Motif ID: TCF4_dimer.p2

Z-value: 2.422


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_514068410.476.4e-02Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_72006015 8.915 LOXL1
lysyl oxidase-like 1
chr9_-_35679799 6.343 TPM2
tropomyosin 2 (beta)
chr9_-_35679902 6.126 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr15_+_72005847 5.759 LOXL1
lysyl oxidase-like 1
chr15_+_72005839 5.661 NM_005576
LOXL1
lysyl oxidase-like 1
chr15_-_46725087 5.501 NM_000138
FBN1
fibrillin 1
chr4_-_81213207 5.401


chr2_+_219991342 4.868 NM_001927
DES
desmin
chr9_-_74757735 4.591 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr8_-_49996353 3.964 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr7_+_115953582 3.937 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr7_-_45927263 3.868 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr2_+_170074457 3.831 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr6_-_139737042 3.757 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chr3_-_87122936 3.536 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr21_+_46355797 3.490 COL6A2
collagen, type VI, alpha 2
chr7_-_130891861 3.406 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr11_+_65536037 3.278 NM_001323
CST6
cystatin E/M
chr2_-_175337386 3.079 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr15_+_72005875 3.005 LOXL1
lysyl oxidase-like 1
chr12_+_76749199 2.991 NM_014903
NAV3
neuron navigator 3
chr12_-_90029328 2.991 LUM
lumican
chr4_-_57671273 2.974 NM_001553
IGFBP7
insulin-like growth factor binding protein 7
chr15_+_72005864 2.974 LOXL1
lysyl oxidase-like 1
chr2_-_192420168 2.946 NM_004657
SDPR
serum deprivation response
chr4_-_57671307 2.939 IGFBP7
insulin-like growth factor binding protein 7
chr12_-_90029672 2.862 NM_002345
LUM
lumican
chr10_+_31648103 2.859 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr10_-_92671005 2.856 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr2_-_189752575 2.854 NM_000393
COL5A2
collagen, type V, alpha 2
chr10_+_11100111 2.848 CELF2
CUGBP, Elav-like family member 2
chr4_-_40911212 2.845 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr21_+_29439768 2.814 C21orf7
chromosome 21 open reading frame 7
chr2_-_192419896 2.812 SDPR
serum deprivation response
chr4_-_57671112 2.792 IGFBP7
insulin-like growth factor binding protein 7
chr5_+_148501178 2.750 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr1_+_221955876 2.735 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr1_+_181259317 2.731


chrX_-_13866451 2.718 GPM6B
glycoprotein M6B
chrX_-_135691168 2.665 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_-_37752731 2.663 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr8_+_22492586 2.650 PDLIM2
PDZ and LIM domain 2 (mystique)
chr11_-_47427263 2.616 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr10_+_104394185 2.590 NM_030912
TRIM8
tripartite motif containing 8
chr17_+_42641712 2.586 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr12_+_79634820 2.578 NM_005593
MYF5
myogenic factor 5
chr1_-_95165089 2.557 NM_001839
CNN3
calponin 3, acidic
chr10_-_92670764 2.547 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr7_+_93861808 2.519 NM_000089
COL1A2
collagen, type I, alpha 2
chr10_+_11099860 2.491 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr10_+_31647425 2.490 ZEB1
zinc finger E-box binding homeobox 1
chr11_-_6298284 2.480 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr15_+_61127367 2.444 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr6_-_139737432 2.444 CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr6_-_139737477 2.440 NM_006079
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr7_+_93862137 2.427 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr4_-_158111995 2.396 NM_016205
PDGFC
platelet derived growth factor C
chr1_-_199613427 2.372 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr10_+_11100075 2.370 CELF2
CUGBP, Elav-like family member 2
chr1_-_199613406 2.250 TNNT2
troponin T type 2 (cardiac)
chr2_-_210888010 2.200 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chrX_-_106905545 2.197 TSC22D3
TSC22 domain family, member 3
chr3_-_15875932 2.177 NM_015199
ANKRD28
ankyrin repeat domain 28
chr1_-_85703198 2.173 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr9_+_33614214 2.098 ANXA2P2
annexin A2 pseudogene 2
chr3_-_101316038 2.084 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chrX_+_70438352 2.081 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr3_+_160269734 1.986 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr11_-_118799452 1.978 NM_006288
THY1
Thy-1 cell surface antigen
chr1_-_143643064 1.976 PDE4DIP
phosphodiesterase 4D interacting protein
chr10_-_75080784 1.974 NM_024875
SYNPO2L
synaptopodin 2-like
chr19_-_12747263 1.950 HOOK2
hook homolog 2 (Drosophila)
chr1_-_191422346 1.948 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr12_-_123023312 1.938 CCDC92
coiled-coil domain containing 92
chr16_-_63713382 1.937 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr10_+_124210980 1.924 NM_002775
HTRA1
HtrA serine peptidase 1
chr4_-_158111504 1.913 PDGFC
platelet derived growth factor C
chr9_-_96441409 1.879 FBP1
fructose-1,6-bisphosphatase 1
chr5_+_140844810 1.849 NM_018928
NM_032406
PCDHGC4

protocadherin gamma subfamily C, 4

chr17_+_58058774 1.839 MRC2
mannose receptor, C type 2
chr3_+_8750485 1.829 NM_033337
NM_001234
CAV3

caveolin 3

chr5_-_151046680 1.815 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr2_+_71149193 1.804 NAGK
N-acetylglucosamine kinase
chr5_-_176832476 1.789 NM_080881
DBN1
drebrin 1
chr16_-_63713466 1.788 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr8_+_120289735 1.787 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr16_-_63713485 1.781 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr19_-_51666629 1.767 NM_001103149
NM_018215
PNMAL1

PNMA-like 1

chr15_+_81567327 1.753 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr19_-_50517971 1.742 CKM
creatine kinase, muscle
chr8_-_41641881 1.736 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr11_+_69165018 1.725 NM_053056
CCND1
cyclin D1
chr11_-_63770957 1.721 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_+_85819004 1.720 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr1_+_201364050 1.715 ADORA1
adenosine A1 receptor
chr10_+_11247059 1.712 CELF2
CUGBP, Elav-like family member 2
chr8_+_37773991 1.712 GPR124
G protein-coupled receptor 124
chrX_-_106905657 1.712 NM_198057
TSC22D3
TSC22 domain family, member 3
chr15_-_23659329 1.707 NM_024490
ATP10A
ATPase, class V, type 10A
chrX_-_13866565 1.697 NM_001001994
GPM6B
glycoprotein M6B
chr17_+_65677255 1.690 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr10_+_124211353 1.682 HTRA1
HtrA serine peptidase 1
chr2_-_179380301 1.666 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr11_-_118799058 1.643 THY1
Thy-1 cell surface antigen
chr10_+_17311347 1.633 VIM
vimentin
chrX_+_135079120 1.614 NM_001159704
FHL1
four and a half LIM domains 1
chr11_-_63689780 1.609 MACROD1
MACRO domain containing 1
chr2_-_152299229 1.607 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr17_-_10393664 1.602 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr15_-_21483457 1.592 NDN
necdin homolog (mouse)
chr5_+_71438796 1.588 NM_005909
MAP1B
microtubule-associated protein 1B
chr21_-_38210531 1.583 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr7_+_44754978 1.581 NM_031449
ZMIZ2
zinc finger, MIZ-type containing 2
chr19_-_51666503 1.571 PNMAL1
PNMA-like 1
chr10_+_11246934 1.568 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr2_-_1727324 1.562 PXDN
peroxidasin homolog (Drosophila)
chr11_-_63690069 1.561 NM_014067
MACROD1
MACRO domain containing 1
chr10_+_17311788 1.559 VIM
vimentin
chr9_-_16717887 1.549 BNC2
basonuclin 2
chr5_+_34692239 1.540 RAI14
retinoic acid induced 14
chr5_-_172687798 1.530 STC2
stanniocalcin 2
chr19_-_12747421 1.522 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr11_-_2108035 1.515 IGF2
insulin-like growth factor 2 (somatomedin A)
chr10_+_17311962 1.513 VIM
vimentin
chr19_-_11169184 1.511 NM_001136191
KANK2
KN motif and ankyrin repeat domains 2
chr21_+_25933459 1.509 NM_021219
JAM2
junctional adhesion molecule 2
chr17_+_45488356 1.482 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr16_+_87765661 1.478 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr2_-_1727247 1.475 PXDN
peroxidasin homolog (Drosophila)
chr2_+_223625105 1.470 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr3_-_180272229 1.470 ZMAT3
zinc finger, matrin-type 3
chr11_+_86189138 1.460 NM_007173
PRSS23
protease, serine, 23
chrX_-_13866366 1.457


