554		RGN	regucalcin (senescence marker protein-30)
chr14_+_85066265	0.550		FLRT2	fibronectin leucine rich transmembrane protein 2
chr1_+_98899734	0.547	NM_015976 NM_152238	SNX7	sorting nexin 7
chr14_+_94148466	0.543	NM_001085	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr4_-_80079393	0.535	NM_001040202	PAQR3	progestin and adipoQ receptor family member III
chr9_+_494661	0.533	NM_015158	KANK1	KN motif and ankyrin repeat domains 1
chrX_+_102518764	0.531	NM_014380	NGFRAP1	nerve growth factor receptor (TNFRSF16) associated protein 1
chr20_-_45410033	0.529		ZMYND8	zinc finger, MYND-type containing 8
chrX_+_46822688	0.526	NM_004683 NM_152869	RGN	regucalcin (senescence marker protein-30)
chr2_-_86418143	0.526	NM_001164731 NM_001164732 NM_022912	REEP1	receptor accessory protein 1
chr19_+_18357966	0.524	NM_004864	GDF15	growth differentiation factor 15
chrX_+_70359780	0.522	NM_000166	GJB1	gap junction protein, beta 1, 32kDa
chr4_-_70661018	0.517	NM_014465	SULT1B1	sulfotransferase family, cytosolic, 1B, member 1
chr12_-_6321417	0.515	NM_001065	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A
chr17_+_54997667	0.507	NM_001166301 NM_024612	DHX40	DEAH (Asp-Glu-Ala-His) box polypeptide 40

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.67	3.67e-03	GO:0048699	generation of neurons
1.62	7.14e-03	GO:0022008	neurogenesis
1.78	7.56e-03	GO:0000902	cell morphogenesis
1.71	2.44e-02	GO:0032989	cellular component morphogenesis
1.81	2.53e-02	GO:0048858	cell projection morphogenesis
1.79	3.38e-02	GO:0032990	cell part morphogenesis
1.67	3.49e-02	GO:0030182	neuron differentiation
1.82	4.71e-02	GO:0048812	neuron projection morphogenesis

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.58	6.63e-04	GO:0044421	extracellular region part
3.16	3.26e-02	GO:0005604	basement membrane
2.87	3.66e-02	GO:0030027	lamellipodium
2.54	4.94e-02	GO:0044420	extracellular matrix part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
6.11	3.15e-02	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity