Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 1.622


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RFXAPchr13_+_36291306-0.665.6e-03Click!
RFX5chr1_-_149586341-0.657.0e-03Click!
RFX2chr19_-_60614910.322.3e-01Click!
RFX1chr19_-_13977875,
chr19_-_13978096
0.312.4e-01Click!
RFXANKchr19_+_19164007-0.087.7e-01Click!
RFX3chr9_-_3515973-0.048.9e-01Click!


Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_133444175 3.589 JAM3
junctional adhesion molecule 3
chr11_+_133444029 3.392 NM_032801
JAM3
junctional adhesion molecule 3
chr2_-_175578156 2.605 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr15_+_68971835 2.365 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chrX_+_135079461 2.215 NM_001167819
FHL1
four and a half LIM domains 1
chrX_+_135079120 2.151 NM_001159704
FHL1
four and a half LIM domains 1
chr15_-_68971665 1.939 NM_020147
THAP10
THAP domain containing 10
chr14_+_105012106 1.888 NM_001312
CRIP2
cysteine-rich protein 2
chr3_-_124822113 1.853 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr14_-_73250094 1.711 NM_006029
PNMA1
paraneoplastic antigen MA1
chr4_-_156517423 1.702 MAP9
microtubule-associated protein 9
chr4_-_156517394 1.497 MAP9
microtubule-associated protein 9
chr5_+_34720368 1.422 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr7_+_129919157 1.407 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr15_+_94674849 1.374 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr1_+_201862552 1.355 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr14_+_99329198 1.342 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr1_+_201862548 1.338 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr12_-_88270375 1.325 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr3_-_124821868 1.310 MYLK
myosin light chain kinase
chr19_-_63301418 1.303 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr5_-_179712920 1.302 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr16_-_68317855 1.269 NQO1
NAD(P)H dehydrogenase, quinone 1
chrX_-_99778340 1.269 NM_003270
TSPAN6
tetraspanin 6
chr4_-_156517544 1.259 NM_001039580
MAP9
microtubule-associated protein 9
chr3_+_156280129 1.240 NM_000902
MME
membrane metallo-endopeptidase
chr1_-_167603623 1.239 NM_013330
NM_197972
NME7

non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)

chr11_+_102485293 1.215 NM_001080463
NM_001377
DYNC2H1

dynein, cytoplasmic 2, heavy chain 1

chr20_+_43425153 1.177 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 read-through transcript
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr16_+_55836480 1.139 NM_012106
ARL2BP
ADP-ribosylation factor-like 2 binding protein
chr16_-_68317868 1.112 NQO1
NAD(P)H dehydrogenase, quinone 1
chr17_-_5344898 1.107 NM_001162371
LOC728392
hypothetical protein LOC728392
chr9_-_109291866 1.097 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr1_+_84402962 1.095 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_-_88270128 1.070 DUSP6
dual specificity phosphatase 6
chr17_-_5345167 1.056 LOC728392
hypothetical protein LOC728392
chr5_-_16795336 1.043 MYO10
myosin X
chr20_+_42593849 1.024 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr1_-_59022275 1.019 NM_002228
JUN
jun proto-oncogene
chr22_+_37382574 1.018 NM_001002880
NM_015373
CBY1

chibby homolog 1 (Drosophila)

chr6_+_52392907 1.009 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chr20_+_43478120 0.990 NM_001184728
NM_001184729
NM_001184730
NM_015937
PIGT



phosphatidylinositol glycan anchor biosynthesis, class T



chr17_-_61618276 0.989 NM_145036
CCDC46
coiled-coil domain containing 46
chr17_+_23686674 0.984 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr4_+_87734489 0.980 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr22_+_37382617 0.979 CBY1
chibby homolog 1 (Drosophila)
chr3_-_109423858 0.978 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr7_-_35044177 0.971 NM_015283
DPY19L1
dpy-19-like 1 (C. elegans)
chr8_+_59628372 0.968 SDCBP
syndecan binding protein (syntenin)
chr8_+_59628281 0.959 NM_001007067
NM_001007068
NM_001007069
NM_001007070
NM_005625
SDCBP




syndecan binding protein (syntenin)




chr7_+_150560459 0.955 NM_019015
CHPF2
chondroitin polymerizing factor 2
chr8_+_59628352 0.955 SDCBP
syndecan binding protein (syntenin)
chr3_-_151171576 0.931 PFN2
profilin 2
chr7_+_65307816 0.928 TPST1
tyrosylprotein sulfotransferase 1
chr1_-_114103276 0.916 NM_006608
PHTF1
putative homeodomain transcription factor 1
chr6_+_88174408 0.911 NM_001031743
C6orf165
chromosome 6 open reading frame 165
chr12_-_88270369 0.900 DUSP6
dual specificity phosphatase 6
chr7_+_65307691 0.867 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr1_+_201862845 0.855 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr10_+_70418482 0.855 NM_015634
KIAA1279
KIAA1279
chr16_+_56230707 0.840 NM_001145774
GPR56
G protein-coupled receptor 56
chr1_-_114103616 0.829 PHTF1
putative homeodomain transcription factor 1
chr14_-_101841222 0.810 NM_014226
RAGE
renal tumor antigen
chr9_-_109291575 0.761 KLF4
Kruppel-like factor 4 (gut)
chr1_-_161380562 0.749 RGS5
regulator of G-protein signaling 5
chr12_+_103204842 0.744 NM_003330
NM_182729
NM_182742
NM_182743
TXNRD1



thioredoxin reductase 1



chr12_-_90029672 0.734 NM_002345
LUM
lumican
chr5_-_149649593 0.734 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr1_+_19796044 0.729 NM_001032363
C1orf15-NBL1
C1orf151
C1ORF15-NBL1 read-through transcript
chromosome 1 open reading frame 151
chr6_-_43592670 0.727 YIPF3
Yip1 domain family, member 3
chr7_+_100584397 0.703 NM_001283
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
chr8_+_120497732 0.703 NM_002514
NOV
nephroblastoma overexpressed gene
chr1_+_98899734 0.692 NM_015976
NM_152238
SNX7

sorting nexin 7

chr2_+_231771623 0.690 ARMC9
armadillo repeat containing 9
chr7_-_44195405 0.682 NM_000162
GCK
glucokinase (hexokinase 4)
chr6_-_76051351 0.681 NM_001143958
NM_018247
TMEM30A

transmembrane protein 30A

chr19_-_52045890 0.679 NM_004069
NM_021575
AP2S1

adaptor-related protein complex 2, sigma 1 subunit

chr3_+_159771646 0.675 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr16_-_68317945 0.658 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr17_-_58877276 0.658 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr17_+_76133337 0.658 RPTOR
regulatory associated protein of MTOR, complex 1
chr12_+_103205148 0.643 TXNRD1
thioredoxin reductase 1
chr6_+_20510019 0.638 NM_001949
E2F3
E2F transcription factor 3
chr15_-_41589958 0.629 NM_005657
TP53BP1
tumor protein p53 binding protein 1
chr11_-_62230078 0.616 NM_032667
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_+_201711578 0.607 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr2_+_231771622 0.607 ARMC9
armadillo repeat containing 9
chr16_-_46052254 0.603 ITFG1
integrin alpha FG-GAP repeat containing 1
chr16_-_87450734 0.602 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr3_+_14141440 0.592 NM_024334
TMEM43
transmembrane protein 43
chr3_-_49030920 0.589 NM_001009996
DALRD3
DALR anticodon binding domain containing 3
chr1_+_78217510 0.586 DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr2_+_231771584 0.583 NM_025139
ARMC9
armadillo repeat containing 9
chr5_-_142045770 0.581 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr2_+_183289205 0.579 NM_018981
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr15_-_41572558 0.578 NM_001141979
NM_001141980
TP53BP1

tumor protein p53 binding protein 1

chr11_-_10519265 0.576 NM_016422
RNF141
ring finger protein 141
chr21_-_45532176 0.576 NM_015227
NM_133635
POFUT2

protein O-fucosyltransferase 2

chr6_-_2787111 0.575 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr13_+_35904408 0.575 NM_001111045
NM_003914
CCNA1

cyclin A1

chr6_-_76051216 0.574 TMEM30A
transmembrane protein 30A
chr7_+_106472243 0.571 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr15_+_88593765 0.568 NM_001029964
TTLL13
tubulin tyrosine ligase-like family, member 13
chr7_-_124192265 0.567 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr5_+_92944680 0.563 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr6_-_76051197 0.553 TMEM30A
transmembrane protein 30A
chr16_-_46052482 0.546 NM_030790
ITFG1
integrin alpha FG-GAP repeat containing 1
chr11_-_114880275 0.545 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr19_-_2734313 0.540 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr13_-_95092283 0.538 DZIP1
DAZ interacting protein 1
chr13_+_23361591 0.531 NM_001135816
PCOTH
prostate collagen triple helix
chr1_+_167603817 0.527 NM_003666
BLZF1
basic leucine zipper nuclear factor 1
chr19_-_2734332 0.524 NM_003021
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr5_-_149649380 0.521 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr9_+_115396020 0.519 NM_144489
RGS3
regulator of G-protein signaling 3
chr1_-_181871490 0.519 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr1_+_37795101 0.519 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr8_-_102033409 0.516 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_98359347 0.511 NM_033512
TSPYL5
TSPY-like 5
chr16_-_56393871 0.510 KIFC3
kinesin family member C3
chr11_+_131285747 0.506 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr7_-_139987044 0.505 DENND2A
DENN/MADD domain containing 2A
chr4_+_153920563 0.505 ARFIP1
ADP-ribosylation factor interacting protein 1
chr13_-_35818491 0.504 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr5_-_142046175 0.502 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr6_-_2787068 0.501 NM_030666
SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr4_+_153920382 0.497 NM_001025593
NM_001025595
NM_014447
ARFIP1


ADP-ribosylation factor interacting protein 1


chr7_+_138469029 0.496 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr11_-_33752468 0.487 NM_012175
NM_033406
FBXO3

F-box protein 3

chr3_-_10337837 0.480 NM_183352
SEC13
SEC13 homolog (S. cerevisiae)
chr15_+_99237555 0.479 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr3_-_49736297 0.475 NM_013334
NM_021971
GMPPB

GDP-mannose pyrophosphorylase B

chr12_-_129889569 0.473 NM_001980
NM_194356
STX2

syntaxin 2

chr8_-_98359248 0.468 TSPYL5
TSPY-like 5
chr1_-_181871416 0.467 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr9_+_131855805 0.464 NM_001136557
NM_001136558
NM_020960
GPR107


G protein-coupled receptor 107


chr22_-_41815277 0.463 NM_012263
TTLL1
tubulin tyrosine ligase-like family, member 1
chr19_+_43971689 0.459 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr10_+_99390431 0.457 NM_018425
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr2_-_9688552 0.456 NM_006826
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr3_-_10337724 0.448 NM_001136232
SEC13
SEC13 homolog (S. cerevisiae)
chr19_-_2734225 0.448 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr1_-_44593510 0.444 ERI3
ERI1 exoribonuclease family member 3
chr7_-_22506320 0.440 NM_001164460
NM_207342
MGC87042

STEAP family protein MGC87042

chr11_-_65869113 0.439 NM_001024957
NM_015399
BRMS1

breast cancer metastasis suppressor 1

chr16_-_56393881 0.438 NM_001130100
NM_005550
KIFC3

kinesin family member C3

chrX_+_48341496 0.436 WDR13
WD repeat domain 13
chr6_-_43592679 0.435 NM_015388
YIPF3
Yip1 domain family, member 3
chrX_+_48341164 0.434 NM_001166426
WDR13
WD repeat domain 13
chr10_-_17283623 0.433 TRDMT1
tRNA aspartic acid methyltransferase 1
chr3_-_10337776 0.429 SEC13
SEC13 homolog (S. cerevisiae)
chr19_-_55062611 0.429 NM_007254
PNKP
polynucleotide kinase 3'-phosphatase
chr9_-_34610489 0.426 NM_007234
NM_024348
DCTN3

dynactin 3 (p22)

chr8_+_22518218 0.426 KIAA1967
KIAA1967
chr1_-_44593287 0.424 ERI3
ERI1 exoribonuclease family member 3
chrX_+_129301493 0.423 NM_003951
NM_022810
SLC25A14

solute carrier family 25 (mitochondrial carrier, brain), member 14

chr18_+_52469559 0.421 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr1_-_167663278 0.421 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr19_-_51666629 0.417 NM_001103149
NM_018215
PNMAL1