chrX_+_48221323 1.451 NM_177434
FTSJ1
FtsJ homolog 1 (E. coli)
chr17_+_45488330 1.449 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr8_-_122722674 1.448 NM_005328
HAS2
hyaluronan synthase 2
chrX_-_135690770 1.440 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr11_-_63770840 1.422 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_-_135690699 1.413 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_+_144236346 1.403 NM_003637
ITGA10
integrin, alpha 10
chr11_+_12088639 1.397 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr2_-_1727292 1.391 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr1_-_32940943 1.384 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr4_+_40953698 1.378 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr6_-_46566969 1.376 RCAN2
regulator of calcineurin 2
chr20_+_19818209 1.368 NM_018993
RIN2
Ras and Rab interactor 2
chr6_+_129245978 1.365 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr1_-_109386112 1.357 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr15_-_53996597 1.347 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr5_+_34692352 1.339 NM_001145520
RAI14
retinoic acid induced 14
chr3_-_180272291 1.324 NM_022470
NM_152240
ZMAT3

zinc finger, matrin-type 3

chr11_+_1816808 1.311 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr17_-_15109315 1.309 NM_000304
PMP22
peripheral myelin protein 22
chr11_+_74950766 1.288 NM_001235
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr8_+_1909437 1.271 NM_014867
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr17_+_42641426 1.268 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr10_+_99248605 1.265 NM_024954
UBTD1
ubiquitin domain containing 1
chr1_-_40140126 1.262 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr1_-_201411533 1.257 NM_004997
MYBPH
myosin binding protein H
chr7_-_37922902 1.248 SFRP4
secreted frizzled-related protein 4
chr9_-_139060285 1.245 NPDC1
neural proliferation, differentiation and control, 1
chr9_-_139060377 1.238 NPDC1
neural proliferation, differentiation and control, 1
chr2_+_33213111 1.238 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr3_+_35656012 1.222 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_-_161058120 1.203 RBMS1
RNA binding motif, single stranded interacting protein 1
chr1_-_201321711 1.186 MYOG
myogenin (myogenic factor 4)
chr10_-_62373828 1.183 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chrX_-_6156655 1.179 NM_181332
NLGN4X
neuroligin 4, X-linked
chr2_-_161058550 1.173 NM_002897
NM_016836
RBMS1

RNA binding motif, single stranded interacting protein 1

chr3_+_49034494 1.169 NDUFAF3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr7_+_100302885 1.167 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr7_+_115926855 1.165 CAV2
caveolin 2
chr11_+_113815317 1.165 NM_015523
REXO2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
chr22_-_17891777 1.163 CLDN5
claudin 5
chr5_+_95092384 1.160 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chrX_-_106130098 1.152 NM_001085354
NM_024657
MORC4

