Motif ID: IKZF2.p2

Z-value: 1.623


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF2chr2_-_213723298-0.292.8e-01Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_37070862 7.201 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr2_+_189547377 5.894 COL3A1
collagen, type III, alpha 1
chr2_+_189547323 5.433 NM_000090
COL3A1
collagen, type III, alpha 1
chr2_+_189547358 5.317 COL3A1
collagen, type III, alpha 1
chr1_-_56817823 4.082 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chrX_+_135079120 4.029 NM_001159704
FHL1
four and a half LIM domains 1
chr1_-_56817802 3.824 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_-_237987509 3.799 COL6A3
collagen, type VI, alpha 3
chr2_-_237987579 3.677 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr17_-_45617899 3.366 COL1A1
collagen, type I, alpha 1
chr7_+_102340579 3.358 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr7_+_93862137 3.081 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr2_-_237987554 3.020 COL6A3
collagen, type VI, alpha 3
chr12_-_90097384 2.950 NM_133503
DCN
decorin
chr12_-_90100710 2.798 DCN
decorin
chr12_-_90100679 2.769 DCN
decorin
chr7_+_93388951 2.681 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chrX_-_135690770 2.664 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr21_-_27261276 2.528 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr12_-_90029328 2.520 LUM
lumican
chr12_-_90029672 2.391 NM_002345
LUM
lumican
chrX_-_114158388 2.105 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr2_-_190635566 2.048 NM_005259
MSTN
myostatin
chr1_+_161305558 2.036 NM_001113381
RGS4
regulator of G-protein signaling 4
chrX_-_135690699 1.972 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_191422346 1.944 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr1_-_151784889 1.935 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr2_-_151052391 1.804 NM_005168
RND3
Rho family GTPase 3
chr1_-_56817568 1.795 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_+_169326641 1.795 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr5_-_111119846 1.794 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr20_+_9146036 1.776 NM_182797
PLCB4
phospholipase C, beta 4
chr1_-_56817717 1.749 PPAP2B
phosphatidic acid phosphatase type 2B
chr7_-_136678815 1.746 PTN
pleiotrophin
chr9_+_74956494 1.720 NM_000700
ANXA1
annexin A1
chr2_-_189752575 1.712 NM_000393
COL5A2
collagen, type V, alpha 2
chrX_+_135079461 1.706 NM_001167819
FHL1
four and a half LIM domains 1
chr16_-_63713382 1.677 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr19_-_48382398 1.669 NM_001130014
NM_002781
PSG5

pregnancy specific beta-1-glycoprotein 5

chr4_+_54790020 1.646 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chrX_+_135058402 1.637 NM_001159700
FHL1
four and a half LIM domains 1
chr7_-_136679045 1.606 NM_002825
PTN
pleiotrophin
chr1_+_154120170 1.599 SYT11
synaptotagmin XI
chr7_-_136678973 1.551 PTN
pleiotrophin
chrX_+_100692071 1.539 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr5_-_121440704 1.539 NM_001178102
LOX
lysyl oxidase
chr3_+_69895310 1.537 NM_001184967
MITF
microphthalmia-associated transcription factor
chr3_+_158637273 1.509 NM_002852
PTX3
pentraxin 3, long
chr19_-_48133089 1.504 NM_002783
PSG7
pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
chr13_-_33148899 1.499 STARD13
StAR-related lipid transfer (START) domain containing 13
chr4_+_169654742 1.470 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr1_+_161305188 1.465 NM_005613
RGS4
regulator of G-protein signaling 4
chr2_-_162808123 1.431 NM_004460
FAP
fibroblast activation protein, alpha
chr2_-_217248967 1.420 IGFBP5
insulin-like growth factor binding protein 5
chr5_-_42847716 1.408 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr19_-_48401532 1.389 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr12_+_118100977 1.388 NM_014365
HSPB8
heat shock 22kDa protein 8
chr2_-_210888010 1.377 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr15_+_72005847 1.365 LOXL1
lysyl oxidase-like 1
chr2_-_37727472 1.364 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr2_-_231697999 1.340 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr8_-_18585721 1.333 PSD3
pleckstrin and Sec7 domain containing 3
chr1_+_160868822 1.330 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr2_-_217268492 1.329 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr1_+_160868932 1.314 DDR2
discoidin domain receptor tyrosine kinase 2
chr1_-_79244948 1.301 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr1_+_100957883 1.297 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr2_+_73973600 1.296 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr12_+_76749199 1.294 NM_014903
NAV3
neuron navigator 3
chr6_+_129245978 1.280 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr2_-_144994349 1.277 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr1_+_169421011 1.274 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr12_+_26239535 1.271 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr15_+_72005875 1.267 LOXL1
lysyl oxidase-like 1
chrX_+_135106578 1.259 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr15_+_72005864 1.254 LOXL1
lysyl oxidase-like 1
chr17_-_44042924 1.250 HOXB7
homeobox B7
chr2_+_73973640 1.248 ACTG2
actin, gamma 2, smooth muscle, enteric
chr17_-_64462976 1.247 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr7_-_136678901 1.244 PTN
pleiotrophin
chr5_-_151046638 1.239 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr4_-_115120251 1.212 NM_024590
ARSJ
arylsulfatase family, member J
chr4_-_158111504 1.208 PDGFC
platelet derived growth factor C
chr12_+_7038240 1.197 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr15_+_72005839 1.190 NM_005576
LOXL1
lysyl oxidase-like 1
chr1_-_149047329 1.185 NM_000396
CTSK
cathepsin K
chr2_-_175578156 1.179 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr6_-_169395847 1.160 THBS2
thrombospondin 2
chr5_-_111121691 1.159 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr8_+_70567581 1.146 NM_001128205
NM_001128206
SULF1

sulfatase 1

chrX_+_100220491 1.144 NM_021637
TMEM35
transmembrane protein 35
chr8_+_70567634 1.136 SULF1
sulfatase 1
chrX_-_10504852 1.123 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr8_+_70541412 1.118 NM_001128204
NM_015170
SULF1

sulfatase 1

chr11_+_113671744 1.118 NM_006169
NNMT
nicotinamide N-methyltransferase
chr4_-_158111995 1.110 NM_016205
PDGFC
platelet derived growth factor C
chr7_+_134226690 1.082 NM_033139
NM_033140
CALD1

caldesmon 1

chr10_+_11087259 1.070 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chrX_-_135691168 1.058 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr22_+_31526801 1.044 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr11_-_102174102 1.030 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chrX_+_149364377 1.010 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr15_+_30721161 1.009 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr7_+_134226727 1.006 CALD1
caldesmon 1
chr11_-_102174032 1.001 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr5_+_32824701 0.995 NM_024563
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr2_-_215967442 0.991 FN1
fibronectin 1
chr16_+_81218074 0.981 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chrX_+_55951280 0.977


chr3_+_69998064 0.975 NM_198177
MITF
microphthalmia-associated transcription factor
chr12_+_26239755 0.973 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr12_+_74160779 0.953 NM_006851
GLIPR1
GLI pathogenesis-related 1
chrX_+_102518764 0.950 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr13_-_32678142 0.948 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_+_194887630 0.947 NM_000186
NM_001014975
CFH

complement factor H

chr13_+_100902942 0.944 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr1_+_39569396 0.937 NM_033044
MACF1
microtubule-actin crosslinking factor 1
chr1_-_68470585 0.925 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr5_+_92944680 0.898 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr19_-_47961653 0.891 NM_001130167
NM_001130168
NM_182707
PSG8