PNMA-like 1

chr6_-_43592481 0.417 YIPF3
Yip1 domain family, member 3
chr1_-_44593522 0.416 NM_024066
ERI3
ERI1 exoribonuclease family member 3
chr9_-_34610483 0.416 DCTN3
dynactin 3 (p22)
chr15_-_82998516 0.413 NM_032856
WDR73
WD repeat domain 73
chr15_-_53487748 0.411 NM_004748
NM_020739
CCPG1

cell cycle progression 1

chr8_-_102033444 0.409 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr14_+_73555802 0.404 NM_025057
C14orf45
chromosome 14 open reading frame 45
chr14_-_22127902 0.403 DAD1
defender against cell death 1
chr1_+_207926172 0.402 NM_181755
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr14_-_22127954 0.402 NM_001344
DAD1
defender against cell death 1
chr9_-_34610460 0.398 DCTN3
dynactin 3 (p22)
chr15_-_82998500 0.397 WDR73
WD repeat domain 73
chr8_+_22518231 0.394 KIAA1967
KIAA1967
chr21_-_33935883 0.392 NM_145858
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr8_+_22518212 0.387 KIAA1967
KIAA1967
chr6_-_32271868 0.385 NOTCH4
notch 4
chr2_-_9688450 0.385 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chrX_+_48341066 0.384 WDR13
WD repeat domain 13
chr8_+_9450849 0.384 NM_003747
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr16_+_56219802 0.383 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr1_-_181871473 0.381 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr19_+_3523958 0.381 HMG20B
high-mobility group 20B
chr1_+_109458093 0.379 NM_020775
KIAA1324
KIAA1324
chr5_+_148501178 0.378 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr2_+_170044194 0.378 NM_152384
BBS5
Bardet-Biedl syndrome 5
chr14_-_23734598 0.377 NM_001014842
NM_006405
TM9SF1

transmembrane 9 superfamily member 1

chr7_-_102707901 0.377 DPY19L2P2
dpy-19-like 2 pseudogene 2 (C. elegans)
chr3_+_62279707 0.377 C3orf14
chromosome 3 open reading frame 14
chr1_+_201711505 0.375 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr16_-_46052596 0.373 ITFG1
integrin alpha FG-GAP repeat containing 1
chr8_+_22518477 0.372 NM_021174
KIAA1967
KIAA1967
chr2_-_47257156 0.371 CALM2
calmodulin 2 (phosphorylase kinase, delta)
chr14_-_23734433 0.371 TM9SF1
transmembrane 9 superfamily member 1
chr3_-_58538110 0.370 FAM107A
family with sequence similarity 107, member A
chr3_+_132228383 0.370 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr2_-_47257183 0.368 NM_001743
CALM2
calmodulin 2 (phosphorylase kinase, delta)
chr19_+_44308224 0.368 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr14_+_101899104 0.366 TECPR2
tectonin beta-propeller repeat containing 2
chr6_-_158985727 0.366 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chr2_-_47257150 0.365 CALM2
calmodulin 2 (phosphorylase kinase, delta)
chr1_-_44593526 0.365 ERI3
ERI1 exoribonuclease family member 3

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
9.89 2.10e-07 GO:0005932 microtubule basal body
1.22 2.21e-05 GO:0005737 cytoplasm
2.28 2.67e-05 GO:0015630 microtubule cytoskeleton
3.97 1.42e-04 GO:0005929 cilium
6.55 4.57e-04 GO:0044441 cilium part
2.87 5.54e-04 GO:0005874 microtubule
1.13 6.40e-04 GO:0044424 intracellular part
6.76 1.14e-03 GO:0005930 axoneme
1.12 1.37e-03 GO:0005622 intracellular
17.03 8.49e-03 GO:0034464 BBSome
1.23 8.88e-03 GO:0044444 cytoplasmic part
7.15 9.11e-03 GO:0030286 dynein complex
2.35 1.73e-02 GO:0005815 microtubule organizing center
14.60 1.92e-02 GO:0060170 cilium membrane
1.71 2.47e-02 GO:0044430 cytoskeletal part
1.56 3.09e-02 GO:0005856 cytoskeleton
1.23 3.64e-02 GO:0044422 organelle part
5.77 4.06e-02 GO:0019861 flagellum

Nothing significant found in function category.