MORC family CW-type zinc finger 4

chr3_+_106568334 1.146 NM_001627
ALCAM
activated leukocyte cell adhesion molecule
chr16_+_7322751 1.146 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr1_-_143643324 1.142 NM_001002811
PDE4DIP
phosphodiesterase 4D interacting protein
chr9_+_34980266 1.139 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr11_-_61415429 1.139 NM_021727
FADS3
fatty acid desaturase 3
chr16_+_54070302 1.137 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr17_-_74432800 1.133 TIMP2
TIMP metallopeptidase inhibitor 2
chr8_+_22492198 1.127 NM_021630
PDLIM2
PDZ and LIM domain 2 (mystique)
chr7_-_150576660 1.126 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr12_-_54517241 1.121 MMP19
matrix metallopeptidase 19
chr6_-_46401363 1.110 NM_005822
RCAN2
regulator of calcineurin 2
chrX_+_99786044 1.109 SRPX2
sushi-repeat containing protein, X-linked 2
chr1_-_146398501 1.106 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr5_-_88235624 1.095 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chrX_+_99785818 1.094 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr12_+_6703686 1.093 NM_001164093
COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr17_-_74433048 1.087 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr14_-_22891263 1.086 NM_020372
SLC22A17
solute carrier family 22, member 17
chr17_-_45619038 1.085 COL1A1
collagen, type I, alpha 1
chr22_+_36401558 1.082 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr11_-_63770983 1.081 NM_138689
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr9_+_34980715 1.078 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr8_+_98857190 1.075 LAPTM4B
lysosomal protein transmembrane 4 beta
chr17_-_37221671 1.071 LEPREL4
leprecan-like 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.19 3.55e-06 GO:0048856 anatomical structure development
1.14 6.17e-05 GO:0032501 multicellular organismal process
1.36 6.22e-05 GO:0048468 cell development
1.16 6.63e-05 GO:0032502 developmental process
1.17 8.96e-05 GO:0007275 multicellular organismal development
1.18 3.27e-04 GO:0048731 system development
1.26 4.19e-04 GO:0007399 nervous system development
1.22 4.88e-04 GO:0030154 cell differentiation
1.34 5.74e-04 GO:0022008 neurogenesis
1.74 5.99e-04 GO:0007517 muscle organ development
1.22 6.39e-04 GO:0048869 cellular developmental process
1.34 8.08e-04 GO:0048699 generation of neurons
1.61 8.87e-04 GO:0061061 muscle structure development
1.35 2.51e-03 GO:0016192 vesicle-mediated transport
1.37 2.66e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.36 3.33e-03 GO:0030182 neuron differentiation
1.70 5.58e-03 GO:0006936 muscle contraction
1.37 1.41e-02 GO:0048666 neuron development
1.63 2.02e-02 GO:0003012 muscle system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.07 6.12e-07 GO:0043292 contractile fiber
1.09 7.58e-07 GO:0005737 cytoplasm
2.12 7.71e-07 GO:0044449 contractile fiber part
2.10 9.25e-07 GO:0030016 myofibril
2.12 1.26e-05 GO:0030017 sarcomere
1.51 4.07e-04 GO:0031012 extracellular matrix
1.10 4.55e-04 GO:0044444 cytoplasmic part
1.09 7.78e-04 GO:0016020 membrane
1.53 8.18e-04 GO:0015629 actin cytoskeleton
1.30 4.56e-03 GO:0031982 vesicle
1.17 6.06e-03 GO:0005829 cytosol
1.49 8.05e-03 GO:0005578 proteinaceous extracellular matrix
1.29 1.05e-02 GO:0031410 cytoplasmic vesicle
1.29 1.64e-02 GO:0031988 membrane-bounded vesicle
1.20 1.82e-02 GO:0005856 cytoskeleton
1.29 2.69e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.90 3.62e-02 GO:0042383 sarcolemma

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.38 5.39e-03 GO:0008092 cytoskeletal protein binding
1.46 1.78e-02 GO:0003779 actin binding
1.77 2.20e-02 GO:0019838 growth factor binding
2.23 2.94e-02 GO:0008307 structural constituent of muscle