pregnancy specific beta-1-glycoprotein 8


chr3_-_124821868 0.887 MYLK
myosin light chain kinase
chr1_+_161305019 0.876 NM_001102445
RGS4
regulator of G-protein signaling 4
chr21_-_38210531 0.873 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr17_-_44037332 0.873 NM_018952
HOXB6
homeobox B6
chr6_-_169395972 0.869 NM_003247
THBS2
thrombospondin 2
chr8_-_108579270 0.859 NM_001146
ANGPT1
angiopoietin 1
chr6_-_132314004 0.859 NM_001901
CTGF
connective tissue growth factor
chr9_-_87904844 0.849 NM_177937
GOLM1
golgi membrane protein 1
chr12_-_103846186 0.845 NM_032148
SLC41A2
solute carrier family 41, member 2
chr8_+_17478214 0.823 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr1_-_146492471 0.810 NM_015383
NBPF14
NBPF1
neuroblastoma breakpoint family, member 14
neuroblastoma breakpoint family, member 1
chrX_-_135577102 0.808 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr16_-_63713466 0.787 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_-_179380301 0.786 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr8_-_49996353 0.776 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr6_+_123151669 0.767 NM_006714
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr4_+_54790190 0.765 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr1_+_157246305 0.745 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr2_+_207115060 0.737 ADAM23
ADAM metallopeptidase domain 23
chr1_+_201711578 0.736 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr18_-_20106187 0.735 NM_018030
OSBPL1A
oxysterol binding protein-like 1A
chr17_+_29606408 0.734 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr8_-_95343716 0.732 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr4_+_154345039 0.732 NM_015271
TRIM2
tripartite motif containing 2
chr3_+_69895651 0.727 NM_006722
MITF
microphthalmia-associated transcription factor
chr16_-_63713485 0.727 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr4_+_25931745 0.726 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr18_+_8707368 0.718 NM_015210
KIAA0802
KIAA0802
chr12_-_48963505 0.700 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr19_-_48278563 0.691 NM_031246
PSG2
pregnancy specific beta-1-glycoprotein 2
chr6_+_52393763 0.677 NM_001172420
EFHC1
EF-hand domain (C-terminal) containing 1
chr11_+_86189138 0.673 NM_007173
PRSS23
protease, serine, 23
chr17_-_44043361 0.672 NM_004502
HOXB7
homeobox B7
chr8_-_42184194 0.672 PLAT
plasminogen activator, tissue
chr11_+_133444029 0.670 NM_032801
JAM3
junctional adhesion molecule 3
chr6_+_121798443 0.670 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_+_99884018 0.655 NM_017734
PALMD
palmdelphin
chr6_-_131426080 0.654 NM_001135555
NM_001135554
NM_001431
EPB41L2


erythrocyte membrane protein band 4.1-like 2


chr2_-_162638174 0.651 DPP4
dipeptidyl-peptidase 4
chr4_+_25931282 0.650 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr6_-_131426014 0.648 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr5_-_111340421 0.645 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr8_-_95343696 0.644 GEM
GTP binding protein overexpressed in skeletal muscle
chr21_+_46367216 0.642 COL6A2
collagen, type VI, alpha 2
chr4_+_124537334 0.637 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr1_+_85819004 0.636 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr11_+_63060848 0.634 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr7_-_136678999 0.633 PTN
pleiotrophin
chr6_-_128883125 0.626 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr4_+_25931725 0.624 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr9_+_109131814 0.619 RAD23B
RAD23 homolog B (S. cerevisiae)
chr7_-_83662152 0.615 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr14_-_34661387 0.607 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr5_+_140698537 0.606 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr17_-_53335748 0.606 NM_017949
CUEDC1
CUE domain containing 1
chr4_+_25931534 0.604 NM_015874
NM_203284
RBPJ

recombination signal binding protein for immunoglobulin kappa J region

chr11_+_7463175 0.601 NM_198474
OLFML1
olfactomedin-like 1
chr20_-_33489383 0.600 NM_000557
GDF5
growth differentiation factor 5
chr5_-_150517528 0.599 NM_001155
ANXA6
annexin A6
chr1_+_53253204 0.599 SCP2
sterol carrier protein 2
chr2_+_223625105 0.598 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr5_+_155686750 0.598 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr15_+_94677572 0.597 NM_001145157
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr9_-_94284455 0.594 ASPN
asporin
chr12_+_5473558 0.587 NM_002527
NTF3
neurotrophin 3
chr14_-_34660902 0.587 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr6_+_134251940 0.581 NM_198392
NM_003206
TCF21

transcription factor 21

chr15_-_88150823 0.579 ANPEP
alanyl (membrane) aminopeptidase
chr1_-_143786993 0.579 NM_022359
PDE4DIP
phosphodiesterase 4D interacting protein
chr5_-_95184221 0.579 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr6_+_123152044 0.578 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr5_+_32747194 0.578 NM_000908
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr2_-_210876560 0.577 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr9_+_111927601 0.575 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr1_+_181380837 0.574 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr9_-_13240313 0.570 NM_003829
MPDZ
multiple PDZ domain protein
chr1_+_53253161 0.565 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr1_-_17179694 0.562 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr10_+_111755715 0.559 NM_019903
ADD3
adducin 3 (gamma)
chr5_+_96237399 0.547 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.58 1.40e-02 GO:0007155 cell adhesion
1.58 1.40e-02 GO:0022610 biological adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 8.99e-04 GO:0005576 extracellular region
3.98 2.97e-03 GO:0005581 collagen
1.90 6.27e-03 GO:0005578 proteinaceous extracellular matrix
6.42 8.75e-03 GO:0005583 fibrillar collagen
1.83 1.26e-02 GO:0015629 actin cytoskeleton
1.77 1.35e-02 GO:0031012 extracellular matrix

Nothing significant found in function category.